Gene: Slc25a21 (solute carrier family 25 member 21) Rattus norvegicus
Analyze
Symbol:
Slc25a21
Name:
solute carrier family 25 member 21
Description:
Predicted to localize to the integral component of membrane and mitochondrial inner membrane. Orthologous to human SLC25A21 (solute carrier family 25 member 21); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
MGC105329; mitochondrial 2-oxodicarboxylate carrier; Odc1; oxodicarboxylate carrier; solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC25A21 (solute carrier family 25 member 21) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Slc25a21 (solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Slc25a21 (solute carrier family 25 member 21) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC25A21 (solute carrier family 25 member 21) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC25A21 (solute carrier family 25 member 21) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc25a21 (solute carrier family 25 member 21) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC25A21 (solute carrier family 25 member 21) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SLC25A21 (solute carrier family 25 member 21)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Slc25a21 (solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
slc25a21 (solute carrier family 25 member 21)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
ODC1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG5254
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG9582
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
slc-25A21
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
ODC2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 77,624,384 - 78,121,339 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 77,624,385 - 77,848,434 (-) Ensembl Rnor_5.0 6 87,150,622 - 87,637,326 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 77,124,451 - 77,632,510 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 77,127,574 - 77,635,636 (-) NCBI Celera 6 73,010,400 - 73,501,204 (-) NCBI Celera Cytogenetic Map 6 q23 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE decreases expression EXP 6480464 Topotecan results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SLC25A21 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SLC25A21 mRNA CTD PMID:21215274 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SLC25A21 mRNA CTD PMID:22504374 aflatoxin B1 affects expression ISO RGD:1350119 6480464 Aflatoxin B1 affects the expression of SLC25A21 protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:1350119 6480464 Aflatoxin B1 results in decreased methylation of SLC25A21 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:1350119 6480464 Aflatoxin B1 results in decreased expression of SLC25A21 mRNA CTD PMID:21632981 , PMID:22100608 belinostat decreases expression ISO RGD:1350119 6480464 belinostat results in decreased expression of SLC25A21 mRNA CTD PMID:27188386 benzo[a]pyrene decreases expression ISO RGD:1350119 6480464 Benzo(a)pyrene results in decreased expression of SLC25A21 mRNA CTD PMID:20106945 more ... bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC25A21 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1350119 6480464 butyraldehyde results in decreased expression of SLC25A21 mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:1552659 6480464 Nanotubes, Carbon results in decreased expression of SLC25A21 mRNA CTD PMID:25620056 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of SLC25A21 mRNA CTD PMID:24386269 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of SLC25A21 mRNA CTD PMID:23640034 dorsomorphin multiple interactions ISO RGD:1350119 6480464 [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of SLC25A21 mRNA CTD PMID:29391264 entinostat decreases expression ISO RGD:1350119 6480464 entinostat results in decreased expression of SLC25A21 mRNA CTD PMID:27188386 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SLC25A21 mRNA CTD PMID:22061828 irinotecan decreases expression ISO RGD:1350119 6480464 Irinotecan analog results in decreased expression of SLC25A21 mRNA CTD PMID:18927307 methimazole increases expression EXP 6480464 Methimazole results in increased expression of SLC25A21 mRNA CTD PMID:22504374 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 pentanal decreases expression ISO RGD:1350119 6480464 pentanal results in decreased expression of SLC25A21 mRNA CTD PMID:26079696 propanal decreases expression ISO RGD:1350119 6480464 propionaldehyde results in decreased expression of SLC25A21 mRNA CTD PMID:26079696 quercetin decreases expression ISO RGD:1350119 6480464 Quercetin results in decreased expression of SLC25A21 mRNA CTD PMID:21632981 riddelliine increases expression EXP 6480464 riddelliine results in increased expression of SLC25A21 mRNA CTD PMID:18047722 SB 431542 multiple interactions ISO RGD:1350119 6480464 [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom decreases expression ISO RGD:1552659 6480464 Silver results in decreased expression of SLC25A21 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1552659 6480464 Silver results in decreased expression of SLC25A21 mRNA CTD PMID:27131904 silver(1+) decreases expression ISO RGD:1552659 6480464 Silver results in decreased expression of SLC25A21 mRNA CTD PMID:27131904 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of SLC25A21 mRNA CTD PMID:22110744 thimerosal multiple interactions ISO RGD:1350119 6480464 [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC25A21 mRNA CTD PMID:27188386 toluene affects expression EXP 6480464 Toluene affects the expression of SLC25A21 mRNA CTD PMID:18653662 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of SLC25A21 mRNA CTD PMID:25729387 urethane decreases expression ISO RGD:1350119 6480464 Urethane results in decreased expression of SLC25A21 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1350119 6480464 Valproic Acid affects the expression of SLC25A21 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1350119 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A21 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1350119 6480464 Valproic Acid results in decreased expression of SLC25A21 mRNA CTD PMID:24383497 more ... zidovudine increases expression ISO RGD:1350119 6480464 Zidovudine results in increased expression of SLC25A21 mRNA CTD PMID:24292225
Gene Ontology Annotations
Cellular Component integral component of membrane IEA UniRule:UR000413536 1600115 GO_REF:0000104 UniProt GO_REF:0000104 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 mitochondrial inner membrane IEA UniProtKB-SubCell:SL-0168 1600115 GO_REF:0000039 UniProt GO_REF:0000039
4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) percentage of deaths in a study population during a period of time (CMO:0001024) 6 7009971 115379601 Rat 4889848 Pur25 Proteinuria QTL 25 14 0.003 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 59803065 94001333 Rat 6893332 Cm74 Cardiac mass QTL 74 0.4 0.64 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 6 60606431 108154445 Rat 6893340 Cm77 Cardiac mass QTL 77 0.26 0.57 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 6 36260288 84763275 Rat 731173 Uae22 Urinary albumin excretion QTL 22 10.1 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 9590290 Uminl2 Urine mineral level QTL 2 3.96 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 6 41679046 86679046 Rat 9590306 Scort18 Serum corticosterone level QTL 18 2.88 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 41679046 86679046 Rat 634307 Bp141 Blood pressure QTL 141 4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 38106308 83106308 Rat 634330 Pia16 Pristane induced arthritis QTL 16 3.9 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 6 48432758 108268790 Rat 1300143 Rf14 Renal function QTL 14 2.92 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 34367436 80490628 Rat 1300075 Glom7 Glomerulus QTL 7 5.6 0.0000002 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 6 75449871 120449871 Rat 9590140 Scort4 Serum corticosterone level QTL 4 14.49 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 41679046 86679046 Rat 1331789 Rf37 Renal function QTL 37 3.224 kidney blood vessel physiology trait (VT:0100012) absolute change in renal vascular resistance (CMO:0001900) 6 75623277 120276465 Rat 1331799 Bp211 Blood pressure QTL 211 3.66407 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 75623277 136426962 Rat 1558641 Cm47 Cardiac mass QTL 47 2.9 0.001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 6 60606431 108154445 Rat 1581550 Pur8 Proteinuria QTL 8 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 75623393 136142742 Rat 1641904 Alcrsp4 Alcohol response QTL 4 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 6 71206251 116206251 Rat 1581563 Uae33 Urinary albumin excretion QTL 33 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 75623393 136142742 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 70176 Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 62263348 107263348 Rat 70196 BpQTLcluster7 Blood pressure QTL cluster 7 6.82 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 75623277 120623277 Rat 2290393 Uae37 Urinary albumin excretion QTL 37 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 724524 Uae2 Urinary albumin excretion QTL 2 2.7 0.0005 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 76902247 114203334 Rat 724536 Uae7 Urinary albumin excretion QTL 7 3.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 75623277 136143011 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2301964 Bp323 Blood pressure QTL 323 4.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 75623393 84763275 Rat 12801471 Schws9 Schwannoma susceptibility QTL 9 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 6 66129520 111129520 Rat
Predicted Target Of
Count of predictions: 58 Count of miRNA genes: 53 Interacting mature miRNAs: 54 Transcripts: ENSRNOT00000034342 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
