RGD Reference Report - Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats.

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Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats.
Authors:	Tóth, Zoltán Mihály, András Mátyás, Adrienne Krisztin-Péva, Beáta
Citation:	Tóth Z, etal., Acta Histochem. 2018 Apr;120(3):236-241. doi: 10.1016/j.acthis.2018.02.004. Epub 2018 Feb 22.
RGD ID:	405650621
Pubmed:	PMID:29478811 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.acthis.2018.02.004 (Journal Full-text)
The aim of the present study was to examine the role of ionotropic glutamate receptors in the cerebellum during generalized seizures. Epileptic neuronal activation was evaluated through the immunohistochemical detection of c-fos protein in the cerebellar cortex. Generalized seizures were precipitated by the intraperitoneal injection of 4-aminopyridine. The animals were pretreated with the NMDA receptor antagonists MK-801 (2 mg/kg), amantadine (50 mg/kg), and the AMPA receptor antagonist GYKI 52466 hydrochloride (50 mg/kg). Two hours after 4-aminopyridine injection, the number of c-fos immunostained cell nuclei was counted in serial immunohistochemical sections of the cerebellar vermis. The number of c-fos immunostained cell nuclei in the granular layer decreased significantly in animals pretreated with the glutamate receptor antagonists compared to the untreated animals having convulsion. We can conclude that mossy fiber stimulation exerts its seizure-generating action mainly through the ionotropic glutamate receptors of the mossy fiber synapses. Both NMDA and AMPA receptor antagonists are effective in reducing glutamate-mediated postsynaptic effects in the cerebellar cortex.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
FOS	Human	epilepsy	treatment	ISO	Fos (Rattus norvegicus)		RGD
Fos	Rat	epilepsy	treatment	IEP			RGD
Fos	Mouse	epilepsy	treatment	ISO	Fos (Rattus norvegicus)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Fos (Fos proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)

Fos (FBJ osteosarcoma oncogene)

Genes (Homo sapiens)

FOS (Fos proto-oncogene, AP-1 transcription factor subunit)

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Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats.