Gata1 (GATA binding protein 1) - Rat Genome Database

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Gene: Gata1 (GATA binding protein 1) Mus musculus
Analyze
Symbol: Gata1
Name: GATA binding protein 1
RGD ID: 10621
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; p53 binding activity; and transcription coactivator binding activity. Involved in several processes, including platelet aggregation; regulation of definitive erythrocyte differentiation; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including hemopoiesis; positive regulation of osteoblast proliferation; and regulation of primitive erythrocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and mesenchyme derived from lateral plate. Used to study myelodysplastic syndrome; myelofibrosis; and thrombocytopenia. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); beta thalassemia; colon adenocarcinoma; and hematologic cancer (multiple). Orthologous to human GATA1 (GATA binding protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eryf1; erythroid transcription factor; Gata; Gata-1; GATA-binding factor 1; GATA-binding protein 1; Gf-1; NF-E1 DNA-binding protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,825,499 - 7,842,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,825,499 - 7,844,310 (-)EnsemblGRCm39 Ensembl
GRCm38X7,959,260 - 7,976,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,959,260 - 7,978,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,536,386 - 7,544,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,116,219 - 7,124,774 (-)NCBIMGSCv36mm8
CeleraX3,501,753 - 3,509,992 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
basophil differentiation  (IEA)
bone mineralization  (IMP)
cell development  (IMP)
cell fate commitment  (IBA)
cell population proliferation  (IMP)
cell-cell signaling  (IMP)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
dendritic cell differentiation  (IDA)
embryonic hemopoiesis  (IMP)
eosinophil differentiation  (IEA)
eosinophil fate commitment  (ISO)
erythrocyte development  (ISO)
erythrocyte differentiation  (IDA,IGI,IMP)
homeostasis of number of cells within a tissue  (IGI)
in utero embryonic development  (IMP)
male gonad development  (ISO)
megakaryocyte differentiation  (IDA,IGI,IMP,ISO)
myeloid cell apoptotic process  (IMP)
myeloid cell differentiation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of bone mineralization  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of myeloid cell apoptotic process  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,ISO)
negative regulation of transcription regulatory region DNA binding  (ISO)
osteoblast proliferation  (IMP)
platelet aggregation  (IMP,ISO)
platelet formation  (IMP,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
primitive erythrocyte differentiation  (IMP)
regulation of definitive erythrocyte differentiation  (IDA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of glycoprotein biosynthetic process  (IMP,ISO)
regulation of primitive erythrocyte differentiation  (IGI)
regulation of transcription by RNA polymerase II  (IEA)
Sertoli cell development  (ISO)
transcription by RNA polymerase II  (IDA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hematocrit  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal hemostasis  (IAGP)
abnormal iron level  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal liver morphology  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal mononuclear cell morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal platelet morphology  (IAGP)
abnormal platelet shape  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen red pulp morphology  (IAGP)
abnormal stress erythropoiesis  (IAGP)
abnormal thrombopoiesis  (IAGP)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
anisocytosis  (IAGP)
autoimmune response  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased circulating interleukin-13 level  (IAGP)
decreased circulating interleukin-4 level  (IAGP)
decreased embryo size  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fetal size  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased survivor rate  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged pericardium  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
impaired hematopoiesis  (IAGP)
increased bone ossification  (IAGP)
increased bone trabecula number  (IAGP)
increased compact bone volume  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased leukocyte cell number  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased number of Howell-Jolly bodies  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte number  (IAGP)
increased trabecular bone volume  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hypoplasia  (IAGP)
myelofibrosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale liver  (IAGP)
pale spleen  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
poikilocytosis  (IAGP)
polychromatophilia  (IAGP)
polyploidy  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
small liver  (IAGP)
thrombocytopenia  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. Akimova T, etal., JCI Insight. 2017 Aug 17;2(16). pii: 94075. doi: 10.1172/jci.insight.94075. eCollection 2017 Aug 17.
2. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Attaya M, etal., Nature 1992 Feb 13;355(6361):647-9.
3. Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder. Birger Y, etal., Blood. 2013 Aug 8;122(6):988-98. doi: 10.1182/blood-2012-10-460998. Epub 2013 May 29.
4. Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats. Choi M, etal., PLoS One. 2014 Oct 23;9(10):e109253. doi: 10.1371/journal.pone.0109253. eCollection 2014.
5. GATA-1 and GATA-2 gene expression is related to the severity of dysplasia in myelodysplastic syndrome. Fadilah SA, etal., Leukemia. 2002 Aug;16(8):1563-5.
6. Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation. Freson K, etal., Blood. 2001 Jul 1;98(1):85-92.
7. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Greene ME, etal., Blood Cells Mol Dis. 2003 Nov-Dec;31(3):351-6.
8. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Kang HJ, etal., Nat Med. 2012 Aug 12. doi: 10.1038/nm.2886.
9. [Expression of GATA-1 and GATA-2 in the bone marrow of patients with Monge's disease]. Li JP, etal., Zhonghua Xue Ye Xue Za Zhi. 2007 Aug;28(8):537-40.
10. [Influence of HIF- 2α on the expression of GATA- 1 in bone marrow CD71(+) cell of high altitude polycythemia rat model]. Liu F, etal., Zhonghua Xue Ye Xue Za Zhi. 2016 Aug 14;37(8):696-701. doi: 10.3760/cma.j.issn.0253-2727.2016.08.013.
11. [Effects of yisui shengxue granules on expressions of alpha-hemoglobin stabilizing protein and erythroid transcription factor GATA-1 mRNAs in bone marrow of patients with beta-thalassemia]. Liu YM, etal., Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):247-50.
12. A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Majewski IJ, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14146-51. Epub 2006 Sep 11.
13. GATA-1 transcription factor is up-regulated in bone marrow hematopoietic progenitor CD34(+) and erythroid CD71(+) cells in myelodysplastic syndromes. Maratheftis CI, etal., Am J Hematol. 2007 Oct;82(10):887-92.
14. X-linked thrombocytopenia caused by a novel mutation of GATA-1. Mehaffey MG, etal., Blood. 2001 Nov 1;98(9):2681-8.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nichols KE, etal., Nat Genet. 2000 Mar;24(3):266-70.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Decreased mRNA expression of GATA1 and GATA2 is associated with tumor aggressiveness and poor outcome in clear cell renal cell carcinoma. Peters I, etal., Target Oncol. 2015 Jun;10(2):267-75. doi: 10.1007/s11523-014-0335-8. Epub 2014 Sep 19.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. The expression pattern of erythrocyte/megakaryocyte-related transcription factors GATA-1 and the stem cell leukemia gene correlates with hematopoietic differentiation and is associated with outcome of acute myeloid leukemia. Shimamoto T, etal., Blood. 1995 Oct 15;86(8):3173-80.
25. Leukemogenesis caused by incapacitated GATA-1 function. Shimizu R, etal., Mol Cell Biol. 2004 Dec;24(24):10814-25.
26. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. Vannucchi AM, etal., Am J Pathol. 2005 Sep;167(3):849-58.
27. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice). Vannucchi AM, etal., Blood. 2002 Aug 15;100(4):1123-32.
28. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis. Vannucchi AM, etal., Blood. 2005 May 1;105(9):3493-501. Epub 2005 Jan 21.
29. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Yu C, etal., Blood. 2002 Sep 15;100(6):2040-5.
30. GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway. Yu J, etal., Mol Cell Biochem. 2019 Jul;457(1-2):191-199. doi: 10.1007/s11010-019-03523-w. Epub 2019 May 9.
