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Term:
phosphonoformic acid (CHEBI:127780)
Annotations: Rat: (9) Mouse: (9) Human: (9) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
((13)C)carbon dioxide 
((13)C)urea 
((2S,3aS,4R,6S)-4-(hydroxymethyl)-6-(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxol-2-yl)methylphosphonic acid 
(+)-calanolide A 
(-)-calanolide B 
(-)-carbovir +  
(1R,2S)-1-(S-L-cysteinyl)-2-hydroxypropylphosphonate 
(1S,2S)-1,2-dihydroxypropylphosphonic acid 
(2-aminoethyl)phosphonic acid +  
(2-chloroethyl)phosphonic acid  
(2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +   
(2R,2(1)S)8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +   
(2S)-2-[5-[(2,4-dichlorophenyl)methylthio]-1,3,4-oxadiazol-2-yl]-1-pyrrolidinecarboxylic acid tert-butyl ester 
(2S)-2-amino-4-phosphonobutanoic acid 
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid +   
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid +   
(2S,3S,3aR,9bR)-7-(3-fluorophenyl)-3-(hydroxymethyl)-6-oxo-1-(pyridine-2-carbonyl)-3,3a,4,9b-tetrahydro-2H-pyrrolo[2,3-a]indolizine-2-carboxylic acid 
(3-aminopropyl)phosphonic acid 
(3R,4R)-4-hydroxy-1,1-dimethyl-3-pyrrolidin-1-iumcarboxylic acid 
(7Z)-14-hydroxy-10,13-dioxoheptadec-7-enoic acid peptidyl-aspartate ester 
(\{[(1R,2R)-2-(uracil-1-yl)cyclopentyl]oxy\}methyl)phosphonic acid 
(\{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino\}methyl)phosphonic acid 
(acetamidomethyl)phosphonic acid 
(aminomethyl)phosphonic acid +   
(hydroxymethyl)silanetriol 
(methylidyneammoniumyl)selanide 
(R)-(1-aminoethyl)phosphonic acid 
(R)-2-(phosphonomethyl)malic acid 
(R)-2-halocarboxylic acid 
(S)-(1-aminoethyl)phosphonic acid +  
(S)-2-halocarboxylic acid 
1,1-bis(phosphonic acid) +   
1,4'-Bipiperidine-1'-carboxylic acid 
1-(1-oxo-2-thiophen-2-ylethyl)-4-piperidinecarboxylic acid ethyl ester 
1-(4,6-dimethyl-2-pyrimidinyl)-4-piperidinecarboxylic acid 
1-(5-carboxypentyl)pyrraline 
1-[(2-hydroxyethoxy)methyl]-6-(phenylsulfanyl)thymine 
1-[(6-hydroxy-2-methyl-5-thiazolo[3,2-b][1,2,4]triazolyl)-(3,4,5-trimethoxyphenyl)methyl]-4-piperidinecarboxylic acid methyl ester 
1-[2-[(4-chlorophenyl)thio]-1-oxopropyl]-4-piperidinecarboxylic acid ethyl ester 
1-[2-[3-(N-ethylanilino)propylamino]-3,4-dioxo-1-cyclobutenyl]-4-piperidinecarboxylic acid ethyl ester 
1-[2-hydroxy-3-[4-(2-methylbutan-2-yl)phenoxy]propyl]-4-piperidinecarboxylic acid ethyl ester 
1-\{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-L-threo-pentofuranosyl\}thymine 
1-amino-1-phenylmethyl phosphonic acid 
1-aminocyclopropylphosphonic acid 
1-deoxy-1-\{[2,6-dihydroxy-5-(5-phosphonopentyl)pyrimidin-4-yl]amino\}-D-ribitol 
1-deoxy-1-\{[2,6-dioxo-5-(5-phosphonopentyl)-1,2,3,6-tetrahydropyrimidin-4-yl]amino\}-D-ribitol 
1-hydroxy-2-aminoethylphosphonic acid 
1-nitroguanidine +  
1beta-hydroxymaprounic acid 3-p-hydroxybenzoate 
1H-diazirine 
1H-tetrazole +  
2-(difluoromethoxy)-2,2-difluoroacetic acid 
2-(pentylsulfanyl)acetic acid +  
2-amino-3-phosphonopropanoic acid 
2-amino-5-phosphonopentanoic acid 
2-bromocarboxylic acid +   
2-dimethylaminoethylphosphonic acid 
2-hydroxyethylphosphonic acid 
2-hydroxypropylphosphonic acid +  
2-methylaminoethylphosphonic acid 
2-methylcyclotrisiloxane 
2-nitroguanidine +   
2-trimethylaminoethylphosphonic acid 
2alpha-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate 
2H-tetrazole 
3-\{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl\}propanoic acid +   
3-Hydroxypropenoate 
3-Methylpyrrole-2,4-dicarboxylic acid 
3-phosphonopyruvic acid 
3H-diazirine 
4-(2-benzamidoethylamino)-1-piperidinecarboxylic acid ethyl ester 
4-[(2-aminophenyl)thio]butylphosphonic acid 
4-[[2-(3-ethylanilino)-3,4-dioxo-1-cyclobutenyl]amino]-1-piperidinecarboxylic acid ethyl ester 
4-[[3-(4-chlorophenyl)-5-isoxazolyl]methyl]-1-[(2-methylpropan-2-yl)oxy-oxomethyl]-4-piperidinecarboxylic acid 
4-\{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl\}-thiazol-2-yl-ammonium +  
4-Methyl-3-oxoadipate-enol-lactone 
5-[(4-nitrobenzyl)(phosphonomethyl)amino]valeric acid 
5-iodo-2'-deoxyuridine 
5-oxo-1-(2-phenylethyl)-3-pyrrolidinecarboxylic acid 
5H-tetrazole 
6-\{hydroxy[(4-nitrobenzyl)oxy]phosphoryl\}hexanoic acid 
[(1R)-1-\{[N-(furan-2-ylcarbonyl)-L-leucyl]amino\}-2-(1H-indol-3-yl)ethyl]phosphonic acid 
[(1R)-2-(3-\{methyl[1-(naphthalen-2-ylcarbonyl)piperidin-4-yl]carbamoyl\}naphthalen-2-yl)-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid 
[(1R,2S)-2-hydroxy-1-thiopropyl]phosphonic acid 
[(ppy)2Ir(mbpy-monoacid)]Cl 
[(S)-1-acetamidoethyl]phosphonic acid 
[2-(3-dibenzo[b,d]furan-4-ylphenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid) 
[6)-alpha-D-Glcp-(1->4)-alpha-D-NeupAc-(2->]n 
[\{4-[(2R,4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl\}(difluoro)methyl]phosphonic acid 
abacavir +   
acyclovir  
adefovir +   
adefovir pivoxil  
alpha-D-Kdo-4P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule +  
alpha-D-Kdo-5P-O(CH2)3S(CH2)2NH(polyacrylamide) macromolecule +  
alpha-Fluoro-beta-ureidopropionic acid 
alpha-N-substituted L-arginine +   
amantadine  
amantadine sulfate 
amino acid +   
aminoguanidine +   
ammonium formate 
amprenavir  
anolignan A 
anolignan B 
aphidicolin  
aromatic carboxylic acid +   
Asn-Ile 
aspartame  
atazanavir +   
azetidinecarboxylic acid +   
benzyl ester +   
biphenylyl carboxylic acid +  
bismuth subcarbonate 
boceprevir 
bromochlorodifluoromethane 
butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
butylphosphonic acid +  
calcium carbonate +   
carbamic acid +   
carbamimidic acid +  
carbamoyl phosphate 
carbazic acid +   
carbidoselanidonitrogen 
carboacyl group +   
carbohydrate acid +   
carbon dioxide  
carbon disulfide  
carbon monoxide  
carbonodithioic O,S-acid 
carbonodithioic S,S-acid 
carbonothioic O,O-acid +   
carbonothioic O,S-acid 
carbonotriselenoic acid 
carbonotrithioic acid 
carbonyl dihydrazine  
carbonyl sulfide  
carbovir +  
carboxyalkyl phosphate +  
carboxyphosphoric acid 
carlosic acid +  
cefalotin +   
cefatrizine 
cefazedone 
cefcapene 
cefditoren +  
cefiderocol 
cefpiramide 
cefpodoxime +   
cefpodoxime proxetil 
CGP 78608 
chlorocarboxylic acid +   
chloroform +   
chloropicrin  
cidofovir anhydrous +  
cidofovir dihydrate 
cinalukast 
clathsterol 
clathsterol disulfonic acid 
clodronic acid  
clodronic acid disodium salt +  
costunolide +   
cyanamide +   
cyanic acid +   
Cycloheptanecarboxylic acid 
Cys-Ser 
daclatasvir 
daclatasvir hydrochloride 
Dalapon 
darunavir +  
dasabuvir 
dasabuvir sodium +  
dasabuvir sodium hydrate +  
Decahydro-2-naphthoic acid 
delavirdine +   
delavirdine mesylate 
Descovy 
dicarboxylic acid +   
dicarboxylic acid monoester +   
didanosine  
Diisopropylamine dichloroacetate 
disodium clodronate tetrahydrate 
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor +   
efavirenz  
elbasvir +  
emivirine 
emtricitabine +   
entecavir (anhydrous) +  
entecavir hydrate 
Epclusa 
ethyl ester +   
etravirine 
famciclovir 
ferrous carbonate 
floxuridine  
Flupropanate 
formaldehyde +   
formamide +   
formamidine +   
formate ester +  
formimidic acid +  
formyl dihydrogen phosphate 
formyl group +   
formyl-CoA 
fosfomycin  
fosmidomycin 
fulminic acid 
ganciclovir +   
gemcitabine +   
gemcitabine hydrochloride 
Genvoya 
gibberellin +  
glyphosate  
glyphosine 
grazoprevir +  
GS-8373 
guanidine +   
guanidinium chloride 
halomethane +   
Harvoni 
hexacarboxylic acid +  
HIV fusion inhibitor +   
hydrogen cyanide +   
hydroxy carboxylic acid +   
hydroxymethylnitramine 
hydroxymethylphosphonic acid +  
hydroxyurea  
hypothiocyanous acid 
indolyl carboxylic acid +   
isocyanic acid +   
isofulminic acid 
isoselenocyanic acid +  
isothiocyanic acid +   
isothiofulminic acid 
lamivudine  
ledipasvir +  
lopinavir  
LSM-10020 
LSM-10238 
LSM-10579 
LSM-10741 
LSM-11260 
LSM-13069 
LSM-14584 
LSM-14673 
LSM-9293 
LSM-9646 
Mafenide acetate 
magnesium carbonate 
magnesium formate dihydrate 
maprounic acid +  
maraviroc  
methane +   
methanediamine 
methanediol +  
methanesulfonic acid +   
methanimine +  
methanol +   
methyl dihydrogen phosphate  
methyl phosphonate 
methyl sulfate 
methylamine +   
methylamine hydrochloride 
methylarsonic acid  
methylarsonous acid 
methylenedinitramine 
methyllithium 
methylmagnesium chloride 
methylmercury chloride  
methylphosphine 
methylphosphonic acid +  
methylselenenic acid 
methylseleninic acid  
methylselenol 
methylsilanetriol 
methylsulfanol 
methyltelluronic acid 
monocarboxylic acid +   
N-(1-naphthyl)carboxamide +  
N-(2-naphthyl)carboxamide +   
N-(phosphonomethyl)iminodiacetic acid 
N-[(R)-4-phosphopantothenoyl]-L-cysteine 
N-acetyl-L-cysteinate 
N-acetyl-L-cysteine +   
N-acyl-amino acid +   
N-formyl amino acid +  
N-hydroxyguanidine 
naptalam 
nevirapine  
nigranoic acid 
nystatin  
nystatin A1 
octacarboxylic acid +  
Odefsey 
ombitasvir +  
oseltamivir +   
oseltamivir acid 
oxazirene 
oxo carboxylic acid +   
paritaprevir +  
penciclovir 
penicillanic acids +   
penillic acid +  
pentacarboxylic acid +   
peramivir 
peramivir hydrate +  
phosphonic acid +   
phosphonic acid derivative +   
phosphono group 
phosphonoacetaldehyde 
phosphonoacetic acid +   
phosphonoformic acid +   
Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
piperazinecarboxylic acid +  
poly(methacrylic acid) macromolecule +  
potassium cyanate 
potassium cyanide  
potassium formate 
pradimicin A 
Pradimicinone II 
Prezcobix 
proteinogenic amino acid +   
pyrazinecarboxylic acid +   
pyrimidinecarboxylic acid +   
raltegravir 
rifamycin B 
rilpivirine 
rilpivirine hydrochloride +  
ritonavir +   
salaspermic acid 
saquinavir  
selenocyanic acid +  
selenourea 
seliciclib 
semicarbazide +   
sodium cyanate  
sodium cyanide  
sodium hexacyclonate 
sodium hydrogencarbonate  
sofosbuvir +  
soulattrolide 
sulfur-containing carboxylic acid +   
swertifrancheside 
swertipunicoside 
Technivie 
telaprevir  
telbivudine 
tellurocyanic acid 
tenofovir (anhydrous) +   
tenofovir alafenamide 
tenofovir alafenamide fumarate +  
tenofovir disoproxil +   
tenofovir disoproxil fumarate  
tenofovir hydrate 
tenofovir(1-) 
tensyuic acid +  
tetracarboxylic acid +   
thiocyanic acid +  
thiofulminic acid 
thiophenecarboxylic acid +   
thiophosgene 
thiourea +   
tipranavir  
treprostinil +   
tricarboxylic acid +   
triflic acid +  
trifluridine +   
trihydroxysilanecarbaldehyde 
trisodium phosphonoformate +  
trisodium phosphonoformate hexahydrate 
Tubulysin A 
Tubulysin D 
urea +   
ureidocarboxylic acid +  
valacyclovir 
valganciclovir 
velpatasvir +  
Viekira Pak 
zalcitabine  
Zepatier 
zidovudine  

Synonyms
Exact Synonyms: dihydroxyphosphanecarboxylic acid oxide
Related Synonyms: Formula=CH3O5P ;   Foscarmet ;   InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6) ;   InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-N ;   SMILES=OC(=O)P(O)(O)=O ;   carboxyphosphonic acid ;   foscarnet ;   phosphonomethanoic acid
Alternate IDs: CHEBI:45085 ;   CHEBI:8158
Xrefs: CAS:4428-95-9 "ChemIDplus" ;   CAS:4428-95-9 "KEGG COMPOUND" ;   DrugBank:DB00529 ;   Drug_Central:1241 "DrugCentral" ;   KEGG:C06456 ;   KNApSAcK:C00000800
Xref Mesh: MESH:D017245
Xrefs: PDBeChem:PPF ;   PMID:11576919 "Europe PMC" ;   PMID:15182735 "Europe PMC" ;   PMID:16858125 "Europe PMC" ;   PMID:19213941 "Europe PMC" ;   PMID:19288498 "Europe PMC" ;   PMID:21056575 "Europe PMC" ;   PMID:21566148 "Europe PMC" ;   Reaxys:1756501 "Reaxys" ;   Wikipedia:Foscarnet
Cyclic Relationships: is_conjugate_acid_of CHEBI:60268 ;   is_conjugate_acid_of CHEBI:91254

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.