|
G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
Flavanones results in increased phosphorylation of ATM protein |
CTD |
PMID:21616090 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
|
|
G |
Atr |
ATR serine/threonine kinase |
decreases phosphorylation |
ISO |
Flavanones results in decreased phosphorylation of ATR protein |
CTD |
PMID:21616090 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Flavanones results in increased expression of BAX protein |
CTD |
PMID:25446852 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Flavanones results in decreased expression of BCL2 protein |
CTD |
PMID:25446852 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp2 |
caspase 2 |
increases cleavage multiple interactions |
ISO |
Flavanones results in increased cleavage of CASP2 protein U 0126 promotes the reaction [Flavanones results in increased cleavage of CASP2 protein] |
CTD |
PMID:21616090 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
|
|
G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
Flavanones results in increased cleavage of CASP3 protein |
CTD |
PMID:25446852 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp7 |
caspase 7 |
multiple interactions increases cleavage |
ISO |
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; PI103 promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; U 0126 promotes the reaction [Flavanones results in increased cleavage of CASP7 protein] |
CTD |
PMID:21616090 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
Flavanones results in decreased expression of CCNA1 protein |
CTD |
PMID:21616090 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
|
|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Flavanones results in decreased expression of CCNB1 protein |
CTD |
PMID:21616090 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Flavanones results in decreased expression of CCND1 protein |
CTD |
PMID:21616090 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
Flavanones results in decreased expression of CCNE1 protein |
CTD |
PMID:21616090 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression decreases response to substance |
ISO |
CDKN1A gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein] Flavanones results in increased expression of CDKN1A protein CDKN1A protein results in decreased susceptibility to Flavanones |
CTD |
PMID:21616090 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Chek2 |
checkpoint kinase 2 |
increases phosphorylation |
ISO |
Flavanones results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:21616090 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Flavanones results in decreased activity of CYP19A1 protein |
CTD |
PMID:17910019 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; PI103 promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; U 0126 promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein] |
CTD |
PMID:21616090 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions decreases expression |
ISO |
Flavanones inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] Flavanones results in decreased expression of HIF1A protein |
CTD |
PMID:25446852 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Flavanones results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:21616090 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Flavanones results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:21616090 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
increases phosphorylation |
ISO |
Flavanones results in increased phosphorylation of MDM2 protein |
CTD |
PMID:21616090 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
Flavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of MTOR protein] Flavanones results in decreased phosphorylation of MTOR protein |
CTD |
PMID:25446852 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Flavanones results in increased cleavage of PARP1 protein]; U 0126 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein] |
CTD |
PMID:21616090 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions decreases phosphorylation |
ISO |
Flavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of RPS6KB1 protein] Flavanones results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:25446852 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
|
|
G |
Tp53 |
tumor protein p53 |
increases expression decreases response to substance multiple interactions |
ISO |
Flavanones results in increased expression of TP53 protein TP53 protein results in decreased susceptibility to Flavanones TP53 gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein] |
CTD |
PMID:21616090 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
Flavanones inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein] Flavanones results in decreased expression of VEGFA protein |
CTD |
PMID:25446852 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21871475 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21871475 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] |
CTD |
PMID:21871475 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] |
CTD |
PMID:21871475 |
|
NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
|
|
G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] |
CTD |
PMID:21871475 |
|
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
|
|
G |
Sphk1 |
sphingosine kinase 1 |
decreases expression decreases activity |
ISO |
ampelopsin results in decreased expression of SPHK1 protein ampelopsin results in decreased activity of SPHK1 protein |
CTD |
PMID:22251058 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] |
CTD |
PMID:34217736 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions decreases activity |
ISO |
taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione] taxifolin results in decreased activity of ABCC1 protein |
CTD |
PMID:15041478 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
taxifolin binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Agt |
angiotensinogen |
decreases expression |
ISO |
taxifolin results in decreased expression of AGT protein modified form |
CTD |
PMID:24269735 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] |
CTD |
PMID:29584932 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:32828744 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Apoa1 |
apolipoprotein A1 |
increases expression |
ISO |
taxifolin results in increased expression of APOA1 protein |
CTD |
PMID:11108730 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
|
|
G |
Apob |
apolipoprotein B |
decreases secretion decreases expression |
ISO |
taxifolin results in decreased secretion of APOB protein taxifolin results in decreased expression of APOB protein |
CTD |
PMID:11108730 PMID:15380446 |
|
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein] |
CTD |
PMID:32525071 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
decreases activity multiple interactions |
EXP |
taxifolin results in decreased activity of CASP3 protein taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein] |
CTD |
PMID:24269735 PMID:32828744 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
decreases activity |
EXP |
taxifolin results in decreased activity of CASP9 protein |
CTD |
PMID:24269735 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA] |
CTD |
PMID:30372826 PMID:32525071 PMID:33741339 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
taxifolin results in decreased expression of CCNA1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
|
|
G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
taxifolin results in decreased expression of CDC25A mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:30372826 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
EXP |
taxifolin affects the localization of CYCS protein |
CTD |
PMID:24269735 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein] |
CTD |
PMID:32525071 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:22422552 PMID:29584932 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression |
ISO |
taxifolin results in decreased expression of CYP2E1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Dcc |
DCC netrin 1 receptor |
increases expression |
ISO |
taxifolin results in increased expression of DCC mRNA |
CTD |
PMID:17541156 |
|
NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
|
|
G |
Egf |
epidermal growth factor |
decreases expression |
ISO |
taxifolin results in decreased expression of EGF mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Fgf18 |
fibroblast growth factor 18 |
decreases expression |
ISO |
taxifolin results in decreased expression of FGF18 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
|
|
G |
Fgf3 |
fibroblast growth factor 3 |
decreases expression |
ISO |
taxifolin results in decreased expression of FGF3 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 1:200,001,261...200,005,187
Ensembl chr 1:200,001,261...200,005,187
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] |
CTD |
PMID:32828744 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Gas6 |
growth arrest specific 6 |
increases expression |
ISO |
taxifolin results in increased expression of GAS6 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
|
|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
taxifolin results in increased expression of GDF15 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] |
CTD |
PMID:32828744 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein] |
CTD |
PMID:32525071 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
taxifolin results in increased expression of GSTM1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions decreases expression |
ISO |
taxifolin results in increased expression of HMOX1 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein] |
CTD |
PMID:16799064 PMID:31152760 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein] |
CTD |
PMID:32525071 |
|
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] |
CTD |
PMID:12044887 PMID:19103272 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein] |
CTD |
PMID:12044887 PMID:19103272 PMID:31152760 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein] |
CTD |
PMID:32828744 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] |
CTD |
PMID:32828744 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Insl3 |
insulin-like 3 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein] |
CTD |
PMID:32525071 |
|
NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
taxifolin results in decreased expression of JUN mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:12044887 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] |
CTD |
PMID:33741339 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Mttp |
microsomal triglyceride transfer protein |
decreases activity |
ISO |
taxifolin results in decreased activity of MTTP protein |
CTD |
PMID:15380446 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression decreases expression multiple interactions |
ISO |
taxifolin results in increased expression of NFE2L2 protein taxifolin results in decreased expression of NFE2L2 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein] |
CTD |
PMID:16799064 PMID:31152760 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression |
ISO |
taxifolin results in increased activity of NQO1 protein taxifolin results in increased expression of NQO1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein |
CTD |
PMID:32828744 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Pdgfb |
platelet derived growth factor subunit B |
decreases expression |
ISO |
taxifolin results in decreased expression of PDGFB mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
|
|
G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] |
CTD |
PMID:32828744 |
|
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein] |
CTD |
PMID:32525071 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21341175 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rasa1 |
RAS p21 protein activator 1 |
decreases expression |
ISO |
taxifolin results in decreased expression of RASA1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein] |
CTD |
PMID:32525071 |
|
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein] |
CTD |
PMID:32525071 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA] |
CTD |
PMID:32525071 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA] |
CTD |
PMID:32525071 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein] |
CTD |
PMID:12044887 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein] taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] |
CTD |
PMID:31152760 PMID:32828744 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Traf3 |
Tnf receptor-associated factor 3 |
increases expression |
ISO |
taxifolin results in increased expression of TRAF3 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression decreases activity |
ISO EXP |
taxifolin results in increased expression of TXNRD1 mRNA taxifolin results in decreased activity of TXNRD1 protein modified form |
CTD |
PMID:16618767 PMID:17541156 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
|
|
G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] |
CTD |
PMID:30372826 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression multiple interactions |
ISO |
taxifolin results in increased expression of UGT1A1 mRNA AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] |
CTD |
PMID:29584932 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO |
taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] |
CTD |
PMID:19555678 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
G |
Xpa |
XPA, DNA damage recognition and repair factor |
increases expression |
ISO |
taxifolin results in increased expression of XPA mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
|
|
G |
Xrcc4 |
X-ray repair cross complementing 4 |
increases expression |
ISO |
taxifolin results in increased expression of XRCC4 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions |
ISO |
naringenin results in increased expression of ABCB1 mRNA naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] |
CTD |
PMID:19148864 PMID:34217736 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions increases activity |
ISO |
[Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione] |
CTD |
PMID:11306701 PMID:12485947 PMID:16156793 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:16156793 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
|
|
G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16156793 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
naringenin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] |
CTD |
PMID:14709902 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
naringenin binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Ahr |
aryl hydrocarbon receptor |
increases activity multiple interactions |
ISO |
naringenin results in increased activity of AHR protein naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] |
CTD |
PMID:17869316 PMID:20450880 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
multiple interactions |
ISO |
naringenin binds to and results in decreased activity of AKR1C1 protein |
CTD |
PMID:16962702 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
naringenin results in decreased activity of AKR1C3 protein |
CTD |
PMID:19007764 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO EXP |
naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein] naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:22692793 PMID:22709785 PMID:25866363 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alb |
albumin |
multiple interactions |
ISO |
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein] |
CTD |
PMID:31063766 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] |
CTD |
PMID:12650720 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
|
|
G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
naringenin results in increased expression of APAF1 protein |
CTD |
PMID:27838343 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions |
EXP |
naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:15030205 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Aqp1 |
aquaporin 1 |
multiple interactions |
ISO |
naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] |
CTD |
PMID:31301536 |
|
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
|
|
G |
Aqp5 |
aquaporin 5 |
multiple interactions |
ISO |
naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] |
CTD |
PMID:31301536 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
|
|
G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
increases expression |
ISO |
naringenin results in increased expression of ARHGDIA mRNA; naringenin results in increased expression of ARHGDIA protein |
CTD |
PMID:27838343 |
|
NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
|
|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]] |
CTD |
PMID:20450880 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
|
|
G |
Bace1 |
beta-secretase 1 |
decreases activity |
ISO |
naringenin results in decreased activity of BACE1 protein |
CTD |
PMID:31194956 |
|
NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
naringenin results in increased expression of BAK1 protein |
CTD |
PMID:27838343 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein] naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA] |
CTD |
PMID:23192364 PMID:30153467 PMID:31254498 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein] |
CTD |
PMID:23085349 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression decreases response to substance |
ISO EXP |
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA] naringenin results in decreased expression of BCL2 mRNA naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein] |
CTD |
PMID:19124070 PMID:23192364 PMID:30153467 PMID:31254498 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
naringenin results in decreased expression of BCL2L1 protein |
CTD |
PMID:27838343 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases expression |
ISO EXP |
naringenin results in increased activity of CASP3 protein naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein] naringenin results in increased expression of CASP3 protein modified form naringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA] |
CTD |
PMID:19124070 PMID:22692793 PMID:23192364 PMID:27838343 PMID:31254498 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp7 |
caspase 7 |
increases expression |
ISO |
naringenin results in increased expression of CASP7 protein modified form |
CTD |
PMID:27838343 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp9 |
caspase 9 |
increases activity multiple interactions increases expression |
ISO EXP |
naringenin results in increased activity of CASP9 protein naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein] naringenin results in increased expression of CASP9 protein modified form naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP9 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP9 mRNA] |
CTD |
PMID:19124070 PMID:23192364 PMID:27838343 PMID:31254498 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions increases activity |
EXP ISO |
naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of CAT protein]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; naringenin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringenin inhibits the reaction [Glucose results in decreased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] naringenin analog results in increased activity of CAT protein naringenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] |
CTD |
PMID:19063931 PMID:19409769 PMID:23192364 PMID:23283742 PMID:23845967 PMID:27417253 PMID:29223569 PMID:30372826 More...
|
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
[Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA naringenin results in decreased expression of CCND1 mRNA |
CTD |
PMID:30153467 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions |
ISO |
naringenin results in decreased expression of CCNE1 mRNA [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA |
CTD |
PMID:30153467 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
[Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA naringenin results in increased expression of CDKN1A mRNA |
CTD |
PMID:30153467 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] |
CTD |
PMID:31301536 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
naringenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:30372826 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Ctsd |
cathepsin D |
multiple interactions |
ISO |
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA |
CTD |
PMID:24586459 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions increases expression |
EXP ISO |
naringenin inhibits the reaction [Glucose affects the localization of CYCS protein] naringenin results in increased expression of CYCS protein |
CTD |
PMID:23192364 PMID:27838343 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
ISO EXP |
naringenin binds to and results in decreased activity of CYP19A1 protein naringenin results in decreased activity of CYP19A1 protein |
CTD |
PMID:9435150 PMID:15319488 PMID:17895526 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases expression |
ISO EXP |
naringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] naringenin results in decreased activity of CYP1A1 protein naringenin results in increased expression of CYP1A1 mRNA naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:11454723 PMID:20930378 PMID:21053930 PMID:27444380 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
naringenin results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 PMID:29753067 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
naringenin binds to and results in decreased activity of CYP1B1 protein naringenin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:21053930 PMID:31621310 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
naringenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO EXP |
naringenin results in decreased activity of CYP2E1 protein |
CTD |
PMID:33007396 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity increases expression |
ISO |
naringenin results in decreased activity of CYP3A4 protein naringenin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:19148864 PMID:21053930 PMID:29753067 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein] |
CTD |
PMID:25866363 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Esr1 |
estrogen receptor 1 |
affects activity increases expression decreases expression affects binding increases activity multiple interactions |
ISO EXP |
naringenin affects the activity of ESR1 protein naringenin results in increased expression of ESR1 mRNA naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form naringenin binds to ESR1 protein naringenin results in increased activity of ESR1 protein [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein |
CTD |
PMID:9751507 PMID:10397250 PMID:10854714 PMID:12650720 PMID:15185748 PMID:15713566 PMID:16118406 PMID:19913605 PMID:22692793 PMID:24586459 PMID:30153467 More...
|
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions increases expression increases activity affects binding |
ISO EXP |
[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein] naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 protein naringenin results in increased activity of ESR2 protein naringenin binds to ESR2 protein |
CTD |
PMID:9751507 PMID:12224631 PMID:16118406 PMID:16566672 PMID:17716812 PMID:19913605 PMID:30153467 More...
|
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions decreases activity |
EXP ISO |
[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein] naringenin results in decreased activity of G6PD protein |
CTD |
PMID:19063931 PMID:25130191 PMID:25228019 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO |
NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein] |
CTD |
PMID:31254498 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
ISO |
naringenin results in increased expression of GCLM protein NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein] |
CTD |
PMID:31254498 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gper1 |
G protein-coupled estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
[Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 protein |
CTD |
PMID:30153467 |
|
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
naringenin inhibits the reaction [arsenic trioxide results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein] |
CTD |
PMID:23283742 PMID:29223569 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA] |
CTD |
PMID:23192364 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions increases expression |
ISO |
[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA naringenin results in increased expression of GPX2 mRNA |
CTD |
PMID:24561720 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
|
|
G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
[Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA |
CTD |
PMID:24561720 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
|
|
G |
Gpx5 |
glutathione peroxidase 5 |
increases expression multiple interactions |
ISO |
naringenin results in increased expression of GPX5 mRNA [Paraquat co-treated with naringenin] results in increased expression of GPX5 mRNA |
CTD |
PMID:24561720 |
|
NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074
|
|
G |
Gpx7 |
glutathione peroxidase 7 |
multiple interactions increases expression |
ISO |
[Paraquat co-treated with naringenin] results in increased expression of GPX7 mRNA naringenin results in increased expression of GPX7 mRNA |
CTD |
PMID:24561720 |
|
NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions increases expression |
EXP ISO |
naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; naringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA] Paraquat inhibits the reaction [naringenin results in increased expression of GSR mRNA] |
CTD |
PMID:19063931 PMID:23192364 PMID:24561720 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gstz1 |
glutathione S-transferase zeta 1 |
multiple interactions increases expression |
ISO |
Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA] |
CTD |
PMID:24561720 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein] |
CTD |
PMID:23845967 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin results in increased expression of and results in increased activity of HMOX1 protein; wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein] naringenin results in increased expression of HMOX1 mRNA; naringenin results in increased expression of HMOX1 protein [Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA naringenin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:22709785 PMID:24561720 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein] |
CTD |
PMID:18057881 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
|
|
G |
Lpo |
lactoperoxidase |
increases expression multiple interactions |
ISO |
naringenin results in increased expression of LPO mRNA Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA] |
CTD |
PMID:24561720 |
|
NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535
|
|
G |
Lrrc27 |
leucine rich repeat containing 27 |
increases expression |
ISO |
naringenin results in increased expression of LRRC27 mRNA; naringenin results in increased expression of LRRC27 protein |
CTD |
PMID:27838343 |
|
NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:194,005,182...194,035,084
|
|
G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
increases expression |
ISO |
naringenin results in increased expression of MAP3K5 protein |
CTD |
PMID:27838343 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases activity decreases phosphorylation |
EXP ISO |
naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] naringenin results in decreased activity of MAPK1 protein naringenin results in decreased phosphorylation of MAPK1 protein naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases activity decreases phosphorylation |
EXP ISO |
naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] naringenin results in decreased activity of MAPK3 protein naringenin results in decreased phosphorylation of MAPK3 protein naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
naringenin results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:27838343 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
ISO |
naringenin results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27838343 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions |
ISO |
naringenin results in decreased expression of MMP2 mRNA naringenin results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:30153467 PMID:30431227 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringenin results in decreased expression of and results in decreased activity of MMP9 protein naringenin results in decreased expression of MMP9 mRNA |
CTD |
PMID:25866363 PMID:30153467 PMID:30431227 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Nanog |
Nanog homeobox |
decreases expression |
ISO |
naringenin results in decreased expression of NANOG protein |
CTD |
PMID:27468969 |
|
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity increases expression |
ISO |
[naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; naringenin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein] naringenin results in increased activity of NFE2L2 protein naringenin results in increased expression of NFE2L2 mRNA |
CTD |
PMID:24561720 PMID:31254498 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
naringenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:10188978 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nfkbil1 |
NFKB inhibitor like 1 |
increases expression |
ISO |
naringenin results in increased expression of NFKBIL1 mRNA; naringenin results in increased expression of NFKBIL1 protein |
CTD |
PMID:27838343 |
|
NCBI chr20:3,589,974...3,608,348
Ensembl chr20:3,590,642...3,605,616
|
|
G |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
increases expression |
ISO |
naringenin results in increased expression of NME1 mRNA; naringenin results in increased expression of NME1 protein |
CTD |
PMID:27838343 |
|
NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:10188978 PMID:12512693 PMID:15316927 PMID:18274639 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
ISO |
[Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA naringenin results in increased expression of NQO1 mRNA; naringenin results in increased expression of NQO1 protein |
CTD |
PMID:24561720 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
naringenin results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
naringenin results in increased cleavage of PARP1 protein naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein] |
CTD |
PMID:27838343 PMID:31254498 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pgd |
phosphogluconate dehydrogenase |
decreases activity |
ISO |
naringenin results in decreased activity of PGD protein |
CTD |
PMID:25130191 |
|
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
|
|
G |
Pgr |
progesterone receptor |
increases expression multiple interactions |
EXP ISO |
naringenin results in increased expression of PGR mRNA [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA |
CTD |
PMID:10397250 PMID:24586459 |
|
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
|
|
G |
Pon1 |
paraoxonase 1 |
increases expression |
ISO |
naringenin results in increased expression of PON1 mRNA |
CTD |
PMID:15169886 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP ISO |
HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein] naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein] |
CTD |
PMID:31063766 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions |
ISO EXP |
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARB protein] HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein] |
CTD |
PMID:31063766 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP ISO |
HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein] |
CTD |
PMID:29223569 PMID:31063766 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Prdx1 |
peroxiredoxin 1 |
decreases expression |
ISO |
naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 protein |
CTD |
PMID:27838343 |
|
NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
|
|
G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein] |
CTD |
PMID:25866363 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein] |
CTD |
PMID:25866363 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
|
|
G |
Prkcg |
protein kinase C, gamma |
multiple interactions |
ISO |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein] |
CTD |
PMID:25866363 |
|
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
|
|
G |
Prom1 |
prominin 1 |
decreases expression |
ISO |
naringenin results in decreased expression of PROM1 protein |
CTD |
PMID:27468969 |
|
NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
|
|
G |
Psen2 |
presenilin 2 |
multiple interactions |
ISO |
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA |
CTD |
PMID:24586459 |
|
NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
naringenin results in increased expression of PTGS1 mRNA |
CTD |
PMID:24561720 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21341175 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
naringenin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] |
CTD |
PMID:18274639 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rptor |
regulatory associated protein of MTOR, complex 1 |
increases expression |
ISO |
naringenin results in increased expression of RPTOR mRNA; naringenin results in increased expression of RPTOR protein |
CTD |
PMID:27838343 |
|
NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
EXP |
naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:22709785 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
naringenin binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
G |
Si |
sucrase-isomaltase |
decreases activity multiple interactions |
EXP ISO |
naringenin results in decreased activity of SI protein naringenin binds to and results in decreased activity of SI protein |
CTD |
PMID:24412302 |
|
NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
|
|
G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
ISO EXP |
naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] [naringenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 PMID:17976262 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases activity |
ISO |
naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] naringenin results in decreased activity of SLC2A1 protein |
CTD |
PMID:14642735 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] |
CTD |
PMID:29223569 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G |
Slc5a1 |
solute carrier family 5 member 1 |
multiple interactions |
ISO |
naringenin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] |
CTD |
PMID:17495124 |
|
NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
|
|
G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions |
ISO |
naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] |
CTD |
PMID:22394605 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
naringenin results in decreased expression of SNAI1 protein |
CTD |
PMID:30431227 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
naringenin results in decreased expression of SNAI2 protein |
CTD |
PMID:30431227 |
|
NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
increases expression |
ISO |
naringenin results in increased expression of SOCS3 mRNA |
CTD |
PMID:23782265 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA] |
CTD |
PMID:23192364 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA] |
CTD |
PMID:23192364 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
decreases expression |
ISO |
naringenin results in decreased expression of SOX2 protein |
CTD |
PMID:27468969 |
|
NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
|
|
G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
EXP |
naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA] |
CTD |
PMID:22709785 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
naringenin results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:27468969 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
ISO EXP |
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin] |
CTD |
PMID:11181495 |
|
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] |
CTD |
PMID:23845967 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO EXP |
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein] naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] naringenin results in decreased activity of TNF protein naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein] |
CTD |
PMID:18720166 PMID:19135038 PMID:22709785 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
[Tamoxifen co-treated with naringenin] results in increased expression of TP53 mRNA; naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; naringenin results in increased expression of and results in increased phosphorylation of TP53 protein naringenin results in increased expression of TP53 mRNA |
CTD |
PMID:15795422 PMID:27838343 PMID:30153467 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tpo |
thyroid peroxidase |
decreases activity |
EXP |
naringenin results in decreased activity of TPO protein |
CTD |
PMID:26884060 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
|
|
G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
naringenin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] |
CTD |
PMID:30372826 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation increases expression |
ISO |
UGT1A1 protein results in increased glucuronidation of naringenin naringenin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:14557274 PMID:31621310 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of naringenin |
CTD |
PMID:14557274 PMID:18816295 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G |
Ugt2b15 |
UDP glucuronosyltransferase family 2 member B15 |
increases metabolic processing |
EXP |
UGT2B15 protein results in increased metabolism of naringenin |
CTD |
PMID:7574722 |
|
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
|
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
3-hydroxyflavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
3-hydroxyflavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
4'-hydroxyflavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
4'-hydroxyflavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
6-prenylnaringenin results in increased expression of CYP1A1 mRNA; 6-prenylnaringenin results in increased expression of CYP1A1 protein 6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; 6-prenylnaringenin inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA] |
CTD |
PMID:27269377 PMID:32986415 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
6-prenylnaringenin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:27269377 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:32986415 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]; 6-prenylnaringenin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein] |
CTD |
PMID:32986415 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
7-hydroxyflavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
ISO |
7-hydroxyflavanone results in decreased activity of CYP19A1 protein |
CTD |
PMID:15319488 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
7-hydroxyflavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
|
G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
multiple interactions |
ISO |
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA |
CTD |
PMID:29471006 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] |
CTD |
PMID:29471006 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:29471006 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein] |
CTD |
PMID:29471006 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] |
CTD |
PMID:29471006 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
|
G |
Ces1d |
carboxylesterase 1D |
decreases activity |
ISO |
bavachinin results in decreased activity of CES1 protein |
CTD |
PMID:26560012 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Diosmin binds to and results in increased activity of AHR protein |
CTD |
PMID:14644660 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP |
Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] |
CTD |
PMID:21477647 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] |
CTD |
PMID:21477647 PMID:32061149 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein] |
CTD |
PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp7 |
caspase 7 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] |
CTD |
PMID:22056647 PMID:23665045 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] |
CTD |
PMID:32061149 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] |
CTD |
PMID:29187079 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] |
CTD |
PMID:32061149 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] |
CTD |
PMID:23665045 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] |
CTD |
PMID:23665045 PMID:29187079 PMID:32061149 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:21477647 PMID:23665045 PMID:29187079 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
eriocitrin results in increased expression of BAX protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
eriocitrin results in decreased expression of BCL2 protein |
CTD |
PMID:34724282 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp7 |
caspase 7 |
increases expression |
ISO |
eriocitrin results in increased expression of CASP7 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp9 |
caspase 9 |
increases expression |
ISO |
eriocitrin results in increased expression of CASP9 protein |
CTD |
PMID:34724282 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
eriocitrin results in decreased expression of CCND1 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:34724282 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
eriocitrin results in decreased expression of PCNA protein |
CTD |
PMID:34724282 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of SRC protein |
CTD |
PMID:34724282 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:34724282 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] |
CTD |
PMID:20438634 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of GSTP1 protein |
CTD |
PMID:15041478 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO EXP |
eriodictyol results in increased expression of HMOX1 protein eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein] |
CTD |
PMID:16799064 PMID:28978146 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] |
CTD |
PMID:23942037 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:21544733 PMID:31860763 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] |
CTD |
PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21544733 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions |
ISO EXP |
eriodictyol results in increased expression of NFE2L2 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein] eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein |
CTD |
PMID:16799064 PMID:28978146 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] |
CTD |
PMID:20438634 PMID:21544733 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31860763 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] |
CTD |
PMID:20438634 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tbk1 |
TANK-binding kinase 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of TBK1 protein |
CTD |
PMID:19426678 |
|
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO |
eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] eriodictyol results in decreased activity of TNF protein |
CTD |
PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
flavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Ar |
androgen receptor |
affects binding |
EXP |
flavanone binds to AR protein |
CTD |
PMID:14565775 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
flavanone results in increased expression of BAX protein |
CTD |
PMID:22056764 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone results in decreased activity of CASP3 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:22056764 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:22056764 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
flavanone results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:22056764 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
flavanone results in increased expression of CDKN1A protein |
CTD |
PMID:22056764 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
flavanone results in increased expression of CDKN1B protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
flavanone affects the localization of CYCS protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression decreases activity |
ISO |
flavanone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] flavanone results in increased expression of CYP1A1 mRNA flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] flavanone results in decreased activity of CYP1A1 protein |
CTD |
PMID:17090139 PMID:20930378 PMID:21053930 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
flavanone results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
flavanone binds to and results in decreased activity of CYP1B1 protein flavanone analog results in increased expression of CYP1B1 mRNA |
CTD |
PMID:21053930 PMID:31621310 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] flavanone results in decreased activity of CYP3A4 protein |
CTD |
PMID:21053930 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
flavanone results in increased expression of FAS mRNA |
CTD |
PMID:22056764 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Faslg |
Fas ligand |
increases expression |
ISO |
flavanone results in increased expression of FASLG mRNA |
CTD |
PMID:22056764 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
|
|
G |
Maoa |
monoamine oxidase A |
decreases activity |
ISO |
flavanone results in decreased activity of MAOA protein |
CTD |
PMID:23009399 |
|
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
flavanone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
flavanone results in increased cleavage of PARP1 protein |
CTD |
PMID:22056764 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
flavanone results in increased expression of PPARG protein |
CTD |
PMID:22056764 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO |
flavanone results in increased expression of PTEN protein |
CTD |
PMID:22056764 |
|
NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
flavanone results in decreased phosphorylation of RB1 protein |
CTD |
PMID:22056764 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
flavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
flavanone results in increased expression of and results in increased phosphorylation of TP53 protein |
CTD |
PMID:22056764 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
flavanone analog results in increased expression of UGT1A1 mRNA |
CTD |
PMID:31621310 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:16156793 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:16156793 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
|
|
G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16156793 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression |
ISO |
hesperetin results in decreased expression of ADIPOQ mRNA |
CTD |
PMID:25345581 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] |
CTD |
PMID:33522063 |
|
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
|
|
G |
Ahr |
aryl hydrocarbon receptor |
increases activity multiple interactions |
ISO |
hesperetin results in increased activity of AHR protein [2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein] |
CTD |
PMID:17869316 PMID:21720915 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:19222219 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
affects expression multiple interactions increases expression |
ISO EXP |
hesperetin affects the expression of BAX protein [Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein] hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein hesperetin analog results in increased expression of BAX mRNA |
CTD |
PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression multiple interactions decreases expression |
ISO EXP |
hesperetin affects the expression of BCL2 protein hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein] hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein hesperetin analog results in decreased expression of BCL2 mRNA |
CTD |
PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
affects cleavage multiple interactions increases expression increases activity |
ISO EXP |
hesperetin affects the cleavage of CASP3 protein hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form hesperetin analog results in increased activity of CASP3 protein hesperetin analog results in increased expression of CASP3 mRNA |
CTD |
PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
increases activity multiple interactions decreases activity |
ISO EXP |
hesperetin results in increased activity of CAT protein hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] |
CTD |
PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 PMID:26546711 More...
|
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:24707119 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] |
CTD |
PMID:24707119 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO EXP |
hesperetin results in decreased expression of CCND1 hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] |
CTD |
PMID:17927510 PMID:27818223 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
hesperetin results in decreased expression of CDK2 |
CTD |
PMID:17927510 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein] hesperetin results in decreased expression of CDK4 |
CTD |
PMID:17927510 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein] hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA |
CTD |
PMID:17927510 PMID:25345581 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
hesperetin results in increased expression of CDKN1B |
CTD |
PMID:17927510 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
hesperetin results in decreased expression of CEBPA protein |
CTD |
PMID:25345581 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:27818223 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] |
CTD |
PMID:24707119 |
|
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
|
|
G |
Cyb5a |
cytochrome b5 type A |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein] |
CTD |
PMID:19497424 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
|
|
G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein |
CTD |
PMID:22142698 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP19A1 protein |
CTD |
PMID:10403137 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
ISO |
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] hesperetin results in decreased activity of CYP1A1 protein hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] |
CTD |
PMID:10781868 PMID:21720915 PMID:26546711 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:29753067 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] |
CTD |
PMID:19497424 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
hesperetin results in decreased expression of FABP4 mRNA |
CTD |
PMID:25345581 |
|
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] |
CTD |
PMID:21134734 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein] |
CTD |
PMID:21134734 PMID:26546711 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
hesperetin results in increased expression of HMOX1 protein [Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:31153982 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] |
CTD |
PMID:33522063 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] |
CTD |
PMID:24707119 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] |
CTD |
PMID:24707119 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions affects expression |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]] hesperetin affects the expression of IL1B protein |
CTD |
PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions affects expression |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]] hesperetin affects the expression of IL6 protein |
CTD |
PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jak1 |
Janus kinase 1 |
multiple interactions |
ISO |
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein] |
CTD |
PMID:28428136 |
|
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:33522063 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Lpl |
lipoprotein lipase |
decreases expression |
ISO |
hesperetin results in decreased expression of LPL mRNA |
CTD |
PMID:25345581 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:31153982 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:31153982 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] [Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19222219 PMID:31153982 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mir410 |
microRNA 410 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] |
CTD |
PMID:32762101 |
|
NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO EXP |
hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein] hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:31153982 PMID:33522063 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein] |
CTD |
PMID:27818223 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO |
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein] [Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein hesperetin results in increased expression of NFE2L2 protein |
CTD |
PMID:26546711 PMID:31153982 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:12512693 PMID:15316927 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nox4 |
NADPH oxidase 4 |
decreases expression multiple interactions |
ISO |
hesperetin results in decreased expression of NOX4 protein hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein] |
CTD |
PMID:31153982 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
EXP ISO |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein] [Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein hesperetin results in increased expression of NQO1 protein |
CTD |
PMID:19497424 PMID:31153982 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
hesperetin results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein] |
CTD |
PMID:26546711 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] |
CTD |
PMID:19497424 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression multiple interactions |
ISO |
hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein [hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein] |
CTD |
PMID:25345581 PMID:28428136 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
EXP |
hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 |
|
NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions affects activity |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] hesperetin affects the activity of PTGS2 protein |
CTD |
PMID:15240993 PMID:16101151 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] |
CTD |
PMID:26546711 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Retn |
resistin |
decreases expression |
ISO |
hesperetin results in decreased expression of RETN mRNA |
CTD |
PMID:25345581 |
|
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
hesperetin binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
G |
Sirt6 |
sirtuin 6 |
multiple interactions increases expression |
ISO |
[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein hesperetin results in increased expression of SIRT6 protein |
CTD |
PMID:31153982 |
|
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
|
|
G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
[hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] |
CTD |
PMID:33522063 |
|
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
|
|
G |
Sod1 |
superoxide dismutase 1 |
increases expression |
ISO |
hesperetin results in increased expression of SOD1 protein |
CTD |
PMID:19023542 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
hesperetin results in increased expression of SOD2 protein |
CTD |
PMID:19023542 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sox18 |
SRY-box transcription factor 18 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]] |
CTD |
PMID:32762101 |
|
NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
|
|
G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:28428136 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:33522063 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression decreases expression |
ISO EXP |
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] hesperetin affects the expression of TNF protein hesperetin results in decreased expression of TNF mRNA |
CTD |
PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 PMID:28428136 PMID:32762101 PMID:33522063 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] |
CTD |
PMID:15795422 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Utrn |
utrophin |
increases expression |
ISO |
hesperetin results in increased expression of UTRN mRNA |
CTD |
PMID:22028826 |
|
NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
|
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] |
CTD |
PMID:32627286 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] |
CTD |
PMID:28935427 PMID:30779474 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:30779474 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Alb |
albumin |
multiple interactions increases expression |
ISO |
[Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein Hesperidin results in increased expression of ALB protein |
CTD |
PMID:29481770 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein] Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA] |
CTD |
PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein] Hesperidin results in decreased expression of BCL2 mRNA Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA] |
CTD |
PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 PMID:33908150 PMID:34748272 More...
|
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Becn1 |
beclin 1 |
multiple interactions decreases expression |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein] Hesperidin results in decreased expression of BECN1 protein |
CTD |
PMID:33908150 PMID:34748272 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression |
EXP |
Hesperidin results in increased expression of BMP2 mRNA |
CTD |
PMID:21820093 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] [Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA] Hesperidin results in increased activity of CASP3 protein |
CTD |
PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 PMID:33908150 PMID:34748272 More...
|
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] |
CTD |
PMID:22093918 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions increases activity |
EXP ISO |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] Hesperidin results in increased activity of CAT protein Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein] |
CTD |
PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 PMID:30779474 PMID:31095933 PMID:32050098 PMID:33908150 PMID:34748272 More...
|
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] |
CTD |
PMID:30368987 PMID:30811821 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] |
CTD |
PMID:30779474 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] |
CTD |
PMID:17400256 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Fabp9 |
fatty acid binding protein 9 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] |
CTD |
PMID:32050098 |
|
NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873
|
|
G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] |
CTD |
PMID:16427799 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity multiple interactions |
ISO |
Hesperidin results in decreased activity of G6PD protein Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein] |
CTD |
PMID:16427799 PMID:25130191 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gck |
glucokinase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] |
CTD |
PMID:16427799 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
decreases activity multiple interactions |
ISO EXP |
Hesperidin results in decreased activity of GPT protein Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein] [Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein |
CTD |
PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] |
CTD |
PMID:22093918 PMID:30098279 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] |
CTD |
PMID:22093918 PMID:30098279 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] |
CTD |
PMID:16427799 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein] |
CTD |
PMID:28935427 PMID:32050098 PMID:34748272 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] |