Additional References at PubMed
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PMID:28869965   PMID:28910278   PMID:28935682   PMID:29099969   PMID:29197504   PMID:29244083   PMID:29408805   PMID:29435140   PMID:29442367   PMID:29442374   PMID:29467297   PMID:29580867  
PMID:29898395   PMID:29967467   PMID:30130433   PMID:30185409   PMID:30285291   PMID:30321752   PMID:30530752   PMID:31109364   PMID:31253725   PMID:31303423   PMID:31369572   PMID:31409672  
PMID:31433857   PMID:31469835   PMID:31481482   PMID:31582556   PMID:31601784   PMID:31672904   PMID:31729420   PMID:31813828   PMID:32130902   PMID:32294451   PMID:32444652   PMID:32450947  
PMID:32527952   PMID:32533074   PMID:33141023   PMID:33178185   PMID:33454424   PMID:34062116   PMID:34225769   PMID:34429328   PMID:34450641   PMID:34671097   PMID:34815802   PMID:34843900  
PMID:34940950   PMID:35204735   PMID:35482420   PMID:35649376   PMID:35709757   PMID:35906245  


Genomics

Comparative Map Data
Gata1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,825,499 - 7,842,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,825,499 - 7,844,310 (-)EnsemblGRCm39 Ensembl
GRCm38X7,959,260 - 7,976,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,959,260 - 7,978,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,536,386 - 7,544,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,116,219 - 7,124,774 (-)NCBIMGSCv36mm8
CeleraX3,501,753 - 3,509,992 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.59NCBI
GATA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,786,590 - 48,794,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX48,786,540 - 48,794,311 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,644,998 - 48,652,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,529,906 - 48,537,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,401,209 - 48,408,964NCBI
CeleraX53,010,810 - 53,018,547 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,304,230 - 46,311,086 (+)NCBIHuRef
CHM1_1X48,676,125 - 48,683,862 (+)NCBICHM1_1
T2T-CHM13v2.0X48,197,083 - 48,204,804 (+)NCBIT2T-CHM13v2.0
Gata1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X14,529,706 - 14,537,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,529,702 - 14,537,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,343,293 - 19,351,113 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X20,732,001 - 20,739,823 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X16,997,169 - 17,004,991 (-)NCBIRnor_WKY
Rnor_6.0X15,273,937 - 15,281,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,378,789 - 15,382,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,273,933 - 15,281,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,054,178 - 16,062,000 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,564,259 - 26,572,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,617,727 - 26,625,550 (+)NCBI
CeleraX14,614,331 - 14,622,295 (+)NCBICelera
Cytogenetic MapXq12NCBI
Gata1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543334,061 - 342,061 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543334,581 - 342,042 (+)NCBIChiLan1.0ChiLan1.0
GATA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X48,945,394 - 48,953,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,945,394 - 48,953,126 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X41,088,724 - 41,092,190 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GATA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,991,321 - 41,998,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,971,582 - 41,998,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,366,765 - 16,373,724 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,127,527 - 42,134,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,127,523 - 42,134,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,113,779 - 42,120,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,102,035 - 42,108,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,196,190 - 42,203,150 (+)NCBIUU_Cfam_GSD_1.0
Gata1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,488,565 - 34,510,496 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936721742,862 - 750,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,898,442 - 42,905,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,898,431 - 42,905,939 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,745,326 - 47,752,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,912,638 - 45,920,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,917,231 - 45,920,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,392,674 - 11,400,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893595,967 - 602,979 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893595,948 - 602,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,962,254 - 7,963,131UniSTSGRCm38
MGSCv37X7,539,380 - 7,540,257UniSTSGRCm37
CeleraX3,506,121 - 3,506,998UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
cM MapX1.9UniSTS
cM MapX1.9UniSTS
cM MapX1.9UniSTS
cM MapX1.9UniSTS
cM MapX1.9UniSTS
UniSTS:237997  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,959,755 - 7,960,042UniSTSGRCm38
