RGD Reference Report - Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats. - Rat Genome Database

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Glutamate co-transmission from developing medial nucleus of the trapezoid body--lateral superior olive synapses is cochlear dependent in kanamycin-treated rats.

Authors: Lee, JH  Pradhan, J  Maskey, D  Park, KS  Hong, SH  Suh, MW  Kim, MJ  Ahn, SC 
Citation: Lee JH, etal., Biochem Biophys Res Commun. 2011 Feb 11;405(2):162-7. doi: 10.1016/j.bbrc.2010.12.129. Epub 2011 Jan 5.
RGD ID: 9999192
Pubmed: PMID:21215254   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2010.12.129   (Journal Full-text)

Cochlear dependency of glutamate co-transmission at the medial nucleus of the trapezoid body (MNTB)--the lateral superior olive (LSO) synapses was investigated using developing rats treated with high dose kanamycin. Rats were treated with kanamycin from postnatal day (P) 3 to P8. A scanning electron microscopic study on P9 demonstrated partial cochlear hair cell damage. A whole cell voltage clamp experiment demonstrated the increased glutamatergic portion of postsynaptic currents (PSCs) elicited by MNTB stimulation in P9-P11 kanamycin-treated rats. The enhanced VGLUT3 immunoreactivities (IRs) in kanamycin-treated rats and asymmetric VGLUT3 IRs in the LSO of unilaterally cochlear ablated rats supported the electrophysiologic data. Taken together, it is concluded that glutamate co-transmission is cochlear-dependent and enhanced glutamate co-transmission in kanamycin-treated rats is induced by partial cochlear damage.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC17A8Humancochlear disease  ISOSlc17a8 (Rattus norvegicus) RGD 
Slc17a8Ratcochlear disease  IEP  RGD 
Slc17a8Mousecochlear disease  ISOSlc17a8 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc17a8  (solute carrier family 17 member 8)

Genes (Mus musculus)
Slc17a8  (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8)

Genes (Homo sapiens)
SLC17A8  (solute carrier family 17 member 8)


Additional Information