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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6v1
Name: cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
Acc ID: CHEBI:119573
Term: delavirdine
Definition: The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.
Chemical ID: MESH:D020008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6v1decreases activityISORGD:7374166480464CTDDelavirdine results in decreased activity of CYP2C19 protein

PMID:11225565
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