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Gene: Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) Rattus norvegicus

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Symbol:

Ndufs2

Name:

NADH:ubiquinone oxidoreductase core subunit S2

RGD ID:

1307109

Description:

Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2); PARTICIPATES IN doxorubicin pharmacokinetics pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CI-49kD; complex I-49kD; LOC103690046; LOC289218; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like; NADH-ubiquinone oxidoreductase 49 kDa subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gas-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ND-49	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ND-49L	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	nduf-2.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ndufs2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,186,867 - 86,203,914 (-)	NCBI		GRCr8
mRatBN7.2	13	83,654,402 - 83,671,474 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,654,406 - 83,671,420 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	86,160,251 - 86,172,822 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,558,491 - 87,571,027 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,790,115 - 84,802,527 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,606,848 - 89,623,506 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,606,840 - 89,619,398 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	95,769,663 - 95,770,563 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	94,233,713 - 94,250,285 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	87,124,431 - 87,137,497 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	87,313,317 - 87,326,381 (-)	NCBI
Celera	13	83,285,589 - 83,298,039 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	Experimental Diabetes Mellitus		IEP		6484699	protein:decreased expression:dorsal root ganglia (rat)	RGD
Ndufs2	Rat	hypertrophic cardiomyopathy	susceptibility	ISO	RGD:1316107	1600573	associated with Mitochondrial Encephalomyopathies;DNA:missense mutations: :p.R228Q, p.P229Q, p.S413P (human)	RGD
Ndufs2	Rat	inherited metabolic disorder		ISO	RGD:1316107	1600573	mitochondrial complex I deficiency, OMIM:252010, DNA:point mutation:exon:R228Q	RGD
Ndufs2	Rat	Leigh disease		ISO	RGD:1316107	6482269	DNA:missense mutation:cds:p.M292T (human)	RGD
Ndufs2	Rat	multiple sclerosis		ISO	RGD:1316107	6482255		RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	autoimmune interstitial lung, joint, and kidney disease		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Autoimmune interstitial lung disease-arthritis syndrome	ClinVar	PMID:28492532
Ndufs2	Rat	gastrointestinal stromal tumor		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
Ndufs2	Rat	genetic disease		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:20818383\|PMID:20819849\|PMID:24215330\|PMID:24642831\|PMID:25741868\|PMID:27502960\|PMID:27604308\|PMID:28050010\|PMID:28492532\|PMID:29272804\|PMID:29353736\|PMID:29573043\|PMID:31180159\|PMID:32180488
Ndufs2	Rat	Leber hereditary optic neuropathy		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Leber optic atrophy	ClinVar	PMID:25741868
Ndufs2	Rat	Leber Hereditary Optic Neuropathy, Autosomal Recessive 2		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Leber hereditary optic neuropathy, autosomal recessive 2 \| ClinVar Annotator: more ...	ClinVar	PMID:17576681\|PMID:20818383\|PMID:22200994\|PMID:25741868\|PMID:28031252\|PMID:28050010\|PMID:28492532\|PMID:9536098
Ndufs2	Rat	mitochondrial complex I deficiency		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: MITOCHONDRIAL NADH DEHYDROGENASE COMPONENT OF COMPLEX I, DEFICIENCY OF \| more ...	ClinVar	PMID:17576681\|PMID:20818383\|PMID:20819849\|PMID:22200994\|PMID:24215330\|PMID:24642831\|PMID:25741868\|PMID:27502960\|PMID:27604308\|PMID:28031252\|PMID:28492532\|PMID:29573043\|PMID:9536098
Ndufs2	Rat	nuclear type mitochondrial complex I deficiency 1		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Mitochondrial complex I deficiency, nuclear type 1	ClinVar	PMID:17576681\|PMID:22200994\|PMID:25741868\|PMID:28031252\|PMID:28492532\|PMID:29573043\|PMID:9536098
Ndufs2	Rat	nuclear type mitochondrial complex I deficiency 6		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 6	ClinVar	PMID:11220739\|PMID:17576681\|PMID:20818383\|PMID:20819849\|PMID:22200994\|PMID:25741868\|PMID:28031252\|PMID:28492532\|PMID:29272804\|PMID:29353736\|PMID:29573043\|PMID:30634555\|PMID:31180159\|PMID:31411514\|PMID:32180488\|PMID:36462614\|PMID:9536098
Ndufs2	Rat	optic atrophy		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Optic atrophy	ClinVar	PMID:17576681\|PMID:25741868\|PMID:28492532\|PMID:9536098
Ndufs2	Rat	parathyroid carcinoma		ISO	RGD:1316107	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	cardiomyopathy		ISO	RGD:1316107	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:14729820
Ndufs2	Rat	mitochondrial encephalomyopathy		ISO	RGD:1316107	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:14729820

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	Leber Hereditary Optic Neuropathy, Autosomal Recessive 2		ISO	RGD:1316107	7240710		OMIM
Ndufs2	Rat	nuclear type mitochondrial complex I deficiency 6		ISO	RGD:1316107	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	(+)-dexrazoxane	multiple interactions	ISO	RGD:1316108	6480464	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS2 mRNA	CTD	PMID:26873546
Ndufs2	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1316108	6480464	1,2-Dimethylhydrazine results in increased expression of NDUFS2 mRNA	CTD	PMID:22206623
Ndufs2	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1316108	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NDUFS2 mRNA]	CTD	PMID:22206623
Ndufs2	Rat	1,3,5-trinitro-1,3,5-triazinane	decreases expression	EXP		6480464	cyclonite results in decreased expression of NDUFS2 mRNA	CTD	PMID:25559034
Ndufs2	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1316108	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFS2 mRNA	CTD	PMID:17942748
Ndufs2	Rat	17beta-estradiol	decreases expression	ISO	RGD:1316108	6480464	Estradiol results in decreased expression of NDUFS2 mRNA	CTD	PMID:39298647
Ndufs2	Rat	2,2,2-tetramine	multiple interactions	EXP		6480464	Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS2 protein]	CTD	PMID:19634143
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1316108	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDUFS2 mRNA	CTD	PMID:17942748
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of NDUFS2 mRNA	CTD	PMID:34747641
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1316107	6480464	Tetrachlorodibenzodioxin results in decreased expression of NDUFS2 mRNA	CTD	PMID:23152189
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1316108	6480464	Tetrachlorodibenzodioxin affects the expression of NDUFS2 mRNA	CTD	PMID:21570461
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of NDUFS2 mRNA	CTD	PMID:21215274
Ndufs2	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1316108	6480464	Tetrachlorodibenzodioxin results in increased expression of NDUFS2 mRNA	CTD	PMID:20399798
Ndufs2	Rat	4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1316108	6480464	4,4'-diaminodiphenylmethane results in increased expression of NDUFS2 mRNA	CTD	PMID:18648102
Ndufs2	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Ndufs2	Rat	4,4'-sulfonyldiphenol	affects methylation	ISO	RGD:1316108	6480464	bisphenol S affects the methylation of NDUFS2 gene	CTD	PMID:31683443
Ndufs2	Rat	acetamide	decreases expression	EXP		6480464	acetamide results in decreased expression of NDUFS2 mRNA	CTD	PMID:31881176
Ndufs2	Rat	arsane	increases methylation	ISO	RGD:1316107	6480464	Arsenic results in increased methylation of NDUFS2 promoter	CTD	PMID:21291286
Ndufs2	Rat	arsane	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	arsenic atom	increases methylation	ISO	RGD:1316107	6480464	Arsenic results in increased methylation of NDUFS2 promoter	CTD	PMID:21291286
Ndufs2	Rat	arsenic atom	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	arsenous acid	increases expression	ISO	RGD:1316107	6480464	Arsenic Trioxide results in increased expression of NDUFS2 mRNA	CTD	PMID:22521957
Ndufs2	Rat	arsenous acid	decreases expression	ISO	RGD:1316108	6480464	Arsenic Trioxide results in decreased expression of NDUFS2 mRNA	CTD	PMID:35676786
Ndufs2	Rat	atrazine	decreases expression	ISO	RGD:1316107	6480464	Atrazine results in decreased expression of NDUFS2 mRNA	CTD	PMID:22378314
Ndufs2	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1316108	6480464	Benzo(a)pyrene results in increased expression of NDUFS2 mRNA	CTD	PMID:22228805
Ndufs2	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1316107	6480464	Benzo(a)pyrene results in increased methylation of NDUFS2 5' UTR; Benzo(a)pyrene results in increased methylation of more ...	CTD	PMID:27901495
Ndufs2	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1316108	6480464	Benzo(a)pyrene results in increased methylation of NDUFS2 exon; Benzo(a)pyrene results in increased methylation of NDUFS2 more ...	CTD	PMID:27901495
Ndufs2	Rat	beta-lapachone	increases expression	ISO	RGD:1316107	6480464	beta-lapachone results in increased expression of NDUFS2 mRNA	CTD	PMID:38218311
Ndufs2	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1316108	6480464	Diethylhexyl Phthalate results in increased expression of NDUFS2 mRNA	CTD	PMID:33754040
Ndufs2	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of NDUFS2 mRNA	CTD	PMID:25181051
Ndufs2	Rat	bisphenol A	increases expression	ISO	RGD:1316107	6480464	bisphenol A results in increased expression of NDUFS2 protein	CTD	PMID:34186270\|PMID:37567409
Ndufs2	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Ndufs2	Rat	bisphenol A	increases expression	ISO	RGD:1316108	6480464	bisphenol A results in increased expression of NDUFS2 mRNA; bisphenol A results in increased expression more ...	CTD	PMID:33221593\|PMID:38021376
Ndufs2	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of NDUFS2 mRNA	CTD	PMID:30816183\|PMID:32528016\|PMID:34947998
Ndufs2	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of NDUFS2 gene	CTD	PMID:28505145
Ndufs2	Rat	bisphenol AF	increases expression	ISO	RGD:1316107	6480464	bisphenol AF results in increased expression of NDUFS2 protein	CTD	PMID:34186270
Ndufs2	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Ndufs2	Rat	cadmium dichloride	decreases expression	ISO	RGD:1316107	6480464	Cadmium Chloride results in decreased expression of NDUFS2 mRNA	CTD	PMID:38568856
Ndufs2	Rat	CGP 52608	multiple interactions	ISO	RGD:1316107	6480464	CGP 52608 promotes the reaction [RORA protein binds to NDUFS2 gene]	CTD	PMID:28238834
Ndufs2	Rat	clofibrate	decreases expression	ISO	RGD:1316108	6480464	Clofibrate results in decreased expression of NDUFS2 mRNA	CTD	PMID:17585979
Ndufs2	Rat	cocaine	affects expression	ISO	RGD:1316107	6480464	Cocaine affects the expression of NDUFS2 protein	CTD	PMID:19393250
Ndufs2	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1316107	6480464	Copper Sulfate results in decreased expression of NDUFS2 mRNA	CTD	PMID:19549813
Ndufs2	Rat	cyclophosphamide	decreases expression	ISO	RGD:1316108	6480464	Cyclophosphamide results in decreased expression of NDUFS2 mRNA	CTD	PMID:15331540
Ndufs2	Rat	cyclosporin A	decreases expression	ISO	RGD:1316107	6480464	Cyclosporine results in decreased expression of NDUFS2 mRNA	CTD	PMID:20106945
Ndufs2	Rat	diarsenic trioxide	increases expression	ISO	RGD:1316107	6480464	Arsenic Trioxide results in increased expression of NDUFS2 mRNA	CTD	PMID:22521957
Ndufs2	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1316108	6480464	Arsenic Trioxide results in decreased expression of NDUFS2 mRNA	CTD	PMID:35676786
Ndufs2	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1316107	6480464	di-n-butylphosphoric acid affects the expression of NDUFS2 mRNA	CTD	PMID:37042841
Ndufs2	Rat	doxorubicin	multiple interactions	ISO	RGD:1316108	6480464	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of NDUFS2 mRNA	CTD	PMID:26873546
Ndufs2	Rat	doxorubicin	increases expression	ISO	RGD:1316107	6480464	Doxorubicin results in increased expression of NDUFS2 mRNA	CTD	PMID:29803840
Ndufs2	Rat	doxorubicin	decreases expression	ISO	RGD:1316108	6480464	Doxorubicin results in decreased expression of NDUFS2 mRNA	CTD	PMID:26873546
Ndufs2	Rat	epoxiconazole	increases expression	ISO	RGD:1316108	6480464	epoxiconazole results in increased expression of NDUFS2 mRNA	CTD	PMID:35436446
Ndufs2	Rat	fenthion	increases expression	ISO	RGD:1316108	6480464	Fenthion results in increased expression of NDUFS2 mRNA	CTD	PMID:34813904
Ndufs2	Rat	folic acid	multiple interactions	ISO	RGD:1316108	6480464	Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NDUFS2 mRNA]	CTD	PMID:22206623
Ndufs2	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of NDUFS2 protein	CTD	PMID:22061828
Ndufs2	Rat	hypochlorous acid	decreases expression	ISO	RGD:1316108	6480464	Hypochlorous Acid results in decreased expression of NDUFS2 mRNA	CTD	PMID:19376150
Ndufs2	Rat	isoniazide	affects expression	ISO	RGD:1316108	6480464	Isoniazid affects the expression of NDUFS2 mRNA	CTD	PMID:24848797
Ndufs2	Rat	ivermectin	decreases expression	ISO	RGD:1316107	6480464	Ivermectin results in decreased expression of NDUFS2 protein	CTD	PMID:32959892
Ndufs2	Rat	lead(0)	decreases expression	ISO	RGD:1316107	6480464	Lead results in decreased expression of NDUFS2 mRNA	CTD	PMID:19921347
Ndufs2	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:1316107	6480464	[Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of NDUFS2 mRNA	CTD	PMID:31059760
Ndufs2	Rat	manganese atom	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	manganese(0)	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	menadione	affects expression	ISO	RGD:1316107	6480464	Vitamin K 3 affects the expression of NDUFS2 mRNA	CTD	PMID:20044591
Ndufs2	Rat	mercury atom	decreases expression	ISO	RGD:1316107	6480464	Mercury results in decreased expression of NDUFS2 mRNA	CTD	PMID:16823088
Ndufs2	Rat	mercury(0)	decreases expression	ISO	RGD:1316107	6480464	Mercury results in decreased expression of NDUFS2 mRNA	CTD	PMID:16823088
Ndufs2	Rat	Mesaconitine	increases expression	EXP		6480464	mesaconitine results in increased expression of NDUFS2 protein	CTD	PMID:37182599
Ndufs2	Rat	methidathion	increases expression	ISO	RGD:1316108	6480464	methidathion results in increased expression of NDUFS2 mRNA	CTD	PMID:34813904
Ndufs2	Rat	niclosamide	decreases expression	ISO	RGD:1316107	6480464	Niclosamide results in decreased expression of NDUFS2 mRNA	CTD	PMID:22576131
Ndufs2	Rat	oxybenzone	decreases expression	EXP		6480464	oxybenzone results in decreased expression of NDUFS2 mRNA	CTD	PMID:30316929
Ndufs2	Rat	paracetamol	affects expression	ISO	RGD:1316108	6480464	Acetaminophen affects the expression of NDUFS2 mRNA	CTD	PMID:17562736
Ndufs2	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of NDUFS2 mRNA	CTD	PMID:33387578
Ndufs2	Rat	paracetamol	multiple interactions	ISO	RGD:1316107	6480464	[Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of NDUFS2 mRNA	CTD	PMID:31059760
Ndufs2	Rat	paracetamol	decreases expression	ISO	RGD:1316107	6480464	Acetaminophen results in decreased expression of NDUFS2 mRNA	CTD	PMID:25704631\|PMID:29067470\|PMID:31059760
Ndufs2	Rat	paraquat	decreases expression	ISO	RGD:1316107	6480464	Paraquat results in decreased expression of NDUFS2 protein	CTD	PMID:34064677
Ndufs2	Rat	perfluorooctanoic acid	decreases expression	ISO	RGD:1316107	6480464	perfluorooctanoic acid results in decreased expression of NDUFS2 protein	CTD	PMID:26879310
Ndufs2	Rat	pyrroloquinoline quinone	multiple interactions	EXP		6480464	PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS2 mRNA]	CTD	PMID:26276080
Ndufs2	Rat	resveratrol	multiple interactions	ISO	RGD:1316107	6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of NDUFS2 mRNA	CTD	PMID:23557933
Ndufs2	Rat	rotenone	decreases expression	ISO	RGD:1316108	6480464	Rotenone results in decreased expression of NDUFS2 mRNA	CTD	PMID:23186747
Ndufs2	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of NDUFS2 protein	CTD	PMID:35544339
Ndufs2	Rat	rotenone	multiple interactions	EXP		6480464	PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS2 mRNA]	CTD	PMID:26276080
Ndufs2	Rat	rotenone	decreases expression	EXP		6480464	Rotenone results in decreased expression of NDUFS2 mRNA	CTD	PMID:26276080
Ndufs2	Rat	rotenone	decreases expression	ISO	RGD:1316107	6480464	Rotenone results in decreased expression of NDUFS2 mRNA	CTD	PMID:24755484
Ndufs2	Rat	sodium arsenite	decreases expression	ISO	RGD:1316107	6480464	sodium arsenite results in decreased expression of NDUFS2 mRNA	CTD	PMID:38568856
Ndufs2	Rat	sodium arsenite	multiple interactions	ISO	RGD:1316107	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ndufs2	Rat	sodium fluoride	increases expression	ISO	RGD:1316108	6480464	Sodium Fluoride results in increased expression of NDUFS2 mRNA	CTD	PMID:21340527
Ndufs2	Rat	streptozocin	multiple interactions	EXP		6480464	Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS2 protein]	CTD	PMID:19634143
Ndufs2	Rat	streptozocin	increases expression	EXP		6480464	Streptozocin results in increased expression of NDUFS2 protein	CTD	PMID:19634143
Ndufs2	Rat	sunitinib	decreases expression	ISO	RGD:1316107	6480464	Sunitinib results in decreased expression of NDUFS2 mRNA	CTD	PMID:31533062
Ndufs2	Rat	thiram	decreases expression	ISO	RGD:1316107	6480464	Thiram results in decreased expression of NDUFS2 mRNA	CTD	PMID:38568856
Ndufs2	Rat	titanium dioxide	decreases expression	ISO	RGD:1316108	6480464	titanium dioxide results in decreased expression of NDUFS2 mRNA	CTD	PMID:23557971
Ndufs2	Rat	titanium dioxide	decreases methylation	ISO	RGD:1316108	6480464	titanium dioxide results in decreased methylation of NDUFS2 promoter alternative form	CTD	PMID:35295148
Ndufs2	Rat	triphenyl phosphate	affects expression	ISO	RGD:1316107	6480464	triphenyl phosphate affects the expression of NDUFS2 mRNA	CTD	PMID:37042841
Ndufs2	Rat	urethane	decreases expression	ISO	RGD:1316107	6480464	Urethane results in decreased expression of NDUFS2 mRNA	CTD	PMID:28818685
Ndufs2	Rat	valproic acid	increases expression	ISO	RGD:1316107	6480464	Valproic Acid results in increased expression of NDUFS2 mRNA	CTD	PMID:23179753
Ndufs2	Rat	valproic acid	increases methylation	ISO	RGD:1316107	6480464	Valproic Acid results in increased methylation of NDUFS2 gene	CTD	PMID:29154799
Ndufs2	Rat	zidovudine	decreases expression	ISO	RGD:1316107	6480464	Zidovudine results in decreased expression of NDUFS2 mRNA	CTD	PMID:16894629

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	biological_process		ND		1598407	02/07: no relevant rat data	RGD
Ndufs2	Rat	cellular response to oxygen levels	involved_in	IMP		42722001	PMID:30922174	UniProt
Ndufs2	Rat	cellular response to oxygen levels	involved_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	cellular response to oxygen levels	involved_in	ISO	RGD:1316108	1624291	PMID:26437605, PMID:29887397, PMID:30922174	RGD	PMID:26437605\|PMID:29887397\|PMID:30922174
Ndufs2	Rat	cellular response to oxygen levels	involved_in	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	cellular response to oxygen levels	involved_in	ISO	RGD:1316107	1624291	PMID:30922174	RGD	PMID:30922174
Ndufs2	Rat	gliogenesis	involved_in	ISS	UniProtKB:Q91WD5	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ndufs2	Rat	gliogenesis	involved_in	ISO	RGD:1316108	1624291	PMID:31297047	RGD	PMID:31297047
Ndufs2	Rat	gliogenesis	involved_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrial ATP synthesis coupled electron transport	involved_in	ISO	RGD:1316107	1624291	PMID:24746669	RGD	PMID:24746669
Ndufs2	Rat	mitochondrial ATP synthesis coupled electron transport	involved_in	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrial electron transport, NADH to ubiquinone	involved_in	IMP		42722001	PMID:30922174	UniProt
Ndufs2	Rat	mitochondrial electron transport, NADH to ubiquinone	involved_in	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrial electron transport, NADH to ubiquinone	involved_in	IBA	PANTHER:PTN000241916\|RGD:1307109\|UniProtKB:O75306\|WB:WBGene00001520	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ndufs2	Rat	mitochondrial electron transport, NADH to ubiquinone	involved_in	ISO	RGD:1316107	1624291	PMID:30922174	RGD	PMID:30922174
Ndufs2	Rat	mitochondrial respiratory chain complex I assembly	involved_in	ISS	UniProtKB:Q91WD5	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ndufs2	Rat	mitochondrial respiratory chain complex I assembly	involved_in	ISO	RGD:1316108	1624291	PMID:26437605	RGD	PMID:26437605
Ndufs2	Rat	mitochondrial respiratory chain complex I assembly	involved_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	neural precursor cell proliferation	involved_in	ISS	UniProtKB:Q91WD5	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ndufs2	Rat	neural precursor cell proliferation	involved_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	neural precursor cell proliferation	involved_in	ISO	RGD:1316108	1624291	PMID:31297047	RGD	PMID:31297047
Ndufs2	Rat	neurogenesis	involved_in	ISS	UniProtKB:Q91WD5	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ndufs2	Rat	neurogenesis	involved_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	neurogenesis	involved_in	ISO	RGD:1316108	1624291	PMID:31297047	RGD	PMID:31297047
Ndufs2	Rat	proton transmembrane transport	involved_in	IEA	GO:0008137	1600115	GO_REF:0000108	GOC	GO_REF:0000108

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	mitochondrial inner membrane	located_in	IDA		42722001	PMID:30922174	UniProt
Ndufs2	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB-SubCell:SL-0168	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Ndufs2	Rat	mitochondrial inner membrane	located_in	ISO	RGD:1316107	1624291	PMID:28844695	RGD	PMID:28844695
Ndufs2	Rat	mitochondrial inner membrane	located_in	IEA	UniProtKB-KW:KW-0999	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	mitochondrial inner membrane	is_active_in	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrial inner membrane	is_active_in	ISO	RGD:1316108	1624291	PMID:38575788	RGD	PMID:38575788
Ndufs2	Rat	mitochondrion	located_in	ISO	RGD:1316107	1624291	PMID:9585441	RGD	PMID:9585441
Ndufs2	Rat	mitochondrion	located_in	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	mitochondrion	located_in	IEA	UniProtKB-KW:KW-0496	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	respiratory chain complex I	part_of	IDA		42722001	PMID:30922174	UniProt
Ndufs2	Rat	respiratory chain complex I	part_of	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	respiratory chain complex I	part_of	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	respiratory chain complex I	part_of	IBA	FB:FBgn0039909\|MGI:2385112\|PANTHER:PTN000241916\|RGD:1307109\|UniProtKB:O75306\|UniProtKB:P17694\|UniProtKB:P93306	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ndufs2	Rat	respiratory chain complex I	part_of	ISO	RGD:1316107	1624291	PMID:11112787, PMID:12611891, PMID:17209039, PMID:24746669	RGD	PMID:11112787\|PMID:12611891\|PMID:17209039\|PMID:24746669
Ndufs2	Rat	respiratory chain complex I	part_of	ISO	RGD:1316108	1624291	PMID:38575788	RGD	PMID:38575788

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	4 iron, 4 sulfur cluster binding	enables	IEA	UniProtKB-KW:KW-0004	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	iron-sulfur cluster binding	enables	IEA	UniProtKB-KW:KW-0411	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	NAD binding	enables	IEA	InterPro:IPR001135	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	ISO	RGD:1316107	1624291	PMID:28031252	RGD	PMID:28031252
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	contributes_to	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	IEA	RHEA:29091	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	IEA	EC:7.1.1.2	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	contributes_to	ISO	RGD:1316107	1624291	PMID:22036843, PMID:30922174	RGD	PMID:22036843\|PMID:30922174
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	contributes_to	IMP		42722001	PMID:30922174	UniProt
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	ISO	RGD:1316108	1624291	PMID:26437605, PMID:29887397, PMID:31297047	RGD	PMID:26437605\|PMID:29887397\|PMID:31297047
Ndufs2	Rat	NADH dehydrogenase (ubiquinone) activity	enables	ISS	UniProtKB:O75306	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ndufs2	Rat	NADH dehydrogenase activity	contributes_to	ISO	RGD:1316107	1624291	PMID:14749350	RGD	PMID:14749350
Ndufs2	Rat	NADH dehydrogenase activity	contributes_to	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	oxidoreductase activity	enables	IEA	UniProtKB-KW:KW-0560	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ndufs2	Rat	oxidoreductase activity, acting on NAD(P)H	enables	IEA	InterPro:IPR001135\|InterPro:IPR014029\|InterPro:IPR022885	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Ndufs2	Rat	oxygen sensor activity	enables	IMP		42722001	PMID:30922174	UniProt
Ndufs2	Rat	oxygen sensor activity	enables	IEA	UniProtKB:Q91WD5\|ensembl:ENSMUSP00000013737	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	oxygen sensor activity	enables	ISO	RGD:1316108	1624291	PMID:26437605, PMID:29887397, PMID:30922174	RGD	PMID:26437605\|PMID:29887397\|PMID:30922174
Ndufs2	Rat	oxygen sensor activity	enables	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ndufs2	Rat	oxygen sensor activity	enables	ISO	RGD:1316107	1624291	PMID:30922174	RGD	PMID:30922174
Ndufs2	Rat	protein binding	enables	ISO	RGD:1316107	1624291	UniProtKB:O75489\|UniProtKB:Q7L592\|UniProtKB:Q99650\|UniProtKB:Q9BU61 PMID:15250827, PMID:19463981, PMID:19688755, PMID:20406883, PMID:24089531, PMID:24344204, PMID:27499296, PMID:28514442, PMID:32807793, PMID:33961781	RGD	PMID:15250827\|PMID:19463981\|PMID:19688755\|PMID:20406883\|PMID:24089531\|PMID:24344204\|PMID:27499296\|PMID:28514442\|PMID:32807793\|PMID:33961781
Ndufs2	Rat	protein binding	enables	ISO	RGD:1316108	1624291	UniProtKB:Q924Z4 PMID:32279995	RGD	PMID:32279995
Ndufs2	Rat	quinone binding	enables	IEA	InterPro:IPR001135	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Ndufs2	Rat	ubiquitin protein ligase binding	enables	ISO	RGD:1316107	1624291	UniProtKB:O60260 PMID:19725078	RGD	PMID:19725078
Ndufs2	Rat	ubiquitin protein ligase binding	enables	IEA	UniProtKB:O75306\|ensembl:ENSP00000503117	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	doxorubicin pharmacokinetics pathway		ISO	RGD:1316107	10402751		SMPDB	SMP:00650

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ndufs2	Rat	Alzheimer's disease pathway		IEA		6907045		KEGG	rno:05010
Ndufs2	Rat	Huntington's disease pathway		IEA		6907045		KEGG	rno:05016
Ndufs2	Rat	oxidative phosphorylation pathway		IEA		6907045		KEGG	rno:00190
Ndufs2	Rat	Parkinson's disease pathway		IEA		6907045		KEGG	rno:05012

BioCyc Pathways

aerobic respiration I (cytochrome c)

Disease Annotations Click to see Annotation Detail View

autoimmune interstitial lung, joint, and kidney disease (ISO)

cardiomyopathy (ISO)

Experimental Diabetes Mellitus (IEP)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

inherited metabolic disorder (ISO)

Leber hereditary optic neuropathy (ISO)

Leber Hereditary Optic Neuropathy, Autosomal Recessive 2 (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

mitochondrial encephalomyopathy (ISO)

multiple sclerosis (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

nuclear type mitochondrial complex I deficiency 6 (ISO)

optic atrophy (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

1,2-dimethylhydrazine (ISO)

1,3,5-trinitro-1,3,5-triazinane (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2,2-tetramine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acetamide (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

CGP 52608 (ISO)

clofibrate (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

hypochlorous acid (ISO)

isoniazide (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

mercury atom (ISO)

mercury(0) (ISO)

Mesaconitine (EXP)

methidathion (ISO)

niclosamide (ISO)

oxybenzone (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctanoic acid (ISO)

pyrroloquinoline quinone (EXP)

resveratrol (ISO)

rotenone (EXP,ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

streptozocin (EXP)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to oxygen levels (IEA,IMP,ISO)

gliogenesis (IEA,ISO,ISS)

mitochondrial ATP synthesis coupled electron transport (IEA,ISO)

mitochondrial electron transport, NADH to ubiquinone (IBA,IEA,IMP,ISO)

mitochondrial respiratory chain complex I assembly (IEA,ISO,ISS)

neural precursor cell proliferation (IEA,ISO,ISS)

neurogenesis (IEA,ISO,ISS)

proton transmembrane transport (IEA)

Cellular Component

membrane (IEA)

mitochondrial inner membrane (IDA,IEA,ISO)

mitochondrion (IEA,ISO)

respiratory chain complex I (IBA,IDA,IEA,ISO)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

NAD binding (IEA)

NADH dehydrogenase (ubiquinone) activity (IEA,IMP,ISO,ISS)

NADH dehydrogenase activity (IEA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H (IEA)

oxygen sensor activity (IEA,IMP,ISO)

protein binding (ISO)

quinone binding (IEA)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Alzheimer's disease pathway (IEA)

doxorubicin pharmacokinetics pathway (ISO)

Huntington's disease pathway (IEA)

oxidative phosphorylation pathway (IEA)

Parkinson's disease pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.	Akude E, etal., Diabetes. 2011 Jan;60(1):288-97. Epub 2010 Sep 28.
2.	Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.	Ban M, etal., PLoS One. 2008 Aug 6;3(8):e2891.
3.	Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.	Dunham-Snary KJ, etal., Circ Res. 2019 Jun 7;124(12):1727-1746. doi: 10.1161/CIRCRESAHA.118.314284. Epub 2019 Mar 29.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
7.	Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy.	Loeffen J, etal., Ann Neurol. 2001 Feb;49(2):195-201.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation
16.	The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families.	Tuppen HA, etal., Brain. 2010 Oct;133(10):2952-63. Epub 2010 Sep 6.

Additional References at PubMed

PMID:9585441	PMID:11112787	PMID:12477932	PMID:12611891	PMID:12857734	PMID:14651853	PMID:14749350	PMID:17209039	PMID:18614015	PMID:19725078	PMID:21700703	PMID:24746669
PMID:29476059

Genomics

Comparative Map Data

Ndufs2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,186,867 - 86,203,914 (-)	NCBI		GRCr8
mRatBN7.2	13	83,654,402 - 83,671,474 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,654,406 - 83,671,420 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	86,160,251 - 86,172,822 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,558,491 - 87,571,027 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,790,115 - 84,802,527 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,606,848 - 89,623,506 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,606,840 - 89,619,398 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	95,769,663 - 95,770,563 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	94,233,713 - 94,250,285 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	87,124,431 - 87,137,497 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	87,313,317 - 87,326,381 (-)	NCBI
Celera	13	83,285,589 - 83,298,039 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

NDUFS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,197,417 - 161,214,395 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,197,104 - 161,214,723 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	161,167,207 - 161,184,185 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,435,729 - 159,450,809 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	157,982,177 - 157,997,255	NCBI
Celera	1	134,236,257 - 134,251,337 (+)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,526,050 - 132,541,132 (+)	NCBI		HuRef
CHM1_1	1	162,565,343 - 162,580,438 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,334,507 - 160,351,847 (+)	NCBI		T2T-CHM13v2.0

Ndufs2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	171,062,426 - 171,078,956 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	171,062,422 - 171,078,957 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	171,234,853 - 171,251,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,234,853 - 171,251,388 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	173,164,991 - 173,177,243 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	173,071,535 - 173,083,787 (-)	NCBI		MGSCv36	mm8
Celera	1	173,691,078 - 173,703,327 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.25	NCBI

Ndufs2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	12,961,915 - 12,971,095 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	12,961,873 - 12,971,278 (+)	NCBI	ChiLan1.0	ChiLan1.0

NDUFS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,637,595 - 88,654,983 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	88,327,913 - 88,341,098 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	136,609,822 - 136,626,851 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,526,690 - 140,538,705 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,526,690 - 140,538,705 (+)	Ensembl	panpan1.1		panPan2

NDUFS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,271,603 - 21,281,140 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	21,271,675 - 21,285,279 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,346,459 - 21,356,011 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,389,447 - 21,399,000 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	21,389,447 - 21,398,979 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	21,285,733 - 21,286,858 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,691,735 - 21,701,283 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,100,884 - 22,110,441 (-)	NCBI		UU_Cfam_GSD_1.0

Ndufs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,294,911 - 7,305,582 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936903	499,300 - 514,893 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936903	503,633 - 514,235 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDUFS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	89,246,960 - 89,257,085 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	89,246,958 - 89,257,090 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	97,103,640 - 97,113,761 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDUFS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,767,864 - 2,780,336 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,768,064 - 2,780,704 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	1,816,231 - 1,830,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndufs2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	172,707 - 185,073 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	172,543 - 189,031 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ndufs2
102 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	118
Count of miRNA genes:	98
Interacting mature miRNAs:	108
Transcripts:	ENSRNOT00000058423
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	74862117	85581182	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	46088046	91088046	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	59874408	85581182	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34663461	87525369	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	69060519	86800898	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	46197976	84753113	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	69060519	86800898	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	69060519	86800898	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC082067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058423 ⟹ ENSRNOP00000055224

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	83,654,406 - 83,671,420 (-)	Ensembl
Rnor_6.0 Ensembl	13	89,606,840 - 89,619,398 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094027 ⟹ ENSRNOP00000090418

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	83,654,406 - 83,671,420 (-)	Ensembl

RefSeq Acc Id:

NM_001011907 ⟹ NP_001011907

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,199,403 (-)	NCBI
mRatBN7.2	13	83,654,407 - 83,666,945 (-)	NCBI
Rnor_6.0	13	89,606,853 - 89,619,388 (-)	NCBI
Rnor_5.0	13	95,769,663 - 95,770,563 (-)	NCBI
RGSC_v3.4	13	87,124,431 - 87,137,497 (-)	RGD
Celera	13	83,285,589 - 83,298,039 (-)	RGD

Sequence:

show sequence

GTAAAGATGGCGGCCCTCAGGGCTGTGTGCAGCCTCCGCGGTGTCGGGGCCCAGGTGCTGCGGG
CCGGGTCTGGGATTCGTCTGCCGAGTCAGCCCAGCAGAGGTGCTCGGCGATGGCAGCCAGATAT
AGAATGGGCAGAGCAGTTTTCGGGAGCTGTCATGTATCCCTCCAAGGAAACAGCCCACTGGAAA
CCTCCTCCTTGGAATGATGTGGATGTTTTGAAGGAGAAAGTGGTGACCAACGTGACCCTGAACT
TTGGGCCCCAGCACCCAGCAGCTCATGGAGTCCTGAGACTCGTGCTGGAATTGAGTGGAGAGAT
GGTGCGGAAATGTGACCCTCACATCGGGCTCCTACACCGAGGCACGGAGAAGCTCATCGAGTAC
AAGACCTATCTGCAGGCCCTTCCATATTTTGACCGGTTGGACTATGTGTCCATGATGTGTAATG
AACAGGCGTATTCACTAGCTGTGGAGAAGTTGCTAAACATCCAGCCTCCTCCCCGGGCGCAGTG
GATCCGAGTGCTCTTTGGAGAGATCACACGGATTTTAAACCATATCATGGCTGTCACCACACAT
GCCCTGGACATTGGTGCCATGACGCCTTTCTTCTGGATGTTTGAAGAAAGGGAGAAGATGTTCG
AGTTCTATGAGCGGGTGTCTGGAGCCCGTATGCATGCTGCTTATATCCGACCAGGAGGAGTGCA
CCAGGACCTACCTCTTGGGCTTATGGATGACATTTATGAATTTTCCAAGAACTTCTCTCTTCGG
ATTGATGAGGTGGAGGAGATGCTGACCAACAATAGAATCTGGCGAAATAGGACAGTCGACATTG
GGGTTGTATCTGCAGAAGATGCACTGAACTATGGATTCAGTGGAGTGATGCTCCGAGGCTCAGG
CATCCAGTGGGACTTGCGGAAGACCCAGCCATATGATGTTTACGACCAGGTGGAGTTTGATGTT
CCTATTGGTTCTCGAGGGGACTGCTACGATAGGTATCTGTGTCGTGTGGAAGAGATGCGCCAGT
CCCTTCGAATCATCGAACAGTGTCTGAACAAGATGCCGCCGGGGGAGATCAAGGTTGATGACGC
CAAAGTGTCCCCACCTAAACGAGCAGAGATGAAGACGTCCATGGAGTCACTAATTCATCACTTT
AAGCTGTATACTGAGGGCTACCAAGTTCCTCCAGGAGCCACATACACCGCCATTGAAGCTCCTA
AGGGCGAGTTTGGGGTGTACTTGGTATCTGATGGCAGCAGCCGACCTTATCGGTGTAAGATCAA
GGCTCCCGGTTTTGCCCACCTGGCAGGTTTGGACAAGATGTCTAAAGGACACATGCTGGCAGAT
GTCGTAGCCATCATAGGCACCCAGGATATTGTATTTGGAGAAATAGACCGATGAGCAAAAGCAC
AGCCTGTGAGCTCCCTTGCCTGTCAGCTGCTTCATCGAGCGAGGCCTTTGTGTGGTGGGAAACG
AGGCTGTGTTTCAGCAAACATACATGTACTCGTTGACTTAGCTGCACAGGCTTTCTGTGCATGT
ACTAGAAAAGGAGAAATTATATTAAATTAGCCACCTTTGGCCCCTAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063272123 ⟹ XP_063128193

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,203,573 (-)	NCBI

RefSeq Acc Id:

XM_063272124 ⟹ XP_063128194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,200,289 (-)	NCBI

RefSeq Acc Id:

XM_063272125 ⟹ XP_063128195

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,203,913 (-)	NCBI

RefSeq Acc Id:

XM_063272126 ⟹ XP_063128196

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,203,914 (-)	NCBI

RefSeq Acc Id:

XM_063272127 ⟹ XP_063128197

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,186,867 - 86,203,571 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011907	(Get FASTA)	NCBI Sequence Viewer
	XP_063128193	(Get FASTA)	NCBI Sequence Viewer
	XP_063128194	(Get FASTA)	NCBI Sequence Viewer
	XP_063128195	(Get FASTA)	NCBI Sequence Viewer
	XP_063128196	(Get FASTA)	NCBI Sequence Viewer
	XP_063128197	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82067	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055224
	ENSRNOP00000055224.3
	ENSRNOP00000090418
GenBank Protein	Q641Y2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001011907 ⟸ NM_001011907
- Peptide Label:	precursor
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAALRAVCSLRGVGAQVLRAGSGIRLPSQPSRGARRWQPDIEWAEQFSGAVMYPSKETAHWKPP PWNDVDVLKEKVVTNVTLNFGPQHPAAHGVLRLVLELSGEMVRKCDPHIGLLHRGTEKLIEYKT YLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIQPPPRAQWIRVLFGEITRILNHIMAVTTHAL DIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYEFSKNFSLRID EVEEMLTNNRIWRNRTVDIGVVSAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPI GSRGDCYDRYLCRVEEMRQSLRIIEQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKL YTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVV AIIGTQDIVFGEIDR hide sequence

Ensembl Acc Id:

ENSRNOP00000055224 ⟸ ENSRNOT00000058423

Ensembl Acc Id:

ENSRNOP00000090418 ⟸ ENSRNOT00000094027

RefSeq Acc Id:	XP_063128196 ⟸ XM_063272126
- Peptide Label:	isoform X1
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128195 ⟸ XM_063272125
- Peptide Label:	isoform X1
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128193 ⟸ XM_063272123
- Peptide Label:	isoform X1
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128197 ⟸ XM_063272127
- Peptide Label:	isoform X1
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128194 ⟸ XM_063272124
- Peptide Label:	isoform X1
- UniProtKB:	Q641Y2 (UniProtKB/Swiss-Prot), A0A8I6ABR8 (UniProtKB/TrEMBL)

Protein Domains

NADH-quinone oxidoreductase subunit D

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641Y2-F1-model_v2	AlphaFold	Q641Y2	1-463	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698998

Promoter ID:

EPDNEW_R9523

Type:

multiple initiation site

Name:

Ndufs2_1

Description:

NADH:ubiquinone oxidoreductase core subunit S2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	89,619,409 - 89,619,469	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307109	AgrOrtholog
BioCyc Gene	G2FUF-17381	BioCyc
BioCyc Pathway	PWY-3781 [aerobic respiration I (cytochrome c)]	BioCyc
BioCyc Pathway Image	PWY-3781	BioCyc
Ensembl Genes	ENSRNOG00000038372	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000058423	ENTREZGENE
	ENSRNOT00000058423.5	UniProtKB/Swiss-Prot
	ENSRNOT00000094027	ENTREZGENE
Gene3D-CATH	1.10.645.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7132777	IMAGE-MGC_LOAD
InterPro	NADH_Q_OxRdtase_suD	UniProtKB/Swiss-Prot
	NADH_UbQ_OxRdtase_49kDa_CS	UniProtKB/Swiss-Prot
	NDH1_su_D/H	UniProtKB/Swiss-Prot
	NiFe-Hase_large	UniProtKB/Swiss-Prot
KEGG Report	rno:289218	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95229	IMAGE-MGC_LOAD
NCBI Gene	289218	ENTREZGENE
PANTHER	NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR11993	UniProtKB/Swiss-Prot
Pfam	Complex1_49kDa	UniProtKB/Swiss-Prot
PhenoGen	Ndufs2	PhenoGen
PROSITE	COMPLEX1_49K	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000038372	RatGTEx
Superfamily-SCOP	SSF56762	UniProtKB/Swiss-Prot
UniProt	A0A8I6ABR8	ENTREZGENE, UniProtKB/TrEMBL
	NDUS2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Ndufs2	NADH:ubiquinone oxidoreductase core subunit S2	LOC103690046	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like	Data merged from RGD:9076367	737654	PROVISIONAL
2017-03-29	Ndufs2	NADH:ubiquinone oxidoreductase core subunit S2	Ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103690046	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	Ndufs2_predicted	NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ndufs2_predicted	NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways