Fos (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fos (Fos proto-oncogene, AP-1 transcription factor subunit) Chinchilla lanigera
Analyze
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 8986103
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to hormone stimulus (ortholog); PARTICIPATES IN endothelin signaling pathway; fibroblast growth factor signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute myocardial infarction (ortholog); alcohol dependence (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nuclear matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FBJ murine osteosarcoma viral oncogene homolog; proto-oncogene c-Fos
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute myocardial infarction  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
Alcoholic Intoxication  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Binge Drinking  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cervical squamous cell carcinoma  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (ISO)
endometriosis  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Fetal Growth Retardation  (ISO)
Fibrous Dysplasia of Bone  (ISO)
functional diarrhea  (ISO)
gastric ulcer  (ISO)
glomerulonephritis  (ISO)
Heat Stroke  (ISO)
Hematuria  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
hypospadias  (ISO)
Inhalant Abuse  (ISO)
intellectual disability  (ISO)
irritable bowel syndrome  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
middle cerebral artery infarction  (ISO)
migraine  (ISO)
morphine dependence  (ISO)
morphine withdrawal syndrome  (ISO)
myocardial infarction  (ISO)
Neoplastic Cell Transformation  (ISO)
nervous system disease  (ISO)
nicotine dependence  (ISO)
Nociceptive Pain  (ISO)
obesity  (ISO)
ovarian carcinoma  (ISO)
Pick's disease  (ISO)
post-traumatic stress disorder  (ISO)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (ISO)
sleeping sickness  (ISO)
status epilepticus  (ISO)
temporal lobe epilepsy  (ISO)
Tendon Injuries  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
trigeminal neuralgia  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Wernicke encephalopathy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to calcium ion  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to phorbol 13-acetate 12-myristate  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebral cortex development  (ISO)
conditioned taste aversion  (ISO)
female pregnancy  (ISO)
medium-term memory  (ISO)
mononuclear cell differentiation  (ISO)
myoblast proliferation  (ISO)
nervous system development  (ISO)
neural retina development  (ISO)
neuron differentiation  (ISO)
osteoclast differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to activity  (ISO)
response to cAMP  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to ethanol  (ISO)
response to forskolin  (ISO)
response to gravity  (ISO)
response to immobilization stress  (ISO)
response to insulin  (ISO)
response to light stimulus  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to progesterone  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal muscle cell proliferation  (ISO)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,283,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000007567   ⟹   ENSCLAP00000007450
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)Ensembl
RefSeq Acc Id: XM_005409369   ⟹   XP_005409426
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005409426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000007450
  ENSCLAP00000007450.1
RefSeq Acc Id: XP_005409426   ⟸   XM_005409369
- UniProtKB: A0A8C2UYQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000007450   ⟸   ENSCLAT00000007567
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007567 ENTREZGENE
  ENSCLAT00000007567.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro AP-1 UniProtKB/TrEMBL
  bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
NCBI Gene Fos ENTREZGENE
PANTHER PTHR23351 UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
PRINTS LEUZIPPRFOS UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/TrEMBL
UniProt A0A8C2UYQ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Fos  Fos proto-oncogene, AP-1 transcription factor subunit    FBJ murine osteosarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED