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Gene: MSH2 (mutS homolog 2) Chlorocebus sabaeus

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Symbol:

MSH2

Name:

mutS homolog 2

RGD ID:

18608379

Description:

ENCODES a protein that exhibits ADP binding (ortholog); ATP binding (ortholog); dinucleotide insertion or deletion binding (ortholog); INVOLVED IN B cell differentiation (ortholog); B cell mediated immunity (ortholog); determination of adult lifespan (ortholog); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; ASSOCIATED WITH ascending colon cancer (ortholog); bile duct cancer (ortholog); breast cancer (ortholog); FOUND IN MutSalpha complex (inferred); MutSbeta complex (inferred); nucleoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA mismatch repair protein Msh2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSH2 (mutS homolog 2)	NCBI	Ortholog
Mus musculus (house mouse):	Msh2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Msh2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Msh2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSH2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSH2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msh2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSH2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Msh2 (mutS homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	59,730,101 - 59,802,857 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	59,729,789 - 59,802,819 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	52,045,654 - 52,118,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ascending colon cancer (ISO)

bile duct cancer (ISO)

breast cancer (ISO)

breast carcinoma (ISO)

cerebral palsy (ISO)

cervix uteri carcinoma in situ (ISO)

colitis (ISO)

colon cancer (ISO)

colon carcinoma (ISO)

Colon Diverticulum (ISO)

Colonic Polyps (ISO)

colorectal adenocarcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency (ISO)

endometrial carcinoma (ISO)

Endometrial Neoplasms (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Seizures (ISO)

Germ Cell and Embryonal Neoplasms (ISO)

glioblastoma (ISO)

hepatoblastoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

hereditary nonpolyposis colorectal cancer type 2 (ISO)

hereditary nonpolyposis colorectal cancer type 4 (ISO)

high grade glioma (ISO)

Huntington's disease (ISO)

Hydatidiform Mole (ISO)

Hydatidiform Mole, Invasive (ISO)

laryngeal squamous cell carcinoma (ISO)

lung adenocarcinoma (ISO)

lung cancer (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

Lynch syndrome (ISO)

Lynch syndrome 1 (ISO)

mismatch repair cancer syndrome (ISO)

Mismatch Repair Cancer Syndrome 1 (ISO)

Mismatch Repair Cancer Syndrome 2 (ISO)

Muir-Torre syndrome (ISO)

Neoplasm Metastasis (ISO)

osteosarcoma (ISO)

ovarian cancer (ISO)

ovarian cyst (ISO)

Ovarian Neoplasms (ISO)

Pitt-Hopkins-like syndrome 2 (ISO)

prostate cancer (ISO)

renal cell carcinoma (ISO)

Renal Cell Carcinoma 1 (ISO)

rhabdomyosarcoma (ISO)

sarcoma (ISO)

sigmoid colon cancer (ISO)

sigmoid neoplasm (ISO)

stomach cancer (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

Urogenital Neoplasms (ISO)

Uterine Cervical Neoplasms (ISO)

uterine corpus cancer (ISO)

Vulvar Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IEA,ISO)

B cell mediated immunity (IEA,ISO)

determination of adult lifespan (IEA,ISO)

DNA damage response (IEA,ISO)

DNA repair (IEA,ISO)

double-strand break repair (IEA,ISO)

germ cell development (IEA,ISO)

in utero embryonic development (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IEA,ISO)

isotype switching (IEA,ISO)

maintenance of DNA repeat elements (IEA)

male gonad development (IEA,ISO)

mismatch repair (IEA,ISO)

mitotic intra-S DNA damage checkpoint signaling (IEA,ISO)

mitotic recombination (IEA)

negative regulation of DNA recombination (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,ISO)

oxidative phosphorylation (IEA,ISO)

positive regulation of helicase activity (ISO)

positive regulation of isotype switching to IgA isotypes (IEA)

positive regulation of isotype switching to IgG isotypes (IEA)

postreplication repair (IEA,ISO)

regulation of cell cycle (IEA,ISO)

response to amino acid (ISO)

response to quercetin (ISO)

response to UV-B (IEA,ISO)

response to X-ray (IEA,ISO)

response to xenobiotic stimulus (ISO)

somatic hypermutation of immunoglobulin genes (IEA,ISO)

somatic recombination of immunoglobulin gene segments (IEA,ISO)

somatic recombination of immunoglobulin genes involved in immune response (IEA,ISO)

spermatogenesis (ISO)

Cellular Component

MutSalpha complex (IEA)

MutSbeta complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

ADP binding (IEA,ISO)

ATP binding (IEA,ISO)

ATP hydrolysis activity (IEA)

ATP-dependent activity, acting on DNA (IEA)

ATP-dependent DNA damage sensor activity (IEA)

centromeric DNA binding (IEA)

chromatin binding (IEA)

damaged DNA binding (IEA)

dinucleotide insertion or deletion binding (IEA,ISO)

dinucleotide repeat insertion binding (IEA,ISO)

DNA binding (IEA)

double-stranded DNA binding (IEA,ISO)

four-way junction DNA binding (IEA,ISO)

guanine/thymine mispair binding (IEA,ISO)

magnesium ion binding (IEA,ISO)

mismatched DNA binding (IEA,ISO)

MutLalpha complex binding (IEA,ISO)

oxidized purine DNA binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

single guanine insertion binding (IEA,ISO)

single thymine insertion binding (IEA,ISO)

single-stranded DNA binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered mismatch repair pathway (ISO)

colorectal cancer pathway (ISO)

mismatch repair pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MSH2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	59,730,101 - 59,802,857 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	59,729,789 - 59,802,819 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	52,045,654 - 52,118,250 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MSH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	47,403,067 - 47,709,830 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	47,403,067 - 47,663,146 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	47,630,206 - 47,936,969 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	47,483,767 - 47,563,864 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	47,541,913 - 47,622,011	NCBI
Celera	2	47,469,014 - 47,549,030 (+)	NCBI		Celera
Cytogenetic Map	2	p21-p16.3	NCBI
HuRef	2	47,367,170 - 47,445,840 (+)	NCBI		HuRef
CHM1_1	2	47,560,266 - 47,640,762 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	47,408,101 - 47,714,827 (+)	NCBI		T2T-CHM13v2.0

Msh2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	87,979,960 - 88,031,141 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	87,979,758 - 88,031,141 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	87,672,532 - 87,723,713 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	87,672,330 - 87,723,713 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	88,071,897 - 88,123,053 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	87,580,883 - 87,632,039 (+)	NCBI		MGSCv36	mm8
Celera	17	92,079,522 - 92,130,140 (+)	NCBI		Celera
Cytogenetic Map	17	E4	NCBI
cM Map	17	57.87	NCBI

Msh2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	12,567,368 - 12,626,534 (-)	NCBI		GRCr8
mRatBN7.2	6	6,813,793 - 6,872,960 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	6,813,795 - 6,872,938 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	7,095,880 - 7,155,017 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	7,405,284 - 7,464,421 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	6,932,416 - 6,991,551 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	11,215,951 - 11,274,916 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	11,215,963 - 11,274,932 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	21,198,374 - 21,256,838 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	11,199,906 - 11,258,350 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	11,199,905 - 11,258,350 (+)	NCBI
Celera	6	6,571,260 - 6,630,220 (-)	NCBI		Celera
Cytogenetic Map	6	q12	NCBI

Msh2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	14,187,805 - 14,247,698 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	14,188,315 - 14,247,608 (+)	NCBI	ChiLan1.0	ChiLan1.0

MSH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	78,853,510 - 78,981,234 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	78,857,477 - 78,985,200 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	47,524,468 - 47,602,376 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	48,447,207 - 48,525,638 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	48,447,207 - 48,554,461 (+)	Ensembl	panpan1.1		panPan2

MSH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	49,517,448 - 49,594,001 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	49,517,369 - 49,594,210 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	49,372,675 - 49,449,176 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	50,390,734 - 50,467,292 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	50,390,727 - 50,467,285 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	50,098,560 - 50,174,750 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	50,386,621 - 50,461,201 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	50,572,222 - 50,649,102 (+)	NCBI		UU_Cfam_GSD_1.0

Msh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	33,515,476 - 33,584,710 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	4,944,007 - 5,013,356 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	4,943,987 - 5,013,356 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	93,081,219 - 93,163,585 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	93,082,958 - 93,163,556 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	99,052,166 - 99,101,600 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	3	99,274,469 - 99,306,160 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Msh2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	28,780,614 - 28,861,704 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	28,780,596 - 28,861,523 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MSH2
1750 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007970712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011666 ⟹ ENSCSAP00000009731

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	59,729,789 - 59,802,819 (-)	Ensembl

RefSeq Acc Id:

XM_007970712 ⟹ XP_007968903

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	59,730,101 - 59,802,857 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	52,045,654 - 52,118,250 (+)	NCBI

Sequence:

show sequence

GATTGGGTGTGGCCGCCGTGACCGGACGCCGCTCGGGGGACGTGGGAGGGGAGGCGGGAAACAG
CATAGTGGGTGTGGGGTCGCGCAGTTCCTTCTGCCAGGAGGTGAGGAGGTTCCGACATGGCGGT
GCAACCTAAGGAGACGCTGCAGCTGGAGAGCGCGGCCGAAGTCGGCTTCGTGCGTTTCTTTCAG
AGCATGCCGGAGAAACCGACCACCACGGTGCGCCTTTTCGACCGGGGCGACTTCTATACGGCTC
ACGGCGAGGACGCGCTGCTGGCAGCCCGGGAGGTGTTCAAGACCCAGGGGGTGATCAAGTATAT
GGGGCCGGCAGGAGCAAAGAATCTGCAGAGTGTTGTTCTTAGTAAAATGAATTTTGAATCTTTT
GTAAAAGATCTTCTTCTGGTTCGTCAGTATAGAGTTGAAGTTTATAAGAACAGAGCTGGAAATA
AGGCATCCAAGGAGAATGATTGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTATCTCAGTT
TGAAGACATTCTCTTTGGTAACAATGATATGTCAGCTTCAATTGGTGTTGTGGGTGTTAAAATG
TCCACAGTTGATGGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCACACAGAGGAAGCTAG
GACTGTGTGAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGG
ACCAAAGGAATGTGTTTTACCTGGAGGAGAGACTGCTGGAGACATGGGGAAACTAAGACAGATT
ATTCAAAGAGGAGGGATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACGAAAGACATTT
ATCAGGACCTCAACCGGCTGTTGAAAGGCAAAAAGGGAGAACAGATGAATAGTGCTGTATTGCC
AGAAATGGAGAATCAGGTTGCAGTTTCATCATTGTCTGCGGTAATCAAGTTTTTAGAACTCTTA
TCAGATGATTCCAATTTTGGACAGTTTGAACTGACTACTTTTGACTTCAGCCAGTACATGAAAT
TGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCTGTTGAAGATACCACTGGCTC
TCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCTCAAGGACAAAGACTTGTTAACCAG
TGGATTAAGCAGCCTCTCATGGATAAAAACAGAATAGAGGAGAGATTGAATTTAGTGGAAGCTT
TTGTAGAAGATGCAGAATTGAGGCAGACTTTACAAGAAGATTTACTGCGTCGATTCCCAGATCT
TAACCGACTTGCCAAGAAGTTTCAAAGACAAGCAGCAAACTTACAAGATTGTTACCGACTCTAT
CAGGGTATAAATCAACTACCCAATGTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGA
AATTACTGTTGGCAGTTTTTGTGACTCCTCTTACTGATCTTCGTTCTGATTTCTCCAAGTTTCA
GGAAATGATAGAAACAACTTTAGATATGGATCAGGTAGAAAACCATGAATTCCTTGTAAAACCT
TCATTTGATCCTAATCTCAGTGAATTAAGAGAAATAATGAATGACTTGGAAAAGAAGATGCAGT
CAACATTAATAAGTGCAGCCAGAGATCTTGGCTTGGACCCTGGCAAACAGATTAAACTGGATTC
CAGTACACAGTTTGGATATTACTTTCGTGTAACCTGTAAGGAAGAAAAAGTCCTTCGTAACAAT
AAAAACTTTAGTACTGTAGATATCCAGAAGAACGGTGTTAAATTTACCAACAGCAAATTGACTT
CTTTAAATGAAGAGTATACCAAAAATAAAACAGAATATGAAGAAGCCCAGGATGCCATTGTTAA
AGAAATTGTCAATATTTCTTCAGGCTATGTAGAACCAATGCAAACACTCAATGATGTATTAGCT
CAGCTAGATGCTGTTGTCAGCTTTGCTCATGTGTCAAATGGAGCACCTGTTCCATATGTACGAC
CAGCCATTTTGGAGAAAGGACAAGGAAGAATTATATTAAAAGCATCCAGGCATGCTTGTGTTGA
AGTTCAAGATGAAATCACGTTTATTCCTAATGATATATACTTTGAAAAAGATAAACAGATGTTC
CACATCATTACTGGCCCCAATATGGGAGGTAAATCTACATATATTCGACAAACTGGGGTGATAG
TACTCATGGCCCAAATTGGGTGTTTTGTGCCATGTGAGTCTGCAGAAGTGTCCATTGTGGACTG
CATCTTGGCCCGGGTAGGGGCTGGTGACAGTCAGTTGAAAGGAGTCTCCACATTCATGGCTGAA
ATGTTGGAAACTGCTTCTATTCTCAGGTCAGCAACCAAAGATTCATTAATAATCATAGATGAAT
TGGGAAGAGGAACTTCTACCTACGATGGATTTGGGTTAGCATGGGCTATATCAGAATACATTGC
AACAAAGATTGGTGCTTTTTGCATGTTTGCAACTCATTTTCATGAGCTTACTGCCTTGGCCAAT
CAGATACCAACCGTTAATAATCTACATGTCACAGCACTCACCACTGAAGACACCTTAACTATGC
TTTATCAGGTGAAGAAAGGTGTCTGTGATCAAAGTTTTGGGATTCATGTTGCAGAGCTTGCTAA
TTTCCCTAAGCATGTAATAGAGTGTGCTAAACAGAAAGCCCTGGAACTCGAAGAGTTTCAGTAT
ATTGGAGAATCACAAGGATATGATATGGAACCAGCAGCAAAGAAGTGCTATCTGGAAAGAGAGC
AAGGTGAAAAAATTATTCAGGAGTTCCTGTCCAAGGTGAAACAAATGCCCTTTACTGAAATGTC
AGAAGAAAACATCACAATAAAGTTAAAACAGCTAAAAGCTGAAGTAATAGCAAAGAATAATAGC
TTTGTAAATGAAATCATTTCACGAATAAAAGTTACTACGTGAAAAATCCCAGTAATGGAATGAA
GGTAATATTGATAAGCTAATTGTCTGTGATACTTTTATGTTGTTTTATATTAATTCTTTTTCCA
TAGTGTTAACTGTCAGTGCCCATGGGCTATCAACTTAATAAGATATTTAGTAATATTTGTCTCT
GAGGACATTTTCAAAGATCTTTATTTTGAAAAATGAGAGCTGTAACTGAGGACTGTTTGCAGTT
GACATAGGCAATAATAAGTGATGTGCTGAATTTTATAAATAAAATCATGTAGTTTGTGGAATTT
GA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007968903	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009731.1

RefSeq Acc Id:	XP_007968903 ⟸ XM_007970712
- UniProtKB:	A0A0D9RM92 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009731 ⟸ ENSCSAT00000011666

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013571	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011666.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1420.10	UniProtKB/TrEMBL
	3.30.420.110	UniProtKB/TrEMBL
	3.40.1170.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	DNA_mismatch_repair_Msh2	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS-lik_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_C	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_clamp	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_core	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_N	UniProtKB/TrEMBL
	DNA_mismatch_repair_MutS_sf	UniProtKB/TrEMBL
	DNA_mmatch_repair_MutS_con_dom	UniProtKB/TrEMBL
	Msh2	UniProtKB/TrEMBL
	MutS_con_dom_sf	UniProtKB/TrEMBL
	MutS_family	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	csab:103220322	UniProtKB/TrEMBL
NCBI Gene	MSH2	ENTREZGENE
PANTHER	PTHR11361	UniProtKB/TrEMBL
	PTHR11361:SF35	UniProtKB/TrEMBL
Pfam	MutS_I	UniProtKB/TrEMBL
	MutS_II	UniProtKB/TrEMBL
	MutS_III	UniProtKB/TrEMBL
	MutS_IV	UniProtKB/TrEMBL
	MutS_V	UniProtKB/TrEMBL
PIRSF	MSH2	UniProtKB/TrEMBL
PROSITE	DNA_MISMATCH_REPAIR_2	UniProtKB/TrEMBL
SMART	MUTSac	UniProtKB/TrEMBL
	MUTSd	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48334	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0D9RM92	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations