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Accession:CHEBI:31536 term browser browse the term
Definition:An organofluorine compound that is 5-fluorocytosine substituted at the 1 position by a 2-(hydroxymethyl)-1,3-oxathiolan-5-yl group (2R,5S configuration). It is used in combination therapy for the treatment of HIV-1 infection.
Synonyms:related_synonym: (-)-2'-deoxy-5-fluoro-3'-thiacytidine;   (-)-FTC;   (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine;   (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one;   (2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone;   4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one;   5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine;   Formula=C8H10FN3O3S;   InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1;   InChIKey=XQSPYNMVSIKCOC-NTSWFWBYSA-N;   SMILES=Nc1nc(=O)n(cc1F)[C@@H]1CS[C@H](CO)O1
 alt_id: CHEBI:174911
 xref: Beilstein:5908714;   CAS:143491-57-0;   DrugBank:DB00879;   Drug_Central:1003;   KEGG:C12599;   KEGG:D01199
 xref_mesh: MESH:D000068679
 xref: PDBeChem:ETV;   PMID:11491420;   PMID:14609348;   PMID:14693538;   PMID:15206508;   PMID:15249567;   PMID:15588339;   PMID:15875341;   PMID:15977972;   PMID:16034488;   PMID:16323102;   PMID:16401810;   PMID:17526857;   PMID:19493710;   PMID:22915463;   PMID:22917277;   PMID:22935078;   PMID:23337366;   PMID:23361642;   PMID:25017682;   Patent:US5538975;   Patent:WO9214743;   Wikipedia:Emtricitabine

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emtricitabine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Dck deoxycytidine kinase JBrowse link 14 20,935,442 20,952,939 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

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  CHEBI ontology 19758
    role 19705
      biological role 19704
        antimicrobial agent 17270
          antiviral agent 10181
            antiviral drug 1786
              emtricitabine 5
                Descovy 0
                Genvoya 0
                Odefsey 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            heteroorganic entity 19099
                              organochalcogen compound 18800
                                organooxygen compound 18713
                                  carbohydrates and carbohydrate derivatives 12122
                                    carbohydrate 12122
                                      carbohydrate derivative 11746
                                        glycosyl compound 10800
                                          N-glycosyl compound 5323
                                            nucleoside analogue 702
                                              emtricitabine 5
                                                Descovy 0
                                                Genvoya 0
                                                Odefsey 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.