Neurog2 (neurogenin 2) - Rat Genome Database

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Gene: Neurog2 (neurogenin 2) Rattus norvegicus
Analyze
Symbol: Neurog2
Name: neurogenin 2
RGD ID: 1309061
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in nervous system development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within several processes, including cell maturation; generation of neurons; and positive regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human NEUROG2 (neurogenin 2); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC295475; neurogenin-2; Ngn2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,767,205 - 218,769,772 (+)NCBIGRCr8
mRatBN7.22216,092,709 - 216,095,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2216,093,363 - 216,094,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2223,756,727 - 223,759,297 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02221,656,421 - 221,658,993 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02216,511,588 - 216,514,155 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02231,962,517 - 231,963,441 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,962,517 - 231,963,308 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02251,307,723 - 251,309,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42224,896,395 - 224,897,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12224,874,615 - 224,883,866 (+)NCBI
Celera2208,408,723 - 208,409,647 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Lo L, etal., Development 2002 Apr;129(7):1553-67.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12895419   PMID:14697366   PMID:15229646   PMID:15328020   PMID:15655114   PMID:16396906   PMID:16410412   PMID:16648472   PMID:16723737   PMID:16766700   PMID:17141158   PMID:17936272  
PMID:18524626   PMID:18579678   PMID:18781144   PMID:19050759   PMID:19409883   PMID:22348101   PMID:23434913   PMID:24685606   PMID:24946204   PMID:26283493   PMID:33527539  


Genomics

Comparative Map Data
Neurog2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82218,767,205 - 218,769,772 (+)NCBIGRCr8
mRatBN7.22216,092,709 - 216,095,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2216,093,363 - 216,094,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2223,756,727 - 223,759,297 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02221,656,421 - 221,658,993 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02216,511,588 - 216,514,155 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02231,962,517 - 231,963,441 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,962,517 - 231,963,308 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02251,307,723 - 251,309,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42224,896,395 - 224,897,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12224,874,615 - 224,883,866 (+)NCBI
Celera2208,408,723 - 208,409,647 (+)NCBICelera
Cytogenetic Map2q42NCBI
NEUROG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384112,513,516 - 112,516,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4112,513,516 - 112,516,180 (-)EnsemblGRCh38hg38GRCh38
GRCh374113,434,672 - 113,437,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364113,654,121 - 113,656,777 (-)NCBINCBI36Build 36hg18NCBI36
Build 344113,792,277 - 113,794,932NCBI
Celera4110,728,735 - 110,731,391 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4109,166,318 - 109,168,977 (-)NCBIHuRef
CHM1_14113,411,494 - 113,414,150 (-)NCBICHM1_1
T2T-CHM13v2.04115,821,850 - 115,824,514 (-)NCBIT2T-CHM13v2.0
Neurog2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393127,426,382 - 127,429,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3127,426,784 - 127,429,280 (+)EnsemblGRCm39 Ensembl
GRCm383127,632,733 - 127,635,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3127,633,135 - 127,635,631 (+)EnsemblGRCm38mm10GRCm38
MGSCv373127,336,063 - 127,338,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363127,625,167 - 127,627,653 (+)NCBIMGSCv36mm8
Celera3134,123,313 - 134,125,799 (+)NCBICelera
Cytogenetic Map3G2NCBI
cM Map356.54NCBI
Neurog2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545714,268,078 - 14,287,050 (+)NCBIChiLan1.0ChiLan1.0
NEUROG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23110,588,563 - 110,593,089 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14110,881,946 - 110,885,219 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04105,002,447 - 105,005,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NEUROG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13232,310,939 - 32,313,492 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3232,312,097 - 32,312,915 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,718,315 - 9,719,427 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03232,537,051 - 32,538,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3232,538,120 - 32,538,938 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13232,520,746 - 32,521,859 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03232,282,363 - 32,283,477 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,577,156 - 7,578,271 (+)NCBIUU_Cfam_GSD_1.0
Neurog2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053018,558,748 - 8,561,327 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365633,348,052 - 3,350,623 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365633,348,052 - 3,350,623 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEUROG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8110,201,161 - 110,201,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18110,200,681 - 110,206,081 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NEUROG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1760,296,442 - 60,299,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl760,297,586 - 60,298,404 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603739,056,009 - 39,058,089 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Neurog2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248386,324,036 - 6,325,511 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Neurog2
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:66
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000014570
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat

Markers in Region
UniSTS:470670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22216,094,019 - 216,094,092 (+)MAPPERmRatBN7.2
Rnor_6.02231,963,174 - 231,963,246NCBIRnor6.0
Rnor_5.02251,308,698 - 251,308,770UniSTSRnor5.0
RGSC_v3.42224,897,052 - 224,897,124UniSTSRGSC3.4
Celera2208,409,380 - 208,409,452UniSTS
Cytogenetic Map2q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium 32 1
Low 17 4
Below cutoff 1 1 13 10 1

Sequence


RefSeq Acc Id: ENSRNOT00000014570   ⟹   ENSRNOP00000014570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2216,093,363 - 216,094,154 (+)Ensembl
Rnor_6.0 Ensembl2231,962,517 - 231,963,308 (+)Ensembl
RefSeq Acc Id: NM_001398677   ⟹   NP_001385606
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82218,767,205 - 218,769,772 (+)NCBI
mRatBN7.22216,092,709 - 216,095,276 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385606 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014570
  ENSRNOP00000014570.3
RefSeq Acc Id: ENSRNOP00000014570   ⟸   ENSRNOT00000014570
RefSeq Acc Id: NP_001385606   ⟸   NM_001398677
- UniProtKB: D4A2E3 (UniProtKB/TrEMBL),   A6HVL7 (UniProtKB/TrEMBL)
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2E3-F1-model_v2 AlphaFold D4A2E3 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309061 AgrOrtholog
BioCyc Gene G2FUF-51270 BioCyc
Ensembl Genes ENSRNOG00000010972 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014570 ENTREZGENE
  ENSRNOT00000014570.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Ngn2 UniProtKB/TrEMBL
KEGG Report rno:295475 UniProtKB/TrEMBL
NCBI Gene 295475 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/TrEMBL
  PTHR19290:SF105 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Neurog2 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010972 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A6HVL7 ENTREZGENE, UniProtKB/TrEMBL
  D4A2E3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Neurog2  neurogenin 2   Neurog2_predicted  neurogenin 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Neurog2_predicted  neurogenin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED