Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) - Rat Genome Database

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Gene: Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) Rattus norvegicus
Analyze
Symbol: Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
RGD ID: 1307109
Description: Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2); PARTICIPATES IN doxorubicin pharmacokinetics pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CI-49kD; complex I-49kD; LOC103690046; LOC289218; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like; NADH-ubiquinone oxidoreductase 49 kDa subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,654,402 - 83,671,474 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
Rnor_6.01389,606,848 - 89,623,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,769,663 - 95,770,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01394,233,713 - 94,250,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,124,431 - 87,137,497 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,313,317 - 87,326,381 (-)NCBI
Celera1383,285,589 - 83,298,039 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Akude E, etal., Diabetes. 2011 Jan;60(1):288-97. Epub 2010 Sep 28.
2. Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility. Ban M, etal., PLoS One. 2008 Aug 6;3(8):e2891.
3. Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Dunham-Snary KJ, etal., Circ Res. 2019 Jun 7;124(12):1727-1746. doi: 10.1161/CIRCRESAHA.118.314284. Epub 2019 Mar 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy. Loeffen J, etal., Ann Neurol. 2001 Feb;49(2):195-201.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families. Tuppen HA, etal., Brain. 2010 Oct;133(10):2952-63. Epub 2010 Sep 6.
Additional References at PubMed
PMID:9585441   PMID:11112787   PMID:12477932   PMID:12611891   PMID:12857734   PMID:14651853   PMID:14749350   PMID:17209039   PMID:18614015   PMID:19725078   PMID:21700703   PMID:24746669  
PMID:29476059  


Genomics

Comparative Map Data
Ndufs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,654,402 - 83,671,474 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
Rnor_6.01389,606,848 - 89,623,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,769,663 - 95,770,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01394,233,713 - 94,250,285 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,124,431 - 87,137,497 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,313,317 - 87,326,381 (-)NCBI
Celera1383,285,589 - 83,298,039 (-)NCBICelera
Cytogenetic Map13q24NCBI
NDUFS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,197,417 - 161,214,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1161,197,104 - 161,214,723 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,167,207 - 161,184,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,435,729 - 159,450,809 (+)NCBINCBI36hg18NCBI36
Build 341157,982,177 - 157,997,255NCBI
Celera1134,236,257 - 134,251,337 (+)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,526,050 - 132,541,132 (+)NCBIHuRef
CHM1_11162,565,343 - 162,580,438 (+)NCBICHM1_1
T2T-CHM13v2.01160,334,858 - 160,351,847 (+)NCBI
Ndufs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,062,422 - 171,078,956 (-)NCBIGRCm39mm39
GRCm39 Ensembl1171,062,422 - 171,078,957 (-)Ensembl
GRCm381171,234,853 - 171,251,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,234,853 - 171,251,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,164,991 - 173,177,243 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,071,535 - 173,083,787 (-)NCBImm8
Celera1173,691,078 - 173,703,327 (-)NCBICelera
Cytogenetic Map1H3NCBI
Ndufs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,961,915 - 12,971,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,961,873 - 12,971,278 (+)NCBIChiLan1.0ChiLan1.0
NDUFS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11140,526,690 - 140,538,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,526,690 - 140,538,705 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01136,609,822 - 136,626,851 (+)NCBIMhudiblu_PPA_v0panPan3
NDUFS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,271,603 - 21,281,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,271,675 - 21,285,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,346,459 - 21,356,011 (-)NCBI
ROS_Cfam_1.03821,389,447 - 21,399,000 (-)NCBI
ROS_Cfam_1.0 Ensembl3821,389,447 - 21,398,979 (-)Ensembl
UMICH_Zoey_3.13821,285,733 - 21,286,858 (-)NCBI
UNSW_CanFamBas_1.03821,691,735 - 21,701,283 (-)NCBI
UU_Cfam_GSD_1.03822,100,884 - 22,110,441 (-)NCBI
Ndufs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,294,911 - 7,305,582 (+)NCBI
SpeTri2.0NW_004936903503,633 - 514,235 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,246,960 - 89,257,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,246,958 - 89,257,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,103,640 - 97,113,761 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDUFS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,767,864 - 2,780,336 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl202,768,064 - 2,780,704 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,816,231 - 1,830,038 (-)NCBIVero_WHO_p1.0
Ndufs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794172,707 - 185,073 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624794172,543 - 189,031 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:98
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000058423
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058423   ⟹   ENSRNOP00000055224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
Rnor_6.0 Ensembl1389,606,840 - 89,619,398 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094027   ⟹   ENSRNOP00000090418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,654,406 - 83,671,420 (-)Ensembl
RefSeq Acc Id: NM_001011907   ⟹   NP_001011907
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,654,407 - 83,666,945 (-)NCBI
Rnor_6.01389,606,853 - 89,619,388 (-)NCBI
Rnor_5.01395,769,663 - 95,770,563 (-)NCBI
RGSC_v3.41387,124,431 - 87,137,497 (-)RGD
Celera1383,285,589 - 83,298,039 (-)RGD
Sequence:
RefSeq Acc Id: XM_003751277   ⟹   XP_003751325
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,654,402 - 83,671,474 (-)NCBI
Rnor_6.01389,606,848 - 89,623,506 (-)NCBI
Rnor_5.01394,233,713 - 94,250,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598711   ⟹   XP_017454200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,654,402 - 83,666,963 (-)NCBI
Rnor_6.01389,606,848 - 89,619,376 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090505   ⟹   XP_038946433
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,654,402 - 83,671,415 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001011907 (Get FASTA)   NCBI Sequence Viewer  
  XP_003751325 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454200 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946433 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82067 (Get FASTA)   NCBI Sequence Viewer  
  Q641Y2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001011907   ⟸   NM_001011907
- Peptide Label: precursor
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_003751325   ⟸   XM_003751277
- Peptide Label: isoform X1
- UniProtKB: Q641Y2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454200   ⟸   XM_017598711
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000055224   ⟸   ENSRNOT00000058423
RefSeq Acc Id: XP_038946433   ⟸   XM_039090505
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000090418   ⟸   ENSRNOT00000094027

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641Y2-F1-model_v2 AlphaFold Q641Y2 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698998
Promoter ID:EPDNEW_R9523
Type:multiple initiation site
Name:Ndufs2_1
Description:NADH:ubiquinone oxidoreductase core subunit S2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,619,409 - 89,619,469EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307109 AgrOrtholog
BioCyc Gene G2FUF-17381 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
Ensembl Genes ENSRNOG00000038372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055224 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000090418.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058423 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000094027.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.645.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132777 IMAGE-MGC_LOAD
InterPro NADH_Q_OxRdtase_suD UniProtKB/Swiss-Prot
  NADH_UbQ_OxRdtase_49kDa_CS UniProtKB/Swiss-Prot
  NDH1_su_D/H UniProtKB/Swiss-Prot
  NiFe-Hase_large UniProtKB/Swiss-Prot
KEGG Report rno:289218 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95229 IMAGE-MGC_LOAD
NCBI Gene 289218 ENTREZGENE
PANTHER PTHR11993 UniProtKB/Swiss-Prot
Pfam Complex1_49kDa UniProtKB/Swiss-Prot
PhenoGen Ndufs2 PhenoGen
PROSITE COMPLEX1_49K UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56762 UniProtKB/Swiss-Prot
TIGRFAMs NuoD UniProtKB/Swiss-Prot
UniProt A0A8I6ABR8_RAT UniProtKB/TrEMBL
  NDUS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ndufs2  NADH:ubiquinone oxidoreductase core subunit S2  LOC103690046  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like  Data Merged 737654 PROVISIONAL
2017-03-29 Ndufs2  NADH:ubiquinone oxidoreductase core subunit S2  Ndufs2  NADH dehydrogenase (ubiquinone) Fe-S protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690046  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Ndufs2  NADH dehydrogenase (ubiquinone) Fe-S protein 2  Ndufs2_predicted  NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ndufs2_predicted  NADH dehydrogenase (ubiquinone) Fe-S protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED