Gene: Gata1 (GATA binding protein 1) Rattus norvegicus
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Symbol:
Gata1
Name:
GATA binding protein 1
RGD ID:
2663
Description:
Exhibits chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including Sertoli cell development; cellular response to cAMP; and cellular response to follicle-stimulating hormone stimulus. Localizes to nucleus. Biomarker of mental depression. Human ortholog(s) of this gene implicated in Down syndrome; X-linked thrombocytopenia with beta-thalassemia; beta thalassemia; and bone marrow cancer (multiple). Orthologous to human GATA1 (GATA binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Eryf1; erythroid transcription factor; GATA-1; GATA-binding factor 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; NF-E1 DNA-binding protein
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 15,273,937 - 15,281,759 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 15,378,789 - 15,382,066 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 16,054,178 - 16,062,000 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 26,564,259 - 26,572,081 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 26,617,727 - 26,625,550 (+) NCBI Celera X 14,614,331 - 14,622,295 (+) NCBI Celera Cytogenetic Map X q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute myeloid leukemia disease_progression ISO RGD:731384 10450754 RGD Altitude Sickness ISO RGD:731384 10450750 mRNA, protein:increased expression:bone marrow, mononuclear cell RGD beta thalassemia treatment ISO RGD:731384 10450613 RGD Familial Myelofibrosis ISO RGD:10621 10450737 RGD Fibrosis ISO RGD:10621 10450614 RGD major depressive disorder ISO RGD:731384 6892958 mRNA:increased expression:dorsolateral prefrontal cortex RGD mental depression IEP 6892958 mRNA:increased expression:prefrontal cortex RGD mental depression ISO RGD:10621 6892958 RGD myelodysplastic syndrome severity ISO RGD:731384 10450753 RGD myelodysplastic syndrome ISO RGD:10621 10450734 RGD myelodysplastic syndrome disease_progression ISO RGD:731384 10450752 mRNA:increased expression:bone marrow RGD myelofibrosis ISO RGD:731384 10450748 RGD myeloid leukemia ISO RGD:10621 10450751 RGD myeloid leukemia associated with Down Syndrome ISO RGD:731384 10450612 RGD thrombocytopenia ISO RGD:10621 10450735 RGD Thrombocytopenia 1 ISO RGD:731384 10450747 associated with Beta-Thalassemia, DNA:missense mutation: :p.R216Q (human) RGD transient myeloproliferative syndrome ISO RGD:731384 10450612 RGD X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 10450749 DNA:missense mutation: :p.G208S, [622G>T, 623G>C] (human) RGD X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 10450740 DNA:missense mutation: :p.M205V, 613G>A (human) RGD X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 10450743 DNA:missense mutation: :p.D218G, 653A>G (human) RGD
Imported Annotations - ClinVar
anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Anemia ClinVar PMID:32581362 autistic disorder ISO RGD:731384 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 congenital disorder of glycosylation type IIm ISO RGD:731384 8554872 ClinVar Annotator: match by term: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIm ClinVar PMID:28492532 Diamond-Blackfan anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Diamond-Blackfan anemia ClinVar PMID:25741868 , PMID:28492532 Diamond-Blackfan anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Diamond-Blackfan anemia ClinVar PMID:16783379 more ... Diamond-Blackfan anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Diamond-Blackfan anemia ClinVar PMID:28492532 Diamond-Blackfan anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Diamond-Blackfan anemia ClinVar PMID:24728327 , PMID:28492532 Down syndrome ISO RGD:731384 8554872 ClinVar Annotator: match by term: Complete trisomy 21 syndrome ClinVar PMID:25741868 , PMID:28492532 megakaryocytic leukemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Acute megakaryoblastic leukemia ClinVar PMID:15070711 myeloid leukemia associated with Down Syndrome ISO RGD:731384 8554872 ClinVar Annotator: match by term: Leukemia, megakaryoblastic, of Down syndrome ClinVar PMID:12172547 syndromic X-linked intellectual disability Lubs type ISO RGD:731384 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 thrombocytopenia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Thrombocytopenia ClinVar PMID:23278136 , PMID:32581362 thrombocytopenia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Thrombocytopenia ClinVar PMID:11418466 more ... thrombocytopenia ISO RGD:731384 8554872 ClinVar Annotator: match by term: Thrombocytopenia ClinVar PMID:25741868 , PMID:31064749 X-Linked Anemia with or without Neutropenia and/or Platelet Abnormalities ISO RGD:731384 8554872 ClinVar Annotator: match by term: ANEMIA, X-LINKED, WITH OR WITHOUT NEUTROPENIA AND/OR PLATELET ABNORMALITIES ClinVar PMID:24453067 , PMID:24952648 X-Linked Anemia with or without Neutropenia and/or Platelet Abnormalities ISO RGD:731384 8554872 ClinVar Annotator: match by term: ANEMIA, X-LINKED, WITH OR WITHOUT NEUTROPENIA AND/OR PLATELET ABNORMALITIES ClinVar PMID:15895080 more ... X-Linked Anemia with or without Neutropenia and/or Platelet Abnormalities ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300835 ClinVar PMID:22706301 X-linked thrombocytopenia with beta-thalassemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:314050 ClinVar PMID:10733494 more ... X-linked thrombocytopenia with beta-thalassemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:314050 ClinVar PMID:12200364 more ... X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA-1-related thrombocytopenia with dyserythropoiesis ClinVar PMID:23278136 , PMID:32581362 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA1-Related X-Linked Cytopenia ClinVar PMID:11418466 more ... X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA-1-related thrombocytopenia with dyserythropoiesis ClinVar PMID:24453067 , PMID:24952648 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA-1-related thrombocytopenia with dyserythropoiesis ClinVar PMID:15895080 more ... X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA-1-related thrombocytopenia with dyserythropoiesis ClinVar PMID:16783379 more ... X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: GATA-1-related thrombocytopenia with dyserythropoiesis ClinVar PMID:11566888 more ... X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300367 ClinVar PMID:11809723 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300367 ClinVar PMID:10700180 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by term: THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA ClinVar PMID:28492532 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300367 ClinVar PMID:16103636 , PMID:17713552 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300367 ClinVar PMID:16783379 X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 8554872 ClinVar Annotator: match by OMIM:300367 ClinVar PMID:22706301
Imported Annotations - CTD
myelodysplastic syndrome ISO RGD:731384 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28963909 thrombocytopenia ISO RGD:731384 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16966598 transient myeloproliferative syndrome ISO RGD:731384 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24056718 Imported Annotations - MGI
myelofibrosis ISS RGD:10621 13592920 OMIM:254450 MouseDO Imported Annotations - OMIM
Down syndrome ISO RGD:731384 7240710 OMIM X-Linked Anemia with or without Neutropenia and/or Platelet Abnormalities ISO RGD:731384 7240710 OMIM X-linked thrombocytopenia with beta-thalassemia ISO RGD:731384 7240710 OMIM X-Linked Thrombocytopenia, with or without Dyserythropoietic Anemia ISO RGD:731384 7240710 OMIM
1-octadec-9-enoylglycero-3-phosphate multiple interactions ISO RGD:731384 6480464 [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA more ... CTD PMID:21915944 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:10621 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:10621 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10621 6480464 Tetrachlorodibenzodioxin affects the expression of GATA1 mRNA CTD PMID:21570461 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of GATA1 mRNA CTD PMID:15644576 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731384 6480464 Tetrachlorodibenzodioxin results in increased expression of GATA1 mRNA CTD PMID:12377990 2-butoxyethanol increases expression ISO RGD:10621 6480464 n-butoxyethanol results in increased expression of GATA1 mRNA CTD PMID:19812364 5-aza-2'-deoxycytidine multiple interactions ISO RGD:731384 6480464 [Decitabine co-treated with trichostatin A] results in increased expression of GATA1 mRNA more ... CTD PMID:17185465 , PMID:23973255 aclacinomycin A multiple interactions ISO RGD:731384 6480464 Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA] more ... CTD PMID:10656287 , PMID:14623254 aclacinomycin A increases expression ISO RGD:731384 6480464 Aclarubicin results in increased expression of GATA1 mRNA CTD PMID:10656287 aclacinomycin A increases activity ISO RGD:731384 6480464 Aclarubicin results in increased activity of GATA1 protein CTD PMID:14623254 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of GATA1 mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO RGD:731384 6480464 Aflatoxin B1 results in decreased methylation of GATA1 gene CTD PMID:27153756 all-trans-retinoic acid multiple interactions ISO RGD:731384 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GATA1 mRNA CTD PMID:16443354 all-trans-retinoic acid multiple interactions ISO RGD:10621 6480464 GATA1 protein results in decreased susceptibility to [Lithium Chloride co-treated with Tretinoin] CTD PMID:19230972 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GATA1 mRNA CTD PMID:16483693 anagrelide multiple interactions ISO RGD:731384 6480464 anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA], anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 arsenite(3-) decreases methylation ISO RGD:731384 6480464 arsenite results in decreased methylation of GATA1 promoter CTD PMID:23974009 arsenous acid decreases expression ISO RGD:731384 6480464 Arsenic Trioxide results in decreased expression of GATA1 protein CTD PMID:16360329 benzene-1,2,4-triol multiple interactions ISO RGD:731384 6480464 hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] CTD PMID:21414390 benzene-1,2,4-triol affects methylation ISO RGD:731384 6480464 hydroxyhydroquinone affects the methylation of GATA1 promoter CTD PMID:30327826 benzo[a]pyrene affects methylation ISO RGD:731384 6480464 Benzo(a)pyrene affects the methylation of GATA1 promoter CTD PMID:27901495 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GATA1 mRNA CTD PMID:25181051 bisphenol A affects methylation ISO RGD:10621 6480464 bisphenol A affects the methylation of GATA1 promoter CTD PMID:27334623 butyric acid multiple interactions ISO RGD:731384 6480464 Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA] more ... CTD PMID:10656287 more ... butyric acid increases expression ISO RGD:731384 6480464 Butyric Acid results in increased expression of GATA1 mRNA CTD PMID:10656287 , PMID:14757314 calcium atom affects expression EXP 6480464 Calcium affects the expression of GATA1 mRNA CTD PMID:15913539 calcium(0) affects expression EXP 6480464 Calcium affects the expression of GATA1 mRNA CTD PMID:15913539 capsaicin increases expression ISO RGD:10621 6480464 Capsaicin results in increased expression of GATA1 mRNA CTD PMID:17603282 carbon nanotube increases expression ISO RGD:10621 6480464 Nanotubes, Carbon results in increased expression of GATA1 mRNA CTD PMID:25554681 catechol increases expression ISO RGD:731384 6480464 catechol results in increased expression of GATA1 mRNA CTD PMID:23022512 , PMID:28552822 catechol multiple interactions ISO RGD:731384 6480464 catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA], Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA] CTD PMID:28552822 Chebulinic acid decreases expression ISO RGD:731384 6480464 chebulinic acid results in decreased expression of GATA1 mRNA CTD PMID:14769215 Chebulinic acid multiple interactions ISO RGD:731384 6480464 chebulinic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA] CTD PMID:14769215 chromium(6+) decreases expression EXP 6480464 chromium hexavalent ion results in decreased expression of GATA1 protein CTD PMID:32679048 cobalt dichloride decreases expression ISO RGD:731384 6480464 cobaltous chloride results in decreased expression of GATA1 mRNA CTD PMID:22941251 diarsenic trioxide decreases expression ISO RGD:731384 6480464 Arsenic Trioxide results in decreased expression of GATA1 protein CTD PMID:16360329 doxorubicin increases activity ISO RGD:731384 6480464 Doxorubicin analog results in increased activity of GATA1 protein, Doxorubicin results in increased activity of GATA1 protein CTD PMID:14623254 , PMID:17097070 doxorubicin increases expression ISO RGD:731384 6480464 Doxorubicin analog results in increased expression of GATA1 mRNA, Doxorubicin results in increased expression of GATA1 mRNA CTD PMID:17097070 doxorubicin multiple interactions ISO RGD:731384 6480464 Doxorubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter] CTD PMID:14623254 genistein decreases expression ISO RGD:10621 6480464 Genistein results in decreased expression of GATA1 mRNA CTD PMID:21048042 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of GATA1 mRNA CTD PMID:22061828 hemin increases expression ISO RGD:731384 6480464 Hemin results in increased expression of GATA1 mRNA CTD PMID:21414390 more ... hemin multiple interactions ISO RGD:731384 6480464 catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA] more ... CTD PMID:21414390 more ... hydroquinone decreases expression ISO RGD:731384 6480464 hydroquinone results in decreased expression of GATA1 mRNA CTD PMID:21414390 hydroquinone multiple interactions ISO RGD:731384 6480464 decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]], hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] CTD PMID:21414390 , PMID:23973255 L-ascorbic acid multiple interactions ISO RGD:731384 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GATA1 mRNA CTD PMID:16443354 lithium chloride multiple interactions ISO RGD:10621 6480464 GATA1 protein results in decreased susceptibility to [Lithium Chloride co-treated with Tretinoin] CTD PMID:19230972 N-acetyl-L-cysteine multiple interactions ISO RGD:731384 6480464 Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA], Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA] CTD PMID:10656287 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:10621 6480464 Ethylnitrosourea results in increased mutagenesis of GATA1 gene CTD PMID:16966598 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GATA1 mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of GATA1 mRNA CTD PMID:25729387 phenol multiple interactions ISO RGD:731384 6480464 decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]], Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] CTD PMID:21414390 , PMID:23973255 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:731384 6480464 Tetradecanoylphorbol Acetate promotes the reaction [GATA1 protein binds to GSTP1 promoter] CTD PMID:14623254 phorbol 13-acetate 12-myristate increases activity ISO RGD:731384 6480464 Tetradecanoylphorbol Acetate results in increased activity of GATA1 protein CTD PMID:14623254 pomalidomide decreases expression ISO RGD:731384 6480464 pomalidomide results in decreased expression of GATA1 mRNA, pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 pyrrolidine dithiocarbamate multiple interactions ISO RGD:731384 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA], pyrrolidine dithiocarbamic acid inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA] CTD PMID:10656287 quercetin multiple interactions ISO RGD:731384 6480464 Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA] more ... CTD PMID:10656287 , PMID:21915944 sodium arsenate increases expression ISO RGD:10621 6480464 sodium arsenate results in increased expression of GATA1 mRNA CTD PMID:30953684 Tellimagrandin I decreases expression ISO RGD:731384 6480464 tellimagrandin I results in decreased expression of GATA1 mRNA CTD PMID:14757314 Tellimagrandin I multiple interactions ISO RGD:731384 6480464 tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA] CTD PMID:14757314 titanium dioxide decreases expression ISO RGD:10621 6480464 titanium dioxide results in decreased expression of GATA1 mRNA CTD PMID:29264374 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of GATA1 mRNA CTD PMID:25729387 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of GATA1 mRNA CTD PMID:25729387 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of GATA1 mRNA CTD PMID:27618143 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of GATA1 gene CTD PMID:27618143 trichostatin A multiple interactions ISO RGD:731384 6480464 [decitabine co-treated with trichostatin A] results in increased expression of GATA1 mRNA CTD PMID:17185465 valproic acid increases methylation ISO RGD:731384 6480464 Valproic Acid results in increased methylation of GATA1 gene CTD PMID:29154799 vorinostat increases expression ISO RGD:731384 6480464 Vorinostat results in increased expression of GATA1 mRNA, Vorinostat results in increased expression of GATA1 protein CTD PMID:28963909 zidovudine decreases activity ISO RGD:731384 6480464 Zidovudine results in decreased activity of GATA1 protein CTD PMID:10651068 , PMID:8599995 zidovudine decreases expression ISO RGD:731384 6480464 Zidovudine results in decreased expression of GATA1 mRNA CTD PMID:8599995
Biological Process animal organ regeneration IDA 4110831 RGD basophil differentiation ISO RGD:731384 1624291 (PMID:7678994) RGD PMID:7678994 cell development ISO RGD:10621 1624291 MGI:MGI:2177587 (MGI:MGI:894135 , PMID:9233806) RGD MGI:MGI:894135 , PMID:9233806 cell fate commitment IBA MGI:MGI:95662 more ... 13792537 PMID:21873635 GO_Central cell-cell signaling ISO RGD:10621 1624291 MGI:MGI:2177586 (MGI:MGI:3653541 , PMID:15005853) RGD MGI:MGI:3653541 , PMID:15005853 cellular response to cAMP IEP 2317795 RGD cellular response to follicle-stimulating hormone stimulus IEP 2317795 RGD cellular response to lipopolysaccharide IDA 5131526 RGD cellular response to thyroid hormone stimulus ISO RGD:731384 1624291 (PMID:19375645) RGD PMID:19375645 dendritic cell differentiation ISO RGD:10621 1624291 (MGI:MGI:3763343, PMID:17505015) RGD MGI:MGI:3763343 , PMID:17505015 embryonic hemopoiesis ISO RGD:10621 1624291 MGI:MGI:2429992 (MGI:MGI:1203270 , PMID:9576834) RGD MGI:MGI:1203270 , PMID:9576834 eosinophil differentiation ISO RGD:731384 1624291 (PMID:8507862) RGD PMID:8507862 eosinophil fate commitment ISO RGD:731384 1624291 (PMID:12045236) RGD PMID:12045236 erythrocyte development ISO RGD:731384 1624291 (PMID:10700180) RGD PMID:10700180 erythrocyte differentiation ISO RGD:731384 1624291 (PMID:7678994) RGD PMID:7678994 erythrocyte differentiation ISO RGD:10621 1624291 MGI:MGI:1095400 more ... RGD MGI:MGI:1195019 more ... homeostasis of number of cells within a tissue ISO RGD:10621 1624291 MGI:MGI:95662 (MGI:MGI:3027433 , PMID:14504093) RGD MGI:MGI:3027433 , PMID:14504093 in utero embryonic development ISO RGD:10621 1624291 MGI:MGI:2429992 (MGI:MGI:1203270 , PMID:9576834) RGD MGI:MGI:1203270 , PMID:9576834 male gonad development ISO RGD:731384 1624291 (PMID:10700180) RGD PMID:10700180 megakaryocyte differentiation ISO RGD:10621 1624291 MGI:MGI:1095400 more ... RGD MGI:MGI:1195019 more ... megakaryocyte differentiation ISO RGD:731384 1624291 (PMID:10700180) RGD PMID:10700180 myeloid cell differentiation ISO RGD:10621 1624291 MGI:MGI:1857600 more ... RGD MGI:MGI:81144 more ... negative regulation of apoptotic process ISO RGD:731384 1624291 (PMID:17167422) RGD PMID:17167422 negative regulation of apoptotic process ISO RGD:10621 1624291 MGI:MGI:2179748 (MGI:MGI:76931 , PMID:7568185) RGD MGI:MGI:76931 , PMID:7568185 negative regulation of bone mineralization ISO RGD:10621 1624291 MGI:MGI:2177586 (MGI:MGI:3653541 , PMID:15005853) RGD MGI:MGI:3653541 , PMID:15005853 negative regulation of cell population proliferation ISO RGD:10621 1624291 MGI:MGI:2177587 (MGI:MGI:894135 , PMID:9233806) RGD MGI:MGI:894135 , PMID:9233806 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO RGD:731384 1624291 (PMID:17167422) RGD PMID:17167422 negative regulation of transcription by RNA polymerase II ISO RGD:731384 1624291 (PMID:22235304) RGD PMID:22235304 negative regulation of transcription by RNA polymerase II ISS UniProtKB:P15976 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription by RNA polymerase II IBA MGI:MGI:95661 more ... 13792537 PMID:21873635 GO_Central negative regulation of transcription by RNA polymerase II ISO RGD:10621 1624291 MGI:MGI:98834 (MGI:MGI:3763343 more ... RGD MGI:MGI:3763343 more ... negative regulation of transcription regulatory region DNA binding ISO RGD:731384 1624291 (PMID:15920471) RGD PMID:15920471 platelet aggregation ISO RGD:731384 1624291 (PMID:15701726) RGD PMID:15701726 platelet aggregation ISO RGD:10621 1624291 (MGI:MGI:3580921, PMID:15701726) RGD MGI:MGI:3580921 , PMID:15701726 platelet formation ISO RGD:731384 1624291 (PMID:10700180), (PMID:11675338), (PMID:12483298) RGD PMID:10700180 more ... platelet formation ISO RGD:10621 1624291 MGI:MGI:2177587 (MGI:MGI:894135 , PMID:9233806) RGD MGI:MGI:894135 , PMID:9233806 positive regulation of cytosolic calcium ion concentration IMP 9587812 RGD positive regulation of erythrocyte differentiation ISO RGD:731384 1624291 (PMID:17167422) RGD PMID:17167422 positive regulation of mast cell degranulation IMP 9587812 RGD positive regulation of osteoblast proliferation ISO RGD:10621 1624291 MGI:MGI:2177586 (MGI:MGI:3653541 , PMID:15005853) RGD MGI:MGI:3653541 , PMID:15005853 positive regulation of peptidyl-tyrosine phosphorylation ISO RGD:731384 1624291 (PMID:15701726) RGD PMID:15701726 positive regulation of peptidyl-tyrosine phosphorylation ISO RGD:10621 1624291 (MGI:MGI:3580921, PMID:15701726) RGD MGI:MGI:3580921 , PMID:15701726 positive regulation of transcription by RNA polymerase II ISO RGD:10621 1624291 MGI:MGI:102812 (MGI:MGI:1195019 more ... RGD MGI:MGI:1195019 more ... positive regulation of transcription by RNA polymerase II ISO RGD:731384 1624291 (PMID:12200364), (PMID:15920471), (PMID:20133935), (PMID:2467208) RGD PMID:12200364 more ... positive regulation of transcription by RNA polymerase II IBA CGD:CAL0000197994 more ... 13792537 PMID:21873635 GO_Central positive regulation of transcription, DNA-templated ISO RGD:731384 1624291 (PMID:24245781) RGD PMID:24245781 positive regulation of transcription, DNA-templated ISS UniProtKB:P15976 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription, DNA-templated ISO RGD:10621 1624291 (MGI:MGI:5606145, PMID:24245781) RGD MGI:MGI:5606145 , PMID:24245781 regulation of definitive erythrocyte differentiation ISO RGD:731384 1624291 (PMID:12200364), (PMID:15920471) RGD PMID:12200364 , PMID:15920471 regulation of definitive erythrocyte differentiation ISO RGD:10621 1624291 (MGI:MGI:5284816, PMID:12200364) RGD MGI:MGI:5284816 , PMID:12200364 regulation of glycoprotein biosynthetic process ISO RGD:731384 1624291 (PMID:15701726) RGD PMID:15701726 regulation of glycoprotein biosynthetic process ISO RGD:10621 1624291 (MGI:MGI:3580921, PMID:15701726) RGD MGI:MGI:3580921 , PMID:15701726 regulation of primitive erythrocyte differentiation ISO RGD:10621 1624291 MGI:MGI:95662 (MGI:MGI:3027433 , PMID:14504093) RGD MGI:MGI:3027433 , PMID:14504093 regulation of transcription, DNA-templated TAS 728595 RGD Sertoli cell development IEP 2317794 RGD transcriptional activation by promoter-enhancer looping ISO RGD:10621 1624291 (MGI:MGI:5284796, PMID:15644435) RGD MGI:MGI:5284796 , PMID:15644435 Cellular Component nucleoplasm ISO RGD:731384 1624291 RGD GO_REF:0000052 nucleus IDA 1598733 RGD nucleus IBA FB:FBgn0003117 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:10621 1624291 (MGI:MGI:1306996 more ... RGD MGI:MGI:1306996 more ... nucleus ISO RGD:731384 1624291 (PMID:10700180), (PMID:17167422), (PMID:2467208) RGD PMID:10700180 more ... protein-DNA complex ISO RGD:731384 1624291 (PMID:12609092) RGD PMID:12609092 transcription regulator complex ISO RGD:731384 1624291 (PMID:15920471) RGD PMID:15920471 transcription repressor complex ISO RGD:731384 1624291 (PMID:15920471) RGD PMID:15920471 Molecular Function C2H2 zinc finger domain binding ISO RGD:731384 1624291 UniProtKB:Q8IX07 (PMID:12483298) RGD PMID:12483298 chromatin binding IDA 6892958 RGD chromatin binding ISO RGD:10621 1624291 (MGI:MGI:3763343 more ... RGD MGI:MGI:3763343 more ... chromatin DNA binding ISO RGD:731384 1624291 (PMID:22235304) RGD PMID:22235304 chromatin DNA binding ISS UniProtKB:P15976 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cis-regulatory region sequence-specific DNA binding ISO RGD:10621 1624291 (MGI:MGI:5009777, PMID:20855530) RGD MGI:MGI:5009777 , PMID:20855530 DNA binding IDA 728595 RGD DNA binding ISO RGD:10621 1624291 (MGI:MGI:1355654 more ... RGD MGI:MGI:1355654 more ... DNA binding ISO RGD:731384 1624291 (PMID:11418466), (PMID:12609092), (PMID:22235304), (PMID:8628290) RGD PMID:11418466 more ... DNA binding, bending ISO RGD:10621 1624291 (MGI:MGI:4946306, PMID:21436399) RGD MGI:MGI:4946306 , PMID:21436399 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:10621 1624291 (MGI:MGI:1195019 more ... RGD MGI:MGI:1195019 more ... DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:731384 1624291 (PMID:15920471) RGD PMID:15920471 DNA-binding transcription factor activity ISO RGD:731384 1624291 (PMID:2467208) RGD PMID:2467208 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:10621 1624291 (MGI:MGI:77668, PMID:8524811) RGD MGI:MGI:77668 , PMID:8524811 DNA-binding transcription factor activity, RNA polymerase II-specific IBA FB:FBgn0003117 more ... 13792537 PMID:21873635 GO_Central p53 binding ISO RGD:10621 1624291 PR:P02340 (MGI:MGI:3850294, PMID:19411634) RGD MGI:MGI:3850294 , PMID:19411634 protein binding ISO RGD:10621 1624291 PR:O35615 more ... RGD MGI:MGI:1342875 more ... protein binding ISO RGD:731384 1624291 UniProtKB:A0A140G945 more ... RGD PMID:11418466 more ... RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:731384 1624291 (PMID:15920471), (PMID:20133935), (PMID:24245781) RGD PMID:15920471 more ... RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA MGI:MGI:107516 more ... 13792537 PMID:21873635 GO_Central RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS UniProtKB:P15976 1600115 GO_REF:0000024 UniProt GO_REF:0000024 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:10621 1624291 (MGI:MGI:71650, PMID:7896801) RGD MGI:MGI:71650 , PMID:7896801 RNA polymerase II transcription factor binding ISO RGD:731384 1624291 UniProtKB:Q8IX07 (PMID:11675338), (PMID:15920471) RGD PMID:11675338 , PMID:15920471 RNA polymerase II transcription factor binding ISO RGD:10621 1624291 UniProtKB:P17433 (MGI:MGI:3773481 , PMID:18063754) RGD MGI:MGI:3773481 , PMID:18063754 RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO RGD:731384 1624291 (PMID:2467208) RGD PMID:2467208 sequence-specific DNA binding IDA 728595 RGD sequence-specific DNA binding ISO RGD:10621 1624291 (MGI:MGI:1306996 more ... RGD MGI:MGI:1306996 more ... sequence-specific DNA binding ISO RGD:731384 1624291 (PMID:12200364) RGD PMID:12200364 sequence-specific double-stranded DNA binding ISO RGD:731384 1624291 (PMID:28473536) RGD PMID:28473536 transcription regulatory region sequence-specific DNA binding ISO RGD:731384 1624291 (PMID:10700180) RGD PMID:10700180 zinc ion binding IEA InterPro:IPR000679 , InterPro:IPR013088 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
