Fh (fumarate hydratase) - Rat Genome Database

Name: Fh
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fh (fumarate hydratase) Rattus norvegicus

Analyze

Symbol:

Name:

fumarate hydratase

RGD ID:

2614

Description:

Exhibits fumarate hydratase activity. Involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency. Orthologous to human FH (fumarate hydratase); PARTICIPATES IN citric acid cycle pathway; altered citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1,2,4-trimethylbenzene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Fh1; fumarase; fumarate hydratase 1; fumarate hydratase, mitochondrial; MGC105468

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FH (fumarate hydratase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fh1 (fumarate hydratase 1)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fh (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FH (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FH (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fh (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FH (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	FH (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fh (fumarate hydratase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Fh1 (fumarate hydratase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	FH (fumarate hydratase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	fh (fumarate hydratase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	FUM1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Fum1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Fum2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Fum3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Fum4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	fum-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Allele / Splice:

Fh^em1

Genetic Models:

SD-Fh^em1+/-

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	87,524,331 - 87,550,215 (-)	NCBI
Rnor_6.0 Ensembl	13	93,651,484 - 93,677,377 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	13	93,651,486 - 93,677,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	98,116,496 - 98,142,636 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	91,329,837 - 91,355,722 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	91,518,725 - 91,544,617 (-)	NCBI
Celera	13	87,123,119 - 87,148,786 (-)	NCBI		Celera
Cytogenetic Map	13	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

B-lymphoblastic leukemia/lymphoma (ISO)

breast cancer (ISO)

COVID-19 (ISO)

fumarase deficiency (ISO)

genetic disease (ISO)

Hereditary Leiomyomatosis and Renal Cell Cancer (ISO)

Hereditary Neoplastic Syndromes (ISO)

leiomyoma cutis (ISO)

microcephaly (ISO)

Neurodevelopmental Disorders (ISO)

renal cell carcinoma (ISO)

uterine fibroid (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(R)-adrenaline (EXP)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

7H-xanthine (EXP)

9H-xanthine (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aluminium atom (ISO)

aluminium(0) (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

atrazine (ISO)

bexarotene (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

C60 fullerene (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

cocaine (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

gold atom (ISO)

gold(0) (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

irinotecan (EXP)

isotretinoin (ISO)

lamivudine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methapyrilene (EXP)

methotrexate (ISO)

methylmercury chloride (ISO)

morphine (EXP)

olaparib (ISO)

ouabain (ISO)

ozone (EXP)

paracetamol (ISO)

phenobarbital (ISO)

phlorizin (ISO)

pinosylvin (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

quercetin (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (EXP,ISO)

streptozocin (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

trans-pinosylvin (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to DNA damage stimulus (ISO,ISS)

DNA repair (IEA)

fumarate metabolic process (IBA,IDA,ISO,ISS,TAS)

homeostasis of number of cells within a tissue (ISO)

malate metabolic process (IBA,IDA,ISO)

negative regulation of histone H3-K36 methylation (ISO,ISS)

positive regulation of cold-induced thermogenesis (ISO,ISS)

positive regulation of double-strand break repair via nonhomologous end joining (ISO,ISS)

regulation of arginine metabolic process (ISO,ISS)

tricarboxylic acid cycle (IBA,IDA,IEA)

urea cycle (ISO,ISS)

Cellular Component

chromosome (IEA)

cytoplasm (ISO)

cytosol (IEA,ISO)

mitochondrion (IBA,IDA,ISO)

nucleus (IEA,ISO)

site of double-strand break (ISO)

tricarboxylic acid cycle enzyme complex (IEA)

Molecular Function

fumarate hydratase activity (IBA,IDA,IMP,ISO,ISS)

histone binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered citric acid cycle pathway (ISO)

citric acid cycle pathway (IDA,ISO)

fumaric aciduria pathway (ISO)

mitochondrial complex II deficiency pathway (ISO)

pyruvate dehydrogenase E2 deficiency pathway (ISO)

pyruvate dehydrogenase E3 deficiency pathway (ISO)

renal cell carcinoma pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal kidney morphology (IMP)

abnormal lymphocyte morphology (IMP)

decreased blood uric acid level (IMP)

decreased eosinophil cell number (IMP)

decreased hematocrit (IMP)

decreased leukocyte cell number (IMP)

decreased litter size (IMP)

decreased lymphocyte cell number (IMP)

decreased monocyte cell number (IMP)

embryonic lethality (IMP)

increased blood urea nitrogen level (IMP)

increased body weight (IMP)

increased circulating creatinine level (IMP)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
4.	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline
6.	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions
9.	Sudarshan S, etal., Br J Cancer. 2007 Feb 12;96(3):403-7. Epub 2007 Jan 9.
10.	Suzuki T, etal., J Biol Chem 1989 Feb 15;264(5):2581-6.
11.	Wei MH, etal., J Med Genet. 2006 Jan;43(1):18-27. Epub 2005 Jun 3.
12.	Yang H, etal., Diabetes. 2016 Nov;65(11):3396-3409. doi: 10.2337/db16-0136. Epub 2016 Aug 23.
13.	Yu D, etal., Oncotarget. 2016 Sep 20;7(38):61656-61669. doi: 10.18632/oncotarget.11429.

Additional References at PubMed

PMID:8200987	PMID:12477932	PMID:14651853	PMID:17111171	PMID:17418408	PMID:18614015	PMID:20231875	PMID:20458337	PMID:20833797	PMID:21498518	PMID:22507198	PMID:23376485
PMID:23643539	PMID:26237645	PMID:27037871	PMID:28754823	PMID:29456767	PMID:30718813	PMID:30761759	PMID:31235845

Genomics

Comparative Map Data

Fh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	87,524,331 - 87,550,215 (-)	NCBI
Rnor_6.0 Ensembl	13	93,651,484 - 93,677,377 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	13	93,651,486 - 93,677,371 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	13	98,116,496 - 98,142,636 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	91,329,837 - 91,355,722 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	91,518,725 - 91,544,617 (-)	NCBI
Celera	13	87,123,119 - 87,148,786 (-)	NCBI		Celera
Cytogenetic Map	13	q25	NCBI

FH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	241,497,603 - 241,519,755 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	1	241,497,603 - 241,519,761 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	241,497,603 - 241,519,755 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	241,660,903 - 241,683,055 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	239,727,526 - 239,749,677 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	237,986,946 - 238,009,095	NCBI
Celera	1	214,915,854 - 214,938,092 (-)	NCBI
Cytogenetic Map	1	q43	NCBI
HuRef	1	212,119,119 - 212,141,338 (-)	NCBI		HuRef
CHM1_1	1	242,933,564 - 242,955,781 (-)	NCBI		CHM1_1

Fh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	175,428,944 - 175,453,201 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	1	175,427,940 - 175,453,201 (-)	Ensembl
GRCm38	1	175,601,378 - 175,625,635 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	175,600,374 - 175,625,635 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	177,531,509 - 177,555,766 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	177,438,053 - 177,462,253 (-)	NCBI			mm8
Celera	1	182,687,061 - 182,711,324 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI

Fh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	10,535,323 - 10,561,627 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	10,535,801 - 10,558,649 (+)	NCBI	ChiLan1.0	ChiLan1.0

FH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	222,041,142 - 222,063,271 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	222,041,142 - 222,064,212 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	217,059,847 - 217,081,795 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

FH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	32,900,250 - 32,927,436 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	32,901,586 - 32,927,412 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	32,378,016 - 32,404,992 (-)	NCBI
ROS_Cfam_1.0	7	32,726,854 - 32,753,856 (-)	NCBI
UMICH_Zoey_3.1	7	32,562,040 - 32,588,973 (-)	NCBI
UNSW_CanFamBas_1.0	7	32,586,108 - 32,613,094 (-)	NCBI
UU_Cfam_GSD_1.0	7	32,834,235 - 32,861,236 (-)	NCBI

