Gata1 (GATA binding protein 1) - Rat Genome Database

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Gene: Gata1 (GATA binding protein 1) Rattus norvegicus
Analyze
Symbol: Gata1
Name: GATA binding protein 1
RGD ID: 2663
Description: Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including Sertoli cell development; cellular response to cAMP; and cellular response to follicle-stimulating hormone stimulus. Predicted to be located in nucleoplasm. Predicted to be part of protein-DNA complex and transcription repressor complex. Biomarker of depressive disorder and polycythemia. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone marrow cancer (multiple); colon adenocarcinoma; depressive disorder; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Eryf1; erythroid transcription factor; GATA-1; GATA-binding factor 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; LOC108348091; NF-E1 DNA-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,193,291 - 17,209,462 (+)NCBIGRCr8
mRatBN7.2X14,529,706 - 14,537,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,529,702 - 14,537,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,343,293 - 19,351,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,732,001 - 20,739,823 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,997,169 - 17,004,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,273,937 - 15,281,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,378,789 - 15,382,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,273,933 - 15,281,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,054,178 - 16,062,000 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,564,259 - 26,572,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,617,727 - 26,625,550 (+)NCBI
CeleraX14,614,331 - 14,622,295 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IDA)
basophil differentiation  (ISO)
bone mineralization  (ISO)
cell development  (ISO)
cell fate commitment  (IBA)
cell population proliferation  (ISO)
cell-cell signaling  (ISO)
cellular response to cAMP  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to lipopolysaccharide  (IDA)
dendritic cell differentiation  (ISO)
embryonic hemopoiesis  (ISO)
eosinophil differentiation  (ISO)
eosinophil fate commitment  (ISO)
erythrocyte development  (ISO)
erythrocyte differentiation  (ISO)
homeostasis of number of cells within a tissue  (ISO)
in utero embryonic development  (ISO)
male gonad development  (ISO)
megakaryocyte differentiation  (ISO)
myeloid cell apoptotic process  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
osteoblast proliferation  (ISO)
platelet aggregation  (ISO)
platelet formation  (ISO)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of mast cell degranulation  (IMP)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
primitive erythrocyte differentiation  (ISO)
regulation of definitive erythrocyte differentiation  (ISO)
regulation of DNA-templated transcription  (TAS)
regulation of glycoprotein biosynthetic process  (ISO)
regulation of primitive erythrocyte differentiation  (ISO)
Sertoli cell development  (IEP)
transcription by RNA polymerase II  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. Akimova T, etal., JCI Insight. 2017 Aug 17;2(16). pii: 94075. doi: 10.1172/jci.insight.94075. eCollection 2017 Aug 17.
2. Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder. Birger Y, etal., Blood. 2013 Aug 8;122(6):988-98. doi: 10.1182/blood-2012-10-460998. Epub 2013 May 29.
3. Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats. Choi M, etal., PLoS One. 2014 Oct 23;9(10):e109253. doi: 10.1371/journal.pone.0109253. eCollection 2014.
4. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. El Gazzar MA Inflamm Res. 2007 Aug;56(8):345-51.
5. GATA-1 and GATA-2 gene expression is related to the severity of dysplasia in myelodysplastic syndrome. Fadilah SA, etal., Leukemia. 2002 Aug;16(8):1563-5.
6. Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation. Freson K, etal., Blood. 2001 Jul 1;98(1):85-92.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Greene ME, etal., Blood Cells Mol Dis. 2003 Nov-Dec;31(3):351-6.
10. GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1. Ishijima Y, etal., Genes Cells. 2012 Apr;17(4):285-301. doi: 10.1111/j.1365-2443.2012.01588.x. Epub 2012 Mar 5.
11. Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat. Juskeviciute E, etal., BMC Genomics. 2008 Nov 6;9:527.
12. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Kang HJ, etal., Nat Med. 2012 Aug 12. doi: 10.1038/nm.2886.
13. [Expression of GATA-1 and GATA-2 in the bone marrow of patients with Monge's disease]. Li JP, etal., Zhonghua Xue Ye Xue Za Zhi. 2007 Aug;28(8):537-40.
14. [Influence of HIF- 2α on the expression of GATA- 1 in bone marrow CD71(+) cell of high altitude polycythemia rat model]. Liu F, etal., Zhonghua Xue Ye Xue Za Zhi. 2016 Aug 14;37(8):696-701. doi: 10.3760/cma.j.issn.0253-2727.2016.08.013.
15. [Effects of yisui shengxue granules on expressions of alpha-hemoglobin stabilizing protein and erythroid transcription factor GATA-1 mRNAs in bone marrow of patients with beta-thalassemia]. Liu YM, etal., Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):247-50.
16. A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Majewski IJ, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14146-51. Epub 2006 Sep 11.
17. GATA-1 transcription factor is up-regulated in bone marrow hematopoietic progenitor CD34(+) and erythroid CD71(+) cells in myelodysplastic syndromes. Maratheftis CI, etal., Am J Hematol. 2007 Oct;82(10):887-92.
18. Expression of GATA-binding transcription factors in rat hepatocytes. Matsuda K, etal., FEBS Lett 1994 Oct 24;353(3):269-72.
19. X-linked thrombocytopenia caused by a novel mutation of GATA-1. Mehaffey MG, etal., Blood. 2001 Nov 1;98(9):2681-8.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nichols KE, etal., Nat Genet. 2000 Mar;24(3):266-70.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
25. Conserved structure, regulatory elements, and transcriptional regulation from the GATA-1 gene testis promoter. Onodera K, etal., J Biochem. 1997 Feb;121(2):251-63.
26. Decreased mRNA expression of GATA1 and GATA2 is associated with tumor aggressiveness and poor outcome in clear cell renal cell carcinoma. Peters I, etal., Target Oncol. 2015 Jun;10(2):267-75. doi: 10.1007/s11523-014-0335-8. Epub 2014 Sep 19.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
32. The expression pattern of erythrocyte/megakaryocyte-related transcription factors GATA-1 and the stem cell leukemia gene correlates with hematopoietic differentiation and is associated with outcome of acute myeloid leukemia. Shimamoto T, etal., Blood. 1995 Oct 15;86(8):3173-80.
33. Leukemogenesis caused by incapacitated GATA-1 function. Shimizu R, etal., Mol Cell Biol. 2004 Dec;24(24):10814-25.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. Vannucchi AM, etal., Am J Pathol. 2005 Sep;167(3):849-58.
36. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice). Vannucchi AM, etal., Blood. 2002 Aug 15;100(4):1123-32.
37. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis. Vannucchi AM, etal., Blood. 2005 May 1;105(9):3493-501. Epub 2005 Jan 21.
38. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Yu C, etal., Blood. 2002 Sep 15;100(6):2040-5.
39. GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway. Yu J, etal., Mol Cell Biochem. 2019 Jul;457(1-2):191-199. doi: 10.1007/s11010-019-03523-w. Epub 2019 May 9.
40. Gonadotropins, via cAMP, negatively regulate GATA-1 gene expression in testicular cells. Zhang Z, etal., Endocrinology. 2002 Mar;143(3):829-36.
Additional References at PubMed
PMID:1302015   PMID:1987478   PMID:2467208   PMID:7568185   PMID:7678994   PMID:7867497   PMID:7896801   PMID:7924983   PMID:8195185   PMID:8507862   PMID:8524811   PMID:8628290  
PMID:8901585   PMID:9139715   PMID:9230307   PMID:9233806   PMID:9427697   PMID:9576834   PMID:9787185   PMID:10773455   PMID:12023274   PMID:12045236   PMID:12483298   PMID:12609092  
PMID:14504093   PMID:15005853   PMID:15613485   PMID:15644435   PMID:15701726   PMID:15920471   PMID:15993847   PMID:17167422   PMID:17505015   PMID:18063754   PMID:19011221   PMID:19375645  
PMID:19398553   PMID:19411634   PMID:20133935   PMID:20855530   PMID:21245044   PMID:21436399   PMID:22235304   PMID:22835905   PMID:24245781   PMID:34890016   PMID:35674159  


Genomics

Comparative Map Data
Gata1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,193,291 - 17,209,462 (+)NCBIGRCr8
mRatBN7.2X14,529,706 - 14,537,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,529,702 - 14,537,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,343,293 - 19,351,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,732,001 - 20,739,823 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,997,169 - 17,004,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,273,937 - 15,281,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,378,789 - 15,382,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,273,933 - 15,281,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,054,178 - 16,062,000 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,564,259 - 26,572,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,617,727 - 26,625,550 (+)NCBI
CeleraX14,614,331 - 14,622,295 (+)NCBICelera
Cytogenetic MapXq12NCBI
GATA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,786,590 - 48,794,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,786,540 - 48,794,311 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,644,998 - 48,652,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,529,906 - 48,537,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,401,209 - 48,408,964NCBI
CeleraX53,010,810 - 53,018,547 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,304,230 - 46,311,086 (+)NCBIHuRef
CHM1_1X48,676,125 - 48,683,862 (+)NCBICHM1_1
T2T-CHM13v2.0X48,197,083 - 48,204,804 (+)NCBIT2T-CHM13v2.0
Gata1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,825,504 - 7,842,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,825,499 - 7,844,310 (-)EnsemblGRCm39 Ensembl
GRCm38X7,959,260 - 7,976,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,959,260 - 7,978,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,536,386 - 7,544,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,116,219 - 7,124,774 (-)NCBIMGSCv36mm8
CeleraX3,501,753 - 3,509,992 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.59NCBI
Gata1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543334,061 - 342,061 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543334,581 - 342,042 (+)NCBIChiLan1.0ChiLan1.0
GATA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,280,196 - 50,283,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,283,568 - 50,287,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,088,724 - 41,092,190 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,945,394 - 48,953,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,945,394 - 48,953,126 (+)Ensemblpanpan1.1panPan2
GATA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,991,321 - 41,998,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,971,582 - 41,998,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,366,765 - 16,373,724 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,127,527 - 42,134,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,127,523 - 42,134,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,113,779 - 42,120,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,102,035 - 42,108,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,196,190 - 42,203,150 (+)NCBIUU_Cfam_GSD_1.0
Gata1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,488,565 - 34,510,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721742,862 - 750,768 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721742,862 - 750,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,898,442 - 42,905,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,898,431 - 42,905,939 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,745,326 - 47,752,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,912,638 - 45,920,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,917,231 - 45,920,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,392,674 - 11,400,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893595,967 - 602,979 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893595,948 - 602,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gata1
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:259
Count of miRNA genes:167
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000029272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
RH129447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,537,012 - 14,537,210 (+)MAPPERmRatBN7.2
Rnor_6.0X15,382,055 - 15,382,252NCBIRnor6.0
Rnor_6.0X15,281,242 - 15,281,439NCBIRnor6.0
Rnor_5.0X16,163,290 - 16,163,487UniSTSRnor5.0
Rnor_5.0X16,061,483 - 16,061,680UniSTSRnor5.0
RGSC_v3.4X26,571,564 - 26,571,761UniSTSRGSC3.4
CeleraX14,621,778 - 14,621,975UniSTS
RH 3.4 MapX165.4UniSTS
Cytogenetic MapXq12UniSTS
RH130040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,537,245 - 14,537,445 (+)MAPPERmRatBN7.2
Rnor_6.0X15,382,288 - 15,382,487NCBIRnor6.0
Rnor_6.0X15,281,475 - 15,281,674NCBIRnor6.0
Rnor_5.0X16,061,716 - 16,061,915UniSTSRnor5.0
Rnor_5.0X16,163,523 - 16,163,722UniSTSRnor5.0
RGSC_v3.4X26,571,797 - 26,571,996UniSTSRGSC3.4
CeleraX14,622,011 - 14,622,210UniSTS
Cytogenetic MapXq12UniSTS
Gata1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,533,837 - 14,534,724 (+)MAPPERmRatBN7.2
Rnor_6.0X15,378,880 - 15,379,766NCBIRnor6.0
Rnor_6.0X15,278,067 - 15,278,953NCBIRnor6.0
Rnor_5.0X16,058,308 - 16,059,194UniSTSRnor5.0
Rnor_5.0X16,160,115 - 16,161,001UniSTSRnor5.0
RGSC_v3.4X26,568,389 - 26,569,275UniSTSRGSC3.4
CeleraX14,618,603 - 14,619,489UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 18 18 3 18
Low 16 6 6 8 6 11 10 31 3
Below cutoff 2 18 13 6 5 6 1 2 38 9 11 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029272   ⟹   ENSRNOP00000038111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX15,378,789 - 15,382,066 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075082   ⟹   ENSRNOP00000067336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,529,702 - 14,537,530 (+)Ensembl
Rnor_6.0 EnsemblX15,273,933 - 15,281,759 (+)Ensembl
RefSeq Acc Id: NM_012764   ⟹   NP_036896
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,201,637 - 17,209,459 (+)NCBI
mRatBN7.2X14,529,706 - 14,537,530 (+)NCBI
Rnor_6.0X15,273,937 - 15,281,759 (+)NCBI
Rnor_5.0X16,054,178 - 16,062,000 (+)NCBI
RGSC_v3.4X26,564,259 - 26,572,081 (+)RGD
CeleraX14,614,331 - 14,622,295 (+)RGD
Sequence:
RefSeq Acc Id: XM_063279819   ⟹   XP_063135889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,193,291 - 17,209,462 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036896 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135889 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA02735 (Get FASTA)   NCBI Sequence Viewer  
  EDL83808 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067336
  ENSRNOP00000067336.1
  ENSRNOP00055039763
  ENSRNOP00060033058
  ENSRNOP00065014011
GenBank Protein P43429 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036896   ⟸   NM_012764
- UniProtKB: P43429 (UniProtKB/Swiss-Prot),   A6KP60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038111   ⟸   ENSRNOT00000029272
RefSeq Acc Id: ENSRNOP00000067336   ⟸   ENSRNOT00000075082
RefSeq Acc Id: XP_063135889   ⟸   XM_063279819
- Peptide Label: isoform X1
- UniProtKB: P43429 (UniProtKB/Swiss-Prot),   A6KP60 (UniProtKB/TrEMBL)
Protein Domains
GATA-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43429-F1-model_v2 AlphaFold P43429 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2663 AgrOrtholog
BioCyc Gene G2FUF-2935 BioCyc
Ensembl Genes ENSRNOG00000025534 Ensembl
  ENSRNOG00000047663 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027943 UniProtKB/Swiss-Prot
  ENSRNOG00060023142 UniProtKB/Swiss-Prot
  ENSRNOG00065011306 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075082 ENTREZGENE
  ENSRNOT00000075082.3 UniProtKB/Swiss-Prot
  ENSRNOT00055048355 UniProtKB/Swiss-Prot
  ENSRNOT00060040056 UniProtKB/Swiss-Prot
  ENSRNOT00065018341 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Transcription_factor_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25172 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25172 ENTREZGENE
PANTHER ERYTHROID TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  PTHR10071 UniProtKB/Swiss-Prot
  PTHR10071:SF190 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR GATA FAMILY MEMBER UniProtKB/TrEMBL
Pfam GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gata1 PhenoGen
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025534 RatGTEx
  ENSRNOG00000047663 RatGTEx
  ENSRNOG00055027943 RatGTEx
  ENSRNOG00060023142 RatGTEx
  ENSRNOG00065011306 RatGTEx
SMART ZnF_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230471
UniProt A6KP60 ENTREZGENE, UniProtKB/TrEMBL
  GATA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gata1  GATA binding protein 1  LOC108348091  erythroid transcription factor  Data merged from RGD:11399827 737654 PROVISIONAL
2016-08-02 LOC108348091  erythroid transcription factor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gata1  GATA-binding protein 1 (globin transcription factor 1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in fetal liver 728595
gene_function binds DNA at the GAT(A/T) motif 728595
gene_process may be involved with transcriptional repression of serine dehydratase 728595