Fh1 (fumarate hydratase 1) - Rat Genome Database

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Gene: Fh1 (fumarate hydratase 1) Mus musculus
Analyze
Symbol: Fh1
Name: fumarate hydratase 1
RGD ID: 10587
MGI Page MGI
Description: Enables fumarate hydratase activity. Involved in several processes, including fumarate metabolic process; positive regulation of cold-induced thermogenesis; and tricarboxylic acid cycle. Acts upstream of or within homeostasis of number of cells within a tissue. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EF-3; Fh; Fh-1; fuma; fumarase; fumarate hydratase, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm17962   Gm7190  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,428,944 - 175,453,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,427,940 - 175,453,201 (-)EnsemblGRCm39 Ensembl
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBIMGSCv36mm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-adrenaline  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7H-xanthine  (ISO)
8-Epidiosbulbin E acetate  (EXP)
9H-xanthine  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
erastin  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Macrosphelide A  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
morphine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
olaparib  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phlorizin  (EXP)
pinosylvin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
talazoparib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
mitochondrial matrix  (IDA)
mitochondrion  (HDA,IBA,ISO)
nucleus  (IEA,ISO)
site of double-strand break  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. HIF and fumarate hydratase in renal cancer. Sudarshan S, etal., Br J Cancer. 2007 Feb 12;96(3):403-7. Epub 2007 Jan 9.
15. Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. Wei MH, etal., J Med Genet. 2006 Jan;43(1):18-27. Epub 2005 Jun 3.
Additional References at PubMed
PMID:8889548   PMID:9032278   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12761039   PMID:12904583   PMID:14681479   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16916647   PMID:17418408   PMID:17626619   PMID:18245842   PMID:18554416   PMID:18614015   PMID:18782761   PMID:18799693   PMID:19423573  
PMID:20354140   PMID:20660115   PMID:20978192   PMID:21267068   PMID:21630274   PMID:21677750   PMID:21849978   PMID:21873635   PMID:22014577   PMID:22405071   PMID:22496890   PMID:22645311  
PMID:22677546   PMID:22737085   PMID:23643539   PMID:25613188   PMID:26123588   PMID:27215380   PMID:27554470   PMID:27580029   PMID:28130547   PMID:28202494   PMID:28245920   PMID:28954230  
PMID:29199018   PMID:29222160   PMID:29688375   PMID:30415925   PMID:30457570   PMID:31648943   PMID:31693883   PMID:32325033   PMID:35012549   PMID:36293380   PMID:37142655   PMID:38418556  
PMID:38615945  


Genomics

Comparative Map Data
Fh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,428,944 - 175,453,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,427,940 - 175,453,201 (-)EnsemblGRCm39 Ensembl
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBIMGSCv36mm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.58NCBI
FH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,497,603 - 241,519,755 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,497,511 - 241,519,799 (-)EnsemblGRCh38hg38GRCh38
GRCh371241,660,903 - 241,683,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,727,526 - 239,749,677 (-)NCBINCBI36Build 36hg18NCBI36
Build 341237,986,946 - 238,009,095NCBI
Celera1214,915,854 - 214,938,092 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,119,119 - 212,141,338 (-)NCBIHuRef
CHM1_11242,933,564 - 242,955,781 (-)NCBICHM1_1
T2T-CHM13v2.01240,909,033 - 240,931,170 (-)NCBIT2T-CHM13v2.0
Fh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,056,565 - 90,082,450 (-)NCBIGRCr8
mRatBN7.21387,524,331 - 87,550,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,524,337 - 87,550,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,024,127 - 90,050,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,424,397 - 91,450,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,603,544 - 88,629,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,651,486 - 93,677,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,651,484 - 93,677,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,116,496 - 98,142,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,329,837 - 91,355,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,518,725 - 91,544,617 (-)NCBI
Celera1387,123,119 - 87,148,786 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,535,323 - 10,561,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,535,801 - 10,558,649 (+)NCBIChiLan1.0ChiLan1.0
FH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,627,088 - 7,649,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,851,062 - 7,873,025 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,059,847 - 217,081,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,041,142 - 222,063,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,041,142 - 222,064,212 (-)Ensemblpanpan1.1panPan2
FH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,900,250 - 32,927,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,901,586 - 32,927,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,378,016 - 32,404,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0732,726,854 - 32,753,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl732,726,854 - 32,753,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,562,040 - 32,588,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,586,108 - 32,613,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0732,834,235 - 32,861,236 (-)NCBIUU_Cfam_GSD_1.0
Fh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934445,782,142 - 45,811,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365268,935,991 - 8,965,367 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365268,936,096 - 8,965,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,404,176 - 12,431,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,404,143 - 12,431,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,852,719 - 14,879,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,576,931 - 78,599,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,575,300 - 78,599,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605580,709,772 - 80,732,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477111,856,884 - 11,887,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477111,861,537 - 11,886,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:891
Count of miRNA genes:426
Interacting mature miRNAs:492
Transcripts:ENSMUST00000027810, ENSMUST00000130996, ENSMUST00000133218, ENSMUST00000154956, ENSMUST00000176740
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
10045887Cplaq13_mcircadian period of locomotor activity 13 (mouse)Not determined1172831765181400659Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169137569179647565Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse

