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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621223
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc28a1
Name: solute carrier family 28 member 1
Acc ID: CHEBI:10101
Term: zalcitabine
Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.
Chemical ID: MESH:D016047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc28a1increases uptakeEXP 6480464CTDSLC28A1 protein results in increased uptake of ZalcitabinePMID:8027026 PMID:8700147
Slc28a1multiple interactionsEXP 6480464CTDZalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]PMID:8700147 PMID:8713072
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