CTD |
PMID:32050098 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:17400256 PMID:22074828 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein] Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] |
CTD |
PMID:17400256 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
|
|
G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Hesperidin results in decreased expression of IL6 protein [naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] |
CTD |
PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Lep |
leptin |
decreases expression multiple interactions |
EXP |
Hesperidin results in decreased expression of LEP protein [naringin co-treated with Hesperidin] results in decreased expression of LEP protein |
CTD |
PMID:21820093 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Lepr |
leptin receptor |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] |
CTD |
PMID:16427799 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
|
|
G |
Map1lc3a |
microtubule-associated protein 1 light chain 3 alpha |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein] |
CTD |
PMID:33908150 PMID:34748272 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19110045 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:19110045 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mir126b |
microRNA 126b |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] |
CTD |
PMID:32050098 |
|
NCBI chr 3:9,415,087...9,415,159
|
|
G |
Mir181a2 |
microRNA 181a-2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] |
CTD |
PMID:32050098 |
|
NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases secretion |
ISO |
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] Hesperidin results in decreased secretion of MMP9 protein |
CTD |
PMID:19110045 PMID:20138977 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions decreases activity |
EXP |
Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] Hesperidin results in decreased activity of MPO protein |
CTD |
PMID:31095933 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein] |
CTD |
PMID:28935427 PMID:32050098 PMID:34748272 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA] |
CTD |
PMID:22093918 PMID:34748272 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:12512693 PMID:22093918 PMID:33908150 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] |
CTD |
PMID:30368987 PMID:33908150 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] |
CTD |
PMID:28935427 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] |
CTD |
PMID:30779474 |
|
NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP ISO |
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein] Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein] |
CTD |
PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] |
CTD |
PMID:30368987 PMID:30811821 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein] Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA] |
CTD |
PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] |
CTD |
PMID:30623541 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sgpp2 |
sphingosine-1-phosphate phosphatase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] |
CTD |
PMID:30811821 |
|
NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] |
CTD |
PMID:32050098 |
|
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] |
CTD |
PMID:16427799 |
|
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] |
CTD |
PMID:16427799 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] |
CTD |
PMID:32050098 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sphk1 |
sphingosine kinase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] |
CTD |
PMID:30811821 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Tfeb |
transcription factor EB |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] |
CTD |
PMID:30368987 |
|
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
|
|
G |
Tnc |
tenascin C |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] |
CTD |
PMID:30368987 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 PMID:34748272 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
Hesperidin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:24633329 |
|
NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] |
CTD |
PMID:30066062 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tradd |
TNFRSF1A-associated via death domain |
increases expression |
ISO |
Hesperidin results in increased expression of TRADD mRNA |
CTD |
PMID:24633329 |
|
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions decreases expression |
ISO |
Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] Hesperidin results in decreased expression of VCAM1 |
CTD |
PMID:17400256 PMID:30991044 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein |
CTD |
PMID:33908150 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
|
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] |
CTD |
PMID:29902531 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] |
CTD |
PMID:29902531 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] |
CTD |
PMID:31850465 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
homoeriodictyol results in increased expression of GCLM mRNA |
CTD |
PMID:29902531 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
ISO |
[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein |
CTD |
PMID:28834253 |
|
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:31850465 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:31850465 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:31850465 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:31850465 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:31850465 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
homoeriodictyol results in increased expression of NQO1 mRNA NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] |
CTD |
PMID:29902531 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31850465 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] |
CTD |
PMID:31850465 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:31850465 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
|
G |
Pgr |
progesterone receptor |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR protein] isobavachin results in increased expression of PGR mRNA; isobavachin results in increased expression of PGR protein |
CTD |
PMID:16892383 |
|
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
|
|
G |
Tff1 |
trefoil factor 1 |
increases expression multiple interactions |
ISO |
isobavachin results in increased expression of TFF1 mRNA Fulvestrant inhibits the reaction [isobavachin results in increased expression of TFF1 mRNA] |
CTD |
PMID:16892383 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
|
|
|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
decreases activity |
ISO |
isoxanthohumol results in decreased activity of AKR1B10 protein |
CTD |
PMID:35065925 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
isoxanthohumol results in decreased activity of AKR1C3 protein |
CTD |
PMID:35065925 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
ISO |
isoxanthohumol results in increased expression of CYP1A2 mRNA |
CTD |
PMID:15672752 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity |
ISO |
isoxanthohumol results in increased activity of ESR1 protein |
CTD |
PMID:12623674 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
LOC102556347 |
carbonyl reductase [NADPH] 1-like |
multiple interactions decreases activity |
ISO |
isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] isoxanthohumol results in decreased activity of CBR1 protein |
CTD |
PMID:30849340 PMID:35065925 |
|
NCBI chr11:32,892,640...32,895,277
Ensembl chr11:32,857,991...32,895,275
|
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
ISO |
kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter] |
CTD |
PMID:24997323 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
kurarinol results in increased activity of CASP3 protein STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein] |
CTD |
PMID:24997323 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
kurarinol results in decreased expression of CCND1 protein |
CTD |
PMID:24997323 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein |
CTD |
PMID:24997323 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO |
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein] kurarinol results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:24997323 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
ISO |
liquiritigenin results in increased expression of CXCL12 mRNA |
CTD |
PMID:28396216 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
|
|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
liquiritigenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity |
ISO |
liquiritigenin results in increased activity of ESR1 protein |
CTD |
PMID:28396216 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
increases activity |
ISO |
liquiritigenin results in increased activity of ESR2 protein |
CTD |
PMID:25106122 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] liquiritigenin results in increased expression of GCLC protein |
CTD |
PMID:29908794 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
EXP |
liquiritigenin results in increased expression of GCLM protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] |
CTD |
PMID:31589899 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] |
CTD |
PMID:29908794 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] |
CTD |
PMID:29908794 PMID:31589899 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] |
CTD |
PMID:31589899 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases response to substance multiple interactions |
ISO EXP |
NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA] liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
liquiritigenin results in increased expression of NQO1 protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] |
CTD |
PMID:26473469 PMID:29908794 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] |
CTD |
PMID:31589899 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] |
CTD |
PMID:29908794 |
|
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Trpm3 |
transient receptor potential cation channel, subfamily M, member 3 |
decreases activity |
ISO |
liquiritigenin results in decreased activity of TRPM3 protein |
CTD |
PMID:25361167 |
|
NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717
|
|
G |
Tsc22d3 |
TSC22 domain family, member 3 |
multiple interactions |
ISO |
liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] |
CTD |
PMID:23183181 |
|
NCBI chr X:104,217,898...104,277,935
Ensembl chr X:104,217,925...104,276,861
|
|
G |
Txn2 |
thioredoxin 2 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
|
|
G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
EXP |
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
|
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
[brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein |
CTD |
PMID:21800547 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
EXP |
liquiritin results in increased expression of GCLC protein liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA] liquiritin results in increased expression of GCLM protein |
CTD |
PMID:29908794 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] |
CTD |
PMID:31589899 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] |
CTD |
PMID:29908794 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO EXP |
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA] liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] |
CTD |
PMID:29908794 PMID:31589899 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] |
CTD |
PMID:31589899 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases response to substance multiple interactions |
ISO EXP |
NFE2L2 gene mutant form results in decreased susceptibility to liquiritin liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:31589899 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA] |
CTD |
PMID:29908794 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein] |
CTD |
PMID:31589899 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] |
CTD |
PMID:29908794 |
|
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] |
CTD |
PMID:31589899 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Txn2 |
thioredoxin 2 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
|
|
G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
EXP |
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] |
CTD |
PMID:29908794 |
|
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] |
CTD |
PMID:34217736 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
|
|
G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
[naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA |
CTD |
PMID:22198281 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
|
|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein] |
CTD |
PMID:32172062 PMID:32810514 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
ISO |
naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:22198281 |
|
NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
|
|
G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions decreases expression |
ISO |
naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein] naringin results in decreased expression of ACP5 mRNA |
CTD |
PMID:21835177 PMID:24376342 |
|
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
|
|
G |
Ada |
adenosine deaminase |
multiple interactions |
EXP |
naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein] |
CTD |
PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] |
CTD |
PMID:22198281 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone] |
CTD |
PMID:22798349 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein] naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA] |
CTD |
PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Angpt1 |
angiopoietin 1 |
affects expression |
EXP |
naringin affects the expression of ANGPT1 mRNA |
CTD |
PMID:24880026 |
|
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
|
|
G |
Aqp1 |
aquaporin 1 |
multiple interactions |
ISO |
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] |
CTD |
PMID:31301536 |
|
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
|
|
G |
Aqp5 |
aquaporin 5 |
multiple interactions |
ISO |
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] |
CTD |
PMID:31301536 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
|
|
G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions |
ISO |
naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA] |
CTD |
PMID:21835177 |
|
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
|
|
G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP ISO |
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA] naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein] |
CTD |
PMID:21945202 PMID:30878453 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO EXP |
naringin results in increased expression of BAX mRNA naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein] naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein] [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA] |
CTD |
PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions |
EXP |
naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein] |
CTD |
PMID:32172062 PMID:32810514 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA] naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein] naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] |
CTD |
PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression increases secretion multiple interactions |
ISO EXP |
naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein naringin results in increased secretion of BGLAP protein fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein] |
CTD |
PMID:18495116 PMID:21741227 PMID:23596885 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions decreases expression increases secretion increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter] naringin results in decreased expression of BMP2 mRNA fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein] naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein |
CTD |
PMID:18495116 PMID:21820093 PMID:23596885 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
|
|
G |
Bmp3 |
bone morphogenetic protein 3 |
decreases expression |
ISO |
naringin results in decreased expression of BMP3 mRNA |
CTD |
PMID:18495116 |
|
NCBI chr14:10,712,489...10,737,153
Ensembl chr14:10,712,489...10,737,153
|
|
G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
ISO |
naringin results in increased expression of BMP4 mRNA |
CTD |
PMID:24915843 |
|
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
|
|
G |
Calcr |
calcitonin receptor |
multiple interactions |
ISO |
naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA] |
CTD |
PMID:21835177 |
|
NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
|
|
G |
Casp3 |
caspase 3 |
increases expression multiple interactions |
ISO EXP |
naringin results in increased expression of CASP3 mRNA naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein] naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]] |
CTD |
PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 PMID:30130594 PMID:30878453 More...
|
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases expression multiple interactions |
ISO EXP |
naringin results in increased expression of CASP9 mRNA [bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein] |
CTD |
PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
ISO EXP |
naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein] naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein] |
CTD |
PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 PMID:26120027 PMID:26612654 PMID:29658312 PMID:33992719 More...
|
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA] |
CTD |
PMID:22965302 PMID:33992719 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] |
CTD |
PMID:22965302 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein] |
CTD |
PMID:21500970 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions increases expression |
ISO EXP |
naringin results in decreased expression of CCND1 protein naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA] naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein] naringin results in increased expression of CCND1 mRNA |
CTD |
PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO EXP |
naringin results in decreased expression of CCNE1 protein |
CTD |
PMID:18296682 PMID:18951945 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein |
CTD |
PMID:18296682 PMID:18951945 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein] |
CTD |
PMID:18296682 PMID:18951945 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein] naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein] |
CTD |
PMID:18296682 PMID:18951945 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] |
CTD |
PMID:31301536 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
naringin results in increased expression of COL1A1 mRNA |
CTD |
PMID:21741227 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
[Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA |
CTD |
PMID:22198281 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Csf1r |
colony stimulating factor 1 receptor |
multiple interactions |
ISO |
naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA] |
CTD |
PMID:21835177 |
|
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
|
|
G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
ISO |
naringin results in increased expression of CTNNB1 mRNA naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein] |
CTD |
PMID:24915843 PMID:26482937 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Ctsb |
cathepsin B |
multiple interactions |
EXP |
naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] |
CTD |
PMID:17188415 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
|
|
G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] |
CTD |
PMID:17188415 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Ctsk |
cathepsin K |
multiple interactions decreases expression |
ISO |
naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA] naringin results in decreased expression of CTSK mRNA |
CTD |
PMID:21835177 PMID:24376342 |
|
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
|
|
G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
EXP |
naringin results in increased expression of CXCL12 protein |
CTD |
PMID:29510123 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
affects expression multiple interactions |
ISO |
naringin affects the expression of CXCL2 mRNA naringin inhibits the reaction [OVAL protein results in increased expression of CXCL2 protein] |
CTD |
PMID:24131540 PMID:25117567 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
EXP |
naringin results in increased expression of CXCR4 protein |
CTD |
PMID:29510123 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions |
ISO |
naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein] |
CTD |
PMID:25391245 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein] |
CTD |
PMID:28422390 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
|
|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA] |
CTD |
PMID:22798349 |
|
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
naringin results in decreased activity of CYP1A1 protein |
CTD |
PMID:21053930 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
naringin results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
naringin binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:21053930 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO |
naringin results in decreased activity of CYP3A4 protein naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] |
CTD |
PMID:16013069 PMID:21053930 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Dhfr |
dihydrofolate reductase |
decreases activity |
ISO |
naringin results in decreased activity of DHFR protein |
CTD |
PMID:25418905 |
|
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
|
|
G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
multiple interactions |
ISO |
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]] |
CTD |
PMID:26482937 |
|
NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
|
|
G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein] |
CTD |
PMID:22766066 |
|
NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein] |
CTD |
PMID:22766066 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases expression |
EXP |
fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA] |
CTD |
PMID:23596885 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions increases expression |
EXP |
fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA] |
CTD |
PMID:23596885 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA] |
CTD |
PMID:22198281 |
|
NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
|
|
G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
naringin results in increased expression of FADD mRNA |
CTD |
PMID:22847135 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
|
|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
naringin results in increased expression of FAS mRNA |
CTD |
PMID:22847135 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA] |
CTD |
PMID:16427799 PMID:22198281 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
|
|