Markers in Region
Fh1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H4UniSTS
cM Map1 UniSTS
Fh1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027810   ⟹   ENSMUSP00000027810
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,427,940 - 175,453,201 (-)Ensembl
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,428,942 - 175,431,851 (-)Ensembl
GRCm38.p6 Ensembl1175,601,376 - 175,604,285 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133218
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,428,944 - 175,434,213 (-)Ensembl
GRCm38.p6 Ensembl1175,601,378 - 175,606,647 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154956   ⟹   ENSMUSP00000135140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,442,342 - 175,453,139 (-)Ensembl
GRCm38.p6 Ensembl1175,614,776 - 175,625,573 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176740   ⟹   ENSMUSP00000135385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,428,950 - 175,437,279 (-)Ensembl
GRCm38.p6 Ensembl1175,601,384 - 175,609,713 (-)Ensembl
RefSeq Acc Id: NM_010209   ⟹   NP_034339
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,428,944 - 175,453,201 (-)NCBI
GRCm381175,601,378 - 175,625,635 (-)ENTREZGENE
MGSCv371177,531,509 - 177,555,766 (-)RGD
Celera1182,687,061 - 182,711,324 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_034339 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB51039 (Get FASTA)   NCBI Sequence Viewer  
  AAH06048 (Get FASTA)   NCBI Sequence Viewer  
  BAE27597 (Get FASTA)   NCBI Sequence Viewer  
  EDL13210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027810
  ENSMUSP00000027810.8
  ENSMUSP00000135140.2
  ENSMUSP00000135385.2
GenBank Protein P97807 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034339   ⟸   NM_010209
- Peptide Label: precursor
- UniProtKB: Q99JL0 (UniProtKB/Swiss-Prot),   Q3UIA9 (UniProtKB/Swiss-Prot),   Q9DCX0 (UniProtKB/Swiss-Prot),   P97807 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027810   ⟸   ENSMUST00000027810
Ensembl Acc Id: ENSMUSP00000135140   ⟸   ENSMUST00000154956
Ensembl Acc Id: ENSMUSP00000135385   ⟸   ENSMUST00000176740
Protein Domains
Fumarase C C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97807-F1-model_v2 AlphaFold P97807 1-507 view protein structure

Promoters
RGD ID:6875842
Promoter ID:EPDNEW_M1372
Type:initiation region
Name:Fh1_1
Description:Mus musculus fumarate hydratase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381175,625,593 - 175,625,653EPDNEW
RGD ID:6817729
Promoter ID:MM_KWN:3013
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000062946,   OTTMUST00000062956
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,555,554 - 177,556,054 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95530 AgrOrtholog
Ensembl Genes ENSMUSG00000026526 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027810 ENTREZGENE
  ENSMUST00000027810.14 UniProtKB/Swiss-Prot
  ENSMUST00000154956.3 UniProtKB/TrEMBL
  ENSMUST00000176740.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot
  Fumarase/aspartase (C-terminal domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fum_hydII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/Swiss-Prot
  Fumarase_C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/Swiss-Prot
  Fumarate_lyase_fam UniProtKB/Swiss-Prot
  Fumarate_lyase_N UniProtKB/Swiss-Prot
  L-Aspartase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14194 UniProtKB/Swiss-Prot
MGD MGI:95530 ENTREZGENE
NCBI Gene 14194 ENTREZGENE
PANTHER FUMARATE HYDRATASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FumaraseC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lyase_1 UniProtKB/Swiss-Prot
PhenoGen Fh1 PhenoGen
PRINTS FUMRATELYASE UniProtKB/Swiss-Prot
PROSITE FUMARATE_LYASES UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48557 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FUMH_MOUSE UniProtKB/Swiss-Prot
  H3BJV5_MOUSE UniProtKB/TrEMBL
  H3BKG7_MOUSE UniProtKB/TrEMBL
  P97807 ENTREZGENE
  Q3UIA9 ENTREZGENE
  Q99JL0 ENTREZGENE
  Q9DCX0 ENTREZGENE
UniProt Secondary Q3UIA9 UniProtKB/Swiss-Prot
  Q99JL0 UniProtKB/Swiss-Prot
  Q9DCX0 UniProtKB/Swiss-Prot