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Gene: Msh2 (mutS homolog 2) Rattus norvegicus
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Symbol: Msh2
Name: mutS homolog 2
Description: Predicted to contribute to several functions, including ADP binding activity; DNA binding activity; and MutLalpha complex binding activity. Involved in several processes, including response to amino acid; response to organic cyclic compound; and spermatogenesis. Localizes to the nucleus. Biomarker of colitis and visual epilepsy. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Orthologous to human MSH2 (mutS homolog 2); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA mismatch repair protein Msh2; mismatch repair protein; mutS homolog 2 (E. coli); mutS protein homolog 2
Orthologs:
Homo sapiens (human) : MSH2 (mutS homolog 2)  HGNC  Alliance
Mus musculus (house mouse) : Msh2 (mutS homolog 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh2 (mutS homolog 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH2 (mutS homolog 2)
Canis lupus familiaris (dog) : MSH2 (mutS homolog 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh2 (mutS homolog 2)
Sus scrofa (pig) : MSH2 (mutS homolog 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0611,215,951 - 11,274,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0621,198,374 - 21,256,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,199,906 - 11,258,350 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1611,199,905 - 11,258,350 (+)NCBI
Celera66,571,260 - 6,630,220 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model