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Gene: Fh1 (fumarate hydratase 1) Mus musculus
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Symbol: Fh1
Name: fumarate hydratase 1
Description: Exhibits fumarate hydratase activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; regulation of arginine metabolic process; and urea cycle. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency. Orthologous to human FH (fumarate hydratase); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EF-3; Fh; Fh-1; fuma; fumarase; fumarate hydratase, mitochondrial
Orthologs:
Homo sapiens (human) : FH (fumarate hydratase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fh (fumarate hydratase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fh (fumarate hydratase)
Pan paniscus (bonobo/pygmy chimpanzee) : FH (fumarate hydratase)
Canis lupus familiaris (dog) : FH (fumarate hydratase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fh (fumarate hydratase)
Sus scrofa (pig) : FH (fumarate hydratase)
Chlorocebus sabaeus (African green monkey) : FH (fumarate hydratase)
Heterocephalus glaber (naked mole-rat) : Fh (fumarate hydratase)
more info ...
Related Pseudogenes: Gm17962   Gm7190  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBImm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Fh1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10587
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.