Dlg5 (discs large MAGUK scaffold protein 5)

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Gene: Dlg5 (discs large MAGUK scaffold protein 5) Rattus norvegicus

Analyze

Symbol:

Dlg5

Name:

discs large MAGUK scaffold protein 5

RGD ID:

1308753

Description:

Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Predicted to be involved in several processes, including positive regulation of dendritic spine development; positive regulation of smoothened signaling pathway; and regulation of hippo signaling. Predicted to act upstream of or within several processes, including apical protein localization; epithelial cell differentiation; and protein localization to adherens junction. Predicted to be located in adherens junction and ciliary basal body. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

discs large homolog 5; discs, large homolog 5; discs, large homolog 5 (Drosophila); disks large homolog 5; LOC305645

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DLG5 (discs large MAGUK scaffold protein 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dlg5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dlg5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DLG5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DLG5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dlg5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DLG5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DLG5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dlg5 (discs large MAGUK scaffold protein 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DLG5 (discs large MAGUK scaffold protein 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dlg5 (discs large MAGUK scaffold protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dlg5a (discs, large homolog 5a (Drosophila))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dlg5b.1 (discs, large homolog 5b (Drosophila), tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Dlg5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	magu-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	dlg5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	75,786 - 209,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	75,786 - 187,837 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	82,881 - 194,929 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	1,469,453 - 1,581,500 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	81,608 - 193,647 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	120,213 - 230,312 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	120,372 - 228,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	115,133 - 225,208 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	118,948 - 207,783 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	74,450 - 322,113 (+)	NCBI
Celera	15	4,360,539 - 4,471,389 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Genitopatellar Syndrome (ISO)

paroxysmal nonkinesigenic dyskinesia 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aconitine (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

coumarin (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

diazinon (EXP)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

dieldrin (EXP)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

isotretinoin (ISO)

lead diacetate (ISO)

medroxyprogesterone acetate (ISO)

methapyrilene (ISO)

methidathion (ISO)

methimazole (EXP)

methoxyacetic acid (ISO)

methyl methanesulfonate (ISO)

nickel dichloride (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

pentachlorophenol (ISO)

pirinixic acid (ISO)

progesterone (ISO)

promegestone (ISO)

sulfadimethoxine (EXP)

topotecan (EXP)

trichostatin A (ISO)

valproic acid (ISO)

zalcitabine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apical protein localization (ISO)

epithelial to mesenchymal transition (ISO)

epithelial tube branching involved in lung morphogenesis (ISO)

establishment or maintenance of epithelial cell apical/basal polarity (ISO)

maintenance of cell polarity (ISO)

metanephric collecting duct development (ISO)

midbrain development (ISO)

negative regulation of cell migration (ISO)

negative regulation of hippo signaling (IBA,ISO)

negative regulation of T cell proliferation (ISO)

neuroepithelial cell differentiation (ISO)

polarized epithelial cell differentiation (ISO)

positive regulation of dendritic spine development (ISO)

positive regulation of hippo signaling (ISO)

positive regulation of smoothened signaling pathway (ISO)

positive regulation of synapse assembly (ISO)

postsynapse organization (ISO)

protein localization to adherens junction (ISO)

protein-containing complex assembly (ISO)

regulation of apoptotic process (IEA)

zonula adherens assembly (ISO)

Cellular Component

adherens junction (ISO)

cell junction (ISO)

ciliary basal body (ISO)

glutamatergic synapse (ISO)

postsynaptic density (ISO)

Molecular Function

beta-catenin binding (ISO)

cytoskeletal protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12657639	PMID:17765678	PMID:23466739	PMID:25232112	PMID:25644602	PMID:28087714	PMID:28169360

Genomics

Comparative Map Data

Dlg5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	75,786 - 209,735 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	75,786 - 187,837 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	82,881 - 194,929 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	1,469,453 - 1,581,500 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	81,608 - 193,647 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	120,213 - 230,312 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	120,372 - 228,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	115,133 - 225,208 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	118,948 - 207,783 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	74,450 - 322,113 (+)	NCBI
Celera	15	4,360,539 - 4,471,389 (-)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

DLG5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	77,790,791 - 77,940,736 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	77,790,791 - 77,926,755 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	79,550,549 - 79,686,513 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	79,220,555 - 79,356,354 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	79,220,556 - 79,298,959	NCBI
Celera	10	72,837,188 - 72,972,945 (-)	NCBI		Celera
Cytogenetic Map	10	q22.3	NCBI
HuRef	10	73,545,075 - 73,623,451 (-)	NCBI		HuRef
CHM1_1	10	79,833,321 - 79,969,137 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	78,659,856 - 78,795,806 (-)	NCBI		T2T-CHM13v2.0

Dlg5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	24,184,021 - 24,295,988 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	24,184,021 - 24,295,988 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	24,133,953 - 24,245,920 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	24,133,953 - 24,245,920 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	24,953,175 - 25,065,142 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	22,966,418 - 23,078,385 (-)	NCBI		MGSCv36	mm8
Celera	14	20,508,965 - 20,620,834 (-)	NCBI		Celera
Cytogenetic Map	14	A3	NCBI
cM Map	14	14.26	NCBI

Dlg5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	14,510,488 - 14,628,768 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	14,510,488 - 14,628,768 (+)	NCBI	ChiLan1.0	ChiLan1.0

DLG5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	89,944,629 - 90,080,557 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	74,311,249 - 74,447,312 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	76,974,106 - 77,110,109 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	76,972,573 - 77,110,115 (-)	Ensembl	panpan1.1		panPan2

DLG5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	27,687,223 - 27,780,007 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	27,687,287 - 27,806,722 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	27,812,670 - 27,931,793 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	27,989,064 - 28,108,333 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	27,989,135 - 28,108,809 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	27,863,475 - 27,982,805 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	28,062,456 - 28,181,770 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	28,414,697 - 28,534,135 (-)	NCBI		UU_Cfam_GSD_1.0

Dlg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	53,156,825 - 53,260,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	1,649,575 - 1,753,073 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936521	1,649,557 - 1,753,149 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DLG5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	80,249,697 - 80,377,064 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	80,249,693 - 80,377,496 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	86,782,895 - 86,907,451 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DLG5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	53,513,871 - 53,648,510 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	53,513,979 - 53,648,839 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	13,933,918 - 14,070,588 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dlg5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	11,036,716 - 11,155,256 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	11,033,649 - 11,155,271 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dlg5
299 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	104
Count of miRNA genes:	67
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000007828, ENSRNOT00000068181
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat

Markers in Region

D15Rat55

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	168,549 - 168,678 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	211,024 - 211,152	NCBI	Rnor6.0
Rnor_5.0	15	205,920 - 206,048	UniSTS	Rnor5.0
RGSC_v3.4	15	188,498 - 188,626	UniSTS	RGSC3.4
RGSC_v3.4	15	188,497 - 188,626	RGD	RGSC3.4
RGSC_v3.1	15	188,497 - 188,626	RGD
Celera	15	4,379,628 - 4,379,756	UniSTS
RH 3.4 Map	15	22.9	RGD
RH 3.4 Map	15	22.9	UniSTS
RH 2.0 Map	15	0.0	RGD
SHRSP x BN Map	15	3.9298	RGD
FHH x ACI Map	15	0.0	RGD
Cytogenetic Map	15	p16	UniSTS

AA986715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	87,669 - 87,797 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	129,869 - 129,996	NCBI	Rnor6.0
Rnor_5.0	15	125,207 - 125,334	UniSTS	Rnor5.0
RGSC_v3.4	15	84,666 - 84,793	UniSTS	RGSC3.4
Celera	15	4,459,619 - 4,459,746	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH142459

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	163,475 - 163,613 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	205,950 - 206,087	NCBI	Rnor6.0
Rnor_5.0	15	200,846 - 200,983	UniSTS	Rnor5.0
RGSC_v3.4	15	183,424 - 183,561	UniSTS	RGSC3.4
Celera	15	4,384,693 - 4,384,830	UniSTS
RH 3.4 Map	15	18.7	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH127943

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	106,667 - 106,887 (+)	MAPPER	mRatBN7.2
mRatBN7.2	10	33,173,170 - 33,174,731 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	34,153,473 - 34,155,033	NCBI	Rnor6.0
Rnor_6.0	15	148,807 - 149,026	NCBI	Rnor6.0
Rnor_5.0	15	144,153 - 144,372	UniSTS	Rnor5.0
Rnor_5.0	10	33,937,376 - 33,938,936	UniSTS	Rnor5.0
RGSC_v3.4	10	34,070,951 - 34,072,511	UniSTS	RGSC3.4
RGSC_v3.4	15	104,836 - 105,055	UniSTS	RGSC3.4
Celera	15	4,440,546 - 4,440,765	UniSTS
Celera	10	32,559,329 - 32,560,889	UniSTS
Cytogenetic Map	10	q21	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH139450

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	187,567 - 187,729 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	230,041 - 230,202	NCBI	Rnor6.0
Rnor_5.0	15	224,937 - 225,098	UniSTS	Rnor5.0
RGSC_v3.4	15	207,516 - 207,677	UniSTS	RGSC3.4
Celera	15	4,360,649 - 4,360,810	UniSTS
RH 3.4 Map	15	29.2	UniSTS
Cytogenetic Map	15	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	20	6	4		4			66	35	34	11
Low	2	23	51	37	19	37	8	11	8		7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001372003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AW520410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007828 ⟹ ENSRNOP00000007828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	76,021 - 187,837 (+)	Ensembl
Rnor_6.0 Ensembl	15	120,372 - 228,977 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099309 ⟹ ENSRNOP00000080089

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	129,004 - 187,837 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103743 ⟹ ENSRNOP00000081500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	75,786 - 187,837 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112381 ⟹ ENSRNOP00000096092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	75,786 - 187,837 (+)	Ensembl

RefSeq Acc Id:

NM_001372003 ⟹ NP_001358932

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,786 - 187,839 (+)	NCBI

RefSeq Acc Id:

XM_039093224 ⟹ XP_038949152

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,786 - 209,735 (+)	NCBI

RefSeq Acc Id:

XM_039093225 ⟹ XP_038949153

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,786 - 209,735 (+)	NCBI

RefSeq Acc Id:

XM_039093226 ⟹ XP_038949154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,875 - 209,735 (+)	NCBI

RefSeq Acc Id:

XM_039093227 ⟹ XP_038949155

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,874 - 172,461 (+)	NCBI

RefSeq Acc Id:

XM_039093228 ⟹ XP_038949156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	75,874 - 170,554 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001358932	(Get FASTA)	NCBI Sequence Viewer
	XP_038949152	(Get FASTA)	NCBI Sequence Viewer
	XP_038949153	(Get FASTA)	NCBI Sequence Viewer
	XP_038949154	(Get FASTA)	NCBI Sequence Viewer
	XP_038949155	(Get FASTA)	NCBI Sequence Viewer
	XP_038949156	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL86295	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000007828 ⟸ ENSRNOT00000007828

RefSeq Acc Id:	XP_038949152 ⟸ XM_039093224
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLX4 (UniProtKB/TrEMBL), D4A3K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949153 ⟸ XM_039093225
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLX4 (UniProtKB/TrEMBL), D4A3K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001358932 ⟸ NM_001372003
- UniProtKB:	A0A8I6GLX4 (UniProtKB/TrEMBL), D4A3K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949155 ⟸ XM_039093227
- Peptide Label:	isoform X3
- UniProtKB:	A6KKV1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949156 ⟸ XM_039093228
- Peptide Label:	isoform X4
- UniProtKB:	A6KKV1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949154 ⟸ XM_039093226
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZSN2 (UniProtKB/TrEMBL), D4A3K3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000096092 ⟸ ENSRNOT00000112381

RefSeq Acc Id:

ENSRNOP00000081500 ⟸ ENSRNOT00000103743

RefSeq Acc Id:

ENSRNOP00000080089 ⟸ ENSRNOT00000099309

Protein Domains

CARD Guanylate kinase-like PDZ SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3K3-F1-model_v2	AlphaFold	D4A3K3	1-1815	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308753	AgrOrtholog
BioCyc Gene	G2FUF-14615	BioCyc
Ensembl Genes	ENSRNOG00000005783	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007828.7	UniProtKB/TrEMBL
	ENSRNOP00000080089.1	UniProtKB/TrEMBL
	ENSRNOP00000081500	ENTREZGENE
	ENSRNOP00000081500.1	UniProtKB/TrEMBL
	ENSRNOP00000096092	ENTREZGENE
	ENSRNOP00000096092.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007828.9	UniProtKB/TrEMBL
	ENSRNOT00000099309.1	UniProtKB/TrEMBL
	ENSRNOT00000103743	ENTREZGENE
	ENSRNOT00000103743.1	UniProtKB/TrEMBL
	ENSRNOT00000112381	ENTREZGENE
	ENSRNOT00000112381.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	DLG5_SH3	UniProtKB/TrEMBL
	DUF622	UniProtKB/TrEMBL
	Guanylate_kin	UniProtKB/TrEMBL
	Guanylate_kin/L-typ_Ca_channel	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PDZ/DHR/GLGF	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
NCBI Gene	305645	ENTREZGENE
PANTHER	DISKS LARGE HOMOLOG 5	UniProtKB/TrEMBL
	DISKS LARGE HOMOLOG 5	UniProtKB/TrEMBL
Pfam	dbPDZ_assoc	UniProtKB/TrEMBL
	DUF622	UniProtKB/TrEMBL
	Guanylate_kin	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
PhenoGen	Dlg5	PhenoGen
PROSITE	CARD	UniProtKB/TrEMBL
	GUANYLATE_KINASE_2	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	GuKc	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	PDZ	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SSF47986	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I5ZP20_RAT	UniProtKB/TrEMBL
	A0A8I5ZSN2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GLX4	ENTREZGENE, UniProtKB/TrEMBL
	A6KKV1	ENTREZGENE, UniProtKB/TrEMBL
	D4A3K3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-01	Dlg5	discs large MAGUK scaffold protein 5	Dlg5	discs large homolog 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-27	Dlg5	discs large homolog 5	Dlg5	discs, large homolog 5 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Dlg5	discs, large homolog 5 (Drosophila)	Dlg5_predicted	discs, large homolog 5 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dlg5_predicted	discs, large homolog 5 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar