RGD Reference Report - Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats.

Authors: Yang, CQ  Wei, YY  Leng, YX  Zhong, CJ  Zhang, YS  Wan, Y  Duan, LP 
Citation: Yang CQ, etal., Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.
RGD ID: 9999169
Pubmed: PMID:22160634   (View Abstract at PubMed)
DOI: DOI:10.1007/s10620-011-1970-x   (Journal Full-text)

BACKGROUND: According to a recent study, vesicular glutamate transporter-3 (VGLUT3) contributes to injury-induced mechanical hyperalgesia in mice. AIMS: The aims of the study were to investigate whether VGLUT3 is involved in visceral pain, and whether transient intestinal infection or acute cold restraint stress (ACRS) affects VGLUT3 expression levels in rats. METHODS: Changes in VGLUT3 and c-Fos proteins were evaluated in rats which received noxious colorectal distension (CRD) stimulation. Transient intestinal infection was effected by oral administration of Trichinella spiralis (T. spiralis) larvae in Brown Norway rats. On the 100th day post-infection (PI), half of the PI-rats and non infected controls were subjected to an ACRS procedure. The visceromotor response to CRD was measured using the abdominal withdrawal reflex (AWR) score. Immunofluorescence and western blot analysis were used to estimate the expression of VGLUT3 in both peripheral and central neurons. RESULTS: Noxious stimulation induced a significant increase in the expression of VGLUT3 in the L6S1 spinal dorsal horn. Compared with the control group, the pain threshold was significantly decreased in the ACRS, PI, and PI + ACRS groups. VGLUT3 expression in the L6S1 dorsal root ganglion (DRG) and spinal neurons were significantly increased in PI and PI + ACRS groups as compared with the control group. CONCLUSIONS: VGLUT3 is involved in conduction of visceral pain sensation and in visceral hyperalgesia induced by Trichinella spiralis infection in rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FOSHumanHyperalgesia  ISOFos (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and neuronRGD 
FosRatHyperalgesia  IEP protein:increased expression:dorsal horn of spinal cord and neuronRGD 
FosMouseHyperalgesia  ISOFos (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and neuronRGD 
SLC17A8HumanHyperalgesia  ISOSlc17a8 (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and neuronRGD 
Slc17a8RatHyperalgesia  IEP protein:increased expression:dorsal horn of spinal cord and neuronRGD 
Slc17a8MouseHyperalgesia  ISOSlc17a8 (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and neuronRGD 
SLC17A8Humantrichinosis  ISOSlc17a8 (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and dorsal root ganglionRGD 
Slc17a8Rattrichinosis  IEP protein:increased expression:dorsal horn of spinal cord and dorsal root ganglionRGD 
Slc17a8Mousetrichinosis  ISOSlc17a8 (Rattus norvegicus)protein:increased expression:dorsal horn of spinal cord and dorsal root ganglionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fos  (Fos proto-oncogene, AP-1 transcription factor subunit)
Slc17a8  (solute carrier family 17 member 8)

Genes (Mus musculus)
Fos  (FBJ osteosarcoma oncogene)
Slc17a8  (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)

Genes (Homo sapiens)
FOS  (Fos proto-oncogene, AP-1 transcription factor subunit)
SLC17A8  (solute carrier family 17 member 8)


Additional Information