Fh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_ltri_2	NW_024409344	45,782,142 - 45,811,186 (-)	NCBI
SpeTri2.0	NW_004936526	8,936,096 - 8,965,155 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	12,404,176 - 12,431,801 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	12,404,143 - 12,431,843 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	14,852,719 - 14,879,014 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FH
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	78,576,931 - 78,599,998 (-)	NCBI
ChlSab1.1 Ensembl	25	78,575,300 - 78,599,972 (-)	Ensembl

Fh
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624771	11,861,537 - 11,886,154 (-)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	36147533	99968921	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	36147533	99968921	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	51569248	96569248	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	57903612	102903612	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	12193394	108478121	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	71230858	114033958	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	71230858	114033958	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	35301263	107975663	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	62975663	107975663	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	107975663	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	107975663	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	107975663	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	80403559	108770687	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	86833393	114033958	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	24502279	108770533	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	79567081	103613733	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	72583716	114033958	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	66971778	111971778	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	51080989	96080989	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	77694986	114033958	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39501300	93652524	Rat

Genetic Models

This gene Fh is modified in the following models/strains

SD-Fh^em1+/-

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	76
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000004917
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	40	11	8
Low											1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC119639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J04473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004917 ⟹ ENSRNOP00000004917

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	93,651,484 - 93,677,377 (-)	Ensembl

RefSeq Acc Id:

NM_017005 ⟹ NP_058701

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	87,524,331 - 87,550,215 (-)	NCBI
Rnor_6.0	13	93,651,486 - 93,677,371 (-)	NCBI
Rnor_5.0	13	98,116,496 - 98,142,636 (-)	NCBI
RGSC_v3.4	13	91,329,837 - 91,355,722 (-)	RGD
Celera	13	87,123,119 - 87,148,786 (-)	RGD

Sequence:

show sequence

CGTACAGCAGCACCATGAACCGCGCATTCTGTCTCCTCGCTCGCTCGCGTCGCTTCCCGCGGGT
CCCCTCCGCCGGTGCTGTATTGTCAGGGGAAGCGGCCACCCTCCCACGGTGTGCTCCGAACGTC
GTGCGAATGGCAAGCCAAAATTCCTTCCGTATAGAATACGACACCTTTGGTGAACTGAAGGTCC
CAACCGATAAGTATTATGGTGCTCAGACTGTAAGATCTACGATGAACTTTAAGATTGGAGGTGC
GACGGAGAGAATGCCAATCCCAGTCATTAAAGCATTTGGCATCTTGAAGCGAGCTGCTGCTGAA
GTGAACCAGGAGTATGGTCTCGATCCCAAGATTGCTAGTGCAATAATGAAGGCCGCAGATGAGG
TAGCTGAAGGTAAATTAAACGATCACTTTCCTCTGGTGGTATGGCAGACTGGGTCAGGAACCCA
GACGAACATGAATGTAAATGAAGTCATTAGCAACAGGGCAATCGAAATGCTAGGAGGTGAACTT
GGCAGCAAGAAGCCCGTGCACCCCAATGATCACGTTAACAAAAGCCAGAGCTCGAATGACACCT
TCCCCACAGCAATGCACATTGCTGCTGCACTGGAAGTTCACCAGGTCCTGTTGCCAGGATTACA
GAAGCTGCACGATGCCCTCAGTGCAAAATCCAAAGAGTTCGCGCAGGTCATAAAAATTGGGCGG
ACTCATACGCAGGACGCTGTCCCTCTTACTCTTGGACAGGAGTTCAGTGGTTATGTTCAGCAAG
TCCAGTATGCGATGGAGAGGATAAAAGCTGCCATGCCCAGAATCTACGAGCTCGCTGCTGGCGG
CACTGCCGTCGGCACGGGACTAAACACCAGGATCGGCTTCGCAGAAAAGGTGGCTGCAAAAGTC
GCAGCACTCACAGGTTTGCCTTTTGTCACTGCCCCGAATAAGTTTGAAGCTCTGGCCGCTCATG
ATGCTCTGGTGGAGCTTAGTGGAGCCATGAACACTACGGCCTGCAGTCTGATGAAGATTGCCAA
TGACATTCGCTTCCTCGGTTCTGGTCCTCGGTCCGGTTTGGGGGAGCTGATCTTGCCTGAAAAT
GAGCCAGGGAGCAGCATAATGCCAGGAAAGGTGAACCCTACTCAGTGTGAGGCGATGACCATGG
TTGCAGCCCAAGTCATGGGGAATCATGTCGCTGTTACTGTTGGAGGCAGCAATGGACATTTCGA
ACTGAATGTTTTTAAACCGATGATGATTAAGAATGTGTTGCACTCAGCCAGGCTACTGGGAGAT
GCTTCAGTGTCCTTCACAGAGAACTGTGTGGTAGGGATCCAGGCCAACACAGAGAGGATCAACA
AGCTAATGAACGAGTCTTTAATGTTGGTTACAGCTCTTAATCCGCATATAGGGTATGACAAAGC
AGCGAAGATTGCCAAGACTGCACACAAGAACGGATCAACCTTAAAGGAAACGGCTATTGAACTT
GGCTATCTCACAGCAGAGCAGTTTGATGAGTGGGTGAAACCCAAGGACATGCTGGGTCCAAAGT
GACTTAAATTTATATTAAAATAAACATGTATGAAATTTAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058701	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41177	(Get FASTA)	NCBI Sequence Viewer
	AAH87598	(Get FASTA)	NCBI Sequence Viewer
	EDL94769	(Get FASTA)	NCBI Sequence Viewer
	P14408	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_058701 ⟸ NM_017005
- Peptide Label:	precursor
- UniProtKB:	Q5M964 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNRAFCLLARSRRFPRVPSAGAVLSGEAATLPRCAPNVVRMASQNSFRIEYDTFGELKVPTDKY YGAQTVRSTMNFKIGGATERMPIPVIKAFGILKRAAAEVNQEYGLDPKIASAIMKAADEVAEGK LNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDTFPTAM HIAAALEVHQVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAM ERIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVE LSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQV MGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNE SLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK hide sequence

