FH (fumarate hydratase) - Rat Genome Database

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Gene: FH (fumarate hydratase) Pan paniscus
Analyze
Symbol: FH
Name: fumarate hydratase
RGD ID: 12031472
Description: ENCODES a protein that exhibits fumarate hydratase activity (ortholog); histone binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of double-strand break repair via nonhomologous end joining (ortholog); regulation of arginine metabolic process (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; fumaric aciduria pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); breast cancer (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial matrix (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fumarate hydratase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,627,088 - 7,649,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,851,062 - 7,873,025 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,059,847 - 217,081,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,041,142 - 222,063,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,041,142 - 222,064,212 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonoboCOVID-19  ISOFH (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
FHBonobolung non-small cell carcinoma severityISOFH (Homo sapiens)9068941DNA:SNP: (rs1414493) (human)RGDPMID:25576295 and REF_RGD_ID:150340558
1 to 20 of 31 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonoboB-lymphoblastic leukemia/lymphoma  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: B Lymphoblastic Leukemia/Lymphoma and Not Otherwise SpecifiedClinVarPMID:25741868 and PMID:28492532
FHBonobobreast cancer  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of breastClinVar 
FHBonobofumarase deficiency  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: Fumarase deficiencyClinVarPMID:10896297 more ...
FHBonobogastrointestinal stromal tumor  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
FHBonobohepatoblastoma  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVarPMID:25741868 and PMID:28492532
FHBonobohepatocellular carcinoma  ISOFH (Homo sapiens)8554872ClinVar Annotator: match by term: Hepatocellular carcinomaClinVarPMID:10896297 more ...
FHBonoboHereditary Leiomyomatosis and Renal Cell Cancer  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11865300 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
FHBonoboHereditary Neoplastic Syndromes  ISOFH (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10896297 more ...
1 to 20 of 31 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonobofumarase deficiency  ISOFH (Homo sapiens)7240710 OMIM 
FHBonoboHereditary Leiomyomatosis and Renal Cell Cancer  ISOFH (Homo sapiens)7240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonoboarginine metabolic process involved_inIEAUniProtKB:P97807 and ensembl:ENSMUSP00000027810150520179 EnsemblGO_REF:0000107
FHBonoboDNA damage response involved_inISOFH (Homo sapiens)9068941 PMID:20231875 and PMID:26237645UniProtPMID:20231875 and PMID:26237645
FHBonobofumarate metabolic process involved_inIEAPANTHER:PTN000154515150520179 TreeGrafterGO_REF:0000118
FHBonobofumarate metabolic process involved_inIEAUniProtKB:P07954 and ensembl:ENSP00000355518150520179 EnsemblGO_REF:0000107
FHBonobofumarate metabolic process involved_inIEAInterPro:IPR005677150520179 InterProGO_REF:0000002
FHBonobohomeostasis of number of cells within a tissue acts_upstream_of_or_withinIEAUniProtKB:P97807 and ensembl:ENSMUSP00000027810150520179 EnsemblGO_REF:0000107
FHBonobomalate metabolic process involved_inIEAPANTHER:PTN000154515150520179 TreeGrafterGO_REF:0000118
FHBonobomalate metabolic process involved_inIEAUniProtKB:P07954 and ensembl:ENSP00000355518150520179 EnsemblGO_REF:0000107
FHBonobopositive regulation of cold-induced thermogenesis involved_inIEAUniProtKB:P97807 and ensembl:ENSMUSP00000027810150520179 EnsemblGO_REF:0000107
FHBonobopositive regulation of double-strand break repair via nonhomologous end joining involved_inISOFH (Homo sapiens)9068941 PMID:26237645UniProtPMID:26237645
FHBonoboregulation of arginine metabolic process involved_inISOFh1 (Mus musculus)9068941 PMID:23643539UniProtPMID:23643539
FHBonobotricarboxylic acid cycle involved_inIEAPANTHER:PTN000154515150520179 TreeGrafterGO_REF:0000118
FHBonobotricarboxylic acid cycle involved_inIEAInterPro:IPR018951150520179 InterProGO_REF:0000002
FHBonobotricarboxylic acid cycle involved_inIEAUniPathway:UPA00223150520179 UniProtGO_REF:0000041
FHBonobourea cycle involved_inIEAUniProtKB:P97807 and ensembl:ENSMUSP00000027810150520179 EnsemblGO_REF:0000107
FHBonobourea cycle acts_upstream_ofISOFh1 (Mus musculus)9068941 PMID:23643539UniProtPMID:23643539
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonobocytoplasm located_inISOFH (Homo sapiens)9068941 PMID:27037871UniProtPMID:27037871
FHBonobocytosol located_inIEAUniProtKB:P07954 and ensembl:ENSP00000355518150520179 EnsemblGO_REF:0000107
FHBonobomitochondrial matrix is_active_inISOFh1 (Mus musculus)9068941 PMID:31648943 and PMID:5496232MGIPMID:31648943 and PMID:5496232
FHBonobomitochondrion located_inIEAUniProtKB:A0A0S2Z4C3 more ...150520179 EnsemblGO_REF:0000107
FHBonobomitochondrion located_inIEAPANTHER:PTN000154515150520179 TreeGrafterGO_REF:0000118
FHBonobonucleus located_inISOFH (Homo sapiens)9068941 PMID:20231875 and PMID:26237645UniProtPMID:20231875 and PMID:26237645
FHBonobosite of double-strand break located_inISOFH (Homo sapiens)9068941 PMID:26237645UniProtPMID:26237645

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonobocatalytic activity enablesIEAInterPro:IPR008948 and InterPro:IPR020557150520179 InterProGO_REF:0000002
FHBonobofumarate hydratase activity enablesIEAPANTHER:PTN000154515150520179 TreeGrafterGO_REF:0000118
FHBonobofumarate hydratase activity enablesIEAUniProtKB:P07954 and ensembl:ENSP00000355518150520179 EnsemblGO_REF:0000107
FHBonobofumarate hydratase activity enablesIEAARBA:ARBA00026386150520179 UniProtGO_REF:0000117
FHBonobofumarate hydratase activity enablesIEAInterPro:IPR005677150520179 InterProGO_REF:0000002
FHBonobofumarate hydratase activity enablesIEAEC:4.2.1.2150520179 UniProtGO_REF:0000003
FHBonobofumarate hydratase activity  ISOFh (Rattus norvegicus)9068941 RGDPMID:2914923 and REF_RGD_ID:632664
FHBonobohistone binding enablesISOUniProtKB:P0C0S59068941 PMID:26237645UniProtPMID:26237645
FHBonobolyase activity enablesIEAInterPro:IPR018951150520179 InterProGO_REF:0000002
FHBonobolyase activity enablesIEAUniProtKB-KW:KW-0456150520179 UniProtGO_REF:0000043
FHBonoboprotein binding enablesISOUniProtKB:P0C0S59068941 PMID:26237645IntActPMID:26237645
FHBonoboprotein binding enablesISOUniProtKB:Q9NQT49068941 PMID:39251607IntActPMID:39251607
FHBonoboprotein binding enablesISOUniProtKB:O14787-2 more ...9068941 PMID:32296183IntActPMID:32296183
FHBonoboprotein binding enablesISOUniProtKB:O952739068941 PMID:26871637IntActPMID:26871637
FHBonoboprotein binding enablesISOUniProtKB:P113099068941 PMID:25416956IntActPMID:25416956
FHBonoboprotein binding enablesISOUniProtKB:P785279068941 PMID:26237645UniProtPMID:26237645
1 to 16 of 16 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FHBonoboaltered citric acid cycle pathway  ISOFH (Homo sapiens)9068941 RGDPMID:17211469 and REF_RGD_ID:6907135
FHBonoborenal cell carcinoma pathway   ISOFH (Homo sapiens)9068941 RGDPMID:17211469 and REF_RGD_ID:6907135

Imported Annotations - SMPDB

PMID:22301074   PMID:30032202  



FH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v217,627,088 - 7,649,060 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117,851,062 - 7,873,025 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01217,059,847 - 217,081,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,041,142 - 222,063,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,041,142 - 222,064,212 (-)Ensemblpanpan1.1panPan2
FH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381241,497,603 - 241,519,755 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1241,497,511 - 241,519,799 (-)EnsemblGRCh38hg38GRCh38
GRCh371241,660,903 - 241,683,055 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,727,526 - 239,749,677 (-)NCBINCBI36Build 36hg18NCBI36
Build 341237,986,946 - 238,009,095NCBI
Celera1214,915,854 - 214,938,092 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1212,119,119 - 212,141,338 (-)NCBIHuRef
CHM1_11242,933,564 - 242,955,781 (-)NCBICHM1_1
T2T-CHM13v2.01240,909,033 - 240,931,170 (-)NCBIT2T-CHM13v2.0
Fh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,428,944 - 175,453,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,427,940 - 175,453,201 (-)EnsemblGRCm39 Ensembl
GRCm381175,601,378 - 175,625,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,600,374 - 175,625,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,531,509 - 177,555,766 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361177,438,053 - 177,462,253 (-)NCBIMGSCv36mm8
Celera1182,687,061 - 182,711,324 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.58NCBI
Fh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81390,056,565 - 90,082,450 (-)NCBIGRCr8
mRatBN7.21387,524,331 - 87,550,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1387,524,337 - 87,550,266 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1390,024,127 - 90,050,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01391,424,397 - 91,450,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01388,603,544 - 88,629,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01393,651,486 - 93,677,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1393,651,484 - 93,677,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01398,116,496 - 98,142,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41391,329,837 - 91,355,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11391,518,725 - 91,544,617 (-)NCBI
Celera1387,123,119 - 87,148,786 (-)NCBICelera
Cytogenetic Map13q24NCBI
Fh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540610,535,323 - 10,561,627 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540610,535,801 - 10,558,649 (+)NCBIChiLan1.0ChiLan1.0
FH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,900,250 - 32,927,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,901,586 - 32,927,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha732,378,016 - 32,404,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0732,726,854 - 32,753,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl732,726,854 - 32,753,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1732,562,040 - 32,588,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0732,586,108 - 32,613,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0732,834,235 - 32,861,236 (-)NCBIUU_Cfam_GSD_1.0
Fh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934445,782,142 - 45,811,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365268,935,991 - 8,965,367 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365268,936,096 - 8,965,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1012,404,176 - 12,431,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11012,404,143 - 12,431,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,852,719 - 14,879,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12578,576,931 - 78,599,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2578,575,300 - 78,599,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605580,709,772 - 80,732,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477111,856,884 - 11,887,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477111,861,537 - 11,886,154 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.





RefSeq Transcripts XM_003824525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000036277   ⟹   ENSPPAP00000013604
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1222,041,142 - 222,064,212 (-)Ensembl
RefSeq Acc Id: XM_003824525   ⟹   XP_003824573
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v217,627,088 - 7,649,060 (+)NCBI
NHGRI_mPanPan117,851,062 - 7,873,025 (+)NCBI
Mhudiblu_PPA_v01217,059,847 - 217,081,795 (-)NCBI
PanPan1.11222,041,142 - 222,063,271 (-)NCBI
Sequence:
Protein RefSeqs XP_003824573 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013604.1
RefSeq Acc Id: XP_003824573   ⟸   XM_003824525
- UniProtKB: A0A2R9A8K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000013604   ⟸   ENSPPAT00000036277


1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000029968 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036277.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/TrEMBL
  Fumarase/aspartase (C-terminal domain) UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/TrEMBL
InterPro Fum_hydII UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/TrEMBL
  Fumarase_C_C UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/TrEMBL
  Fumarate_lyase_fam UniProtKB/TrEMBL
  Fumarate_lyase_N UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/TrEMBL
KEGG Report pps:100992582 UniProtKB/TrEMBL
NCBI Gene FH ENTREZGENE
PANTHER FUMARATE HYDRATASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11444 UniProtKB/TrEMBL
Pfam FumaraseC_C UniProtKB/TrEMBL
  Lyase_1 UniProtKB/TrEMBL
PRINTS FUMRATELYASE UniProtKB/TrEMBL
PROSITE FUMARATE_LYASES UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/TrEMBL
UniProt A0A2R9A8K1 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows