GATA1 (GATA binding protein 1) - Rat Genome Database

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Gene: GATA1 (GATA binding protein 1) Canis lupus familiaris
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Symbol: GATA1
Name: GATA binding protein 1
RGD ID: 12318317
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); bone mineralization (ortholog); cell development (ortholog); ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute myeloid leukemia (ortholog); Altitude Sickness (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: erythroid transcription factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,991,321 - 41,998,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,971,582 - 41,998,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,366,765 - 16,373,724 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,127,527 - 42,134,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,127,523 - 42,134,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,113,779 - 42,120,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,102,035 - 42,108,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,196,190 - 42,203,150 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
basophil differentiation  (IEA)
bone mineralization  (IEA,ISO)
cell development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell-cell signaling  (IEA,ISO)
cellular response to cAMP  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
eosinophil differentiation  (IEA)
eosinophil fate commitment  (IEA)
erythrocyte development  (IEA)
erythrocyte differentiation  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
male gonad development  (IEA)
megakaryocyte differentiation  (IEA,ISO)
myeloid cell apoptotic process  (IEA,ISO)
myeloid cell differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of bone mineralization  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of myeloid cell apoptotic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
osteoblast proliferation  (IEA,ISO)
platelet aggregation  (IEA)
platelet formation  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of mast cell degranulation  (ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
primitive erythrocyte differentiation  (IEA,ISO)
regulation of definitive erythrocyte differentiation  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of glycoprotein biosynthetic process  (IEA)
regulation of primitive erythrocyte differentiation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
Sertoli cell development  (ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GATA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,991,321 - 41,998,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,971,582 - 41,998,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,366,765 - 16,373,724 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,127,527 - 42,134,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,127,523 - 42,134,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,113,779 - 42,120,737 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,102,035 - 42,108,995 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,196,190 - 42,203,150 (+)NCBIUU_Cfam_GSD_1.0
GATA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,786,590 - 48,794,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,786,540 - 48,794,311 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,644,998 - 48,652,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,529,906 - 48,537,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,401,209 - 48,408,964NCBI
CeleraX53,010,810 - 53,018,547 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,304,230 - 46,311,086 (+)NCBIHuRef
CHM1_1X48,676,125 - 48,683,862 (+)NCBICHM1_1
T2T-CHM13v2.0X48,197,083 - 48,204,804 (+)NCBIT2T-CHM13v2.0
Gata1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,825,504 - 7,842,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,825,499 - 7,844,310 (-)EnsemblGRCm39 Ensembl
GRCm38X7,959,260 - 7,976,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,959,260 - 7,978,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,536,386 - 7,544,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,116,219 - 7,124,774 (-)NCBIMGSCv36mm8
CeleraX3,501,753 - 3,509,992 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.59NCBI
Gata1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,193,291 - 17,209,462 (+)NCBIGRCr8
mRatBN7.2X14,529,706 - 14,537,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,529,702 - 14,537,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,343,293 - 19,351,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,732,001 - 20,739,823 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,997,169 - 17,004,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,273,937 - 15,281,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,378,789 - 15,382,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,273,933 - 15,281,759 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,054,178 - 16,062,000 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,564,259 - 26,572,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,617,727 - 26,625,550 (+)NCBI
CeleraX14,614,331 - 14,622,295 (+)NCBICelera
Cytogenetic MapXq12NCBI
Gata1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543334,061 - 342,061 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955543334,581 - 342,042 (+)NCBIChiLan1.0ChiLan1.0
GATA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,280,196 - 50,283,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,283,568 - 50,287,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,088,724 - 41,092,190 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,945,394 - 48,953,126 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,945,394 - 48,953,126 (+)Ensemblpanpan1.1panPan2
Gata1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,488,565 - 34,510,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721742,862 - 750,768 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721742,862 - 750,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,898,442 - 42,905,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,898,431 - 42,905,939 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,745,326 - 47,752,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,912,638 - 45,920,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,917,231 - 45,920,268 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,392,674 - 11,400,428 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gata1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893595,967 - 602,979 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893595,948 - 602,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GATA1
29 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000024680   ⟹   ENSCAFP00000022898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,971,582 - 41,998,303 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845054929   ⟹   ENSCAFP00845043195
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX42,127,523 - 42,134,481 (+)Ensembl
RefSeq Acc Id: XM_038449959   ⟹   XP_038305887
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X42,127,527 - 42,134,488 (+)NCBI
RefSeq Acc Id: XM_038523408   ⟹   XP_038379336
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X42,113,779 - 42,120,737 (+)NCBI
RefSeq Acc Id: XM_038587377   ⟹   XP_038443305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X42,196,190 - 42,203,150 (+)NCBI
RefSeq Acc Id: XM_038651890   ⟹   XP_038507818
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X42,102,035 - 42,108,995 (+)NCBI
RefSeq Acc Id: XM_538026   ⟹   XP_538026
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X41,991,322 - 41,998,319 (+)NCBI
Dog10K_Boxer_TashaX16,366,765 - 16,373,724 (+)NCBI
Sequence:
RefSeq Acc Id: XP_538026   ⟸   XM_538026
- UniProtKB: A0A8C0S1L4 (UniProtKB/TrEMBL),   A0A8C0LB17 (UniProtKB/TrEMBL),   A0A8I3QVV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000022898   ⟸   ENSCAFT00000024680
RefSeq Acc Id: XP_038379336   ⟸   XM_038523408
RefSeq Acc Id: XP_038507818   ⟸   XM_038651890
RefSeq Acc Id: XP_038305887   ⟸   XM_038449959
- UniProtKB: A0A8C0S1L4 (UniProtKB/TrEMBL),   A0A8C0LB17 (UniProtKB/TrEMBL),   A0A8I3QVV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038443305   ⟸   XM_038587377
- UniProtKB: A0A8C0LB17 (UniProtKB/TrEMBL),   A0A8C0S1L4 (UniProtKB/TrEMBL),   A0A8I3QVV2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845043195   ⟸   ENSCAFT00845054929
Protein Domains
GATA-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015572 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008280 UniProtKB/TrEMBL
  ENSCAFG00040009001 UniProtKB/TrEMBL
  ENSCAFG00845030905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024680.5 UniProtKB/TrEMBL
  ENSCAFT00030015257.1 UniProtKB/TrEMBL
  ENSCAFT00040016752.1 UniProtKB/TrEMBL
  ENSCAFT00845054929 ENTREZGENE
  ENSCAFT00845054929.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report cfa:480906 UniProtKB/TrEMBL
NCBI Gene GATA1 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
  PTHR10071:SF190 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A8C0LB17 ENTREZGENE
  A0A8C0S1L4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QVV2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:111507 ENTREZGENE