RGD Reference Report - The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. - Rat Genome Database

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The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate.

Authors: Fremeau RT, JR  Burman, J  Qureshi, T  Tran, CH  Proctor, J  Johnson, J  Zhang, H  Sulzer, D  Copenhagen, DR  Storm-Mathisen, J  Reimer, RJ  Chaudhry, FA  Edwards, RH 
Citation: Fremeau RT Jr, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14488-14493.
RGD ID: 625707
Pubmed: PMID:12388773   (View Abstract at PubMed)
PMCID: PMC137910   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.222546799   (Journal Full-text)

Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by all known excitatory neurons. We now report the identification of VGLUT3 and its expression by many cells generally considered to release a classical transmitter with properties very different from glutamate. Remarkably, subpopulations of inhibitory neurons as well as cholinergic interneurons, monoamine neurons, and glia express VGLUT3. The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
L-glutamate import involved_inIDA 625707PMID:12388773UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon terminus  IDA 625707 RGD 
dendrite  IDA 625707 RGD 
glial limiting end-foot  IDA 625707 RGD 
multivesicular body  IDA 625707 RGD 
neuronal cell body  IDA 625707 RGD 
synaptic vesicle membrane located_inIDA 625707PMID:12388773UniProt 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
L-glutamate uniporter activity enablesIDA 625707PMID:12388773UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a8  (solute carrier family 17 member 8)

Additional Information