NCCRP1 (NCCRP1, F-box associated domain containing) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NCCRP1 (NCCRP1, F-box associated domain containing) Homo sapiens
Analyze
Symbol: NCCRP1
Name: NCCRP1, F-box associated domain containing
RGD ID: 1602046
HGNC Page HGNC
Description: Is predicted to contribute to ubiquitin protein ligase activity. Involved in positive regulation of cell population proliferation. Localizes to cytoplasm; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: F-box only protein 50; FBXO50; NCC receptor protein 1 homolog; NCCRP-1; non-specific cytotoxic cell receptor protein 1 homolog; non-specific cytotoxic cell receptor protein 1 homolog (zebrafish); nonspecific cytotoxic cell receptor protein 1 homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1939,196,964 - 39,201,884 (+)EnsemblGRCh38hg38GRCh38
GRCh381939,196,964 - 39,201,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,687,604 - 39,692,524 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,379,444 - 44,384,362 (+)NCBINCBI36hg18NCBI36
Celera1936,491,191 - 36,496,097 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1936,134,453 - 36,139,359 (+)NCBIHuRef
CHM1_11939,688,414 - 39,693,332 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:19199708   PMID:19322201   PMID:21182205   PMID:21873635   PMID:22087255   PMID:23376485   PMID:25324306   PMID:25476789   PMID:25963833   PMID:26186194  
PMID:27591049   PMID:28514442   PMID:28560594   PMID:29150431   PMID:29467282   PMID:29507755   PMID:29509190   PMID:30194290   PMID:31180492   PMID:31900314   PMID:32296183  


Genomics

Comparative Map Data
NCCRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1939,196,964 - 39,201,884 (+)EnsemblGRCh38hg38GRCh38
GRCh381939,196,964 - 39,201,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,687,604 - 39,692,524 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,379,444 - 44,384,362 (+)NCBINCBI36hg18NCBI36
Celera1936,491,191 - 36,496,097 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1936,134,453 - 36,139,359 (+)NCBIHuRef
CHM1_11939,688,414 - 39,693,332 (+)NCBICHM1_1
Nccrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,243,017 - 28,247,168 (-)NCBIGRCm39mm39
GRCm39 Ensembl728,243,021 - 28,246,679 (-)Ensembl
GRCm38728,543,592 - 28,547,748 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,543,596 - 28,547,254 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,328,615 - 29,332,273 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,252,356 - 28,256,014 (-)NCBImm8
Celera723,108,697 - 23,112,355 (-)NCBICelera
Cytogenetic Map7A3NCBI
Nccrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2183,835,083 - 83,838,620 (-)NCBI
Rnor_6.0 Ensembl185,213,652 - 85,217,258 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0185,213,578 - 85,218,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0185,558,420 - 85,559,652 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,428,109 - 86,432,474 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0186,767,843 - 86,768,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,654,277 - 83,657,968 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,732,910 - 83,735,887 (-)NCBI
Celera178,228,998 - 78,233,365 (-)NCBICelera
Cytogenetic Map1q21NCBI
Nccrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468353,824 - 356,503 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468353,066 - 356,650 (-)NCBIChiLan1.0ChiLan1.0
NCCRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,844,060 - 44,849,343 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,844,711 - 44,848,796 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01936,295,765 - 36,300,893 (+)NCBIMhudiblu_PPA_v0panPan3
NCCRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,989,951 - 113,993,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,990,024 - 113,993,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,391,401 - 113,396,384 (-)NCBI
ROS_Cfam_1.01114,589,361 - 114,594,343 (-)NCBI
UMICH_Zoey_3.11114,147,467 - 114,151,134 (-)NCBI
UNSW_CanFamBas_1.01113,780,582 - 113,785,548 (-)NCBI
UU_Cfam_GSD_1.01114,775,712 - 114,779,385 (-)NCBI
Nccrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,629,595 - 13,632,450 (+)NCBI
SpeTri2.0NW_0049366612,057,664 - 2,060,519 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCCRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,926,785 - 47,929,954 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,925,879 - 47,929,961 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,341,669 - 43,345,771 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCCRP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,786,642 - 33,791,701 (+)NCBI
ChlSab1.1 Ensembl633,786,800 - 33,790,581 (+)Ensembl
Nccrp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,514,223 - 12,517,666 (+)NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:527
Count of miRNA genes:397
Interacting mature miRNAs:422
Transcripts:ENST00000339852
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 21 1 18
Medium 53 6 9 60 7 4 1304 48 6 27 224 51 65 1 8 683 1
Low 754 214 672 135 357 33 543 354 519 236 866 879 107 234 233 5 1
Below cutoff 1588 2593 953 344 1240 343 2364 1683 2955 135 356 654 3 926 1769 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000339852   ⟹   ENSP00000342137
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,196,964 - 39,201,884 (+)Ensembl
RefSeq Acc Id: NM_001001414   ⟹   NP_001001414
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,196,964 - 39,201,884 (+)NCBI
GRCh371939,687,604 - 39,692,522 (+)RGD
Build 361944,379,444 - 44,384,362 (+)NCBI Archive
Celera1936,491,191 - 36,496,097 (+)RGD
HuRef1936,134,453 - 36,139,359 (+)RGD
CHM1_11939,688,414 - 39,693,332 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526906   ⟹   XP_011525208
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,196,964 - 39,200,326 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001001414   ⟸   NM_001001414
- UniProtKB: Q6ZVX7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525208   ⟸   XM_011526906
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000342137   ⟸   ENST00000339852
Protein Domains
FBA

Promoters
RGD ID:7239889
Promoter ID:EPDNEW_H25687
Type:initiation region
Name:NCCRP1_1
Description:non-specific cytotoxic cell receptor protein 1 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,196,964 - 39,197,024EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.12-13.2(chr19:37319377-42738688)x3 copy number gain See cases [RCV000050636] Chr19:37319377..42738688 [GRCh38]
Chr19:37810279..43242840 [GRCh37]
Chr19:42502119..47934680 [NCBI36]
Chr19:19q13.12-13.2
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh37/hg19 19q13.12-13.2(chr19:37582250-41630908)x3 copy number gain See cases [RCV000239839] Chr19:37582250..41630908 [GRCh37]
Chr19:19q13.12-13.2
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:33739 AgrOrtholog
COSMIC NCCRP1 COSMIC
Ensembl Genes ENSG00000188505 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000342137 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000339852 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.260 UniProtKB/Swiss-Prot
GTEx ENSG00000188505 GTEx
HGNC ID HGNC:33739 ENTREZGENE
Human Proteome Map NCCRP1 Human Proteome Map
InterPro F-box-assoc_dom UniProtKB/Swiss-Prot
  F-box_only UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:342897 UniProtKB/Swiss-Prot
NCBI Gene 342897 ENTREZGENE
OMIM 615901 OMIM
PANTHER PTHR12125 UniProtKB/Swiss-Prot
Pfam FBA UniProtKB/Swiss-Prot
PharmGKB PA164723566 PharmGKB
PROSITE FBA UniProtKB/Swiss-Prot
SMART FBA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot
UniProt FBX50_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6NVV5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 NCCRP1  NCCRP1, F-box associated domain containing  NCCRP1  non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)  Symbol and/or name change 5135510 APPROVED