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Gene: MSH2 (mutS homolog 2) Homo sapiens
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Symbol: MSH2
Name: mutS homolog 2
Description: Exhibits several functions, including protein C-terminus binding activity; protein homodimerization activity; and protein kinase binding activity. Contributes to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Involved in several processes, including DNA metabolic process; negative regulation of DNA recombination; and positive regulation of helicase activity. Localizes to the MutSalpha complex and MutSbeta complex. Implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Biomarker of breast carcinoma; cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: COCA1; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; mismatch repair protein; mutS homolog 2, colon cancer, nonpolyposis type 1; mutS protein homolog 2
Orthologs:
Mus musculus (house mouse) : Msh2 (mutS homolog 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Msh2 (mutS homolog 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh2 (mutS homolog 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH2 (mutS homolog 2)
Canis lupus familiaris (dog) : MSH2 (mutS homolog 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh2 (mutS homolog 2)
Sus scrofa (pig) : MSH2 (mutS homolog 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,403,067 - 47,634,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37247,630,206 - 47,739,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,483,767 - 47,563,864 (+)NCBINCBI36hg18NCBI36
Build 34247,541,913 - 47,622,011NCBI
Celera247,469,014 - 47,549,030 (+)NCBI
Cytogenetic Map2p21-p16.3NCBI
HuRef247,367,170 - 47,445,840 (+)NCBIHuRef
CHM1_1247,560,266 - 47,640,762 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model