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Gene: Fh1 (fumarate hydratase 1) Mus musculus
Symbol: Fh1
Name: fumarate hydratase 1
Description: Exhibits fumarate hydratase activity. Involved in several processes, including positive regulation of cold-induced thermogenesis; regulation of arginine metabolic process; and urea cycle. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency. Orthologous to human FH (fumarate hydratase); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; fumaric aciduria pathway; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EF-3; Fh; Fh-1; fuma; fumarase; fumarate hydratase, mitochondrial
Homo sapiens (human) : FH (fumarate hydratase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fh (fumarate hydratase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fh (fumarate hydratase)
Pan paniscus (bonobo/pygmy chimpanzee) : FH (fumarate hydratase)
Canis lupus familiaris (dog) : FH (fumarate hydratase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fh (fumarate hydratase)
Sus scrofa (pig) : FH (fumarate hydratase)
Chlorocebus sabaeus (African green monkey) : FH (fumarate hydratase)
Heterocephalus glaber (naked mole-rat) : Fh (fumarate hydratase)
more info ...
Related Pseudogenes: Gm17962   Gm7190  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBImm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fh1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10587
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.