Fh<sup>em1</sup> (fumarate hydratase; TALEN induced mutant 1) - Rat Genome Database

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Gene: Fhem1 (fumarate hydratase; TALEN induced mutant 1) Rattus norvegicus
Symbol: Fhem1
Name: fumarate hydratase; TALEN induced mutant 1
RGD ID: 13792797
Description: A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein.
ASSOCIATED WITH abnormal kidney morphology; abnormal lymphocyte morphology; decreased blood uric acid level
Type: allele  of Fh  
Previously known as: Fh^[em1]
Is Marker For: Strains:   SD-Fhem1+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Generation of TALEN-mediated FH knockout rat model. Yu D, etal., Oncotarget. 2016 Sep 20;7(38):61656-61669. doi: 10.18632/oncotarget.11429.


Related Rat Strains
The following Strains have been annotated to Fhem1



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-28 Fhem1  fumarate hydratase; TALEN induced mutant 1  Fhem1    Name changed 629549 APPROVED