RGD Reference Report - Decreased mRNA expression of GATA1 and GATA2 is associated with tumor aggressiveness and poor outcome in clear cell renal cell carcinoma. - Rat Genome Database

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Decreased mRNA expression of GATA1 and GATA2 is associated with tumor aggressiveness and poor outcome in clear cell renal cell carcinoma.

Authors: Peters, Inga  Dubrowinskaja, Natalia  Tezval, Hossein  Kramer, Mario W  von Klot, Christoph A  Hennenlotter, Jörg  Stenzl, Arnulf  Scherer, Ralph  Kuczyk, Markus A  Serth, Jürgen 
Citation: Peters I, etal., Target Oncol. 2015 Jun;10(2):267-75. doi: 10.1007/s11523-014-0335-8. Epub 2014 Sep 19.
RGD ID: 149735195
Pubmed: PMID:25230694   (View Abstract at PubMed)
DOI: DOI:10.1007/s11523-014-0335-8   (Journal Full-text)

GATA-binding proteins 1 (GATA1) and 2 (GATA2) are zinc-finger transcription factors and belong to the GATA family proteins 1-6. GATA1 interacts with the TP53 tumor suppressor gene, and both GATAs have been shown to be involved in cell growth, apoptosis, and tumorigenesis of several solid tumors. GATA1 and GATA2 expression alterations are associated with poor survival and adverse clinicopathology in prostate and colorectal cancer, while the significance and prognostic value in clear cell renal cell carcinoma (ccRCC) has not been investigated as yet. We investigated relative messenger RNA (mRNA) expression levels of GATA1 and GATA2 in 77 ccRCC and 58 paired adjacent noncancerous renal tissues by quantitative real-time reverse-transcribed PCR. Relative mRNA expression levels were determined using the ΔΔCt method. GATA1 and GATA2 expression levels were significantly decreased in tumor tissues compared with normal tissues (p < 0.001, paired t test). In univariate logistic regression analysis, decreased GATA1 and GATA2 expression levels were associated with advanced tumor disease (p = 0.005 and 0.008), positive distant metastasis (p = 0.03 and 0.001), and lymph node metastasis status (p = 0.011 and 0.038). Reduced expression levels of GATA1 and GATA2 were associated with an increased risk of disease recurrence (p = 0.005 and 0.006; hazard ratio = 0.05 and 0.21). Pairwise bivariate analysis after adjusting for clinicopathological parameters revealed relative mRNA expression of GATA1, but not GATA2, as an independent candidate prognosticator for ccRCC. Our results support that GATA1 and GATA2 are involved in ccRCC tumor biology possibly affecting tumor development and aggressiveness.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GATA1Humanclear cell renal cell carcinoma disease_progressionIEP  RGD 
GATA2Humanclear cell renal cell carcinoma disease_progressionIEP  RGD 
Gata1Ratclear cell renal cell carcinoma disease_progressionISOGATA1 (Homo sapiens) RGD 
Gata1Mouseclear cell renal cell carcinoma disease_progressionISOGATA1 (Homo sapiens) RGD 
Gata2Ratclear cell renal cell carcinoma disease_progressionISOGATA2 (Homo sapiens) RGD 
Gata2Mouseclear cell renal cell carcinoma disease_progressionISOGATA2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gata1  (GATA binding protein 1)
Gata2  (GATA binding protein 2)

Genes (Mus musculus)
Gata1  (GATA binding protein 1)
Gata2  (GATA binding protein 2)

Genes (Homo sapiens)
GATA1  (GATA binding protein 1)
GATA2  (GATA binding protein 2)


Additional Information