Slc26a1 (solute carrier family 26 member 1)

Gene: Slc26a1 (solute carrier family 26 member 1) Rattus norvegicus

Analyze

Symbol:

Slc26a1

Name:

solute carrier family 26 member 1

RGD ID:

620136

Description:

Enables sulfate:bicarbonate antiporter activity. Involved in sulfate transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

canalicular sulfate transporter; sat-1; solute carrier family 26 (anion exchanger), member 1; solute carrier family 26 (sulfate transporter), member 1; sulfate anion transporter; sulfate anion transporter 1; sulfate/carbonate antiporter

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC26A1 (solute carrier family 26 member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc26a1 (solute carrier family 26 (sulfate transporter), member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IDUA (alpha-L-iduronidase)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Slc26a1 (solute carrier family 26 (sulfate transporter), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC26A1 (solute carrier family 26 member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc26a1 (solute carrier family 26 member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prestin	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YPR003C	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	sulp-1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sulp-3	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-5	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-7	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc26a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI		GRCr8
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	940,390 - 945,676 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,242,167 - 2,247,453 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	938,860 - 944,146 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	1,581,266 - 1,586,873 (+)	NCBI
Celera	14	1,079,905 - 1,085,191 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

calcium oxalate nephrolithiasis (ISO)

Calcium Oxalate Nephrolithiasis 1 (ISO)

carbohydrate metabolic disorder (ISO)

cherubism (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

Hyperoxaluria (ISO)

interstitial lung disease (ISO)

Mental Retardation, Autosomal Recessive 53 (ISO)

mucopolysaccharidosis (ISO)

mucopolysaccharidosis I (ISO)

mucopolysaccharidosis Ih (ISO)

mucopolysaccharidosis Ih/s (ISO)

nephrocalcinosis (ISO)

nephrolithiasis (ISO)

Scheie syndrome (ISO)

urolithiasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (EXP)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

cisplatin (ISO)

clofibric acid (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

dextran sulfate (ISO)

Diisodecyl phthalate (ISO)

endosulfan (ISO)

epoxiconazole (ISO)

Estradiol dipropionate (EXP)

ethylene glycol (EXP)

fenthion (ISO)

flavonoids (EXP)

flutamide (EXP)

furan (EXP)

gentamycin (EXP)

inulin (ISO)

N-nitrosodiethylamine (EXP)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

progesterone (EXP)

propanal (ISO)

resveratrol (ISO)

tauroursodeoxycholic acid (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vancomycin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bicarbonate transport (IEA)

carboxylic acid transmembrane transport (ISO)

chloride transmembrane transport (IEA)

chloride transport (ISO)

monoatomic anion transmembrane transport (IEA)

oxalate transport (ISO)

sulfate transmembrane transport (IEA)

sulfate transport (IDA,ISO)

Cellular Component

basolateral plasma membrane (IDA,ISO)

membrane (IEA)

plasma membrane (IBA,ISO)

Molecular Function

antiporter activity (IEA)

bicarbonate transmembrane transporter activity (IBA)

chloride transmembrane transporter activity (IBA,ISO,ISS)

monoatomic anion transmembrane transporter activity (IEA)

oxalate transmembrane transporter activity (IBA,ISO,ISS)

protein binding (ISO)

secondary active sulfate transmembrane transporter activity (IEA)

solute:inorganic anion antiporter activity (IDA,IEA,ISO)

sulfate transmembrane transporter activity (IBA,IDA,ISO)

sulfate:bicarbonate antiporter activity (IDA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes.	Bissig M, etal., J Biol Chem 1994 Jan 28;269(4):3017-21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney.	Karniski LP, etal., Am J Physiol. 1998 Jul;275(1):F79-87. doi: 10.1152/ajprenal.1998.275.1.F79.
5.	Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.	Krick W, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F145-54. doi: 10.1152/ajprenal.90401.2008. Epub 2009 Apr 15.
6.	Bicarbonate sulfate exchange in canalicular rat liver plasma membrane vesicles.	Meier PJ, etal., Am J Physiol. 1987 Oct;253(4 Pt 1):G461-8. doi: 10.1152/ajpgi.1987.253.4.G461.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Localization of the sulfate/anion exchanger in the rat liver.	Quondamatteo F, etal., Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G1075-81. doi: 10.1152/ajpgi.00492.2005. Epub 2005 Dec 15.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells.	Schnedler N, etal., J Hepatol. 2011 Mar;54(3):513-20. doi: 10.1016/j.jhep.2010.07.036. Epub 2010 Sep 19.

Additional References at PubMed

PMID:12217875	PMID:12477932	PMID:12590734	PMID:15070814	PMID:19002488	PMID:26671068

Genomics

Comparative Map Data

Slc26a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI		GRCr8
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	940,390 - 945,676 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,242,167 - 2,247,453 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	938,860 - 944,146 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	1,581,266 - 1,586,873 (+)	NCBI
Celera	14	1,079,905 - 1,085,191 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

SLC26A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	978,991 - 993,404 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	979,073 - 993,440 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	972,823 - 987,192 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	962,861 - 977,224 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	971,274 - 977,013	NCBI
Celera	4	909,807 - 924,170 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	944,081 - 958,446 (-)	NCBI		HuRef
CHM1_1	4	972,645 - 987,011 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	977,118 - 991,535 (-)	NCBI		T2T-CHM13v2.0

Slc26a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,817,744 - 108,826,246 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,817,744 - 108,823,435 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	108,669,878 - 108,678,380 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,669,878 - 108,675,569 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	109,099,560 - 109,104,668 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,910,180 - 108,915,871 (-)	NCBI		MGSCv36	mm8
Celera	5	105,792,486 - 105,798,328 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	53.24	NCBI

Slc26a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	475,731 - 479,616 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	476,062 - 484,710 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC26A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	1,305,579 - 1,320,531 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	1,273,068 - 1,293,527 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	1,102,938 - 1,112,987 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	1,021,157 - 1,026,402 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	1,012,920 - 1,026,402 (-)	Ensembl	panpan1.1		panPan2

SLC26A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	91,528,045 - 91,534,104 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	91,485,270 - 91,534,115 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	93,996,593 - 94,000,624 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	92,526,061 - 92,532,133 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	3	91,699,880 - 91,705,945 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	91,752,838 - 91,758,900 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	92,136,646 - 92,142,712 (+)	NCBI		UU_Cfam_GSD_1.0

Slc26a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	68,507,763 - 68,519,289 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	22,208,451 - 22,213,592 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	22,209,445 - 22,213,592 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC26A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	335,427 - 342,444 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	335,420 - 345,955 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC26A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	47,787,201 - 47,802,834 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	47,789,705 - 47,793,743 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666808	62,915 - 72,446 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc26a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	26,164,795 - 26,169,365 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	26,162,730 - 26,168,443 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc26a1
10 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	281
Count of miRNA genes:	182
Interacting mature miRNAs:	202
Transcripts:	ENSRNOT00000000047
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			37	37		37				27	5	1
Low	3	10	20	4	19	4	8	9	72	8	19	10	8
Below cutoff		31						2	2		15

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L23413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000047 ⟹ ENSRNOP00000000047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111929 ⟹ ENSRNOP00000095191

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	1,040,879 - 1,045,849 (+)	Ensembl

RefSeq Acc Id:

NM_022287 ⟹ NP_071623

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,184,971 - 1,190,257 (+)	NCBI
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	RGD
Celera	14	1,079,905 - 1,085,191 (+)	RGD

Sequence:

show sequence

GCCGGCCTGGTGTCCCAGATTAGCCAAAGAGCCTGGTGTGACAGGATGGATGCTTCTCCTGAGC
CCCCGCAGAAGGGCGGGACACTGGTACTGGTCCGACGGCAGCCCCCTGTGTCCCAGGGCTTGCT
GGAAACACTGAAGGCCAGGCTGAAGAAGAGCTGCACCTGCAGTATGCCATGCGCTCAGGCTCTG
GTGCAAGGTCTGTTTCCTGTCATACGCTGGCTGCCCCAGTACCGCCTTAAGGAATACCTGGCAG
GTGATGTCATGTCGGGATTGGTCATTGGCATTATCCTGGTGCCACAGGCCATAGCCTACTCACT
GCTGGCTGGGTTGCAGCCCATCTACAGTCTCTACACTTCCTTCTTCGCCAACCTTATCTACTTC
CTCATGGGTACCTCCCGCCACGTTAATGTGGGCATCTTCAGCCTGCTGTGTCTCATGGTGGGTC
AGGTGGTGGACCGAGAACTCCAGTTGGCTGGCTTTGACCCCTCCCAGGATTCTCTAGGGCCCGG
GAACAATGACAGCACCCTCAACAACACAGCCACACTGACAGTTGGGCTACAGGACTGTGGGCGG
GACTGCCATGCCATTCGTATCGCCACTGCCCTCACTCTGATGGCCGGGCTTTATCAGGTCCTCA
TGGGGATCCTCCGGCTGGGCTTCGTGTCTACCTATCTCTCGCAACCCCTGCTCGATGGCTTTGC
TATGGGAGCTTCTGTGACCATCTTGACTTCTCAGGCTAAACACCTGCTGGGCGTGCGGATCCCT
CGGCACCAGGGCCTAGGCATGGTGATCCACACTTGGCTGAGCTTGCTGCAGAACGTGGGACAGG
CTAATCTGTGTGATGTGGTCACCAGTGCCGTGTGCCTGGCAGTGCTGCTGACAGCTAAGGAACT
CTCGGATCGCTATCGACACTATCTGAAAGTGCCAGTGCCCACAGAGCTATTAGTTATTGTGGTG
GCCACGATTGCGTCCCATTTTGGACAGCTCCATACACGGTTTGGCTCGAGTGTGGCCGGCAACA
TTCCCACTGGTTTTGTGGCCCCACAGATACCAGACCCTAAGATAATGTGGAGTGTGGCCCTGGA
TGCCATGTCCCTGGCCCTCGTGGGCTCAGCCTTCTCCATCTCCTTGGCAGAAATGTTTGCACGT
AGTCATGGCTACTCTGTCAGTGCCAACCAAGAGCTGCTAGCTGTGGGCTGTTGCAACGTGCTGC
CTGCCTTCTTCCACTGTTTTGCCACTAGTGCTGCTCTGTCCAAAACTCTGGTGAAGATAGCCAC
TGGCTGCCAGACCCAGTTGTCCAGTGTGGTCAGTGCTGCTGTGGTGTTGCTGGTGCTGCTGGTG
CTGGCGCCATTGTTTCACGATCTGCAGCGGTGTGTGTTAGCTTGCATCATTGTCGTCAGCCTGA
GGGGGGCGCTGCGCAAGGTGAAGGATCTCCCACAACTTTGGCGGCTAAGCCCTGCGGACGCACT
GGTCTGGGTGGCTACTGCAGCGACCTGTGTTCTAGTCAGCATCGAGGCTGGGCTATTAGCTGGG
GTGTTCTTCTCACTGCTCAGCCTGGCAGGCCGCACGCAGCGTCCACGGGCTGCCCTTCTGGCTC
GAATTGGAGACTCGACCTTCTATGAGGATGCTGCTGAGTTTGAGGGCCTCCTGCCCCCGCCCGA
GGTGCGAGTGTTCCGTTTCACAGGTCCGCTCTACTATGCCAACAAGGATTTCTTCCTTCGGTCA
CTCTACAGTCTGACAGGGCTGGATGCTGGGTACTCAGCCACCAGGAAGGATCGGGGCACAGAGG
TGGGTGTCAGTAACAGAAGTCTTGTTGACCGCAAGGATCTGGGTTCAGTGAGCAGTGGGGATGG
GCTGGTTGTACCCCTGGCATTTGGTTTCCACACAGTGGTCATTGACTGTGCACCACTGCTGTTC
CTGGATGTGGCTGGCATGGCCACATTGAAGGACCTGCGCAAAAACTACAGGGCCCTGGACATCA
CCCTGCTTCTGGCTTGCTGCAGTCCCTCAGTGAGAGACACACTGAGAAAAGGGGGCTTCCTTGG
GGAAGACCAGGGAACTGAAGAGGAGCTGCTGTTCCCCAGTGTACACAGCGCTGTGGAGACAGCA
TGTGCCCGCCGTGAGGAGCTGATGGCTGCTGACTCTGCCCTCTAGCAGGGCCCGCTTCCTCAAG
AGCCAAGACCTGTGTCCACGAGCCAGTCCTGAGCTCTTTTGTAGGAGTGACATGAATGATAAAG
TCATTATAGATAAATCCTTGGACCGCCTTTGCCCTGGAGAAGCCAGGGAACTCCAAGTAGGAAA
GGAAAGTGCAGTACCCTTAACACATTGGAGGATTCCAAACATTCAGTGATTGAGGCGCTCTACC
TCTGAGCCCACTGCTGCCCCCTGGTGCCTATTCAACCCTAGTAGTTGCACCCACACACATGATT
CCCTCAGCCAACACAGTGCCCAGTTTGATAGTCTGTTTATGTTGTCATCTGAAACAGAGTCCTG
CAAATTATATGACCTCCATGATGCCAAAAGGACACTTTCCCATTCCCTGAACCATCGGGTACCA
GATGTGAGCTGAATATGTGGCCACACCTCAAGGGTCTGAATTTCCGAAAGGCCTCCTTAGGCCT
GGTGCTCATCTTGATTGGACCCTTGCAAAGGCAGCCACCTGCTCCAGAGTCACAGTCCAGTGTC
ACTGTCTAACCGATGTGACTGACATAACCTCAACCTGACTTTCGGGCACAATGTCCCAATACAG
CTTATACTGGTAACCACAACGTGGCGTATGTATGGTACAAAGCCAGGCACAGTAGACACTTACC
CCATTCTGCTGTACTTCTAAGAAAACCTCAGGAGGAAACCACCTGTGCTCCATCCAGGGCCTGC
CTTTGGCACAGCCAAGCAGACATTCCCCTCCTCCTCTGCCCAACAGGATGCTCTAACTGGAAGC
ACACCCCAGCCCTGTGCACTACCATGATTCTCCCCCACCCACAGCCCAGCATTGTGTTCCACAG
CTGGCCCCAAAAACGTCAGCTCCACCATCTCGGCTCTCTTAAAACAAGCTCTGACCAGCAATTC
CCAGGGTACCCATTTCAGCGTCACCCACCTGGCTGTGATGAGGTCCAGCAGCCAGTGTATCCGG
ACCTGCTCAATGCCACTGTGAGGCACAGCACCTATGTAGGCAAGGTTCAGTTGCTGGTCCCAAC
TAAGGTCGTACTGGTCAGCCTGGTCGTGAGGCAGTGGGGGGCTAGGGATAGGACAAAGAAGTGA
AGTGTTTGTCCTAAGCAGGGGCCTGCATCATACCAGACTTTACACATGTTATCACCTGACTACC
TAGACCCTTGAGGATGAACTGTGTATCTCCAGAATGTATGATAAAGTAGCCCACTAACCAGAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063273574 ⟹ XP_063129644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071623	(Get FASTA)	NCBI Sequence Viewer
	XP_063129644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17545	(Get FASTA)	NCBI Sequence Viewer
	AAH85735	(Get FASTA)	NCBI Sequence Viewer
	EDL84026	(Get FASTA)	NCBI Sequence Viewer
	EDL84027	(Get FASTA)	NCBI Sequence Viewer
	EDL84028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000047.1
	ENSRNOP00000095191.1
	ENSRNOP00055037958
	ENSRNOP00060014907
	ENSRNOP00065015221
GenBank Protein	P45380	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071623 ⟸ NM_022287

- UniProtKB:

P45380 (UniProtKB/Swiss-Prot), Q5RKK1 (UniProtKB/TrEMBL), A6KPE0 (UniProtKB/TrEMBL), F7EVA2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDASPEPPQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMPCAQALVQGLFPVIRWLPQYR
LKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVNVGIFSL
LCLMVGQVVDRELQLAGFDPSQDSLGPGNNDSTLNNTATLTVGLQDCGRDCHAIRIATALTLMA
GLYQVLMGILRLGFVSTYLSQPLLDGFAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSL
LQNVGQANLCDVVTSAVCLAVLLTAKELSDRYRHYLKVPVPTELLVIVVATIASHFGQLHTRFG
SSVAGNIPTGFVAPQIPDPKIMWSVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAV
GCCNVLPAFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLAC
IIVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIEAGLLAGVFFSLLSLAGRTQRP
RAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYSLTGLDAGYSATR
KDRGTEVGVSNRSLVDRKDLGSVSSGDGLVVPLAFGFHTVVIDCAPLLFLDVAGMATLKDLRKN
YRALDITLLLACCSPSVRDTLRKGGFLGEDQGTEEELLFPSVHSAVETACARREELMAADSAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000000047 ⟸ ENSRNOT00000000047

Ensembl Acc Id:

ENSRNOP00000095191 ⟸ ENSRNOT00000111929

RefSeq Acc Id:	XP_063129644 ⟸ XM_063273574
- Peptide Label:	isoform X1
- UniProtKB:	P45380 (UniProtKB/Swiss-Prot), A6KPE0 (UniProtKB/TrEMBL), F7EVA2 (UniProtKB/TrEMBL), Q5RKK1 (UniProtKB/TrEMBL)

Protein Domains

STAS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P45380-F1-model_v2	AlphaFold	P45380	1-703	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699143

Promoter ID:

EPDNEW_R9667

Type:

initiation region

Name:

Slc26a1_1

Description:

solute carrier family 26 member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	2,050,725 - 2,050,785	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620136	AgrOrtholog
BioCyc Gene	G2FUF-16684	BioCyc
Ensembl Genes	ENSRNOG00000000041	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055026764	UniProtKB/Swiss-Prot
	ENSRNOG00060011282	UniProtKB/Swiss-Prot
	ENSRNOG00065012214	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000000047.3	UniProtKB/TrEMBL
	ENSRNOT00000111929.1	UniProtKB/TrEMBL
	ENSRNOT00055046236	UniProtKB/Swiss-Prot
	ENSRNOT00060019086	UniProtKB/Swiss-Prot
	ENSRNOT00065019857	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.750.24	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7108820	IMAGE-MGC_LOAD
InterPro	S04_transporter_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SLC26A/SulP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SLC26A/SulP_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STAS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STAS_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64076	UniProtKB/TrEMBL
MGC_CLONE	MGC:93448	IMAGE-MGC_LOAD
NCBI Gene	64076	ENTREZGENE
PANTHER	PTHR11814	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11814:SF31	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	STAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sulfate_transp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc26a1	PhenoGen
PROSITE	SLC26A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STAS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000041	RatGTEx
	ENSRNOG00055026764	RatGTEx
	ENSRNOG00060011282	RatGTEx
	ENSRNOG00065012214	RatGTEx
Superfamily-SCOP	SSF52091	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6B257_RAT	UniProtKB/TrEMBL
	A6KPE0	ENTREZGENE, UniProtKB/TrEMBL
	F7EVA2	ENTREZGENE, UniProtKB/TrEMBL
	P45380	ENTREZGENE
	Q5RKK1	ENTREZGENE
	S26A1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q5RKK1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc26a1	solute carrier family 26 member 1	Slc26a1	solute carrier family 26 (anion exchanger), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc26a1	solute carrier family 26 (anion exchanger), member 1	Slc26a1	solute carrier family 26 (sulfate transporter), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Slc26a1	solute carrier family 26 (sulfate transporter), member 1			Symbol and Name status set to approved	625702	APPROVED
2003-05-07	Slc26a1	solute carrier family 26 (sulfate transporter), member 1	sat-1	sulfate anion transporter	Symbol and Name updated to reflect Human and Mouse nomenclature	628472	PROVISIONAL
2002-08-07	sat-1	sulfate anion transporter			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains 12 putative transmembrane spanning domains	730015
gene_process	channel functions in Na(+)-independent sulfate uptake	730015

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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