Slc2a6 (solute carrier family 2 member 6) - Rat Genome Database

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Gene: Slc2a6 (solute carrier family 2 member 6) Rattus norvegicus
Analyze
Symbol: Slc2a6
Name: solute carrier family 2 member 6
RGD ID: 1309317
Description: Predicted to be involved in regulation of glycolytic process. Predicted to be located in lysosomal membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296600; solute carrier family 2 (facilitated glucose transporter), member 6; solute carrier family 2, facilitated glucose transporter member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,348,395 - 10,355,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,348,395 - 10,355,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,408,411 - 13,415,225 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0321,993,812 - 22,000,626 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0320,249,113 - 20,255,927 (-)NCBIRnor_WKY
Rnor_6.035,567,729 - 5,575,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,568,321 - 5,575,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,930,061 - 10,936,876 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,917,992 - 5,924,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,918,815 - 5,925,027 (-)NCBI
Celera35,146,427 - 5,153,242 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
pentanal  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30431159  


Genomics

Comparative Map Data
Slc2a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,348,395 - 10,355,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,348,395 - 10,355,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,408,411 - 13,415,225 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0321,993,812 - 22,000,626 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0320,249,113 - 20,255,927 (-)NCBIRnor_WKY
Rnor_6.035,567,729 - 5,575,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,568,321 - 5,575,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,930,061 - 10,936,876 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,917,992 - 5,924,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.135,918,815 - 5,925,027 (-)NCBI
Celera35,146,427 - 5,153,242 (-)NCBICelera
Cytogenetic Map3p12NCBI
SLC2A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,471,094 - 133,479,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9133,471,094 - 133,479,127 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,336,216 - 136,344,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,326,038 - 135,334,039 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,365,773 - 133,373,772NCBI
Celera9106,886,840 - 106,894,900 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,837,905 - 105,845,965 (-)NCBIHuRef
CHM1_19136,486,719 - 136,494,779 (-)NCBICHM1_1
T2T-CHM13v2.09145,685,501 - 145,693,506 (-)NCBIT2T-CHM13v2.0
Slc2a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,911,375 - 26,918,011 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,911,375 - 26,918,010 (-)EnsemblGRCm39 Ensembl
GRCm38227,021,363 - 27,028,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,021,363 - 27,027,998 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,876,885 - 26,883,518 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,843,377 - 26,849,999 (-)NCBIMGSCv36mm8
Celera226,724,006 - 26,730,639 (-)NCBICelera
Cytogenetic Map2A3NCBI
Slc2a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,796,531 - 2,802,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,796,086 - 2,802,051 (-)NCBIChiLan1.0ChiLan1.0
SLC2A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19133,205,995 - 133,214,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,205,995 - 133,214,051 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09104,589,227 - 104,602,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC2A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,878,325 - 49,885,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,878,634 - 49,885,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,159,453 - 49,166,663 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,752,218 - 50,759,412 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,752,220 - 50,759,454 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,514,270 - 49,521,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,856,019 - 49,863,218 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,934,179 - 49,941,399 (-)NCBIUU_Cfam_GSD_1.0
Slc2a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,936,195 - 199,942,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,432,188 - 3,442,531 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366693,432,206 - 3,438,849 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,063,270 - 273,075,391 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,063,261 - 273,075,455 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,041,084 - 307,049,223 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,649,140 - 4,665,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,657,613 - 4,664,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058323,626 - 331,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,898,427 - 1,903,445 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,897,960 - 1,903,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a6
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:168
Interacting mature miRNAs:190
Transcripts:ENSRNOT00000008034
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat

Markers in Region
RH139471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,348,500 - 10,348,687 (+)MAPPERmRatBN7.2
Rnor_6.035,568,427 - 5,568,613NCBIRnor6.0
Rnor_5.0310,930,167 - 10,930,353UniSTSRnor5.0
RGSC_v3.435,918,098 - 5,918,284UniSTSRGSC3.4
Celera35,146,533 - 5,146,719UniSTS
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 44
Low 1 25 43 27 19 27 8 11 30 31 32 11 8
Below cutoff 18 14 14 14 4 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008034   ⟹   ENSRNOP00000008034
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,348,395 - 10,355,208 (-)Ensembl
Rnor_6.0 Ensembl35,568,321 - 5,575,136 (-)Ensembl
RefSeq Acc Id: NM_001106562   ⟹   NP_001100032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,348,395 - 10,355,208 (-)NCBI
Rnor_6.035,568,321 - 5,575,136 (-)NCBI
Rnor_5.0310,930,061 - 10,936,876 (-)NCBI
RGSC_v3.435,917,992 - 5,924,807 (-)RGD
Celera35,146,427 - 5,153,242 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100032 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93446 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100032   ⟸   NM_001106562
- UniProtKB: D3ZLC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008034   ⟸   ENSRNOT00000008034
Protein Domains
MFS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLC4-F1-model_v2 AlphaFold D3ZLC4 1-321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309317 AgrOrtholog
BioCyc Gene G2FUF-50309 BioCyc
Ensembl Genes ENSRNOG00000005900 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008034 ENTREZGENE
  ENSRNOP00000008034.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008034 ENTREZGENE
  ENSRNOT00000008034.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro Major_facilitator_SF UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Sub_transporter UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
KEGG Report rno:296600 UniProtKB/TrEMBL
NCBI Gene 296600 ENTREZGENE
Pfam Sugar_tr UniProtKB/TrEMBL
PhenoGen Slc2a6 PhenoGen
PRINTS SUGRTRNSPORT UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt D3ZLC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a6  solute carrier family 2 member 6  Slc2a6  solute carrier family 2 (facilitated glucose transporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc2a6  solute carrier family 2 (facilitated glucose transporter), member 6   Slc2a6_predicted  solute carrier family 2 (facilitated glucose transporter), member 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc2a6_predicted  solute carrier family 2 (facilitated glucose transporter), member 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED