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The auditory system has exquisitely intricate mechanisms that convert mechanical stimuli - mechanotransduction, intro electrical signals that are processed by the brain and account for the perception of sound, gravity and movement. The inner ear - a fluid-filled organ, contains the shell-shaped cochlea and the vestibule responsible for sound and for gravitation and movement mechanotransduction, respectively. Within the cochlea, the organ of Corti (OC) contains the hair cells - specialized sens

Pathway Diagram:

Elsevier Inc. PIP2 auditory perception processing Slc17a8 ribbon synapse amplification outer hair cell (OHC) - three rows K+ Ca2+ glutamate superior olivary complex Otof various, non-sensory, supporting cell outer hair cell (OHC) - three rows --+> SGN type II Myo7a ---- Ush1c Espn ---- Myo3a Myo1c MET channel Espn Myo3a Pcdh15 ---- Ush1c Cdh23 ---- Pcdh15 Cdh23 ---- Ush1c Dfnb31 Myo15a Cdh23 Pcdh15 Gpr98 Myo1c ---- PIP2 Pls1 Actb Pls3 Ush2a central nervous system SGN type I ribbon synapse --+> SGN type I SGN type II superior olivary complex ---| outer hair cell (OHC) - three rows Myo6 Myo6 ---- Otof Ptprq Ush1c Ush1c ---- Ush1g Ush1g Myo7a Myo7a ---- Ush1g Cdh23 ---- Myo1c Actg1

Genes in Pathway:

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auditory mechanotransduction pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 12 13,715,843 13,718,813 RGD:8547669
G Adgrv1 adhesion G protein-coupled receptor V1 JBrowse link 2 8,926,843 9,504,455 RGD:8547669
G Cdh23 cadherin-related 23 JBrowse link 20 29,857,018 30,263,758 RGD:8547667
G Espn espin JBrowse link 5 169,293,356 169,331,338 RGD:8547667
G Myo15a myosin XVA JBrowse link 10 46,840,098 46,897,362 RGD:8547667
G Myo1c myosin 1C JBrowse link 10 63,803,311 63,819,614 RGD:8547667
G Myo3a myosin IIIA JBrowse link 17 88,952,635 89,167,538 RGD:8547667
G Myo6 myosin VI JBrowse link 8 87,583,649 87,731,271 RGD:8547669
G Myo7a myosin VIIA JBrowse link 1 163,001,313 163,071,545 RGD:8547667
G Otof otoferlin JBrowse link 6 27,328,343 27,424,864 RGD:8547672
G Pcdh15 protocadherin related 15 JBrowse link 20 14,952,213 15,334,745 RGD:8547667
G Pls1 plastin 1 JBrowse link 8 103,557,361 103,659,625 RGD:8547669
G Pls3 plastin 3 JBrowse link X 119,030,311 119,124,268 RGD:8547669
G Ptprq protein tyrosine phosphatase, receptor type, Q JBrowse link 7 49,763,657 50,034,932 RGD:8547669
G Slc17a8 solute carrier family 17 member 8 JBrowse link 7 30,215,231 30,274,993 RGD:8547672
G Ush1c USH1 protein network component harmonin JBrowse link 1 102,207,096 102,256,779 RGD:8547667
G Ush1g USH1 protein network component sans JBrowse link 10 103,866,566 103,873,416 RGD:8547671
G Ush2a usherin JBrowse link 13 106,750,738 107,434,195 RGD:8547669
G Whrn whirlin JBrowse link 5 79,235,541 79,317,206 RGD:8547667

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the auditory mechanotransduction pathway
Phenotype Annotations Associated with Genes in the auditory mechanotransduction pathway

References Associated with the auditory mechanotransduction pathway:

Ontology Path Diagram:

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