FH (fumarate hydratase) - Rat Genome Database

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Gene: FH (fumarate hydratase) Sus scrofa
Analyze
Symbol: FH
Name: fumarate hydratase
RGD ID: 14257886
Description: ENCODES a protein that exhibits fumarate hydratase activity; histone binding (ortholog); INVOLVED IN fumarate metabolic process; malate metabolic process; DNA damage response (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; fumaric aciduria pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN mitochondrial matrix (ortholog); site of double-strand break (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fumarase; fumarate hydratase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,404,176 - 12,431,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,404,143 - 12,431,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,852,719 - 14,879,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:21498518   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,404,176 - 12,431,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,404,143 - 12,431,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,852,719 - 14,879,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,497,603 - 241,519,755 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,497,511 - 241,519,799 (-)EnsemblGRCh38hg38GRCh38
GRCh371241,660,903 - 241,683,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,727,526 - 239,749,677 (-)NCBINCBI36Build 36hg18NCBI36
Build 341237,986,946 - 238,009,095NCBI
Celera1214,915,854 - 214,938,092 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,119,119 - 212,141,338 (-)NCBIHuRef
CHM1_11242,933,564 - 242,955,781 (-)NCBICHM1_1
T2T-CHM13v2.01240,909,033 - 240,931,170 (-)NCBIT2T-CHM13v2.0
Fh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,428,944 - 175,453,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,427,940 - 175,453,201 (-)EnsemblGRCm39 Ensembl
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBIMGSCv36mm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.58NCBI
Fh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,056,565 - 90,082,450 (-)NCBIGRCr8
mRatBN7.21387,524,331 - 87,550,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,524,337 - 87,550,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,024,127 - 90,050,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,424,397 - 91,450,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,603,544 - 88,629,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,651,486 - 93,677,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,651,484 - 93,677,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,116,496 - 98,142,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,329,837 - 91,355,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,518,725 - 91,544,617 (-)NCBI
Celera1387,123,119 - 87,148,786 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,535,323 - 10,561,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,535,801 - 10,558,649 (+)NCBIChiLan1.0ChiLan1.0
FH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,627,088 - 7,649,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,851,062 - 7,873,025 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,059,847 - 217,081,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,041,142 - 222,063,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,041,142 - 222,064,212 (-)Ensemblpanpan1.1panPan2
FH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,900,250 - 32,927,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,901,586 - 32,927,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,378,016 - 32,404,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0732,726,854 - 32,753,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl732,726,854 - 32,753,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,562,040 - 32,588,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,586,108 - 32,613,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0732,834,235 - 32,861,236 (-)NCBIUU_Cfam_GSD_1.0
Fh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934445,782,142 - 45,811,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365268,935,991 - 8,965,367 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365268,936,096 - 8,965,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,576,931 - 78,599,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,575,300 - 78,599,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605580,709,772 - 80,732,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477111,856,884 - 11,887,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477111,861,537 - 11,886,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FH
807 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 4 3 5 2 20 2 1 3
Low 1 3 2
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000030683   ⟹   ENSSSCP00000026068
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1012,404,176 - 12,431,824 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000040701   ⟹   ENSSSCP00000046547
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1012,404,176 - 12,431,801 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000049181   ⟹   ENSSSCP00000036663
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1012,405,896 - 12,431,734 (-)Ensembl
RefSeq Acc Id: NM_001243588   ⟹   NP_001230517
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,405,599 - 12,431,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064041   ⟹   XP_020919700
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,405,709 - 12,431,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064042   ⟹   XP_020919701
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,405,703 - 12,431,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064043   ⟹   XP_020919702
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,405,703 - 12,431,822 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064044   ⟹   XP_020919703
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11012,404,143 - 12,431,800 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020919703   ⟸   XM_021064044
- Peptide Label: isoform X3
- UniProtKB: A0A286ZIY0 (UniProtKB/TrEMBL),   A0A4X1TEC9 (UniProtKB/TrEMBL),   A0A8D1PP57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230517   ⟸   NM_001243588
- UniProtKB: P10173 (UniProtKB/Swiss-Prot),   A0A287AR55 (UniProtKB/TrEMBL),   A0A4X1THY9 (UniProtKB/TrEMBL),   A0A8D1TV76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919702   ⟸   XM_021064043
- Peptide Label: isoform X3
- UniProtKB: A0A286ZIY0 (UniProtKB/TrEMBL),   A0A4X1TEC9 (UniProtKB/TrEMBL),   A0A8D1PP57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919701   ⟸   XM_021064042
- Peptide Label: isoform X2
- UniProtKB: A0A480Q1V4 (UniProtKB/TrEMBL),   A0A8D0R605 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919700   ⟸   XM_021064041
- Peptide Label: isoform X1
- UniProtKB: A0A480W635 (UniProtKB/TrEMBL),   A0A480V3D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000026068   ⟸   ENSSSCT00000030683
RefSeq Acc Id: ENSSSCP00000046547   ⟸   ENSSSCT00000040701
RefSeq Acc Id: ENSSSCP00000036663   ⟸   ENSSSCT00000049181

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028178 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015040602 UniProtKB/TrEMBL
  ENSSSCG00025019492 UniProtKB/TrEMBL
  ENSSSCG00030028801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035057562 UniProtKB/TrEMBL
  ENSSSCG00040010550 UniProtKB/TrEMBL
  ENSSSCG00045029869 UniProtKB/TrEMBL
  ENSSSCG00050050985 UniProtKB/TrEMBL
  ENSSSCG00055003954 UniProtKB/TrEMBL
  ENSSSCG00060021622 UniProtKB/TrEMBL
  ENSSSCG00065076536 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070009166 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030683 ENTREZGENE
  ENSSSCT00000030683.3 UniProtKB/TrEMBL
  ENSSSCT00000030683.4 UniProtKB/Swiss-Prot
  ENSSSCT00015054124.1 UniProtKB/TrEMBL
  ENSSSCT00015054624.1 UniProtKB/TrEMBL
  ENSSSCT00015055011.1 UniProtKB/TrEMBL
  ENSSSCT00025026609.1 UniProtKB/TrEMBL
  ENSSSCT00025026679.1 UniProtKB/TrEMBL
  ENSSSCT00030040221.1 UniProtKB/Swiss-Prot
  ENSSSCT00030040243.1 UniProtKB/TrEMBL
  ENSSSCT00030040253.1 UniProtKB/TrEMBL
  ENSSSCT00035077001.1 UniProtKB/TrEMBL
  ENSSSCT00035077023.1 UniProtKB/TrEMBL
  ENSSSCT00040013911.1 UniProtKB/TrEMBL
  ENSSSCT00040014045.1 UniProtKB/TrEMBL
  ENSSSCT00045051205.1 UniProtKB/TrEMBL
  ENSSSCT00045051501.1 UniProtKB/TrEMBL
  ENSSSCT00050069433.1 UniProtKB/TrEMBL
  ENSSSCT00050069445.1 UniProtKB/TrEMBL
  ENSSSCT00055007822.1 UniProtKB/TrEMBL
  ENSSSCT00055007828.1 UniProtKB/TrEMBL
  ENSSSCT00060029365.1 UniProtKB/TrEMBL
  ENSSSCT00060029387.1 UniProtKB/TrEMBL
  ENSSSCT00065105714.1 UniProtKB/Swiss-Prot
  ENSSSCT00065105721.1 UniProtKB/TrEMBL
  ENSSSCT00065105750.1 UniProtKB/TrEMBL
  ENSSSCT00070017807.1 UniProtKB/TrEMBL
  ENSSSCT00070017813.1 UniProtKB/TrEMBL
  ENSSSCT00070017818.1 UniProtKB/TrEMBL
  ENSSSCT00070017828.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (C-terminal domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fum_hydII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase_C_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100627128 UniProtKB/Swiss-Prot
NCBI Gene FH ENTREZGENE
PANTHER FUMARATE HYDRATASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11444 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FumaraseC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lyase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FUMRATELYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FUMARATE_LYASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZIY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AR55 ENTREZGENE
  A0A480Q1V4 ENTREZGENE, UniProtKB/TrEMBL
  A0A480V3D2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480W635 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TEC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TEE0_PIG UniProtKB/TrEMBL
  A0A4X1THT6_PIG UniProtKB/TrEMBL
  A0A4X1THY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0R605 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PP57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TV76 ENTREZGENE, UniProtKB/TrEMBL
  FUMH_PIG UniProtKB/Swiss-Prot
  I3LPP1_PIG UniProtKB/TrEMBL
  P10173 ENTREZGENE
UniProt Secondary A0A287AR55 UniProtKB/Swiss-Prot
VGNC ID VGNC:96300 ENTREZGENE