FOS (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database
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Gene: FOS (Fos proto-oncogene, AP-1 transcription factor subunit) Sus scrofa
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Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 13921310
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN aging (ortholog); cellular response to calcium ion (ortholog); cellular response to extracellular stimulus (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); amphetamine abuse (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog); INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 5-(2-methylpiperazine-1-sulfonyl)isoquinoline; actinomycin D
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-fos; cellular oncogene fos; proto-oncogene c-Fos; proto-oncogene protein c-fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8793856   PMID:8898353   PMID:10894939   PMID:14681463   PMID:23164930  


Genomics

Comparative Map Data
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1475,278,826 - 75,282,230 (+)EnsemblGRCh38hg38GRCh38
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371475,745,477 - 75,748,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBI
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39mm39
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBImm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26105,121,170 - 105,124,036 (+)NCBI
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0panPan3
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBI
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)Ensembl
Fos
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 1 7 1 1 2
Low 1 4 1 5 1 16 1 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002650   ⟹   ENSSSCP00000002583
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,363 - 98,455,554 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000060279   ⟹   ENSSSCP00000043744
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,349 - 98,453,576 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081591   ⟹   ENSSSCP00000070926
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,365 - 98,452,775 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084794   ⟹   ENSSSCP00000068601
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl798,449,349 - 98,451,238 (+)Ensembl
RefSeq Acc Id: NM_001123113   ⟹   NP_001116585
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116585 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFU76701 (Get FASTA)   NCBI Sequence Viewer  
  CAB39278 (Get FASTA)   NCBI Sequence Viewer  
  CAB40144 (Get FASTA)   NCBI Sequence Viewer  
  O97930 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001116585   ⟸   NM_001123113
- UniProtKB: O97930 (UniProtKB/Swiss-Prot),   A0A140TAJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002583   ⟸   ENSSSCT00000002650
RefSeq Acc Id: ENSSSCP00000043744   ⟸   ENSSSCT00000060279
RefSeq Acc Id: ENSSSCP00000068601   ⟸   ENSSSCT00000084794
RefSeq Acc Id: ENSSSCP00000070926   ⟸   ENSSSCT00000081591
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007778 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002583 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043744 UniProtKB/TrEMBL
  ENSSSCP00000068601 UniProtKB/TrEMBL
  ENSSSCP00000070926 UniProtKB/TrEMBL
  ENSSSCP00070012448 UniProtKB/TrEMBL
  ENSSSCP00070012450 UniProtKB/TrEMBL
  ENSSSCP00070012456 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002650 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000060279 UniProtKB/TrEMBL
  ENSSSCT00000081591 UniProtKB/TrEMBL
  ENSSSCT00000084794 UniProtKB/TrEMBL
  ENSSSCT00070015046 UniProtKB/TrEMBL
  ENSSSCT00070015049 UniProtKB/TrEMBL
  ENSSSCT00070015056 UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  c-Fos/v-Fos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100144486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene FOS ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AIM1_PIG UniProtKB/TrEMBL
  A0A4X1TAK4_PIG UniProtKB/TrEMBL
  A0A4X1TAR5_PIG UniProtKB/TrEMBL
  A0A4X1TB96_PIG UniProtKB/TrEMBL
  A0A5G2QUH7_PIG UniProtKB/TrEMBL
  A0A5G2RHQ3_PIG UniProtKB/TrEMBL
  FOS_PIG UniProtKB/Swiss-Prot, ENTREZGENE