RGD Reference Report - Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. - Rat Genome Database

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Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra.

Authors: Martin-Ibanez, R  Jenstad, M  Berghuis, P  Edwards, RH  Hioki, H  Kaneko, T  Mulder, J  Canals, JM  Ernfors, P  Chaudhry, FA  Harkany, T 
Citation: Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
RGD ID: 9999155
Pubmed: PMID:16519671   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1460-9568.2006.04601.x   (Journal Full-text)

The excitability of dopaminergic (DA) neurons in the substantia nigra is controlled by the convergent activity of multiple glutamatergic afferents. Here, we show that vesicular glutamate transporter 3 (VGLUT3)-immunoreactive (ir) terminals segregate to the perisomatic region of DA neurons in the substantia nigra pars compacta, and VGLUT3 decorates a synapse population distinct from those marked by vesicular glutamate transporters 1 and 2. VGLUT3-ir nerve endings form asymmetric terminals on DA neurons. Retrograde tracing suggests the superior colliculus as an origin of excitatory VGLUT3-ir afferents. Collectively, our data indicate that VGLUT3 identifies a novel excitatory terminal subset that contributes to the tuning of DA cell excitability in the substantia nigra.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc17a6Ratexcitatory synapse  IDA  RGD 
Slc17a7Ratexcitatory synapse  IDA  RGD 
Slc17a8Ratexcitatory synapse  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a6  (solute carrier family 17 member 6)
Slc17a7  (solute carrier family 17 member 7)
Slc17a8  (solute carrier family 17 member 8)


Additional Information