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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620667
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dck
Name: deoxycytidine kinase
Acc ID: CHEBI:63577
Term: lamivudine
Definition: A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B.
Chemical ID: MESH:D019259
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dckmultiple interactionsISORGD:13447476480464CTDDCK protein results in increased phosphorylation of and results in increased activity of Lamivudine

PMID:17530837
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