MSH2 (mutS homolog 2) - Rat Genome Database

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Gene: MSH2 (mutS homolog 2) Pan paniscus
Analyze
Symbol: MSH2
Name: mutS homolog 2
RGD ID: 11808914
Description: ENCODES a protein that exhibits ADP binding (ortholog); ATP binding (ortholog); dinucleotide insertion or deletion binding (ortholog); INVOLVED IN B cell differentiation (ortholog); B cell mediated immunity (ortholog); determination of adult lifespan (ortholog); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; ASSOCIATED WITH ascending colon cancer (ortholog); bile duct cancer (ortholog); breast cancer (ortholog); FOUND IN MutSalpha complex (inferred); MutSbeta complex (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA mismatch repair protein Msh2; mutS homolog 2, colon cancer, nonpolyposis type 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,853,510 - 78,981,234 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,857,477 - 78,985,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,524,468 - 47,602,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,447,207 - 48,525,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,447,207 - 48,554,461 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ascending colon cancer  (ISO)
bile duct cancer  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
cerebral palsy  (ISO)
cervix uteri carcinoma in situ  (ISO)
colitis  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colon Diverticulum  (ISO)
Colonic Polyps  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Seizures  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
glioblastoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 2  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hydatidiform Mole  (ISO)
Hydatidiform Mole, Invasive  (ISO)
laryngeal squamous cell carcinoma  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
Lynch syndrome 1  (ISO)
mismatch repair cancer syndrome  (ISO)
Mismatch Repair Cancer Syndrome 1  (ISO)
Mismatch Repair Cancer Syndrome 2  (ISO)
Muir-Torre syndrome  (ISO)
Neoplasm Metastasis  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian cyst  (ISO)
Ovarian Neoplasms  (ISO)
Pitt-Hopkins-like syndrome 2  (ISO)
prostate cancer  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
rhabdomyosarcoma  (ISO)
sarcoma  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
stomach cancer  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urogenital Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
Vulvar Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MSH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,853,510 - 78,981,234 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,857,477 - 78,985,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,524,468 - 47,602,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,447,207 - 48,525,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,447,207 - 48,554,461 (+)Ensemblpanpan1.1panPan2
MSH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,403,067 - 47,709,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,403,067 - 47,663,146 (+)EnsemblGRCh38hg38GRCh38
GRCh37247,630,206 - 47,936,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,483,767 - 47,563,864 (+)NCBINCBI36Build 36hg18NCBI36
Build 34247,541,913 - 47,622,011NCBI
Celera247,469,014 - 47,549,030 (+)NCBICelera
Cytogenetic Map2p21-p16.3NCBI
HuRef247,367,170 - 47,445,840 (+)NCBIHuRef
CHM1_1247,560,266 - 47,640,762 (+)NCBICHM1_1
T2T-CHM13v2.0247,408,101 - 47,714,827 (+)NCBIT2T-CHM13v2.0
Msh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,979,960 - 88,031,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,979,758 - 88,031,141 (+)EnsemblGRCm39 Ensembl
GRCm381787,672,532 - 87,723,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,672,330 - 87,723,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,071,897 - 88,123,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,580,883 - 87,632,039 (+)NCBIMGSCv36mm8
Celera1792,079,522 - 92,130,140 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
Msh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,567,368 - 12,626,534 (-)NCBIGRCr8
mRatBN7.266,813,793 - 6,872,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,813,795 - 6,872,938 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx67,095,880 - 7,155,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,405,284 - 7,464,421 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,932,416 - 6,991,551 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,215,951 - 11,274,916 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,215,963 - 11,274,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,198,374 - 21,256,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,199,906 - 11,258,350 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1611,199,905 - 11,258,350 (+)NCBI
Celera66,571,260 - 6,630,220 (-)NCBICelera
Cytogenetic Map6q12NCBI
Msh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,187,805 - 14,247,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544114,188,315 - 14,247,608 (+)NCBIChiLan1.0ChiLan1.0
MSH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,517,448 - 49,594,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,517,369 - 49,594,210 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,372,675 - 49,449,176 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01050,390,734 - 50,467,292 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,390,727 - 50,467,285 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,098,560 - 50,174,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,386,621 - 50,461,201 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,572,222 - 50,649,102 (+)NCBIUU_Cfam_GSD_1.0
Msh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,515,476 - 33,584,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,944,007 - 5,013,356 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,943,987 - 5,013,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,081,219 - 93,163,585 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,082,958 - 93,163,556 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,052,166 - 99,101,600 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2399,274,469 - 99,306,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,730,101 - 59,802,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,729,789 - 59,802,819 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604552,045,654 - 52,118,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,780,614 - 28,861,704 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473828,780,596 - 28,861,523 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000044809   ⟹   ENSPPAP00000022004
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,447,207 - 48,525,638 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044824   ⟹   ENSPPAP00000022019
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,447,332 - 48,554,461 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044829   ⟹   ENSPPAP00000022024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,447,332 - 48,520,718 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044836   ⟹   ENSPPAP00000022031
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,447,332 - 48,473,848 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044854   ⟹   ENSPPAP00000022048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,447,530 - 48,525,359 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044857   ⟹   ENSPPAP00000022051
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A48,472,295 - 48,525,359 (+)Ensembl
RefSeq Acc Id: XM_003822678   ⟹   XP_003822726
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21278,903,355 - 78,981,234 (-)NCBI
NHGRI_mPanPan12A78,907,317 - 78,985,200 (-)NCBI
Mhudiblu_PPA_v02A47,524,468 - 47,602,376 (+)NCBI
PanPan1.12A48,447,207 - 48,525,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055108003   ⟹   XP_054963978
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21278,853,510 - 78,981,233 (-)NCBI
NHGRI_mPanPan12A78,857,477 - 78,985,185 (-)NCBI
RefSeq Acc Id: XM_055108004   ⟹   XP_054963979
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21278,874,378 - 78,981,233 (-)NCBI
NHGRI_mPanPan12A78,878,343 - 78,985,185 (-)NCBI
RefSeq Acc Id: XP_003822726   ⟸   XM_003822678
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AXQ5 (UniProtKB/TrEMBL),   A0A2R9AXS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000022004   ⟸   ENSPPAT00000044809
Ensembl Acc Id: ENSPPAP00000022019   ⟸   ENSPPAT00000044824
Ensembl Acc Id: ENSPPAP00000022024   ⟸   ENSPPAT00000044829
Ensembl Acc Id: ENSPPAP00000022031   ⟸   ENSPPAT00000044836
Ensembl Acc Id: ENSPPAP00000022048   ⟸   ENSPPAT00000044854
Ensembl Acc Id: ENSPPAP00000022051   ⟸   ENSPPAT00000044857
RefSeq Acc Id: XP_054963978   ⟸   XM_055108003
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054963979   ⟸   XM_055108004
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AXR6 (UniProtKB/TrEMBL),   A0A2R9AXS2 (UniProtKB/TrEMBL)
Protein Domains
DNA mismatch repair protein MutS connector   DNA mismatch repair protein MutS core   DNA mismatch repair protein MutS-like N-terminal   DNA mismatch repair proteins mutS family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044809.1 UniProtKB/TrEMBL
  ENSPPAT00000044824.1 UniProtKB/TrEMBL
  ENSPPAT00000044829.1 UniProtKB/TrEMBL
  ENSPPAT00000044836.1 UniProtKB/TrEMBL
  ENSPPAT00000044854.1 UniProtKB/TrEMBL
  ENSPPAT00000044857.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/TrEMBL
  3.40.1170.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_Msh2 UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS-lik_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_clamp UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_N UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/TrEMBL
  Msh2 UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/TrEMBL
  MutS_family UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report pps:100984592 UniProtKB/TrEMBL
NCBI Gene MSH2 ENTREZGENE
PANTHER PTHR11361 UniProtKB/TrEMBL
  PTHR11361:SF35 UniProtKB/TrEMBL
Pfam MutS_I UniProtKB/TrEMBL
  MutS_II UniProtKB/TrEMBL
  MutS_III UniProtKB/TrEMBL
  MutS_IV UniProtKB/TrEMBL
  MutS_V UniProtKB/TrEMBL
PIRSF MSH2 UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/TrEMBL
SMART MUTSac UniProtKB/TrEMBL
  MUTSd UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9AXL6_PANPA UniProtKB/TrEMBL
  A0A2R9AXQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AXR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AXS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1K3_PANPA UniProtKB/TrEMBL
  A0A2R9B1M8_PANPA UniProtKB/TrEMBL