RefSeq Acc Id:

ENSRNOP00000004917 ⟸ ENSRNOT00000004917

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699039

Promoter ID:

EPDNEW_R9564

Type:

initiation region

Name:

Fh_1

Description:

fumarate hydratase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	93,677,377 - 93,677,437	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2614	AgrOrtholog
Ensembl Genes	ENSRNOG00000003653	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000004917	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004917	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.275.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7311498	IMAGE-MGC_LOAD
InterPro	Fum_hydII	UniProtKB/Swiss-Prot
	Fumarase/histidase_N	UniProtKB/Swiss-Prot
	Fumarase_C_C	UniProtKB/Swiss-Prot
	Fumarate_lyase_CS	UniProtKB/Swiss-Prot
	Fumarate_lyase_fam	UniProtKB/Swiss-Prot
	Fumarate_lyase_N	UniProtKB/Swiss-Prot
	L-Aspartase-like	UniProtKB/Swiss-Prot
KEGG Report	rno:24368	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105468	IMAGE-MGC_LOAD
NCBI Gene	24368	ENTREZGENE
PANTHER	PTHR11444	UniProtKB/Swiss-Prot
Pfam	FumaraseC_C	UniProtKB/Swiss-Prot
	Lyase_1	UniProtKB/Swiss-Prot
PhenoGen	Fh	PhenoGen
PRINTS	FUMRATELYASE	UniProtKB/Swiss-Prot
PROSITE	FUMARATE_LYASES	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48557	UniProtKB/Swiss-Prot
TIGRFAMs	fumC_II	UniProtKB/Swiss-Prot
UniProt	FUMH_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5M964	ENTREZGENE
UniProt Secondary	Q5M964	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-01-17	Fh	fumarate hydratase	Fh1	fumarate hydratase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Fh1	fumarate hydratase 1	Fh	Fumarate hydratase	Symbol and Name updated	625702	APPROVED
2002-06-10	Fh	Fumarate hydratase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in liver	632664
gene_other	possibly both the isozymes are encoded from the same mRNA	632664

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB