Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) - Rat Genome Database

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Gene: Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) Rattus norvegicus
Analyze
Symbol: Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
RGD ID: 1307109
Description: Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2); PARTICIPATES IN doxorubicin pharmacokinetics pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CI-49kD; complex I-49kD; LOC103690046; LOC289218; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like; NADH-ubiquinone oxidoreductase 49 kDa subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,186,867 - 86,203,914 (-)NCBIGRCr8
mRatBN7.21383,654,402 - 83,671,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,160,251 - 86,172,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,558,491 - 87,571,027 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,790,115 - 84,802,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,606,848 - 89,623,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,769,663 - 95,770,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01394,233,713 - 94,250,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,124,431 - 87,137,497 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,313,317 - 87,326,381 (-)NCBI
Celera1383,285,589 - 83,298,039 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Akude E, etal., Diabetes. 2011 Jan;60(1):288-97. Epub 2010 Sep 28.
2. Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility. Ban M, etal., PLoS One. 2008 Aug 6;3(8):e2891.
3. Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Dunham-Snary KJ, etal., Circ Res. 2019 Jun 7;124(12):1727-1746. doi: 10.1161/CIRCRESAHA.118.314284. Epub 2019 Mar 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy. Loeffen J, etal., Ann Neurol. 2001 Feb;49(2):195-201.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families. Tuppen HA, etal., Brain. 2010 Oct;133(10):2952-63. Epub 2010 Sep 6.
Additional References at PubMed
PMID:9585441   PMID:11112787   PMID:12477932   PMID:12611891   PMID:12857734   PMID:14651853   PMID:14749350   PMID:17209039   PMID:18614015   PMID:19725078   PMID:21700703   PMID:24746669  
PMID:29476059  


Genomics

Comparative Map Data
Ndufs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,186,867 - 86,203,914 (-)NCBIGRCr8
mRatBN7.21383,654,402 - 83,671,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,160,251 - 86,172,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,558,491 - 87,571,027 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,790,115 - 84,802,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,606,848 - 89,623,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,769,663 - 95,770,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01394,233,713 - 94,250,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,124,431 - 87,137,497 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,313,317 - 87,326,381 (-)NCBI
Celera1383,285,589 - 83,298,039 (-)NCBICelera
Cytogenetic Map13q24NCBI
NDUFS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,197,417 - 161,214,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,197,104 - 161,214,723 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,167,207 - 161,184,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,435,729 - 159,450,809 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,982,177 - 157,997,255NCBI
Celera1134,236,257 - 134,251,337 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,526,050 - 132,541,132 (+)NCBIHuRef
CHM1_11162,565,343 - 162,580,438 (+)NCBICHM1_1
T2T-CHM13v2.01160,334,507 - 160,351,847 (+)NCBIT2T-CHM13v2.0
Ndufs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,062,426 - 171,078,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,062,422 - 171,078,957 (-)EnsemblGRCm39 Ensembl
GRCm381171,234,853 - 171,251,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,234,853 - 171,251,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,164,991 - 173,177,243 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,071,535 - 173,083,787 (-)NCBIMGSCv36mm8
Celera1173,691,078 - 173,703,327 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.25NCBI
Ndufs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,961,915 - 12,971,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,961,873 - 12,971,278 (+)NCBIChiLan1.0ChiLan1.0
NDUFS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,637,595 - 88,654,983 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,327,913 - 88,341,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,609,822 - 136,626,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,526,690 - 140,538,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,526,690 - 140,538,705 (+)Ensemblpanpan1.1panPan2
NDUFS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,271,603 - 21,281,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,271,675 - 21,285,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,346,459 - 21,356,011 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,389,447 - 21,399,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,389,447 - 21,398,979 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,285,733 - 21,286,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,691,735 - 21,701,283 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,100,884 - 22,110,441 (-)NCBIUU_Cfam_GSD_1.0
Ndufs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,294,911 - 7,305,582 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903499,300 - 514,893 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903503,633 - 514,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,246,960 - 89,257,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,246,958 - 89,257,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,103,640 - 97,113,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,767,864 - 2,780,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,768,064 - 2,780,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,816,231 - 1,830,038 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794172,707 - 185,073 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794172,543 - 189,031 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndufs2
102 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:98
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000058423
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000058423   ⟹   ENSRNOP00000055224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094027   ⟹   ENSRNOP00000090418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
RefSeq Acc Id: NM_001011907   ⟹   NP_001011907
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,199,403 (-)NCBI
mRatBN7.21383,654,407 - 83,666,945 (-)NCBI
Rnor_6.01389,606,853 - 89,619,388 (-)NCBI
Rnor_5.01395,769,663 - 95,770,563 (-)NCBI
RGSC_v3.41387,124,431 - 87,137,497 (-)RGD
Celera1383,285,589 - 83,298,039 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272123   ⟹   XP_063128193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,203,573 (-)NCBI
RefSeq Acc Id: XM_063272124   ⟹   XP_063128194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,200,289 (-)NCBI
RefSeq Acc Id: XM_063272125   ⟹   XP_063128195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,203,913 (-)NCBI
RefSeq Acc Id: XM_063272126   ⟹   XP_063128196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,203,914 (-)NCBI
RefSeq Acc Id: XM_063272127   ⟹   XP_063128197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,186,867 - 86,203,571 (-)NCBI
RefSeq Acc Id: NP_001011907   ⟸   NM_001011907
- Peptide Label: precursor
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055224   ⟸   ENSRNOT00000058423
RefSeq Acc Id: ENSRNOP00000090418   ⟸   ENSRNOT00000094027
RefSeq Acc Id: XP_063128196   ⟸   XM_063272126
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128195   ⟸   XM_063272125
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128193   ⟸   XM_063272123
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128197   ⟸   XM_063272127
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128194   ⟸   XM_063272124
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot),   A0A8I6ABR8 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641Y2-F1-model_v2 AlphaFold Q641Y2 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698998
Promoter ID:EPDNEW_R9523
Type:multiple initiation site
Name:Ndufs2_1
Description:NADH:ubiquinone oxidoreductase core subunit S2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,619,409 - 89,619,469EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307109 AgrOrtholog
BioCyc Gene G2FUF-17381 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000038372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022093 UniProtKB/Swiss-Prot
  ENSRNOG00060025952 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058423.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094027.1 UniProtKB/TrEMBL
  ENSRNOT00055037969 UniProtKB/Swiss-Prot
  ENSRNOT00060044950 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.645.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132777 IMAGE-MGC_LOAD
InterPro NADH_Q_OxRdtase_suD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH_UbQ_OxRdtase_49kDa_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDH1_su_D/H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NiFe-Hase_large UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289218 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95229 IMAGE-MGC_LOAD
NCBI Gene 289218 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11993 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Complex1_49kDa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufs2 PhenoGen
PROSITE COMPLEX1_49K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038372 RatGTEx
  ENSRNOG00055022093 RatGTEx
  ENSRNOG00060025952 RatGTEx
Superfamily-SCOP SSF56762 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ABR8 ENTREZGENE, UniProtKB/TrEMBL
  NDUS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ndufs2  NADH:ubiquinone oxidoreductase core subunit S2  LOC103690046  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like  Data merged from RGD:9076367 737654 PROVISIONAL
2017-03-29 Ndufs2  NADH:ubiquinone oxidoreductase core subunit S2  Ndufs2  NADH dehydrogenase (ubiquinone) Fe-S protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690046  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Ndufs2  NADH dehydrogenase (ubiquinone) Fe-S protein 2  Ndufs2_predicted  NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ndufs2_predicted  NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED