FOS (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: FOS (Fos proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
Analyze
Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 735729
HGNC Page HGNC:3796
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cell surface receptor protein serine/threonine kinase signaling pathway; cellular response to reactive oxygen species; and positive regulation of DNA-templated transcription. Located in nucleoplasm. Part of protein-DNA complex and transcription factor AP-1 complex. Biomarker of several diseases, including Pick's disease; carcinoma (multiple); hypospadias; intestinal benign neoplasm (multiple); and nicotine dependence.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; p55; proto-oncogene c-Fos; transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,283,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 79 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanAberrant Crypt Foci treatmentISOFos (Rattus norvegicus)13432056 RGD 
FOSHumanAberrant Crypt Foci  ISOFos (Rattus norvegicus)13210754mRNA more ...RGD 
FOSHumanacute myocardial infarction treatmentISOFos (Rattus norvegicus)405650598 RGD 
FOSHumanalcohol dependence treatmentISOFos (Rattus norvegicus)405295497 RGD 
FOSHumanalcohol dependence  ISOFos (Rattus norvegicus)405101697protein:increased expression:granular insular cortex more ...RGD 
FOSHumanalcohol dependence treatmentISOFos (Rattus norvegicus)405100722 RGD 
FOSHumanalcohol dependence  ISOFos (Rattus norvegicus)405100958 RGD 
FOSHumanalcohol use disorder treatmentISOFos (Rattus norvegicus)405295495 RGD 
FOSHumanalcohol use disorder  ISOFos (Mus musculus)405255652protein:increased expression:parvocellular oculomotor nucleus RGD 
FOSHumanalcohol use disorder  ISOFos (Rattus norvegicus)405255650protein:increased expression:brainRGD 
FOSHumanalcohol withdrawal syndrome treatmentISOFos (Rattus norvegicus)405255665 RGD 
FOSHumanalcohol withdrawal syndrome  ISOFos (Rattus norvegicus)405101372protein:altered expression:brainRGD 
FOSHumanAlcohol-Related Disorders  ISOFos (Rattus norvegicus)405101375protein:increased expression:liverRGD 
FOSHumanAlcoholic Intoxication  ISOFos (Rattus norvegicus)405255666mRNA:decreased expression:adrenal glandRGD 
FOSHumanAlcoholic Intoxication  ISOFos (Rattus norvegicus)405101372protein:altered expression:brainRGD 
FOSHumanamphetamine abuse  ISOFos (Mus musculus)405100720mRNA:increased expression:nucleus accumbensRGD 
FOSHumanamphetamine abuse  ISOFos (Rattus norvegicus)405255667protein:increased expression:nucleus accumbens and striatumRGD 
FOSHumanautosomal dominant polycystic kidney disease  IEP 7242198protein: increased expression: kidneyRGD 
FOSHumanBinge Drinking  ISOFos (Rattus norvegicus)405295494protein:increased expression:prefrontal cortexRGD 
FOSHumanBrain Hypoxia-Ischemia  ISOFos (Rattus norvegicus)405650622protein:decreased expression:hippocampusRGD 
1 to 20 of 79 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanintellectual disability  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and mildClinVar 
1 to 20 of 30 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanamphetamine abuse  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19689456
FOSHumanamyotrophic lateral sclerosis type 1  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:11796754
FOSHumanAnimal Disease Models  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
FOSHumananxiety disorder  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16488545
FOSHumanBrain Injuries  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:9630518
FOSHumanBreast Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16298037
FOSHumanCocaine-Related Disorders  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17276011 more ...
FOSHumanendometriosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23284138
FOSHumanepilepsy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15973680
FOSHumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
FOSHumanextrahepatic cholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
FOSHumanFibrous Dysplasia of Bone  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:7739708
FOSHumanHeat Stroke  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039931
FOSHumanHemorrhage  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:7844257
FOSHumanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:9029167 and PMID:28284560
FOSHumanHyperalgesia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
FOSHumanHyperkinesis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18355967
FOSHumanhypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:12044476 and PMID:24039778
FOSHumanjuvenile rheumatoid arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
FOSHumanLung Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16289808
1 to 20 of 30 rows

1 to 20 of 1576 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHuman(+)-catechin decreases expressionEXP 6480464Catechin results in decreased expression of FOS mRNACTDPMID:23706674
FOSHuman(+)-pilocarpine multiple interactionsISOFos (Rattus norvegicus)6480464[Pilocarpine co-treated with 2 more ...CTDPMID:7968354 more ...
FOSHuman(+)-pilocarpine decreases expressionISOFos (Rattus norvegicus)6480464Pilocarpine results in decreased expression of FOS mRNACTDPMID:17971868
FOSHuman(+)-pilocarpine increases expressionISOFos (Rattus norvegicus)6480464Pilocarpine results in increased expression of FOS mRNA and Pilocarpine results in increased expression of FOS proteinCTDPMID:17971868 more ...
FOSHuman(+)-Pimaric acid multiple interactionsEXP 6480464pimaric acid inhibits the reaction [JUN protein results in increased expression of FOS protein modified form] and pimaric acid inhibits the reaction [TNF protein results in increased expression of FOS protein]CTDPMID:22705379
FOSHuman(+)-taxifolin multiple interactionsISOFos (Rattus norvegicus)6480464taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]CTDPMID:32828744
FOSHuman(+)-Tetrandrine multiple interactionsISOFos (Rattus norvegicus)6480464tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]CTDPMID:10072926
FOSHuman(-)-alpha-phellandrene increases expressionEXP 6480464alpha phellandrene results in increased expression of FOS mRNACTDPMID:25075043
FOSHuman(-)-anisomycin increases expressionEXP 6480464Anisomycin results in increased expression of FOS mRNACTDPMID:12660819 and PMID:18241849
FOSHuman(-)-citrinin increases expressionEXP 6480464Citrinin results in increased expression of FOS mRNA and Citrinin results in increased expression of FOS proteinCTDPMID:19361540
FOSHuman(-)-citrinin multiple interactionsEXP 6480464U 0126 inhibits the reaction [Citrinin results in increased expression of FOS protein]CTDPMID:19361540
FOSHuman(-)-demecolcine increases expressionEXP 6480464Demecolcine results in increased expression of FOS mRNACTDPMID:23649840
FOSHuman(-)-ephedrine increases expressionEXP 6480464Ephedrine results in increased expression of FOS mRNACTDPMID:12730611
FOSHuman(-)-epigallocatechin 3-gallate decreases activityEXP 6480464epigallocatechin gallate results in decreased activity of FOS proteinCTDPMID:12663506
FOSHuman(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOS mRNACTDPMID:22079256
FOSHuman(-)-selegiline multiple interactionsEXP 6480464Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA]CTDPMID:14724376
FOSHuman(20R)-protopanaxadiol multiple interactionsISOFos (Mus musculus)6480464protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of FOS protein]CTDPMID:29133030
FOSHuman(20S)-ginsenoside Rh1 increases expressionEXP 6480464ginsenoside Rh1 results in increased expression of FOS mRNACTDPMID:16204943
FOSHuman(E)-roxithromycin increases expressionEXP 6480464Roxithromycin results in increased expression of FOS mRNA and Roxithromycin results in increased expression of FOS proteinCTDPMID:32454074
FOSHuman(R)-lipoic acid multiple interactionsISOFos (Rattus norvegicus)6480464[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNACTDPMID:31068541

1 to 20 of 1576 rows

Biological Process
1 to 20 of 99 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumancellular response to calcium ion acts_upstream_of_or_withinIEAUniProtKB:P01101 and ensembl:ENSMUSP00000021674150520179 EnsemblGO_REF:0000107
FOSHumancellular response to epidermal growth factor stimulus involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to epidermal growth factor stimulus  ISOFos (Rattus norvegicus)9068941 RGDPMID:8603605 and REF_RGD_ID:151665808
FOSHumancellular response to hormone stimulus  ISOFos (Rattus norvegicus)9068941 RGDPMID:11460264 and REF_RGD_ID:2293788
FOSHumancellular response to hormone stimulus involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to hypoxia involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to hypoxia  ISOFos (Rattus norvegicus)9068941 RGDPMID:8593588 and REF_RGD_ID:151347626
FOSHumancellular response to parathyroid hormone stimulus involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to parathyroid hormone stimulus  ISOFos (Rattus norvegicus)9068941 RGDPMID:8603605 and REF_RGD_ID:151665808
FOSHumancellular response to phorbol 13-acetate 12-myristate involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to phorbol 13-acetate 12-myristate  ISOFos (Rattus norvegicus)9068941 RGDPMID:8603605 and REF_RGD_ID:151665808
FOSHumancellular response to prolactin involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to prolactin  ISOFos (Rattus norvegicus)9068941 RGDPMID:8584023 and REF_RGD_ID:150524325
FOSHumancellular response to reactive oxygen species involved_inIDA 150520179 PMID:17217916BHF-UCLPMID:17217916
FOSHumancellular response to transforming growth factor beta stimulus involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to transforming growth factor beta stimulus  ISOFos (Rattus norvegicus)9068941 RGDPMID:23110133 and REF_RGD_ID:151665477
FOSHumancellular response to tumor necrosis factor involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to tumor necrosis factor  ISOFos (Rattus norvegicus)9068941 RGDPMID:23110133 and REF_RGD_ID:151665477
FOSHumancellular response to zinc ion starvation involved_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumancellular response to zinc ion starvation  ISOFos (Rattus norvegicus)9068941 RGDPMID:21893222 and REF_RGD_ID:151667428
1 to 20 of 99 rows

Cellular Component
1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanchromatin located_inISAtfclass:1.1.2150520179 NTNU_SBGO_REF:0000113
FOSHumancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
FOSHumancytoplasm part_ofIEAUniProtKB:P01101 and ensembl:ENSMUSP00000021674150520179 EnsemblGO_REF:0000107
FOSHumancytosol located_inIEAUniProtKB-SubCell:SL-0091150520179 UniProtGO_REF:0000044
FOSHumanendoplasmic reticulum  ISOFos (Rattus norvegicus)9068941 RGDPMID:32385110 and REF_RGD_ID:405649740
FOSHumanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
FOSHumanendoplasmic reticulum located_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumanendoplasmic reticulum part_ofIEAUniProtKB:P01101 and ensembl:ENSMUSP00000021674150520179 EnsemblGO_REF:0000107
FOSHumanendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-0095150520179 UniProtGO_REF:0000044
FOSHumannuclear matrix  ISOFos (Rattus norvegicus)9068941 RGDPMID:20053986 and REF_RGD_ID:405650597
FOSHumannuclear matrix located_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumannucleoplasm  ISOFos (Rattus norvegicus)9068941 RGDPMID:20053986 and REF_RGD_ID:405650597
FOSHumannucleoplasm located_inIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-3222533 more ...
FOSHumannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
FOSHumannucleus located_inIEAUniProtKB:P01101 more ...150520179 EnsemblGO_REF:0000107
FOSHumannucleus located_inNAS 150520179 PMID:20102225 and PMID:23661758ComplexPortalPMID:20102225 and PMID:23661758
FOSHumannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
FOSHumannucleus located_inTAS 150520179 PMID:9443941PINCPMID:9443941
FOSHumannucleus located_inIDA 150520179 PMID:12370307 more ...ComplexPortalPMID:12370307 more ...
1 to 20 of 29 rows

Molecular Function
1 to 20 of 53 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanchromatin binding enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP00000021674150520179 EnsemblGO_REF:0000107
FOSHumanDNA binding enablesIEAUniProtKB:P01101 more ...150520179 EnsemblGO_REF:0000107
FOSHumanDNA binding enablesIEAInterPro:IPR000837150520179 InterProGO_REF:0000002
FOSHumanDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
FOSHumanDNA binding  ISOFos (Rattus norvegicus)9068941 RGDPMID:2105492 and REF_RGD_ID:1298921
FOSHumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 150520179 PMID:30670568BHF-UCLPMID:30670568
FOSHumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P01101 and ensembl:ENSMUSP00000021674150520179 EnsemblGO_REF:0000107
FOSHumanDNA-binding transcription factor activity enablesIDA 150520179 PMID:9732876BHF-UCLPMID:9732876
FOSHumanDNA-binding transcription factor activity enablesIEAInterPro:IPR000837 more ...150520179 InterProGO_REF:0000002
FOSHumanDNA-binding transcription factor activity enablesIMP 150520179 PMID:10704222CAFAPMID:10704222
FOSHumanDNA-binding transcription factor activity enablesIEAUniProtKB:P01101 more ...150520179 EnsemblGO_REF:0000107
FOSHumanDNA-binding transcription factor activity  ISOFos (Rattus norvegicus)9068941 RGDPMID:10830307 and REF_RGD_ID:1626699
FOSHumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesISAtfclass:1.1.2150520179 NTNU_SBGO_REF:0000113
FOSHumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0001297 more ...150520179 GO_CentralGO_REF:0000033
FOSHumandouble-stranded DNA binding  ISOFos (Rattus norvegicus)9068941 RGDPMID:10830307 more ...
FOSHumandouble-stranded DNA binding enablesIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumanidentical protein binding enablesIPIUniProtKB:P01100150520179 PMID:23661758 and PMID:25609649IntActPMID:23661758 and PMID:25609649
FOSHumanpromoter-specific chromatin binding  ISOFos (Rattus norvegicus)9068941mRNA:decreased expression:hippocampusRGDPMID:29330744 and REF_RGD_ID:405650592
FOSHumanpromoter-specific chromatin binding enablesIEAUniProtKB:P12841 and ensembl:ENSRNOP00000010712150520179 EnsemblGO_REF:0000107
FOSHumanprotein binding enablesIPIUniProtKB:O14744 more ...150520179 PMID:32814053IntActPMID:32814053
1 to 20 of 53 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanB cell receptor signaling pathway  IEA 6907045 KEGGhsa:04662
FOSHumanChagas disease pathway  IEA 6907045 KEGGhsa:05142
FOSHumancolorectal cancer pathway   IEA 6907045 KEGGhsa:05210
FOSHumanLeishmaniasis pathway  IEA 6907045 KEGGhsa:05140
FOSHumanmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGhsa:04010
FOSHumanrheumatoid arthritis pathway  IEA 6907045 KEGGhsa:05323
FOSHumanT cell receptor signaling pathway  IEA 6907045 KEGGhsa:04660
FOSHumanToll-like receptor signaling pathway   IEA 6907045 KEGGhsa:04620

Imported Annotations - PID (archival)

1 to 11 of 11 rows
1 to 11 of 11 rows
1 to 20 of 37 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanAbnormal facial shape  IAGP 8699517 HPOORPHA:528
FOSHumanAcanthosis nigricans  IAGP 8699517 HPOORPHA:528
FOSHumanAccelerated skeletal maturation  IAGP 8699517 HPOORPHA:528
FOSHumanAdipose tissue loss  IAGP 8699517 HPOORPHA:528
FOSHumanAmenorrhea  IAGP 8699517 HPOORPHA:528
FOSHumanBone cyst  IAGP 8699517 HPOORPHA:528
FOSHumanCirrhosis  IAGP 8699517 HPOORPHA:528
FOSHumanClitoral hypertrophy  IAGP 8699517 HPOORPHA:528
FOSHumanCongestive heart failure  IAGP 8699517 HPOORPHA:528
FOSHumanDiabetes mellitus  IAGP 8699517 HPOORPHA:528
FOSHumanFailure to thrive  IAGP 8699517 HPOORPHA:528
FOSHumanGlobal developmental delay  IAGP 8699517 HPOORPHA:528
FOSHumanHepatic steatosis  IAGP 8699517 HPOORPHA:528
FOSHumanHepatomegaly  IAGP 8699517 HPOORPHA:528
FOSHumanHypercholesterolemia  IAGP 8699517 HPOORPHA:528
FOSHumanHyperinsulinemia  IAGP 8699517 HPOORPHA:528
FOSHumanHypertrichosis  IAGP 8699517 HPOORPHA:528
FOSHumanHypertriglyceridemia  IAGP 8699517 HPOORPHA:528
FOSHumanHypertrophic cardiomyopathy  IAGP 8699517 HPOORPHA:528
FOSHumanIncreased C-peptide level  IAGP 8699517 HPOORPHA:528
1 to 20 of 37 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FOSHumanIntellectual disability, mild  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and mildClinVar 

1 to 20 of 83 rows
#
Reference Title
Reference Citation
1. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation. Aguilar-Valles A, etal., Biol Psychiatry. 2014 Jul 1;76(1):57-65. doi: 10.1016/j.biopsych.2013.09.014. Epub 2013 Oct 31.
2. The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression. Akdağ MZ, etal., Electromagn Biol Med. 2023 Apr 3;42(2):81-97. doi: 10.1080/15368378.2023.2247027. Epub 2023 Aug 20.
3. Swim-stress but not opioid withdrawal increases expression of c-fos immunoreactivity in rat periaqueductal gray neurons which project to the rostral ventromedial medulla. Bellchambers CE, etal., Neuroscience. 1998 Mar;83(2):517-24. doi: 10.1016/s0306-4522(97)00399-0.
4. Temporal and regional expression of Fos-related proteins in response to ischemic injury. Butler TL and Pennypacker KR, Brain Res Bull. 2004 Mar 1;63(1):65-73.
5. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Chae Y, etal., Neurosci Lett. 2004 Mar 25;358(2):87-90. doi: 10.1016/j.neulet.2003.12.121.
6. Conditioned response evoked by nicotine conditioned stimulus preferentially induces c-Fos expression in medial regions of caudate-putamen. Charntikov S, etal., Neuropsychopharmacology. 2012 Mar;37(4):876-84. doi: 10.1038/npp.2011.263. Epub 2011 Nov 2.
7. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
8. An integrated network analysis, RNA-seq and in vivo validation approaches to explore the protective mechanism of Mongolian medicine formulae Ruda-6 against indomethacin-induced gastric ulcer in rats. Feng L, etal., Front Pharmacol. 2023 Aug 10;14:1181133. doi: 10.3389/fphar.2023.1181133. eCollection 2023.
9. Anxiety during alcohol withdrawal involves 5-HT2C receptors and M-channels in the lateral habenula. Fu R, etal., Neuropharmacology. 2020 Feb;163:107863. doi: 10.1016/j.neuropharm.2019.107863. Epub 2019 Nov 26.
10. Protective effects of acetaminophen on ibuprofen-induced gastric mucosal damage in rats with associated suppression of matrix metalloproteinase. Fukushima E, etal., J Pharmacol Exp Ther. 2014 Apr;349(1):165-73. doi: 10.1124/jpet.113.210021. Epub 2014 Feb 4.
11. Heterogeneous neuronal activity in the lateral habenula after short- and long-term cocaine self-administration in rats. Gao P, etal., Eur J Neurosci. 2018 Jan;47(1):83-94. doi: 10.1111/ejn.13780. Epub 2017 Dec 8.
12. MiR-101a-3p Attenuated Pilocarpine-Induced Epilepsy by Downregulating c-FOS. Geng J, etal., Neurochem Res. 2021 May;46(5):1119-1128. doi: 10.1007/s11064-021-03245-w. Epub 2021 Feb 9.
13. Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved. Georges F, etal., Eur J Neurosci. 2000 Dec;12(12):4475-86. doi: 10.1046/j.0953-816x.2000.01334.x.
14. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
15. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
16. The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Hamlin AS, etal., Neuroscience. 2007 May 11;146(2):525-36. doi: 10.1016/j.neuroscience.2007.01.063. Epub 2007 Mar 23.
17. Relapse to cocaine-seeking increases activity-regulated gene expression differentially in the striatum and cerebral cortex of rats following short or long periods of abstinence. Hearing MC, etal., Brain Struct Funct. 2008 Sep;213(1-2):215-27. doi: 10.1007/s00429-008-0182-4. Epub 2008 May 17.
18. Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. Huan SK, etal., Molecules. 2012 May 25;17(6):6277-89. doi: 10.3390/molecules17066277.
19. Molecular changes consistent with increased proliferation and invasion are common in rectal cancer. Hughes R, etal., Clin Transl Oncol. 2011 Oct;13(10):753-9. doi: 10.1007/s12094-011-0728-4.
20. N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats. Jawed H, etal., Mol Cell Biochem. 2014 Feb;387(1-2):81-90. doi: 10.1007/s11010-013-1873-6. Epub 2013 Nov 2.
1 to 20 of 83 rows
1 to 10 of 44 rows
PMID:1406655   PMID:1545828   PMID:1589769   PMID:1631061   PMID:1658710   PMID:1827203   PMID:1828107   PMID:1903538   PMID:2414012   PMID:2511004   PMID:2516827   PMID:3027573  
PMID:3555978   PMID:3817017   PMID:6574479   PMID:7540136   PMID:7623830   PMID:7642615   PMID:7665092   PMID:7685215   PMID:7713192   PMID:7816143   PMID:7816602   PMID:7957556  
PMID:7962462   PMID:7994752   PMID:8065335   PMID:8108109   PMID:8151786   PMID:8248197   PMID:8380166   PMID:8397339   PMID:8440710   PMID:8475068   PMID:8480425   PMID:8524278  
PMID:8557686   PMID:8570175   PMID:8617242   PMID:8621941   PMID:8628277   PMID:8710853   PMID:8737385   PMID:8763994   PMID:8816797   PMID:8816798   PMID:8904195   PMID:8971979  
PMID:9057648   PMID:9121455   PMID:9129988   PMID:9130707   PMID:9160889   PMID:9207128   PMID:9334186   PMID:9346889   PMID:9443941   PMID:9468519   PMID:9488446   PMID:9510247  
PMID:9545246   PMID:9642216   PMID:9671405   PMID:9681824   PMID:9685505   PMID:9732876   PMID:9792677   PMID:9872330   PMID:9888853   PMID:9918847   PMID:10027715   PMID:10330159  
PMID:10388555   PMID:10487758   PMID:10488148   PMID:10497212   PMID:10508860   PMID:10523647   PMID:10567390   PMID:10567391   PMID:10581001   PMID:10704222   PMID:10764760   PMID:10777532  
PMID:10799874   PMID:10847592   PMID:10918580   PMID:10986283   PMID:11053448   PMID:11090181   PMID:11134330   PMID:11260070   PMID:11274169   PMID:11278640   PMID:11287611   PMID:11397794  
PMID:11397816   PMID:11431474   PMID:11641401   PMID:11782371   PMID:11846562   PMID:11891317   PMID:11909859   PMID:11983170   PMID:12052862   PMID:12082260   PMID:12127989   PMID:12147741  
PMID:12183893   PMID:12193410   PMID:12370307   PMID:12419805   PMID:12445807   PMID:12446585   PMID:12477932   PMID:12508121   PMID:12547826   PMID:12592382   PMID:12600988   PMID:12687275  
1 to 10 of 44 rows



FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,283,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in FOS
32 total Variants

1 to 10 of 53 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1 copy number loss See cases [RCV000051548] Chr14:73877072..78042422 [GRCh38]
Chr14:74343775..78508765 [GRCh37]
Chr14:73413528..77578518 [NCBI36]
Chr14:14q24.3		 pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2		 pathogenic
GRCh37/hg19 14q24.2-q24.3(chr14:73152115..77698582) deletion Intellectual disability, mild [RCV000190520] Chr14:73152115..77698582 [GRCh37]
Chr14:14q24.2-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1		 pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3(chr14:74986195-76399258)x1 copy number loss See cases [RCV000137114] Chr14:74986195..76399258 [GRCh38]
Chr14:75452898..76865601 [GRCh37]
Chr14:74522651..75935354 [NCBI36]
Chr14:14q24.3		 uncertain significance
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1 copy number loss See cases [RCV000143265] Chr14:73343213..78835059 [GRCh38]
Chr14:73809921..79301402 [GRCh37]
Chr14:72879674..78371155 [NCBI36]
Chr14:14q24.3-31.1		 pathogenic|likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
1 to 10 of 53 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR139hsa-miR-139-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23001723
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133651
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA19133651
MIR181A2hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956783
MIR222hsa-miR-222-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
MIR222hsa-miR-222-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23400877
MIR222hsa-miR-222-3pMirecordsexternal_infoNANA20299489
MIR222hsa-miR-222-3pOncomiRDBexternal_infoNANA23400877
MIR181A1hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956783
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133651
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA19133651
MIR221hsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
MIR221hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23400877
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA23400877
MIR221hsa-miR-221-5pMirecordsexternal_infoNANA20299489

Predicted Target Of
Summary Value
Count of predictions:2433
Count of miRNA genes:888
Interacting mature miRNAs:1082
Transcripts:ENST00000303562, ENST00000535987, ENST00000554212, ENST00000554617, ENST00000555242, ENST00000555347, ENST00000555672, ENST00000555686, ENST00000556324, ENST00000557139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597457385GWAS1553459_Hinflammatory bowel disease QTL GWAS1553459 (human)2e-13inflammatory bowel disease147527944175279442Human

