Gene: Itpk1 (inositol-tetrakisphosphate 1-kinase) Rattus norvegicus
Analyze
Symbol:
Itpk1
Name:
inositol-tetrakisphosphate 1-kinase
Description:
Predicted to have kinase activity. Predicted to be involved in inositol phosphorylation; necroptotic process; and neural tube development. Predicted to localize to the apical plasma membrane and cytoplasm. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
inositol 1,3,4-triphosphate 5/6 kinase; LOC500709; similar to inositol 1,3,4-triphosphate 5/6 kinase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ITPK1 (inositol-tetrakisphosphate 1-kinase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Itpk1 (inositol 1,3,4-triphosphate 5/6 kinase) HGNC
Treefam, EggNOG, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Itpk1 (inositol-tetrakisphosphate 1-kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ITPK1 (inositol-tetrakisphosphate 1-kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ITPK1 (inositol-tetrakisphosphate 1-kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Itpk1 (inositol-tetrakisphosphate 1-kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ITPK1 (inositol-tetrakisphosphate 1-kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ITPK1 (inositol-tetrakisphosphate 1-kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Itpk1 (inositol 1,3,4-triphosphate 5/6 kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
itpk1a (inositol-tetrakisphosphate 1-kinase a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
itpk1b (inositol-tetrakisphosphate 1-kinase b)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 126,448,920 - 126,582,188 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 126,450,139 - 126,582,134 (-) Ensembl Rnor_5.0 6 135,660,943 - 135,790,645 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 126,837,135 - 126,969,350 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera 6 119,200,722 - 119,330,748 (-) NCBI Celera Cytogenetic Map 6 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:1312967 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of ITPK1 mRNA CTD PMID:22101062 17beta-estradiol increases expression ISO RGD:1312967 6480464 Estradiol results in increased expression of ITPK1 mRNA CTD PMID:16474171 , PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312967 6480464 Tetrachlorodibenzodioxin affects the expression of ITPK1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1312967 6480464 Tetrachlorodibenzodioxin results in increased expression of ITPK1 mRNA CTD PMID:17555868 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312968 6480464 Tetrachlorodibenzodioxin affects the expression of ITPK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ITPK1 mRNA CTD PMID:22298810 2,4-dinitrobenzenesulfonic acid multiple interactions ISO RGD:1312968 6480464 [2, 4-dinitrobenzenesulfonic acid co-treated with GR 159897] results in increased expression of ITPK1 mRNA CTD PMID:30116771 2,4-dinitrobenzenesulfonic acid decreases expression ISO RGD:1312968 6480464 2, 4-dinitrobenzenesulfonic acid results in decreased expression of ITPK1 mRNA CTD PMID:30116771 3,3',5-triiodo-L-thyronine increases expression ISO RGD:1312968 6480464 Triiodothyronine results in increased expression of ITPK1 mRNA CTD PMID:25172293 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1312968 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ITPK1 mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1312967 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ITPK1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1312967 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ITPK1 mRNA CTD PMID:28628672 afimoxifene decreases response to substance ISO RGD:1312967 6480464 ITPK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 increases methylation ISO RGD:1312967 6480464 Aflatoxin B1 results in increased methylation of ITPK1 intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:1312967 6480464 aflatoxin B2 results in decreased methylation of ITPK1 intron CTD PMID:30157460 atrazine decreases expression ISO RGD:1312967 6480464 Atrazine results in decreased expression of ITPK1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:1312968 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to ITPK1 promoter] CTD PMID:19654925 benzo[a]pyrene affects methylation ISO RGD:1312967 6480464 Benzo(a)pyrene affects the methylation of ITPK1 intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1312967 6480464 Benzo(a)pyrene results in decreased expression of ITPK1 mRNA CTD PMID:20064835 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1312967 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene affects methylation ISO RGD:1312967 6480464 benzo(e)pyrene affects the methylation of ITPK1 intron CTD PMID:30157460 bisphenol A increases expression ISO RGD:1312967 6480464 bisphenol A results in increased expression of ITPK1 mRNA CTD PMID:16474171 bisphenol A decreases methylation ISO RGD:1312968 6480464 bisphenol A results in decreased methylation of ITPK1 promoter CTD PMID:27312807 bisphenol A increases methylation ISO RGD:1312968 6480464 bisphenol A results in increased methylation of ITPK1 promoter CTD PMID:27312807 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ITPK1 mRNA CTD PMID:25181051 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of ITPK1 mRNA CTD PMID:26496021 cycloheximide multiple interactions ISO RGD:1312967 6480464 ITPK1 inhibits the reaction [[Cycloheximide co-treated with TNF] results in increased activity of CASP9 protein] more ... CTD PMID:12925536 cyclosporin A decreases expression ISO RGD:1312967 6480464 Cyclosporine results in decreased expression of ITPK1 mRNA CTD PMID:20106945 dexamethasone multiple interactions ISO RGD:1312967 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ITPK1 mRNA CTD PMID:28628672 dibutyl phthalate increases expression ISO RGD:1312968 6480464 Dibutyl Phthalate results in increased expression of ITPK1 mRNA CTD PMID:21266533 dicrotophos increases expression ISO RGD:1312967 6480464 dicrotophos results in increased expression of ITPK1 mRNA CTD PMID:28302478 diethylstilbestrol increases expression ISO RGD:1312967 6480464 Diethylstilbestrol results in increased expression of ITPK1 mRNA CTD PMID:19371625 doxorubicin decreases expression ISO RGD:1312967 6480464 Doxorubicin results in decreased expression of ITPK1 mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of ITPK1 mRNA CTD PMID:29391264 ethanol multiple interactions ISO RGD:1312968 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of ITPK1 mRNA CTD PMID:30517762 ethanol affects splicing ISO RGD:1312968 6480464 Ethanol affects the splicing of ITPK1 mRNA CTD PMID:30319688 genistein increases expression ISO RGD:1312967 6480464 Genistein results in increased expression of ITPK1 mRNA CTD PMID:16474171 indometacin multiple interactions ISO RGD:1312967 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ITPK1 mRNA CTD PMID:28628672 lead(0) affects expression ISO RGD:1312967 6480464 Lead affects the expression of ITPK1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1312967 6480464 Lead affects the expression of ITPK1 mRNA CTD PMID:28903495 methapyrilene affects methylation ISO RGD:1312967 6480464 Methapyrilene affects the methylation of ITPK1 intron CTD PMID:30157460 p-toluidine decreases expression EXP 6480464 4-toluidine results in decreased expression of ITPK1 mRNA CTD PMID:27638505 pentachlorophenol increases expression ISO RGD:1312968 6480464 Pentachlorophenol results in increased expression of ITPK1 mRNA CTD PMID:23892564 pirinixic acid increases expression ISO RGD:1312968 6480464 pirinixic acid results in increased expression of ITPK1 mRNA CTD PMID:18445702 potassium chromate decreases expression ISO RGD:1312967 6480464 potassium chromate(VI) results in decreased expression of ITPK1 mRNA CTD PMID:22714537 sodium arsenite decreases expression ISO RGD:1312968 6480464 sodium arsenite results in decreased expression of ITPK1 mRNA CTD PMID:25270620 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of ITPK1 mRNA CTD PMID:26496021 tetrachloromethane multiple interactions ISO RGD:1312968 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of ITPK1 mRNA CTD PMID:30517762 titanium dioxide increases expression ISO RGD:1312968 6480464 titanium dioxide results in increased expression of ITPK1 mRNA CTD PMID:29264374 trichostatin A decreases expression ISO RGD:1312967 6480464 trichostatin A results in decreased expression of ITPK1 mRNA CTD PMID:28542535 tunicamycin decreases expression ISO RGD:1312967 6480464 Tunicamycin results in decreased expression of ITPK1 mRNA CTD PMID:22378314 valproic acid increases expression ISO RGD:1312968 6480464 Valproic Acid results in increased expression of ITPK1 mRNA CTD PMID:20546886 , PMID:21427059 valproic acid increases expression ISO RGD:1312967 6480464 Valproic Acid results in increased expression of ITPK1 mRNA CTD PMID:23179753 zearalenone increases expression ISO RGD:1312967 6480464 Zearalenone results in increased expression of ITPK1 mRNA CTD PMID:19371625
Gene Ontology Annotations
Biological Process inositol phosphorylation IBA PANTHER:PTN001022327 , TAIR:locus:214899013792537 PMID:21873635 GO_Central inositol trisphosphate metabolic process IEA InterPro:IPR008656 1600115 GO_REF:0000002 InterPro GO_REF:0000002 necroptotic process IEA UniProtKB:Q13572 , ensembl:ENSP000002676151600115 GO_REF:0000107 Ensembl GO_REF:0000107 necroptotic process ISO RGD:1312967 1624291 (PMID:29883610) RGD PMID:29883610 neural tube development ISO RGD:1312968 1624291 MGI:MGI:3587933 (MGI:MGI:3849649 , PMID:19482943) RGD MGI:MGI:3849649 , PMID:19482943 neural tube development IEA UniProtKB:Q8BYN3 , ensembl:ENSMUSP000000460271600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component apical plasma membrane ISO RGD:1312968 1624291 (MGI:MGI:3619853, PMID:16537650) RGD MGI:MGI:3619853 , PMID:16537650 apical plasma membrane IEA UniProtKB:Q8BYN3 , ensembl:ENSMUSP000000460271600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm IBA PANTHER:PTN001022327 more ... 13792537 PMID:21873635 GO_Central cytoplasm IBA PANTHER:PTN001022327 , UniProtKB:Q9SUG3 13792537 PMID:21873635 GO_Central Molecular Function ATP binding IEA UniRule:UR000414645 1600115 GO_REF:0000104 UniProt GO_REF:0000104 ATP binding IEA InterPro:IPR008656 1600115 GO_REF:0000002 InterPro GO_REF:0000002 inositol tetrakisphosphate 1-kinase activity ISO RGD:1312967 1624291 (PMID:8662638) RGD PMID:8662638 inositol tetrakisphosphate 1-kinase activity IBA PANTHER:PTN001022327 more ... 13792537 PMID:21873635 GO_Central inositol tetrakisphosphate 6-kinase activity IEA UniProtKB:Q13572 , ensembl:ENSP000002676151600115 GO_REF:0000107 Ensembl GO_REF:0000107 inositol tetrakisphosphate 6-kinase activity ISO RGD:1312967 1624291 (PMID:29883610) RGD PMID:29883610 inositol-1,3,4-trisphosphate 5-kinase activity ISO RGD:1312967 1624291 (PMID:11042108) RGD PMID:11042108 inositol-1,3,4-trisphosphate 5-kinase activity IBA PANTHER:PTN001022327 more ... 13792537 PMID:21873635 GO_Central inositol-1,3,4-trisphosphate 6-kinase activity ISO RGD:1312967 1624291 (PMID:11042108) RGD PMID:11042108 inositol-1,3,4-trisphosphate 6-kinase activity IBA PANTHER:PTN001022327 more ... 13792537 PMID:21873635 GO_Central magnesium ion binding IEA InterPro:IPR008656 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Molecular Pathway Annotations
724513 Uae14 Urinary albumin excretion QTL 14 6.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 88996335 139410483 Rat 724536 Uae7 Urinary albumin excretion QTL 7 3.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 75623277 136143011 Rat 1331725 Bp212 Blood pressure QTL 212 3.52475 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 97949772 133849286 Rat 1298087 Iddm18 Insulin dependent diabetes mellitus QTL 18 0.0001 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) 6 121224054 135658578 Rat 737976 Pia24 Pristane induced arthritis QTL 24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 6 117355600 147991367 Rat 1331797 Bp213 Blood pressure QTL 213 3.291 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 108154445 133849286 Rat 1331799 Bp211 Blood pressure QTL 211 3.66407 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 75623277 136426962 Rat 1581550 Pur8 Proteinuria QTL 8 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 75623393 136142742 Rat 731173 Uae22 Urinary albumin excretion QTL 22 10.1 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 738034 Anxrr5 Anxiety related response QTL 5 5.9 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) 6 88507712 133507712 Rat 1581563 Uae33 Urinary albumin excretion QTL 33 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 75623393 136142742 Rat 2313399 Anxrr28 Anxiety related response QTL 28 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 6 104381930 138066274 Rat 1358355 Srcrt4 Stress Responsive Cort QTL 4 6.39 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 104363890 147991367 Rat 1300076 Glom8 Glomerulus QTL 8 7 0.000000009 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) 6 91703409 136703409 Rat 2290393 Uae37 Urinary albumin excretion QTL 37 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 2303624 Vencon5 Ventilatory control QTL 5 4.45 respiration trait (VT:0001943) minute ventilation (VE) (CMO:0000132) 6 92879510 137879510 Rat 61414 Pia3 Pristane induced arthritis QTL 3 4.5 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) 6 99273921 144792678 Rat 8552796 Vie3 Viral induced encephalitis QTL 3 2.6 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 6 101207574 147991367 Rat 10054138 Gmadr3 Adrenal mass QTL 3 3.68 0.00045 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 6 89631358 134631358 Rat 10054123 Srcrt6 Stress Responsive Cort QTL 6 2.5 0.0043 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 89631358 134631358 Rat 4145118 Mcs26 Mammary carcinoma susceptibility QTL 26 0.0001 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 111134524 138065254 Rat 12801411 Schws8 Schwannoma susceptibility QTL 8 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 6 99273921 144273921 Rat
Predicted Target Of
Count of predictions: 54 Count of miRNA genes: 46 Interacting mature miRNAs: 52 Transcripts: ENSRNOT00000010656 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