MGSCv37X7,536,881 - 7,537,168UniSTSGRCm37
CeleraX3,509,210 - 3,509,497UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
PMC123124P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,960,973 - 7,961,213UniSTSGRCm38
MGSCv37X7,538,099 - 7,538,339UniSTSGRCm37
CeleraX3,508,039 - 3,508,279UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
PMC133542P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,959,260 - 7,959,704UniSTSGRCm38
MGSCv37X7,536,386 - 7,536,830UniSTSGRCm37
CeleraX3,509,548 - 3,509,992UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
GDB:574073  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,959,988 - 7,960,708UniSTSGRCm38
MGSCv37X7,537,114 - 7,537,834UniSTSGRCm37
CeleraX3,508,544 - 3,509,264UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,962,360 - 7,963,050UniSTSGRCm38
MGSCv37X7,539,486 - 7,540,176UniSTSGRCm37
CeleraX3,506,202 - 3,506,892UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,962,281 - 7,963,051UniSTSGRCm38
MGSCv37X7,539,407 - 7,540,177UniSTSGRCm37
CeleraX3,506,201 - 3,506,971UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,959,417 - 7,959,998UniSTSGRCm38
MGSCv37X7,536,543 - 7,537,124UniSTSGRCm37
CeleraX3,509,254 - 3,509,835UniSTS
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
cM MapX1.9UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS
Gata1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:707
Count of miRNA genes:485
Interacting mature miRNAs:553
Transcripts:ENSMUST00000033502, ENSMUST00000125418, ENSMUST00000128449
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033502   ⟹   ENSMUSP00000033502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,825,499 - 7,834,149 (-)Ensembl
GRCm38.p6 EnsemblX7,959,260 - 7,967,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125418   ⟹   ENSMUSP00000118052
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,828,679 - 7,844,310 (-)Ensembl
GRCm38.p6 EnsemblX7,962,440 - 7,978,071 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128449   ⟹   ENSMUSP00000123620
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,829,268 - 7,830,405 (-)Ensembl
GRCm38.p6 EnsemblX7,963,029 - 7,964,166 (-)Ensembl
RefSeq Acc Id: NM_008089   ⟹   NP_032115
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X7,825,499 - 7,834,149 (-)NCBI
GRCm38X7,959,260 - 7,967,910 (-)NCBI
MGSCv37X7,536,386 - 7,544,941 (-)RGD
CeleraX3,501,658 - 3,509,992 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011247448   ⟹   XP_011245750
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X7,825,504 - 7,842,902 (-)NCBI
GRCm38X7,959,265 - 7,976,663 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032115   ⟸   NM_008089
- UniProtKB: Q7TMX8 (UniProtKB/Swiss-Prot),   P17679 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245750   ⟸   XM_011247448
- Peptide Label: isoform X1
- UniProtKB: Q7TMX8 (UniProtKB/Swiss-Prot),   P17679 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000118052   ⟸   ENSMUST00000125418
RefSeq Acc Id: ENSMUSP00000033502   ⟸   ENSMUST00000033502
RefSeq Acc Id: ENSMUSP00000123620   ⟸   ENSMUST00000128449

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17679-F1-model_v2 AlphaFold P17679 1-413 view protein structure

Promoters
RGD ID:13680018
Promoter ID:EPDNEW_M24158
Type:initiation region
Name:Gata1_1
Description:Mus musculus GATA binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24159  EPDNEW_M24160  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,967,843 - 7,967,903EPDNEW
RGD ID:13680020
Promoter ID:EPDNEW_M24159
Type:single initiation site
Name:Gata1_2
Description:Mus musculus GATA binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24158  EPDNEW_M24160  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,973,787 - 7,973,847EPDNEW
RGD ID:13680022
Promoter ID:EPDNEW_M24160
Type:initiation region
Name:Gata1_3
Description:Mus musculus GATA binding protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24158  EPDNEW_M24159  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,976,557 - 7,976,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95661 AgrOrtholog
Ensembl Genes ENSMUSG00000031162 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033502 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000118052.2 UniProtKB/TrEMBL
  ENSMUSP00000123620.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033502 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000125418.2 UniProtKB/TrEMBL
  ENSMUST00000128449.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot
InterPro GATA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_GATA UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report mmu:14460 UniProtKB/Swiss-Prot
MGD MGI:95661 ENTREZGENE
NCBI Gene 14460 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10071:SF190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GATA UniProtKB/Swiss-Prot
PhenoGen Gata1 PhenoGen
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot
SMART ZnF_GATA UniProtKB/Swiss-Prot
UniProt B1AUB3_MOUSE UniProtKB/TrEMBL
  B1AUB4_MOUSE UniProtKB/TrEMBL
  GATA1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TMX8 ENTREZGENE
UniProt Secondary Q3UIH9 UniProtKB/Swiss-Prot
  Q7TMX8 UniProtKB/Swiss-Prot