Acp5 (acid phosphatase 5, tartrate resistant) - Rat Genome Database

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Gene: Acp5 (acid phosphatase 5, tartrate resistant) Rattus norvegicus
Analyze
Symbol: Acp5
Name: acid phosphatase 5, tartrate resistant
RGD ID: 2022
Description: Exhibits acid phosphatase activity. Involved in several processes, including bone resorption; response to L-ascorbic acid; and response to cholesterol. Localizes to extracellular space. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant); PARTICIPATES IN rheumatoid arthritis pathway; riboflavin metabolic pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acid phosphatase 5; Acid phosphatase 5 tartrate resistant; acid phosphatase type V; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase type 5; TR-AP; Trap; trATPase; TTRRAP; type 5 acid phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,663,984 - 20,670,604 (-)NCBI
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0823,142,733 - 23,149,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0823,197,095 - 23,202,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera822,052,728 - 22,058,674 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,4-dichlorobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminopurine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
azadirachtin A  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
Bergenin  (ISO)
bisphenol A  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chromium atom  (EXP)
cisapride  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocin-1  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diethylstilbestrol  (ISO)
diosgenin  (ISO)
dithionite(2-)  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
guanethidine  (EXP)
Heptachlor epoxide  (ISO)
indometacin  (EXP)
iron dichloride  (EXP)
KN-93  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
Maxacalcitol  (ISO)
methylglyoxal  (EXP,ISO)
modafinil  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
niclosamide  (ISO)
nitric acid  (EXP)
NMN zwitterion  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
phenethyl caffeate  (EXP)
poly(ethylene)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
potassium dichromate  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
stevioside  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tungsten  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vitamin D  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Capeller B, etal., Anticancer Res 2003 Mar-Apr;23(2A):1011-5.
2. Drexler HG and Gignac SM, Leukemia 1994 Mar;8(3):359-68.
3. Ek-Rylander B and Andersson G, Exp Cell Res. 2009 Oct 23.
4. Ek-Rylander B, etal., J Biol Chem 1991 Dec 25;266(36):24684-9.
5. Gameiro GH, etal., Aust Orthod J. 2008 Nov;24(2):121-8.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Hadley KB, etal., J Nutr Biochem. 2009 Apr 13.
9. Hanayama R, etal., Int J Mol Med. 2009 May;23(5):581-8.
10. Hie M, etal., Eur J Pharmacol. 2009 Oct 25;621(1-3):1-9. Epub 2009 Aug 21.
11. Kaija H, etal., Biochem Biophys Res Commun 2002 Mar 22;292(1):128-32.
12. KEGG
13. Korkalainen M, etal., Bone. 2009 Jun;44(6):1134-42. Epub 2009 Mar 2.
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Plakhotin MV, etal., Veterinariia. 1978 Dec;(12):89-90.
19. Potu BK, etal., Ups J Med Sci. 2009;114(3):140-8.
20. RGD automated data pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Roiko K, etal., Gene 1990 May 14;89(2):223-9.
24. Sanbe T, etal., Arch Oral Biol. 2009 Mar;54(3):235-40. Epub 2008 Dec 24.
25. Shen CL, etal., Osteoporos Int. 2010 Jan 13.
26. Shirasu N, etal., Acta Histochem. 2009 Apr 27.
27. Stolina M, etal., Arthritis Res Ther. 2009 Dec 11;11(6):R187.
28. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Waldorff EI, etal., J Bone Miner Res. 2009 Oct 12.
30. Wei P, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Apr;7(4):342-8.
Additional References at PubMed
PMID:1830446   PMID:8200916   PMID:8889548   PMID:8898228   PMID:9308894   PMID:10388567   PMID:10438611   PMID:11168643   PMID:11731469   PMID:14696961   PMID:15489334   PMID:15761664  
PMID:15929988   PMID:15975830   PMID:15993892   PMID:17916452   PMID:19821118   PMID:22878484   PMID:23376485   PMID:23868496   PMID:24223830   PMID:24395179  


Genomics

Comparative Map Data
Acp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,663,984 - 20,670,604 (-)NCBI
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0823,142,733 - 23,149,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0823,197,095 - 23,202,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera822,052,728 - 22,058,674 (-)NCBICelera
Cytogenetic Map8q13NCBI
ACP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1911,574,660 - 11,579,008 (-)EnsemblGRCh38hg38GRCh38
GRCh381911,574,660 - 11,578,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,685,475 - 11,689,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,546,477 - 11,549,496 (-)NCBINCBI36hg18NCBI36
Build 341911,546,476 - 11,549,496NCBI
Celera1911,580,213 - 11,584,539 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1911,259,840 - 11,264,071 (-)NCBIHuRef
CHM1_11911,685,335 - 11,689,686 (-)NCBICHM1_1
Acp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39922,038,023 - 22,047,042 (-)NCBIGRCm39mm39
GRCm39 Ensembl922,038,023 - 22,047,007 (-)Ensembl
GRCm38922,126,727 - 22,135,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl922,126,727 - 22,135,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,931,171 - 21,940,190 (-)NCBIGRCm37mm9NCBIm37
MGSCv36921,877,148 - 21,881,056 (-)NCBImm8
Celera919,395,697 - 19,404,716 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.38NCBI
Acp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,418,364 - 2,421,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,418,113 - 2,421,181 (+)NCBIChiLan1.0ChiLan1.0
ACP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11911,832,575 - 11,836,881 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,832,575 - 11,835,203 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01911,120,451 - 11,125,167 (-)NCBIMhudiblu_PPA_v0panPan3
ACP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,812,444 - 49,816,262 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,814,032 - 49,816,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,684,989 - 49,687,385 (+)NCBI
ROS_Cfam_1.02050,330,836 - 50,334,545 (+)NCBI
UMICH_Zoey_3.12049,542,471 - 49,544,878 (+)NCBI
UNSW_CanFamBas_1.02049,968,636 - 49,971,025 (+)NCBI
UU_Cfam_GSD_1.02050,211,593 - 50,213,981 (+)NCBI
Acp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,712,098 - 208,756,454 (+)NCBI
SpeTri2.0NW_0049366591,598,252 - 1,642,615 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,206,159 - 70,208,328 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,206,159 - 70,209,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,615,520 - 70,616,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q21NCBI
ACP5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,488,572 - 10,493,508 (-)NCBI
ChlSab1.1 Ensembl610,488,460 - 10,491,519 (-)Ensembl
Acp5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,305,913 - 3,309,983 (+)NCBI

Position Markers
RH133500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,664,061 - 20,664,276 (+)MAPPER
Rnor_6.0823,142,811 - 23,143,025NCBIRnor6.0
Rnor_5.0823,197,173 - 23,197,387UniSTSRnor5.0
Celera822,052,806 - 22,053,020UniSTS
RH 3.4 Map8206.61UniSTS
RH94519  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,664,045 - 20,664,190 (+)MAPPER
Rnor_6.0823,142,795 - 23,142,939NCBIRnor6.0
Rnor_5.0823,197,157 - 23,197,301UniSTSRnor5.0
Celera822,052,790 - 22,052,934UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124608226Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125942267Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8736807652368076Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8736807652368076Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8736807652368076Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:54
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000075237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 40 31 19 31 27 24 11
Low 39 17 10 10 8 11 72 8 17 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075237   ⟹   ENSRNOP00000066364
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092200   ⟹   ENSRNOP00000074001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl823,142,734 - 23,146,689 (-)Ensembl
RefSeq Acc Id: NM_001270889   ⟹   NP_001257818
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,984 - 20,669,930 (-)NCBI
Rnor_6.0823,142,733 - 23,148,396 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Celera822,052,728 - 22,058,674 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019144   ⟹   NP_062017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,984 - 20,667,929 (-)NCBI
Rnor_6.0823,142,733 - 23,146,689 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Celera822,052,728 - 22,056,673 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242692   ⟹   XP_006242754
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,984 - 20,670,601 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242693   ⟹   XP_006242755
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,996 - 20,670,602 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242694   ⟹   XP_006242756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,996 - 20,669,914 (-)NCBI
Rnor_6.0823,142,745 - 23,148,380 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595487   ⟹   XP_017450976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2820,663,984 - 20,670,604 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062017   ⟸   NM_019144
- Peptide Label: isoform 1 precursor
- UniProtKB: P29288 (UniProtKB/Swiss-Prot),   A0A0G2K6Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257818   ⟸   NM_001270889
- Peptide Label: isoform 2 precursor
- UniProtKB: P29288 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242754   ⟸   XM_006242692
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242755   ⟸   XM_006242693
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242756   ⟸   XM_006242694
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450976   ⟸   XM_017595487
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074001   ⟸   ENSRNOT00000092200
RefSeq Acc Id: ENSRNOP00000066364   ⟸   ENSRNOT00000075237
Protein Domains
Metallophos

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695807
Promoter ID:EPDNEW_R6330
Type:initiation region
Name:Acp5_1
Description:acid phosphatase 5, tartrate resistant
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0823,146,647 - 23,146,707EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2022 AgrOrtholog
Ensembl Genes ENSRNOG00000046261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000066364 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074001 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000092200 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110955 IMAGE-MGC_LOAD
InterPro Acid_PPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25732 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93494 IMAGE-MGC_LOAD
NCBI Gene 25732 ENTREZGENE
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acp5 PhenoGen
PIRSF Acid_Ptase_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6Z6 ENTREZGENE, UniProtKB/TrEMBL
  P29288 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acp5  acid phosphatase 5, tartrate resistant    acid phosphatase 5  Name updated 1299863 APPROVED
2002-11-06 Acp5  acid phosphatase 5    Acid phosphatase 5, tartrate resistant  Name updated 625702 APPROVED
2002-06-10 Acp5  Acid phosphatase 5, tartrate resistant      Symbol and Name status set to approved 70586 APPROVED