Slc25a21 (solute carrier family 25 member 21)

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Gene: Slc25a21 (solute carrier family 25 member 21) Rattus norvegicus

Analyze

Symbol:

Slc25a21

Name:

solute carrier family 25 member 21

RGD ID:

621444

Description:

Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC105329; mitochondrial 2-oxodicarboxylate carrier; Odc1; oxodicarboxylate carrier; solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC25A21 (solute carrier family 25 member 21)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc25a21 (solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc25a21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC25A21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC25A21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc25a21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC25A21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC25A21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc25a21 (solute carrier family 25 member 21)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IFITM10 (interferon induced transmembrane protein 10)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC25A21 (solute carrier family 25 member 21)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc25a21 (solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc25a21 (solute carrier family 25 member 21)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ODC1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5254	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9582	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	slc-25A21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ODC2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc25a21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	74,203,439 - 74,702,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	74,203,440 - 74,702,680 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	74,616,827 - 75,122,323 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	74,916,140 - 75,421,635 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	74,343,605 - 74,849,121 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	77,624,384 - 78,121,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	77,624,385 - 77,848,434 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	87,150,622 - 87,637,326 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	77,124,451 - 77,632,510 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	77,127,574 - 77,635,636 (-)	NCBI
Celera	6	73,010,400 - 73,501,204 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anodontia (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

choreatic disease (ISO)

genetic disease (ISO)

mitochondrial DNA depletion syndrome 18 (ISO)

Selective Tooth Agenesis 3 (ISO)

tooth agenesis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

butanal (ISO)

carbon nanotube (ISO)

cobalt dichloride (EXP)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

fenvalerate (EXP)

fulvestrant (ISO)

gentamycin (EXP)

irinotecan (ISO)

methimazole (EXP)

methoxychlor (EXP)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

pentanal (ISO)

propanal (ISO)

quercetin (ISO)

riddelliine (EXP)

rotenone (EXP)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

thimerosal (ISO)

thioacetamide (EXP)

toluene (EXP)

topotecan (EXP)

urethane (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid transport (IEA)

mitochondrial alpha-ketoglutarate transmembrane transport (IEA,ISO)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IEA)

Molecular Function

alpha-ketoglutarate transmembrane transporter activity (IEA,ISO)

antiporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location.	Fiermonte G, etal., J Biol Chem 2001 Mar 16;276(11):8225-30.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:18614015	PMID:21873635

Genomics

Comparative Map Data

Slc25a21
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	74,203,439 - 74,702,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	74,203,440 - 74,702,680 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	74,616,827 - 75,122,323 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	74,916,140 - 75,421,635 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	74,343,605 - 74,849,121 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	77,624,384 - 78,121,339 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	77,624,385 - 77,848,434 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	87,150,622 - 87,637,326 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	77,124,451 - 77,632,510 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	77,127,574 - 77,635,636 (-)	NCBI
Celera	6	73,010,400 - 73,501,204 (-)	NCBI		Celera
Cytogenetic Map	6	q23	NCBI

SLC25A21
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	36,677,921 - 37,172,606 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	36,677,921 - 37,172,606 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	37,147,126 - 37,641,811 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	36,218,829 - 36,711,616 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	36,218,828 - 36,711,616	NCBI
Celera	14	17,010,674 - 17,505,455 (-)	NCBI		Celera
Cytogenetic Map	14	q13.3	NCBI
HuRef	14	17,261,499 - 17,756,171 (-)	NCBI		HuRef
CHM1_1	14	37,146,272 - 37,641,918 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	30,867,261 - 31,362,039 (-)	NCBI		T2T-CHM13v2.0

Slc25a21
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	56,759,419 - 57,244,257 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	56,759,419 - 57,244,257 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	56,712,634 - 57,197,472 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	56,712,634 - 57,197,472 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	57,813,621 - 58,298,459 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	57,630,836 - 58,115,484 (-)	NCBI		MGSCv36	mm8
Celera	12	57,878,480 - 58,364,481 (-)	NCBI		Celera
Cytogenetic Map	12	C1	NCBI
cM Map	12	24.54	NCBI

Slc25a21
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	23,952,595 - 24,421,307 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	23,949,794 - 24,421,944 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A21
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	14	37,209,563 - 37,708,394 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	17,431,789 - 17,926,277 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	35,793,261 - 36,287,436 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	35,794,557 - 35,990,633 (-)	Ensembl	panpan1.1		panPan2

SLC25A21
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	15,239,634 - 15,708,964 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	15,238,719 - 15,708,526 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	15,039,326 - 15,508,864 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	15,350,597 - 15,821,777 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	15,350,762 - 15,821,128 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	15,049,508 - 15,519,554 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	15,116,588 - 15,586,598 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	15,406,571 - 15,876,813 (-)	NCBI		UU_Cfam_GSD_1.0

Slc25a21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	47,169,640 - 47,650,696 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936494	10,676,235 - 11,156,083 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936494	10,675,534 - 11,157,829 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A21
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	62,810,937 - 63,325,625 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	62,808,126 - 63,326,634 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	68,085,398 - 68,235,406 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC25A21
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	13,472,050 - 13,974,991 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	13,473,395 - 13,680,176 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	2,472,343 - 3,007,377 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc25a21
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624838	75,767 - 128,843 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624838	68,999 - 129,463 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc25a21
2324 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	58
Count of miRNA genes:	53
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000034342
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	33309549	81132889	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	34434137	77102317	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	35230417	80230417	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	38783989	83783989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	38783989	83783989	Rat
634330	Pia16	Pristane induced arthritis QTL 16	3.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	6	45790088	104200226	Rat
4889848	Pur25	Proteinuria QTL 25	14	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	56728562	90198260	Rat
6893332	Cm74	Cardiac mass QTL 74	0.4	0.64	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	57730540	104085867	Rat
1558641	Cm47	Cardiac mass QTL 47	2.9	0.001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	6	57730540	104085867	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	58632962	103632962	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	61747639	106747639	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641904	Alcrsp4	Alcohol response QTL 4			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	6	67262953	112262953	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	71201409	116201409	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	72202632	115200186	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72202632	117202632	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	72227641	81132889	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	73463459	109394713	Rat

Markers in Region

D6Rat21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,627,755 - 74,627,930 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	78,045,234 - 78,045,408	NCBI	Rnor6.0
Rnor_5.0	6	87,562,651 - 87,562,825	UniSTS	Rnor5.0
RGSC_v3.4	6	77,557,737 - 77,557,911	UniSTS	RGSC3.4
RGSC_v3.4	6	77,557,580 - 77,558,064	RGD	RGSC3.4
RGSC_v3.1	6	77,560,863 - 77,561,037	RGD
Celera	6	73,427,050 - 73,427,224	UniSTS
RH 3.4 Map	6	543.6	RGD
RH 3.4 Map	6	543.6	UniSTS
RH 2.0 Map	6	764.8	RGD
SHRSP x BN Map	6	51.1399	RGD
FHH x ACI Map	6	60.26	RGD
Cytogenetic Map	6	q23	UniSTS

D6Rat49

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,508,247 - 74,508,389 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	77,923,451 - 77,923,592	NCBI	Rnor6.0
Rnor_5.0	6	87,446,671 - 87,446,812	UniSTS	Rnor5.0
RGSC_v3.4	6	77,434,659 - 77,434,801	RGD	RGSC3.4
RGSC_v3.4	6	77,434,660 - 77,434,801	UniSTS	RGSC3.4
RGSC_v3.1	6	77,437,785 - 77,437,927	RGD
Celera	6	73,307,456 - 73,307,597	UniSTS
RH 3.4 Map	6	541.3	RGD
RH 3.4 Map	6	541.3	UniSTS
RH 2.0 Map	6	755.3	RGD
FHH x ACI Map	6	61.34	RGD
Cytogenetic Map	6	q23	UniSTS

D6Rat127

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,356,958 - 74,357,208 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	77,777,639 - 77,777,888	NCBI	Rnor6.0
Rnor_5.0	6	87,302,823 - 87,303,072	UniSTS	Rnor5.0
RGSC_v3.4	6	77,278,409 - 77,278,745	RGD	RGSC3.4
RGSC_v3.4	6	77,278,431 - 77,278,680	UniSTS	RGSC3.4
RGSC_v3.1	6	77,281,557 - 77,281,806	RGD
Celera	6	73,163,912 - 73,164,161	UniSTS
RH 3.4 Map	6	536.9	RGD
RH 3.4 Map	6	536.9	UniSTS
RH 2.0 Map	6	750.7	RGD
SHRSP x BN Map	6	49.9899	RGD
Cytogenetic Map	6	q23	UniSTS

D6Got97

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,520,934 - 74,521,182 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	77,936,274 - 77,936,521	NCBI	Rnor6.0
Rnor_5.0	6	87,459,494 - 87,459,741	UniSTS	Rnor5.0
RGSC_v3.4	6	77,450,259 - 77,450,507	RGD	RGSC3.4
RGSC_v3.4	6	77,450,260 - 77,450,507	UniSTS	RGSC3.4
RGSC_v3.1	6	77,453,386 - 77,453,633	RGD
Celera	6	73,320,170 - 73,320,417	UniSTS
RH 3.4 Map	6	541.3	UniSTS
RH 3.4 Map	6	541.3	RGD
RH 2.0 Map	6	761.2	RGD
Cytogenetic Map	6	q23	UniSTS

BE121226

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,702,700 - 74,702,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	78,120,177 - 78,120,326	NCBI	Rnor6.0
Rnor_5.0	6	87,636,760 - 87,636,909	UniSTS	Rnor5.0
RGSC_v3.4	6	77,632,680 - 77,632,829	UniSTS	RGSC3.4
Celera	6	73,501,374 - 73,501,523	UniSTS
RH 3.4 Map	6	542.2	UniSTS
Cytogenetic Map	6	q23	UniSTS

AU047466

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	74,676,594 - 74,676,750 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	78,094,071 - 78,094,226	NCBI	Rnor6.0
Rnor_5.0	6	87,610,830 - 87,610,985	UniSTS	Rnor5.0
RGSC_v3.4	6	77,606,574 - 77,606,729	UniSTS	RGSC3.4
Celera	6	73,475,249 - 73,475,403	UniSTS
Cytogenetic Map	6	q23	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		6	22	14	3	14				6	4
Low		37	35	27	16	27	1	1	34	29	36	8	1
Below cutoff	1						7	8	40		1	3	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ289714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB883167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC940576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000034342 ⟹ ENSRNOP00000037607

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	74,203,440 - 74,664,321 (-)	Ensembl
Rnor_6.0 Ensembl	6	77,624,385 - 77,848,434 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097338 ⟹ ENSRNOP00000083938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	74,204,725 - 74,431,892 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119506 ⟹ ENSRNOP00000084175

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	74,203,440 - 74,702,680 (-)	Ensembl

RefSeq Acc Id:

NM_133614 ⟹ NP_598298

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	74,203,439 - 74,702,693 (-)	NCBI
Rnor_6.0	6	77,624,384 - 78,120,007 (-)	NCBI
Rnor_5.0	6	87,150,622 - 87,637,326 (-)	NCBI
RGSC_v3.4	6	77,124,451 - 77,632,510 (-)	RGD
Celera	6	73,010,400 - 73,501,204 (-)	RGD

Sequence:

show sequence

GTCAGTGTTCCCCTCCAGCGCCCCTGTGGAAAGGGCAGCCTCAGGCAGCGCCGGGCAAATTCGG
ACCCCCTCCGCCGACCTCGCCGCGAGCCGGTGCCAGAACCGCCGTCTTTAGCTGGACCGCAGCC
ACACAGGGAAGACTTCAGCCCCAGAACCGACGGGACCCGGTCTCCATCGGCGGCGGCCTTCAGC
GAGCGGCGGCCTTCAGAGGAGCTCGCTCCAGCATCTTGGCTACTCTGTCCCCTGGTCACGAAGA
TGTCGGCCTCCAACGTCAGCTTGCTGCACGAGACCTGCAGGCAGGTCGCGGCCGGAGGGTGTGC
AGGTCTTGTAGAAATTTGCCTGATGCATCCCCTCGATGTGGTGAAAACCAGGTTCCAGGTTCAG
AGAAGTGTAACAGACCCACAGAGTTATAAAAGCTTAAGAGACAGCTTTCAGGTGATCTTCCGAA
CAGAGGGGTTGTTTGGCTTTTACAAGGGAATTATCCCACCGATTTTAGCTGAAACACCAAAAAG
AGCTGTCAAGTTTTCCACCTTTGAGCTGTACAAGAAATTTCTGGGATATATGTCACTATCACCA
GGGCTGACATTTCCCATTGCTGGATTAGGATCTGGACTAACAGAAGCCGTCGTGGTTAACCCTT
TTGAGGTGGTAAAAGTTGGTCTACAAGTCAATCGGAACATGTTCACAGAGCAACCATCTACTTT
TGCTTATGCAAGACAAATCATTAAGAAGGAAGGCTGGGGGTTCCAGGGCCTCAACAAAGGATTT
ACAGCAACTCTGGGACGCCACGGAATTTTCAACATGACTTACTTTGGCTTCTACTACAACGTCA
AAGATAATATTCCATCCAGTAAGGATCCAACCTTGGAGTTTTTGAGAAAATTTGGAATTGGTTT
TGTCTCCGGGACAGTGGGCTCAGTCTTTAACATCCCCTTTGATGTTGCGAAGAGTAGGATCCAA
GGACCTCAGCCAGTTCCTGGAGAGATCAAGTACCGAGGCTGCTTCAAAACCATGGAGACGGTCT
ACAGGGAAGAAGGGATTTTAGCCTTATACAAAGGCCTGCTCCCCAAGGTGATGCGACTTGGACC
AGGTGGTGGGGTGATGCTGCTGGTATATGAATACACCTATGCGTGGCTGCAGGAGAACTGGTGA
AGGACTGAGAGACGCTTTCCCCTTGACAACAGAGATGTGGTCTGCAGCCCCACGCAGAGAAGAC
AAGCTAGACGATGCCGTTAAGAGGGGGAGACAGCCTGCTCAGGAGCAAAGCCTGTTCCGATGTT
TTATAATTTTTAGACAAACTGACATGGTAGTTTGGGCCATATACATAACACTGTGAGAAGGAAA
ATAACACGAAGCAGTGGGGTTTGTAAGTTAGGGATCACTAGGATAGAGATCAGATACAGTTCAT
AAAAGCTATACAAAGTGTCTGACCCCCATGCTTCACCACAAAAACTCATTTGATAACTTTTCTG
AGAAGTCTATAAATCCATAAATTCTTGAAAATAAATTGTTCTGCAGCTGATTTCCTGAGAATTA
TTCAAAGGAAGACTTAGGTATGAGTCAGAATTTAAACATGTTTTACAAGGAATTACTTTTCCAT
AAATCATATTTTAAAAGAAAAGAAAGAAAAAACTTAAATACACCAAAACAGCCATTTAAGAATG
TTTAATTTTGTGAGTGCTGAGTTAAAATGTGAGTCTATTGGTTTTCTTTAGTAATTAATGCATC
CTCAGGCTCCGTTTCCCTAAATGTATTTTATATTCCACATGGTGACTTAAGTGGATATATTAAA
ATCATGCTATTTGAAGACTTTTGTTAAAAATAGAATACATGATATTATATTAAACTGCTTTCTC
TTACATAGTTCATTTTGAAAACAAGATTTGTTACTGATTTTTTTTGGGGGGGTGGGGTTAGGTC
ACAAATTGAATGAACTTTTTGGGCCCTTCTCTGTTGCCCAAAGTTGTCTCCAAACACCCATCCT
TAAAAAGGATGTAGGAAAATAAAACTATCTCCAGATTCTTGGGTTTAAGTCACATTTTGAAGCA
TAAAATCAACTATTTAGAATATTAAAATGTCTACATTAAGTGGCAAACATTTCAAAAATGAAAA
TACATTCTTTAGCACTTCTAAACACTCATGCATTAATATGCACTCTGGGAAAAAAAAGAAAGAC
AGCTTTTTGGTCCTGATATAATAACCAAAGCTTATTTTTATGTCTGTACTGTGTAATGAGACTT
CTCCAGTCAAGAAAAAAAAATCTCAACATGTTTTAAGTGACAGTTGTTCTTGACTAACTAGCCC
TGTGGGGTATTTCAACTAGGGGCAAGCTCACCAAAACATTTTGAAAATAAACAGTGAAGATGGC
ATGGTAATTATTATGTTTATTAATTTAGAGCATCTGAAGTATAAAAATAAAAGGCTTTTGACAT
ACTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

XM_039111745 ⟹ XP_038967673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	74,245,822 - 74,702,902 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_598298	(Get FASTA)	NCBI Sequence Viewer
	XP_038967673	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89099	(Get FASTA)	NCBI Sequence Viewer
	CAC27796	(Get FASTA)	NCBI Sequence Viewer
	CBF65811	(Get FASTA)	NCBI Sequence Viewer
	CBU90682	(Get FASTA)	NCBI Sequence Viewer
	EDM03446	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037607.6
	ENSRNOP00000083938.1
	ENSRNOP00000084175
GenBank Protein	Q99JD3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598298 ⟸ NM_133614

- UniProtKB:

Q99JD3 (UniProtKB/Swiss-Prot), A6HBP1 (UniProtKB/TrEMBL), A0A140TAF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSASNVSLLHETCRQVAAGGCAGLVEICLMHPLDVVKTRFQVQRSVTDPQSYKSLRDSFQVIFR
TEGLFGFYKGIIPPILAETPKRAVKFSTFELYKKFLGYMSLSPGLTFPIAGLGSGLTEAVVVNP
FEVVKVGLQVNRNMFTEQPSTFAYARQIIKKEGWGFQGLNKGFTATLGRHGIFNMTYFGFYYNV
KDNIPSSKDPTLEFLRKFGIGFVSGTVGSVFNIPFDVAKSRIQGPQPVPGEIKYRGCFKTMETV
YREEGILALYKGLLPKVMRLGPGGGVMLLVYEYTYAWLQENW

hide sequence

RefSeq Acc Id:

ENSRNOP00000037607 ⟸ ENSRNOT00000034342

RefSeq Acc Id:	XP_038967673 ⟸ XM_039111745
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000083938 ⟸ ENSRNOT00000097338

RefSeq Acc Id:

ENSRNOP00000084175 ⟸ ENSRNOT00000119506

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99JD3-F1-model_v2	AlphaFold	Q99JD3	1-298	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621444	AgrOrtholog
BioCyc Gene	G2FUF-37425	BioCyc
Ensembl Genes	ENSRNOG00000008931	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034342.6	UniProtKB/TrEMBL
	ENSRNOT00000097338.1	UniProtKB/TrEMBL
	ENSRNOT00000119506	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.50.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7306738	IMAGE-MGC_LOAD
InterPro	Mitochondrial_sb/sol_carrier	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171151	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105329	IMAGE-MGC_LOAD
NCBI Gene	171151	ENTREZGENE
PANTHER	MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER	UniProtKB/Swiss-Prot
	MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER	UniProtKB/Swiss-Prot
	MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER	UniProtKB/TrEMBL
	MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER	UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc25a21	PhenoGen
PROSITE	SOLCAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008931	RatGTEx
Superfamily-SCOP	SSF103506	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A140TAF1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G9N8_RAT	UniProtKB/TrEMBL
	A6HBP1	ENTREZGENE, UniProtKB/TrEMBL
	ODC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc25a21	solute carrier family 25 member 21	Slc25a21	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Slc25a21	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	Slc25a21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc25a21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Slc25a21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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