Slc23a2 (solute carrier family 23 member 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc23a2 (solute carrier family 23 member 2) Rattus norvegicus
Analyze
Symbol: Slc23a2
Name: solute carrier family 23 member 2
RGD ID: 619876
Description: Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in several processes, including L-ascorbic acid transmembrane transport; cellular response to ethanol; and positive regulation of dendrite extension. Located in basal plasma membrane and cytoplasm. Orthologous to human SLC23A2 (solute carrier family 23 member 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/L-ascorbic acid transporter 2; sodium-coupled ascorbic acid transporter 2; sodium-dependent vitamin C transporter 2; solute carrier family 23 (ascorbic acid transporter), member 2; solute carrier family 23 (nucleobase transporters), member 2; SVCT2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,755,583 - 139,913,304 (-)NCBIGRCr8
mRatBN7.23119,302,651 - 119,395,289 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,302,666 - 119,460,343 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,206,656 - 123,298,423 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,793,663 - 131,885,649 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,462,752 - 129,554,530 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,632,491 - 124,842,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,632,492 - 124,724,252 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,132,124 - 131,266,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,796,376 - 119,886,011 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13119,701,948 - 119,791,584 (-)NCBI
Celera3118,102,047 - 118,150,099 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
hexadecanoic acid  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
levetiracetam  (EXP)
morphine  (EXP)
nickel sulfate  (ISO)
nifedipine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phosphonoformic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
taurocholic acid  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
2. Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain. Berger UV, etal., J Neurochem. 2003 Aug;86(4):896-906.
3. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Erichsen HC, etal., Am J Epidemiol. 2006 Feb 1;163(3):245-54. Epub 2005 Dec 15.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-κB and miRNA125a-5p. Tian H, etal., Free Radic Biol Med. 2016 Jul;96:362-73. doi: 10.1016/j.freeradbiomed.2016.03.039. Epub 2016 Apr 13.
11. A family of mammalian Na+-dependent L-ascorbic acid transporters. Tsukaguchi H, etal., Nature 1999 May 6;399(6731):70-5.
Additional References at PubMed
PMID:8889548   PMID:10471399   PMID:10556521   PMID:10631088   PMID:11984597   PMID:12559983   PMID:15333707   PMID:15993839   PMID:18247577   PMID:18417304   PMID:19216494   PMID:19418264  
PMID:21733302   PMID:22348976   PMID:22763122   PMID:23708151   PMID:24739976   PMID:28942474  


Genomics

Comparative Map Data
Slc23a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,755,583 - 139,913,304 (-)NCBIGRCr8
mRatBN7.23119,302,651 - 119,395,289 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,302,666 - 119,460,343 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,206,656 - 123,298,423 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,793,663 - 131,885,649 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,462,752 - 129,554,530 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,632,491 - 124,842,225 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,632,492 - 124,724,252 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,132,124 - 131,266,028 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43119,796,376 - 119,886,011 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13119,701,948 - 119,791,584 (-)NCBI
Celera3118,102,047 - 118,150,099 (-)NCBICelera
Cytogenetic Map3q36NCBI
SLC23A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38204,852,358 - 5,010,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl204,852,356 - 5,010,293 (-)EnsemblGRCh38hg38GRCh38
GRCh37204,833,004 - 4,990,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,781,002 - 4,938,939 (-)NCBINCBI36Build 36hg18NCBI36
Build 34204,781,001 - 4,938,939NCBI
Celera204,902,706 - 5,051,861 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef204,787,194 - 4,944,817 (-)NCBIHuRef
CHM1_1204,834,496 - 4,992,439 (-)NCBICHM1_1
T2T-CHM13v2.0204,891,820 - 5,049,741 (-)NCBIT2T-CHM13v2.0
Slc23a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,894,416 - 131,987,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,894,416 - 131,987,028 (-)EnsemblGRCm39 Ensembl
GRCm382132,052,496 - 132,145,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,052,496 - 132,145,108 (-)EnsemblGRCm38mm10GRCm38
MGSCv372131,878,232 - 131,970,844 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362131,743,937 - 131,836,549 (-)NCBIMGSCv36mm8
Celera2133,279,011 - 133,328,217 (-)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.15NCBI
Slc23a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,565,249 - 15,642,153 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,565,344 - 15,677,935 (-)NCBIChiLan1.0ChiLan1.0
SLC23A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,801,682 - 6,017,566 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1205,798,507 - 6,014,383 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0204,874,185 - 5,024,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,670,294 - 4,790,800 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,670,294 - 4,790,800 (-)Ensemblpanpan1.1panPan2
SLC23A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,573,616 - 16,709,296 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,574,168 - 16,709,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,425,818 - 16,531,856 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02416,981,643 - 17,127,359 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,990,701 - 17,127,359 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,613,514 - 16,719,979 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,720,357 - 16,826,526 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,054,182 - 17,160,266 (+)NCBIUU_Cfam_GSD_1.0
Slc23a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,431,608 - 165,545,259 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648513,885,091 - 13,976,550 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648513,885,067 - 13,976,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC23A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1713,848,728 - 14,011,700 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11713,848,726 - 14,012,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21714,819,223 - 14,825,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC23A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,092,619 - 33,209,258 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,128,061 - 33,212,255 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607111,323,229 - 11,470,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc23a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247415,917,019 - 6,000,720 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247415,917,620 - 6,050,922 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc23a2
326 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:422
Count of miRNA genes:246
Interacting mature miRNAs:294
Transcripts:ENSRNOT00000028885
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat

Markers in Region
BF410351  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03131,214,266 - 131,214,464UniSTSRnor5.0
Rnor_5.03131,254,981 - 131,255,179UniSTSRnor5.0
RGSC_v3.43119,875,549 - 119,875,747UniSTSRGSC3.4
Celera3118,183,252 - 118,183,450UniSTS
RH 3.4 Map31023.4UniSTS
Cytogenetic Map3q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 16 19 72 25 32 11
Low 37 41 41 41 8 11 2 10 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA964954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF080453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000028885   ⟹   ENSRNOP00000028885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3119,302,666 - 119,460,343 (-)Ensembl
Rnor_6.0 Ensembl3124,632,492 - 124,724,252 (-)Ensembl
RefSeq Acc Id: NM_017316   ⟹   NP_059012
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,847,343 (-)NCBI
mRatBN7.23119,302,651 - 119,394,413 (-)NCBI
Rnor_6.03124,632,491 - 124,724,252 (-)NCBI
Rnor_5.03131,132,124 - 131,266,028 (-)NCBI
RGSC_v3.43119,796,376 - 119,886,011 (-)RGD
Celera3118,102,047 - 118,150,099 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235067   ⟹   XP_006235129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,817,865 (-)NCBI
mRatBN7.23119,302,651 - 119,364,797 (-)NCBI
Rnor_6.03124,632,491 - 124,692,021 (-)NCBI
Rnor_5.03131,132,124 - 131,266,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235068   ⟹   XP_006235130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,848,011 (-)NCBI
mRatBN7.23119,302,651 - 119,395,289 (-)NCBI
Rnor_6.03124,632,491 - 124,842,225 (-)NCBI
Rnor_5.03131,132,124 - 131,266,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105735   ⟹   XP_038961663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,847,177 (-)NCBI
mRatBN7.23119,302,651 - 119,394,282 (-)NCBI
RefSeq Acc Id: XM_039105736   ⟹   XP_038961664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,777,785 - 139,847,416 (-)NCBI
mRatBN7.23119,324,854 - 119,394,486 (-)NCBI
RefSeq Acc Id: XM_063284409   ⟹   XP_063140479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,913,304 (-)NCBI
RefSeq Acc Id: XM_063284411   ⟹   XP_063140481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,791,557 (-)NCBI
RefSeq Acc Id: XM_063284412   ⟹   XP_063140482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,755,583 - 139,785,533 (-)NCBI
RefSeq Acc Id: XM_063284413   ⟹   XP_063140483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,777,793 - 139,847,415 (-)NCBI
RefSeq Acc Id: NP_059012   ⟸   NM_017316
- UniProtKB: Q9WTW8 (UniProtKB/Swiss-Prot),   A6HQF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235130   ⟸   XM_006235068
- Peptide Label: isoform X1
- UniProtKB: Q9WTW8 (UniProtKB/Swiss-Prot),   A6HQF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235129   ⟸   XM_006235067
- Peptide Label: isoform X1
- UniProtKB: Q9WTW8 (UniProtKB/Swiss-Prot),   A6HQF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028885   ⟸   ENSRNOT00000028885
RefSeq Acc Id: XP_038961663   ⟸   XM_039105735
- Peptide Label: isoform X1
- UniProtKB: Q9WTW8 (UniProtKB/Swiss-Prot),   A6HQF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961664   ⟸   XM_039105736
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063140479   ⟸   XM_063284409
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140481   ⟸   XM_063284411
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140482   ⟸   XM_063284412
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140483   ⟸   XM_063284413
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTW8-F1-model_v2 AlphaFold Q9WTW8 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619876 AgrOrtholog
BioCyc Gene G2FUF-47786 BioCyc
Ensembl Genes ENSRNOG00000021262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055005858 UniProtKB/Swiss-Prot
  ENSRNOG00060002051 UniProtKB/Swiss-Prot
  ENSRNOG00065013821 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028885.5 UniProtKB/Swiss-Prot
  ENSRNOT00055009470 UniProtKB/Swiss-Prot
  ENSRNOT00060003211 UniProtKB/Swiss-Prot
  ENSRNOT00065022743 UniProtKB/Swiss-Prot
InterPro NCS2 UniProtKB/TrEMBL
  Xan_ur_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xant/urac/vitC UniProtKB/Swiss-Prot
KEGG Report rno:50622 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50622 ENTREZGENE
PANTHER PTHR11119:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Xan_ur_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc23a2 PhenoGen
PROSITE XANTH_URACIL_PERMASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021262 RatGTEx
  ENSRNOG00055005858 RatGTEx
  ENSRNOG00060002051 RatGTEx
  ENSRNOG00065013821 RatGTEx
UniProt A6HQF4 ENTREZGENE, UniProtKB/TrEMBL
  A6HQF5_RAT UniProtKB/TrEMBL
  Q9WTW8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc23a2  solute carrier family 23 member 2  Slc23a2  solute carrier family 23 (ascorbic acid transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc23a2  solute carrier family 23 (ascorbic acid transporter), member 2  Slc23a2  solute carrier family 23 (nucleobase transporters), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Slc23a2  solute carrier family 23 (nucleobase transporters), member 2  SVCT2  sodium-coupled ascorbic acid transporter 2  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 SVCT2  sodium-coupled ascorbic acid transporter 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain, eye and other organs 634186
gene_process regulates the supply and metabolism of vitamin C 634186