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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2078
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ak4
Name: adenylate kinase 4
Acc ID: CHEBI:31175
Term: adefovir pivoxil
Definition: An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.
Chemical ID: MESH:C106812
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ak4increases expressionISOAK4 (Homo sapiens)6480464CTDadefovir dipivoxil results in increased expression of AK4 mRNAPMID:25596134
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