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ONTOLOGY REPORT - ANNOTATIONS


Term:abacavir
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Accession:CHEBI:421707 term browser browse the term
Definition:A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
Synonyms:exact_synonym: {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
 related_synonym: ABC;   Formula=C14H18N6O;   InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1;   InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N;   SMILES=Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1;   {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
 alt_id: CHEBI:193608;   CHEBI:2360;   CHEBI:441792;   CHEBI:520984;   CHEBI:525912;   MESH:C106538
 xref: Beilstein:7493116 "Beilstein";   CAS:136470-78-5 "ChemIDplus";   CAS:136470-78-5 "KEGG COMPOUND";   DrugBank:DB01048;   Drug_Central:34 "DrugCentral";   KEGG:C07624;   KEGG:D07057
 xref_mesh: MESH:C106538
 xref: PMID:11678376 "Europe PMC";   PMID:11806176 "Europe PMC";   PMID:12781181 "ChEMBL";   PMID:15887959 "ChEMBL";   PMID:16458506 "ChEMBL";   PMID:16539393 "ChEMBL";   PMID:16759112 "ChEMBL";   PMID:17172311 "ChEMBL";   PMID:17870541 "ChEMBL";   PMID:18029175 "ChEMBL";   PMID:18549801 "Europe PMC";   PMID:24751900 "Europe PMC";   PMID:25017682 "Europe PMC";   PMID:25674793 "Europe PMC";   PMID:26024233 "Europe PMC";   Reaxys:7493116 "Reaxys";   Wikipedia:Abacavir


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abacavir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          antiviral agent 3602
            antiviral drug 1648
              abacavir 14
                abacavir 5'-carboxylic acid 0
                abacavir 5'-glucuronide 0
                abacavir monophosphate 0
                abacavir sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      imidazopyrimidine 5334
                                        purines 5332
                                          aminopurine 4287
                                            2,6-diaminopurines 14
                                              abacavir 14
                                                abacavir 5'-carboxylic acid 0
                                                abacavir 5'-glucuronide 0
                                                abacavir monophosphate 0
                                                abacavir sulfate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.