Slc26a1 (solute carrier family 26 member 1) - Rat Genome Database

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Gene: Slc26a1 (solute carrier family 26 member 1) Rattus norvegicus
Analyze
Symbol: Slc26a1
Name: solute carrier family 26 member 1
RGD ID: 620136
Description: Enables sulfate:bicarbonate antiporter activity. Involved in sulfate transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: canalicular sulfate transporter; sat-1; solute carrier family 26 (anion exchanger), member 1; solute carrier family 26 (sulfate transporter), member 1; sulfate anion transporter; sulfate anion transporter 1; sulfate/carbonate antiporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,040,565 - 1,045,851 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,040,243 - 1,045,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14940,390 - 945,676 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,242,167 - 2,247,453 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014938,860 - 944,146 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,050,805 - 2,056,091 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,050,483 - 2,056,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,046,346 - 2,051,632 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,581,589 - 1,586,875 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,581,266 - 1,586,873 (+)NCBI
Celera141,079,905 - 1,085,191 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. Bissig M, etal., J Biol Chem 1994 Jan 28;269(4):3017-21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney. Karniski LP, etal., Am J Physiol. 1998 Jul;275(1):F79-87. doi: 10.1152/ajprenal.1998.275.1.F79.
5. Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions. Krick W, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F145-54. doi: 10.1152/ajprenal.90401.2008. Epub 2009 Apr 15.
6. Bicarbonate sulfate exchange in canalicular rat liver plasma membrane vesicles. Meier PJ, etal., Am J Physiol. 1987 Oct;253(4 Pt 1):G461-8. doi: 10.1152/ajpgi.1987.253.4.G461.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Localization of the sulfate/anion exchanger in the rat liver. Quondamatteo F, etal., Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G1075-81. doi: 10.1152/ajpgi.00492.2005. Epub 2005 Dec 15.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells. Schnedler N, etal., J Hepatol. 2011 Mar;54(3):513-20. doi: 10.1016/j.jhep.2010.07.036. Epub 2010 Sep 19.
Additional References at PubMed
PMID:12217875   PMID:12477932   PMID:12590734   PMID:15070814   PMID:19002488   PMID:26671068  


Genomics

Comparative Map Data
Slc26a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2141,040,565 - 1,045,851 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,040,243 - 1,045,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14940,390 - 945,676 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,242,167 - 2,247,453 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014938,860 - 944,146 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,050,805 - 2,056,091 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,050,483 - 2,056,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,046,346 - 2,051,632 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,581,589 - 1,586,875 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,581,266 - 1,586,873 (+)NCBI
Celera141,079,905 - 1,085,191 (+)NCBICelera
Cytogenetic Map14p22NCBI
SLC26A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384978,991 - 993,404 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4979,073 - 993,440 (-)EnsemblGRCh38hg38GRCh38
GRCh374972,823 - 987,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364962,861 - 977,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 344971,274 - 977,013NCBI
Celera4909,807 - 924,170 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4944,081 - 958,446 (-)NCBIHuRef
CHM1_14972,645 - 987,011 (-)NCBICHM1_1
T2T-CHM13v2.04977,118 - 991,535 (-)NCBIT2T-CHM13v2.0
Slc26a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,817,744 - 108,826,246 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,817,744 - 108,823,435 (-)EnsemblGRCm39 Ensembl
GRCm385108,669,878 - 108,678,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,669,878 - 108,675,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv375109,099,560 - 109,104,668 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,910,180 - 108,915,871 (-)NCBIMGSCv36mm8
Celera5105,792,486 - 105,798,328 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
Slc26a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514475,731 - 479,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955514476,062 - 484,710 (-)NCBIChiLan1.0ChiLan1.0
SLC26A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan141,273,068 - 1,293,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,102,938 - 1,112,987 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,021,157 - 1,026,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,012,920 - 1,026,402 (-)Ensemblpanpan1.1panPan2
SLC26A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,528,045 - 91,534,104 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,485,270 - 91,534,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha393,996,593 - 94,000,624 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0392,526,061 - 92,532,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1391,699,880 - 91,705,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,752,838 - 91,758,900 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,136,646 - 92,142,712 (+)NCBIUU_Cfam_GSD_1.0
Slc26a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,507,763 - 68,519,289 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,208,451 - 22,213,592 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,209,445 - 22,213,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8335,427 - 342,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18335,420 - 345,955 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC26A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,787,201 - 47,802,834 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,789,705 - 47,793,743 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366680862,915 - 72,446 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc26a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,164,795 - 26,169,365 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475526,162,730 - 26,168,443 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc26a1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:182
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000000047
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37 27 5 1
Low 3 10 20 4 19 4 8 9 72 8 19 10 8
Below cutoff 31 2 2 15

Sequence


RefSeq Acc Id: ENSRNOT00000000047   ⟹   ENSRNOP00000000047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,040,243 - 1,045,849 (+)Ensembl
Rnor_6.0 Ensembl142,050,483 - 2,056,089 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111929   ⟹   ENSRNOP00000095191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,040,879 - 1,045,849 (+)Ensembl
RefSeq Acc Id: NM_022287   ⟹   NP_071623
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,040,565 - 1,045,851 (+)NCBI
Rnor_6.0142,050,805 - 2,056,091 (+)NCBI
Rnor_5.0142,046,346 - 2,051,632 (+)NCBI
RGSC_v3.4141,581,589 - 1,586,875 (+)RGD
Celera141,079,905 - 1,085,191 (+)RGD
Sequence:
RefSeq Acc Id: NP_071623   ⟸   NM_022287
- UniProtKB: P45380 (UniProtKB/Swiss-Prot),   Q5RKK1 (UniProtKB/TrEMBL),   A6KPE0 (UniProtKB/TrEMBL),   F7EVA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000047   ⟸   ENSRNOT00000000047
RefSeq Acc Id: ENSRNOP00000095191   ⟸   ENSRNOT00000111929
Protein Domains
STAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45380-F1-model_v2 AlphaFold P45380 1-703 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699143
Promoter ID:EPDNEW_R9667
Type:initiation region
Name:Slc26a1_1
Description:solute carrier family 26 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0142,050,725 - 2,050,785EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620136 AgrOrtholog
BioCyc Gene G2FUF-16684 BioCyc
Ensembl Genes ENSRNOG00000000041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055026764 UniProtKB/Swiss-Prot
  ENSRNOG00060011282 UniProtKB/Swiss-Prot
  ENSRNOG00065012214 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000047 ENTREZGENE
  ENSRNOT00000000047.3 UniProtKB/TrEMBL
  ENSRNOT00000111929.1 UniProtKB/TrEMBL
  ENSRNOT00055046236 UniProtKB/Swiss-Prot
  ENSRNOT00060019086 UniProtKB/Swiss-Prot
  ENSRNOT00065019857 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.750.24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108820 IMAGE-MGC_LOAD
InterPro S04_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC26A/SulP_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64076 UniProtKB/TrEMBL
MGC_CLONE MGC:93448 IMAGE-MGC_LOAD
NCBI Gene 64076 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11814:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfate_transp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc26a1 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000041 RatGTEx
  ENSRNOG00055026764 RatGTEx
  ENSRNOG00060011282 RatGTEx
  ENSRNOG00065012214 RatGTEx
Superfamily-SCOP SSF52091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6B257_RAT UniProtKB/TrEMBL
  A6KPE0 ENTREZGENE, UniProtKB/TrEMBL
  F7EVA2 ENTREZGENE, UniProtKB/TrEMBL
  P45380 ENTREZGENE
  Q5RKK1 ENTREZGENE
  S26A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5RKK1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc26a1  solute carrier family 26 member 1  Slc26a1  solute carrier family 26 (anion exchanger), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc26a1  solute carrier family 26 (anion exchanger), member 1  Slc26a1  solute carrier family 26 (sulfate transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc26a1  solute carrier family 26 (sulfate transporter), member 1      Symbol and Name status set to approved 625702 APPROVED
2003-05-07 Slc26a1  solute carrier family 26 (sulfate transporter), member 1  sat-1  sulfate anion transporter  Symbol and Name updated to reflect Human and Mouse nomenclature 628472 PROVISIONAL
2002-08-07 sat-1  sulfate anion transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 12 putative transmembrane spanning domains 730015
gene_process channel functions in Na(+)-independent sulfate uptake 730015