RGD Reference Report - Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. - Rat Genome Database

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Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens.

Authors: Tukey, DS  Lee, M  Xu, D  Eberle, SE  Goffer, Y  Manders, TR  Ziff, EB  Wang, J 
Citation: Tukey DS, etal., Mol Brain. 2013 Jul 9;6:32. doi: 10.1186/1756-6606-6-32.
RGD ID: 9999206
Pubmed: PMID:23835161   (View Abstract at PubMed)
PMCID: PMC3710235   (View Article at PubMed Central)
DOI: DOI:10.1186/1756-6606-6-32   (Journal Full-text)

BACKGROUND: Pain and natural rewards such as food elicit different behavioral effects. Both pain and rewards, however, have been shown to alter synaptic activities in the nucleus accumbens (NAc), a key component of the brain reward system. Mechanisms by which external stimuli regulate plasticity at NAc synapses are largely unexplored. Medium spiny neurons (MSNs) from the NAc receive excitatory glutamatergic inputs and modulatory dopaminergic and cholinergic inputs from a variety of cortical and subcortical structures. Glutamate inputs to the NAc arise primarily from prefrontal cortex, thalamus, amygdala, and hippocampus, and different glutamate projections provide distinct synaptic and ultimately behavioral functions. The family of vesicular glutamate transporters (VGLUTs 1-3) plays a key role in the uploading of glutamate into synaptic vesicles. VGLUT1-3 isoforms have distinct expression patterns in the brain, but the effects of external stimuli on their expression patterns have not been studied. RESULTS: In this study, we use a sucrose self-administration paradigm for natural rewards, and spared nerve injury (SNI) model for chronic pain. We examine the levels of VGLUTs (1-3) in synaptoneurosomes of the NAc in these two behavioral models. We find that chronic pain leads to a decrease of VGLUT1, likely reflecting decreased projections from the cortex. Pain also decreases VGLUT3 levels, likely representing a decrease in projections from GABAergic, serotonergic, and/or cholinergic interneurons. In contrast, chronic consumption of sucrose increases VGLUT3 in the NAc, possibly reflecting an increase from these interneuron projections. CONCLUSION: Our study shows that natural rewards and pain have distinct effects on the VGLUT expression pattern in the NAc, indicating that glutamate inputs to the NAc are differentially modulated by rewards and pain.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC17A7Humansciatic neuropathy  ISOSlc17a7 (Rattus norvegicus)protein:decreased expression:nucleus accumbensRGD 
SLC17A8Humansciatic neuropathy  ISOSlc17a8 (Rattus norvegicus)protein:decreased expression:nucleus accumbensRGD 
Slc17a7Ratsciatic neuropathy  IEP protein:decreased expression:nucleus accumbensRGD 
Slc17a7Mousesciatic neuropathy  ISOSlc17a7 (Rattus norvegicus)protein:decreased expression:nucleus accumbensRGD 
Slc17a8Ratsciatic neuropathy  IEP protein:decreased expression:nucleus accumbensRGD 
Slc17a8Mousesciatic neuropathy  ISOSlc17a8 (Rattus norvegicus)protein:decreased expression:nucleus accumbensRGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a7  (solute carrier family 17 member 7)
Slc17a8  (solute carrier family 17 member 8)

Genes (Mus musculus)
Slc17a7  (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7)
Slc17a8  (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)

Genes (Homo sapiens)
SLC17A7  (solute carrier family 17 member 7)
SLC17A8  (solute carrier family 17 member 8)

Additional Information