Timm23 (translocase of inner mitochondrial membrane 23) - Rat Genome Database

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Gene: Timm23 (translocase of inner mitochondrial membrane 23) Rattus norvegicus
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Symbol: Timm23
Name: translocase of inner mitochondrial membrane 23
RGD ID: 3863
Description: Enables enzyme binding activity. Involved in intracellular protein transport; positive regulation of protein processing; and response to 3,3',5-triiodo-L-thyronine. Located in mitochondrial inner membrane. Biomarker of muscular atrophy. Orthologous to several human genes including TIMM23 (translocase of inner mitochondrial membrane 23); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93478; mitochondrial import inner membrane translocase subunit Tim23; translocase of inner mitochondrial membrane 23 homolog; translocase of inner mitochondrial membrane 23 homolog (yeast)
RGD Orthologs
Human
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: Timm23-ps8   Timm23b  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2167,410,308 - 7,436,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,409,688 - 7,436,379 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,422,872 - 7,448,898 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0168,567,729 - 8,593,756 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0167,421,074 - 7,446,970 (-)NCBIRnor_WKY
Rnor_6.0168,324,038 - 8,350,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,324,036 - 8,350,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,241,070 - 8,267,099 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,663,204 - 7,689,233 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,663,201 - 7,689,231 (-)NCBI
Celera167,762,431 - 7,788,452 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway. Colavecchia M, etal., Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E29-35. doi: 10.1152/ajpendo.00294.2002. Epub 2002 Sep 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N and Mihara K, J Biochem (Tokyo) 1998 Apr;123(4):722-32.
5. Characterization of the initial steps of precursor import into rat liver mitoplasts. Ishihara N, etal., J Biochem. 1998 Oct;124(4):824-34.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
11. Effect of denervation-induced muscle disuse on mitochondrial protein import. Singh K and Hood DA, Am J Physiol Cell Physiol. 2011 Jan;300(1):C138-45. doi: 10.1152/ajpcell.00181.2010. Epub 2010 Oct 13.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:10339406   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15044455   PMID:17035996   PMID:18614015   PMID:20053669   PMID:25997101  


Genomics

Comparative Map Data
Timm23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2167,410,308 - 7,436,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,409,688 - 7,436,379 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,422,872 - 7,448,898 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0168,567,729 - 8,593,756 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0167,421,074 - 7,446,970 (-)NCBIRnor_WKY
Rnor_6.0168,324,038 - 8,350,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,324,036 - 8,350,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,241,070 - 8,267,099 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,663,204 - 7,689,233 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,663,201 - 7,689,231 (-)NCBI
Celera167,762,431 - 7,788,452 (+)NCBICelera
Cytogenetic Map16p16NCBI
TIMM23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,972,489 - 46,003,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1045,972,489 - 46,003,742 (+)EnsemblGRCh38hg38GRCh38
GRCh371051,592,080 - 51,623,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,262,094 - 51,293,342 (-)NCBINCBI36Build 36hg18NCBI36
Build 341051,262,093 - 51,293,342NCBI
Celera1042,892,686 - 42,893,221 (-)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1045,699,410 - 45,717,768 (-)NCBIHuRef
HuRef1045,719,195 - 45,722,269 (-)NCBIHuRef
CHM1_11051,874,035 - 51,905,195 (-)NCBICHM1_1
T2T-CHM13v2.01046,853,373 - 46,884,627 (+)NCBIT2T-CHM13v2.0
TIMM23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,972,489 - 46,003,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1045,972,489 - 46,003,742 (+)EnsemblGRCh38hg38GRCh38
GRCh371051,592,080 - 51,623,350 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361051,262,094 - 51,293,342 (-)NCBINCBI36Build 36hg18NCBI36
Build 341051,262,093 - 51,293,342NCBI
Celera1042,892,686 - 42,893,221 (-)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1045,699,410 - 45,717,768 (-)NCBIHuRef
HuRef1045,719,195 - 45,722,269 (-)NCBIHuRef
CHM1_11051,874,035 - 51,905,195 (-)NCBICHM1_1
T2T-CHM13v2.01046,853,373 - 46,884,627 (+)NCBIT2T-CHM13v2.0
Timm23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,902,123 - 31,923,848 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,902,119 - 31,923,855 (-)EnsemblGRCm39 Ensembl
GRCm381432,180,166 - 32,201,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,180,162 - 32,201,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv371432,993,352 - 33,015,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,009,175 - 31,030,880 (-)NCBIMGSCv36mm8
Celera1428,439,007 - 28,460,725 (-)NCBICelera
Cytogenetic Map14BNCBI
TIMM23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11046,414,232 - 46,419,614 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01043,123,802 - 43,157,666 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC486776
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,767,224 - 1,800,922 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,767,299 - 1,800,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,001,734 - 2,035,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,944,580 - 1,978,301 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1281,741,676 - 1,775,395 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,778,558 - 1,812,043 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,910,714 - 1,944,439 (+)NCBIUU_Cfam_GSD_1.0
LOC100157391
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,481,070 - 90,506,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,480,955 - 90,506,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,523,432 - 98,546,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Timm23
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:148
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000026932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
AI010983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2167,415,928 - 7,416,122 (+)MAPPERmRatBN7.2
Rnor_6.0168,329,657 - 8,329,850NCBIRnor6.0
Rnor_5.0168,246,689 - 8,246,882UniSTSRnor5.0
RGSC_v3.4167,668,823 - 7,669,016UniSTSRGSC3.4
Celera167,782,640 - 7,782,833UniSTS
RH 3.4 Map1665.1UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: NM_019352   ⟹   NP_062225
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2167,410,308 - 7,436,340 (-)NCBI
Rnor_6.0168,324,038 - 8,350,067 (-)NCBI
Rnor_5.0168,241,070 - 8,267,099 (-)NCBI
RGSC_v3.4167,663,204 - 7,689,233 (-)RGD
Celera167,762,431 - 7,788,452 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094791   ⟹   XP_038950719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2167,421,715 - 7,436,392 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950719 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83559 (Get FASTA)   NCBI Sequence Viewer  
  BAA21819 (Get FASTA)   NCBI Sequence Viewer  
  O35093 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062225   ⟸   NM_019352
- UniProtKB: O35093 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038950719   ⟸   XM_039094791
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35093-F1-model_v2 AlphaFold O35093 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699940
Promoter ID:EPDNEW_R10463
Type:initiation region
Name:Timm23_1
Description:translocase of inner mitochondrial membrane 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0168,350,071 - 8,350,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3863 AgrOrtholog
BioCyc Gene G2FUF-12116 BioCyc
Ensembl Genes ENSRNOG00000019811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026932 ENTREZGENE
  ENSRNOP00000095080.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026932 ENTREZGENE
  ENSRNOT00000095039.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135081 IMAGE-MGC_LOAD
InterPro Tim23 UniProtKB/Swiss-Prot
  Tim23-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54312 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93478 IMAGE-MGC_LOAD
NCBI Gene 54312 ENTREZGENE
PANTHER PTHR15371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timm23 PhenoGen
TIGR TC204523
TIGRFAMs 3a0801s02tim23 UniProtKB/Swiss-Prot
UniProt A0A8I6AMB8_RAT UniProtKB/TrEMBL
  O35093 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Timm23  translocase of inner mitochondrial membrane 23  Timm23  translocase of inner mitochondrial membrane 23 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Timm23  translocase of inner mitochondrial membrane 23 homolog (yeast)      Name updated 70584 APPROVED