Fos  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,689 - 75,748,849UniSTSGRCh37
GRCh371475,748,724 - 75,748,897UniSTSGRCh37
Build 361474,818,477 - 74,818,650RGDNCBI36
Celera1455,786,775 - 55,786,935UniSTS
Celera1455,786,810 - 55,786,983RGD
HuRef1455,917,132 - 55,917,292UniSTS
HuRef1455,917,167 - 55,917,340UniSTS
GDB:199085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,191 - 75,747,609UniSTSGRCh37
Build 361474,816,944 - 74,817,362RGDNCBI36
Celera1455,785,277 - 55,785,695RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,634 - 55,916,052UniSTS
GDB:201707  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,189 - 75,747,469UniSTSGRCh37
Build 361474,816,942 - 74,817,222RGDNCBI36
Celera1455,785,275 - 55,785,555RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,632 - 55,915,912UniSTS
STS-V01512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,155 - 75,748,346UniSTSGRCh37
Build 361474,817,908 - 74,818,099RGDNCBI36
Celera1455,786,241 - 55,786,432RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,598 - 55,916,789UniSTS
GeneMap99-GB4 RH Map14201.19UniSTS
PMC126057P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,163 - 75,745,363UniSTSGRCh37
Build 361474,814,916 - 74,815,116RGDNCBI36
Celera1455,783,249 - 55,783,449RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,606 - 55,913,806UniSTS
PMC135937P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,746,767 - 75,747,627UniSTSGRCh37
Build 361474,816,520 - 74,817,380RGDNCBI36
Celera1455,784,853 - 55,785,713RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,210 - 55,916,070UniSTS
PMC139817P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,144 - 75,745,281UniSTSGRCh37
Build 361474,814,897 - 74,815,034RGDNCBI36
Celera1455,783,230 - 55,783,367RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,587 - 55,913,724UniSTS
PMC151710P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,746,595 - 75,746,783UniSTSGRCh37
Build 361474,816,348 - 74,816,536RGDNCBI36
Celera1455,784,681 - 55,784,869RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,038 - 55,915,226UniSTS
PMC86910P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,178 - 75,745,344UniSTSGRCh37
Build 361474,814,931 - 74,815,097RGDNCBI36
Celera1455,783,264 - 55,783,430RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,621 - 55,913,787UniSTS
PMC87308P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,075 - 75,748,930UniSTSGRCh37
Build 361474,817,828 - 74,818,683RGDNCBI36
Celera1455,786,161 - 55,787,016RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,518 - 55,917,373UniSTS
WI-19801  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,245 - 75,748,501UniSTSGRCh37
Build 361474,817,998 - 74,818,254RGDNCBI36
Celera1455,786,331 - 55,786,587RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,688 - 55,916,944UniSTS
GeneMap99-GB4 RH Map14201.19UniSTS
Whitehead-RH Map14268.5UniSTS
FOS_V40  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,863 - 75,748,676UniSTSGRCh37
Build 361474,817,616 - 74,818,429RGDNCBI36
Celera1455,785,949 - 55,786,762RGD
HuRef1455,916,306 - 55,917,119UniSTS
G06585  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,385 - 75,748,717UniSTSGRCh37
Build 361474,818,138 - 74,818,470RGDNCBI36
Celera1455,786,471 - 55,786,803RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,828 - 55,917,160UniSTS
BP250015A10G9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,074 - 75,748,590UniSTSGRCh37
Celera1455,786,160 - 55,786,676UniSTS
HuRef1455,916,517 - 55,917,033UniSTS
BP240034A10G4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,411 - 75,748,717UniSTSGRCh37
Celera1455,786,497 - 55,786,803UniSTS
HuRef1455,916,854 - 55,917,160UniSTS
Fos  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,689 - 75,748,849UniSTSGRCh37
GRCh371475,748,724 - 75,748,897UniSTSGRCh37
Build 361474,818,477 - 74,818,650RGDNCBI36
Celera1455,786,775 - 55,786,935UniSTS
Celera1455,786,810 - 55,786,983RGD
HuRef1455,917,132 - 55,917,292UniSTS
HuRef1455,917,167 - 55,917,340UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2435 2788 2249 4957 1724 2351 6 622 1947 465 2269 7295 6463 51 3720 852 1742 1617 174 1


1 to 21 of 21 rows
RefSeq Transcripts NG_029673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB022275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB022276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY212879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENST00000303562   ⟹   ENSP00000306245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,282,230 (+)Ensembl
Ensembl Acc Id: ENST00000535987   ⟹   ENSP00000442268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,283,190 (+)Ensembl
Ensembl Acc Id: ENST00000554212   ⟹   ENSP00000452443
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,280,607 (+)Ensembl
Ensembl Acc Id: ENST00000554617   ⟹   ENSP00000450519
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,826 - 75,280,374 (+)Ensembl
Ensembl Acc Id: ENST00000555242   ⟹   ENSP00000452386
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,977 - 75,280,789 (+)Ensembl
Ensembl Acc Id: ENST00000555347   ⟹   ENSP00000450886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,280,193 - 75,281,587 (+)Ensembl
Ensembl Acc Id: ENST00000555672   ⟹   ENSP00000452440
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,670 - 75,281,157 (+)Ensembl
Ensembl Acc Id: ENST00000555686   ⟹   ENSP00000452590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,643 - 75,281,684 (+)Ensembl
Ensembl Acc Id: ENST00000556324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,279,531 (+)Ensembl
Ensembl Acc Id: ENST00000557139   ⟹   ENSP00000451786
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,978 - 75,280,667 (+)Ensembl
RefSeq Acc Id: NM_005252   ⟹   NP_005243
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381475,278,828 - 75,282,230 (+)NCBI
GRCh371475,745,477 - 75,748,937 (+)NCBI
Build 361474,815,284 - 74,818,666 (+)NCBI Archive
HuRef1455,913,924 - 55,917,380 (+)ENTREZGENE
CHM1_11475,683,266 - 75,686,721 (+)NCBI
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBI
Sequence:
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_005243   ⟸   NM_005252
- UniProtKB: B4DQ65 (UniProtKB/Swiss-Prot),   A8K4E2 (UniProtKB/Swiss-Prot),   P18849 (UniProtKB/Swiss-Prot),   P01100 (UniProtKB/Swiss-Prot),   Q6FG41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000452440   ⟸   ENST00000555672
Ensembl Acc Id: ENSP00000452590   ⟸   ENST00000555686
Ensembl Acc Id: ENSP00000450886   ⟸   ENST00000555347
Ensembl Acc Id: ENSP00000452386   ⟸   ENST00000555242
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-P01100-F1-model_v2 AlphaFold P01100 1-380 view protein structure

RGD ID:6791592
Promoter ID:HG_KWN:19815
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005252
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,814,671 - 74,815,387 (+)MPROMDB
RGD ID:6850224
Promoter ID:EP11145
Type:multiple initiation site
Name:HS_FOS
Description:V-fos FBJ murine osteosarcoma viral oncogene homolog.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 51; Mammalian c-fos proto-oncogene.
Experiment Methods:Nuclease protection; transfected or transformed cells; NEDO full length human cDNA sequencing project.; Oligo-capping
Regulation:(induced by or strongly expressed in) mitogen
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,815,284 - 74,815,344EPD
RGD ID:6791593
Promoter ID:HG_KWN:19816
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:UC001XRO.1,   UC010ASI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,815,806 - 74,817,022 (+)MPROMDB
RGD ID:7228177
Promoter ID:EPDNEW_H19834
Type:initiation region
Name:FOS_1
Description:Fos proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381475,278,828 - 75,278,888EPDNEW


1 to 40 of 43 rows
Database
Acc Id
Source(s)
COSMIC FOS COSMIC
Ensembl Genes ENSG00000170345 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000303562 ENTREZGENE
  ENST00000303562.9 UniProtKB/Swiss-Prot
  ENST00000535987.6 UniProtKB/Swiss-Prot
  ENST00000555686.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
GTEx ENSG00000170345 GTEx
HGNC ID HGNC:3796 ENTREZGENE
Human Proteome Map FOS Human Proteome Map
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2353 UniProtKB/Swiss-Prot
NCBI Gene 2353 ENTREZGENE
OMIM 164810 OMIM
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF4 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PharmGKB PA28212 PharmGKB
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A0A0K0TMT5_HUMAN UniProtKB/TrEMBL
  A0A0K0TMT7_HUMAN UniProtKB/TrEMBL
  A0A0K0TMV9_HUMAN UniProtKB/TrEMBL
  A8K4E2 ENTREZGENE
  B4DQ65 ENTREZGENE
  FOS_HUMAN UniProtKB/Swiss-Prot
  G3V289_HUMAN UniProtKB/TrEMBL
  G3V2V7_HUMAN UniProtKB/TrEMBL
  G3V5J9_HUMAN UniProtKB/TrEMBL
  G3V5N7_HUMAN UniProtKB/TrEMBL
  G3V5N9_HUMAN UniProtKB/TrEMBL
  H0YJM3_HUMAN UniProtKB/TrEMBL
  P01100 ENTREZGENE
  P18849 ENTREZGENE
  Q6FG41 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 FOS  Fos proto-oncogene, AP-1 transcription factor subunit    Fos proto-oncogene, AP-1 trancription factor subunit  Symbol and/or name change 5135510 APPROVED
2016-05-10 FOS  Fos proto-oncogene, AP-1 trancription factor subunit    FBJ murine osteosarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED