ACP5 (acid phosphatase 5, tartrate resistant) - Rat Genome Database

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Gene: ACP5 (acid phosphatase 5, tartrate resistant) Homo sapiens
Analyze
Symbol: ACP5
Name: acid phosphatase 5, tartrate resistant
RGD ID: 10073
HGNC Page HGNC:124
Description: Enables ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in bone resorption. Predicted to act upstream of or within several processes, including bone morphogenesis; negative regulation of metabolic process; and response to bacterium. Predicted to be located in cytosol and membrane. Implicated in spondylometaphyseal dysplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acid phosphatase 5; HPAP; human purple acid phosphatase; MGC117378; SPENCDI; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; tartrate-resistant acid phosphatase type 5; TRAcP; TRACP5a; TRACP5b; TRAP; TrATPase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,574,660 - 11,578,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,574,653 - 11,579,993 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,685,475 - 11,689,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,546,477 - 11,549,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,546,476 - 11,549,496NCBI
Celera1911,580,213 - 11,584,539 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,259,840 - 11,264,071 (-)NCBIHuRef
CHM1_11911,685,335 - 11,689,664 (-)NCBICHM1_1
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
ACP5HumanAlveolar Bone Loss treatmentISORGD:2022329956421associated with hypertension, periodontal diseaseRGD 
ACP5HumanExperimental Diabetes Mellitus  ISORGD:20222315882protein:increased activity:femoral bone (rat)RGD 
ACP5HumanPostmenopausal Osteoporosis  ISORGD:20222315910protein:increased expression:femur (rat)RGD 
ACP5HumanStress Fractures  ISORGD:20222315909protein:increased expression:tibia (rat)RGD 
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Original Reference(s)
ACP5Humanalpha-mannosidosis  IAGPRGD:1564392708554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
ACP5HumanCharcot-Marie-Tooth disease dominant intermediate B  IAGPRGD:1564392708554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:85679578554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:13524805|PMID:16470600|PMID:21217752|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:85679568554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:12786759|PMID:21217755|PMID:27390188|PMID:28492532|PMID:32214327|PMID:37382551
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:155966569|RGD:155991794|RGD:156008664|RGD:156012769|RGD:156016872|RGD:156019757|RGD:156030378|RGD:156050809|RGD:156059649|RGD:156067595|RGD:156070825|RGD:156072704|RGD:156084932|RGD:156088218|RGD:156093322|RGD:156098989|RGD:156100353|RGD:156116578|RGD:156121694|RGD:156125848|RGD:156145289|RGD:156146665|RGD:156171613|RGD:156188223|RGD:156190978|RGD:156192987|RGD:156202872|RGD:156209480|RGD:156210867|RGD:156213139|RGD:156213180|RGD:156244726|RGD:156245197|RGD:156256779|RGD:156272716|RGD:156275319|RGD:156283718|RGD:156284065|RGD:156291158|RGD:156292581|RGD:156309479|RGD:156342115|RGD:156371073|RGD:156377306|RGD:156385297|RGD:156402903|RGD:156403755|RGD:156406983|RGD:156409729|RGD:156442735|RGD:26885919|RGD:26888592|RGD:26890349|RGD:26891808|RGD:26904022|RGD:26909087|RGD:26913806|RGD:26914068|RGD:26917656|RGD:26921553|RGD:38457474|RGD:38457529|RGD:38458022|RGD:38461163|RGD:38462431|RGD:38473959|RGD:38476483|RGD:38478345|RGD:38489539|RGD:38492285|RGD:38492409|RGD:38495168|RGD:401916730|RGD:404996077|RGD:405000696|RGD:405001320|RGD:405005854|RGD:405013837|RGD:405076323|RGD:405103341|RGD:405105380|RGD:405187391|RGD:405188729|RGD:405190316|RGD:405190415|RGD:405193883|RGD:405196200|RGD:405196927|RGD:405197670|RGD:405201281|RGD:405201633|RGD:405201641|RGD:597838952|RGD:597841984|RGD:597859251|RGD:597876566|RGD:597880511|RGD:597882379|RGD:597884368|RGD:597890211|RGD:597912583|RGD:597914714|RGD:597942317|RGD:5979675548554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:127250275|RGD:127266392|RGD:151776737|RGD:151779477|RGD:151799289|RGD:151837937|RGD:151849062|RGD:151881901|RGD:151885403|RGD:156130098|RGD:156282600|RGD:156436376|RGD:38495934|RGD:405010981|RGD:405147117|RGD:5979267948554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:21217755|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:11545422|RGD:11547689|RGD:115516278554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:24033266|PMID:25741868|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:288859148554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:21217755|PMID:25741868|PMID:27943079|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:126728418|RGD:126735095|RGD:126735103|RGD:401855479|RGD:4018566598554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:25741868
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:126750696|RGD:126914760|RGD:13808809|RGD:14707152|RGD:384982038554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:27390188|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:151766413|RGD:384687218554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:17576681|PMID:28492532|PMID:9536098
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:151782813|RGD:155965920|RGD:1564463828554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:26951490|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:1269190518554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:28492532|PMID:31286717
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:110876018554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:21217755|PMID:25741868|PMID:26789720|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:135302498554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:21217755|PMID:25741868|PMID:28492532|PMID:28740483
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:1518282608554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217755|PMID:28492532|PMID:32214327
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:1561219318554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:26346816|PMID:26951490|PMID:28492532
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:138205338554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:21217755|PMID:26951490|PMID:27718324|PMID:28492532|PMID:32214327
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:85679588554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:21217752|PMID:25741868
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGPRGD:85552788554872ClinVar Annotator: match by term: Spondyloenchondrodysplasia with immune dysregulationClinVarPMID:13524805|PMID:21217752|PMID:2363422|PMID:25741868|PMID:26951490|PMID:27125509|PMID:28492532|PMID:38347954
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Original Reference(s)
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
ACP5HumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
ACP5Humanobesity  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20882379
ACP5Humansecondary hyperparathyroidism  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21985997|PMID:22373954
ACP5HumanSpondyloenchondrodysplasia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21217752|PMID:21217755
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Original Reference(s)
ACP5HumanCombined Immunodeficiency with Autoimmunity and Spondylometaphyseal Dysplasia  IAGP 7240710 OMIM 

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Original Reference(s)
ACP5Human(-)-matairesinol decreases activityISORGD:100726480464matairesinol results in decreased activity of ACP5 proteinCTDPMID:24444335
ACP5Human(20S)-ginsenoside Rg3 multiple interactionsISORGD:20226480464ginsenoside Rg3 inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]CTDPMID:27387537
ACP5Human1,2,4-trimethylbenzene decreases expressionISORGD:20226480464pseudocumene results in decreased expression of ACP5 proteinCTDPMID:17337753
ACP5Human1,4-dichlorobenzene increases expressionISORGD:1007264804644-dichlorobenzene results in increased expression of ACP5 mRNACTDPMID:26975756
ACP5Human1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISORGD:1007264804641-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACP5 mRNACTDPMID:30529163
ACP5Human1-naphthyl isothiocyanate increases expressionISORGD:202264804641-Naphthylisothiocyanate results in increased expression of ACP5 mRNACTDPMID:25380136
ACP5Human17alpha-ethynylestradiol increases expressionISORGD:100726480464Ethinyl Estradiol results in increased expression of ACP5 mRNACTDPMID:17942748
ACP5Human17alpha-ethynylestradiol multiple interactionsISORGD:100726480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP5 mRNACTDPMID:17942748
ACP5Human17alpha-ethynylestradiol affects expressionISORGD:100726480464Ethinyl Estradiol affects the expression of ACP5 mRNACTDPMID:17555576
ACP5Human17beta-estradiol decreases expressionISORGD:20226480464Estradiol results in decreased expression of ACP5 proteinCTDPMID:15917159
ACP5Human17beta-estradiol decreases expressionISORGD:100726480464Estradiol results in decreased expression of ACP5 mRNACTDPMID:39298647
ACP5Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of ACP5 mRNACTDPMID:30165855
ACP5Human2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactionsEXP 6480464[CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of ACP5 mRNACTDPMID:38160208
ACP5Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:100726480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP5 mRNA; Tetrachlorodibenzodioxin results in more ...CTDPMID:17942748|PMID:29673856
ACP5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:20226480464Tetrachlorodibenzodioxin results in increased expression of ACP5 mRNACTDPMID:33387578
ACP5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:20226480464Tetrachlorodibenzodioxin affects the expression of ACP5 mRNACTDPMID:34747641
ACP5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:20226480464Tetrachlorodibenzodioxin results in decreased expression of ACP5 mRNACTDPMID:32109520
ACP5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:100726480464Tetrachlorodibenzodioxin results in increased expression of ACP5 mRNACTDPMID:17035482|PMID:21041162
ACP5Human2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:1007264804642,2',4,4',5-brominated diphenyl ether affects the expression of ACP5 mRNACTDPMID:38648751
ACP5Human2-aminopurine multiple interactionsISORGD:1007264804642-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of more ...CTDPMID:25739386

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Biological Process
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Original Reference(s)
ACP5Humanbone morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humanbone resorption  ISORGD:20229068941 RGDPMID:20069278|REF_RGD_ID:2315871
ACP5Humanbone resorption acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humanbone resorption involved_inIBAMGI:87883|PANTHER:PTN000017834|RGD:2022150520179 GO_CentralGO_REF:0000033
ACP5Humancellular response to zinc ion starvation  ISORGD:20229068941 RGDPMID:21893222|REF_RGD_ID:151667428
ACP5Humandefense response to Gram-positive bacterium acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humandephosphorylation acts_upstream_of_or_withinISORGD:100729068941 PMID:9308894MGIPMID:9308894
ACP5Humanmulticellular organismal response to stress  ISORGD:20229068941restraintRGDPMID:19113077|REF_RGD_ID:2315906
ACP5Humannegative regulation of cell adhesion  ISORGD:20229068941 RGDPMID:19854170|REF_RGD_ID:2315877
ACP5Humannegative regulation of inflammatory response acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of interleukin-1 beta production acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of interleukin-12 production acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of macrophage cytokine production acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of nitric oxide biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of superoxide anion generation acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannegative regulation of tumor necrosis factor production acts_upstream_of_or_withinIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humannitric oxide biosynthetic process acts_upstream_ofIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humanossification  ISORGD:20229068941 RGDPMID:19403161|REF_RGD_ID:2315903
ACP5Humanosteoclast differentiation  ISORGD:20229068941 RGDPMID:19361364|REF_RGD_ID:2315902
ACP5Humanpositive regulation of cell migration  ISORGD:20229068941 RGDPMID:19854170|REF_RGD_ID:2315877
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Cellular Component

  
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Original Reference(s)
ACP5Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-196950
ACP5Humanextracellular space  ISORGD:20229068941 RGDPMID:20003323|REF_RGD_ID:2315874
ACP5Humanlysosome located_inIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humanlysosome located_inIEAUniProtKB-KW:KW-0458150520179 UniProtGO_REF:0000043
ACP5Humanlysosome located_inIEAUniProtKB-SubCell:SL-0158150520179 UniProtGO_REF:0000044
ACP5Humanmembrane located_inTAS 150520179 PMID:2338077PINCPMID:2338077

Molecular Function
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Original Reference(s)
ACP5Humanacid phosphatase activity  ISORGD:20229068941 RGDPMID:19854170|REF_RGD_ID:2315877
ACP5Humanacid phosphatase activity enablesIBAMGI:87883|PANTHER:PTN004128707|RGD:2022150520179 GO_CentralGO_REF:0000033
ACP5Humanacid phosphatase activity enablesIEAEC:3.1.3.2150520179 UniProtGO_REF:0000003
ACP5Humanacid phosphatase activity enablesIEAUniProtKB:Q05117|ensembl:ENSMUSP00000150903150520179 EnsemblGO_REF:0000107
ACP5Humanacid phosphatase activity enablesIEAUniRule:UR000436752150520179 UniProtGO_REF:0000104
ACP5Humanacid phosphatase activity enablesTAS 150520179 PMID:8359686PINCPMID:8359686
ACP5Humanacid phosphatase activity enablesIEAInterPro:IPR024927150520179 InterProGO_REF:0000002
ACP5Humanferric iron binding enablesIDA 150520179 PMID:15993892UniProtPMID:15993892
ACP5Humanferric iron binding enablesIBAPANTHER:PTN004128707|UniProtKB:P13686150520179 GO_CentralGO_REF:0000033
ACP5Humanferrous iron binding enablesIDA 150520179 PMID:15993892UniProtPMID:15993892
ACP5Humanferrous iron binding enablesIBAPANTHER:PTN004128707|UniProtKB:P13686150520179 GO_CentralGO_REF:0000033
ACP5Humanhydrolase activity  ISORGD:20229068941 RGDPMID:11890682|REF_RGD_ID:619585
ACP5Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
ACP5Humanhydrolase activity enablesIEAInterPro:IPR004843150520179 InterProGO_REF:0000002
ACP5Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
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Imported Annotations - KEGG (archival)

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ACP5Humanrheumatoid arthritis pathway  IEA 6907045 KEGGhsa:05323
ACP5Humanriboflavin metabolic pathway  IEA 6907045 KEGGhsa:00740
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Original Reference(s)
ACP5HumanAbnormal lateral ventricle morphology  IAGP 8699517 HPOORPHA:1855
ACP5HumanAbnormal periventricular white matter morphology  IAGP 8699517 HPOORPHA:1855
ACP5HumanAbnormality of the nervous system  IAGP 8699517 HPOORPHA:1855
ACP5HumanAnti-dsDNA antibody positivity  IAGP 8699517 HPOORPHA:1855
ACP5HumanAntinuclear antibody positivity  IAGP 8699517 HPOMIM:607944|PMID:26951490|ORPHA:1855
ACP5HumanArthritis  IAGP 8699517 HPOORPHA:1855
ACP5HumanAutoimmune hemolytic anemia  IAGP 8699517 HPOORPHA:1855
ACP5HumanAutoimmune thrombocytopenia  IAGP 8699517 HPOMIM:607944|PMID:26951490|ORPHA:1855
ACP5HumanAutoimmunity  IAGP 8699517 HPOMIM:607944|PMID:26951490|ORPHA:1855
ACP5HumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:607944|PMID:2918547
ACP5HumanBarrel-shaped chest  IAGP 8699517 HPOMIM:607944|PMID:2918547
ACP5HumanBowing of the legs  IAGP 8699517 HPOORPHA:1855
ACP5HumanBrain imaging abnormality  IAGP 8699517 HPOORPHA:1855
ACP5HumanCellular immunodeficiency  IAGP 8699517 HPOMIM:607944
ACP5HumanCerebral calcification  IAGP 8699517 HPOMIM:607944|PMID:26951490|ORPHA:1855
ACP5HumanChildhood onset  IAGP 8699517 HPOMIM:607944|PMID:2918547
ACP5HumanChorea  IAGP 8699517 HPOORPHA:1855
ACP5HumanChronic kidney disease  IAGP 8699517 HPOORPHA:1855
ACP5HumanCombined immunodeficiency  IAGP 8699517 HPOMIM:607944
ACP5HumanCongenital onset  IAGP 8699517 HPOMIM:607944|PMID:2918547
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#
Reference Title
Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Hie M, etal., Eur J Pharmacol. 2009 Oct 25;621(1-3):1-9. Epub 2009 Aug 21.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. [Osteosynthesis of the tubular bones using a polymeric pin]. Plakhotin MV, etal., Veterinariia. 1978 Dec;(12):89-90.
8. Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis. Potu BK, etal., Ups J Med Sci. 2009;114(3):140-8.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
12. Microdamage Repair and Remodeling Requires Mechanical Loading. Waldorff EI, etal., J Bone Miner Res. 2009 Oct 12.
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1 to 10 of 10 rows
PMID:1872798   PMID:2334436   PMID:2338077   PMID:2473026   PMID:2610679   PMID:2775236   PMID:2808373   PMID:2909539   PMID:8125298   PMID:8188227   PMID:8195113   PMID:8200916  
PMID:8359686   PMID:8449511   PMID:8889548   PMID:9521821   PMID:10389595   PMID:10862785   PMID:11983200   PMID:12009023   PMID:12073156   PMID:12450668   PMID:12477932   PMID:12589973  
PMID:12820342   PMID:12845688   PMID:12901871   PMID:15342556   PMID:15489334   PMID:15542543   PMID:15701839   PMID:15878315   PMID:15950921   PMID:15993892   PMID:16169070   PMID:16200454  
PMID:16280328   PMID:16620768   PMID:16869970   PMID:17088078   PMID:17207965   PMID:17357281   PMID:17997709   PMID:18053985   PMID:18221403   PMID:18285546   PMID:18320034   PMID:18410226  
PMID:18421493   PMID:18703035   PMID:18979172   PMID:19010793   PMID:19026169   PMID:19765782   PMID:20416078   PMID:20932965   PMID:20967488   PMID:21217752   PMID:21217755   PMID:21300043  
PMID:21386798   PMID:21873635   PMID:21900206   PMID:22335021   PMID:22357739   PMID:22490295   PMID:22517558   PMID:22844067   PMID:23376485   PMID:23383108   PMID:23604121   PMID:23737138  
PMID:23990468   PMID:24706805   PMID:25450682   PMID:25778334   PMID:26186194   PMID:26427154   PMID:26789720   PMID:26854080   PMID:26951490   PMID:27069189   PMID:27089726   PMID:27390188  
PMID:27432908   PMID:27577203   PMID:27718324   PMID:27840329   PMID:28087412   PMID:28398694   PMID:28428481   PMID:28514442   PMID:28532220   PMID:28915803   PMID:30973000   PMID:30995879  
PMID:31531762   PMID:31650885   PMID:31654098   PMID:32521854   PMID:32788631   PMID:33143325   PMID:33222607   PMID:33563875   PMID:33961781   PMID:34535262   PMID:35013220   PMID:35102444  
PMID:36637040   PMID:37010587   PMID:37382551   PMID:38879488  
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ACP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,574,660 - 11,578,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,574,653 - 11,579,993 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,685,475 - 11,689,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,546,477 - 11,549,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,546,476 - 11,549,496NCBI
Celera1911,580,213 - 11,584,539 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,259,840 - 11,264,071 (-)NCBIHuRef
CHM1_11911,685,335 - 11,689,664 (-)NCBICHM1_1
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBIT2T-CHM13v2.0
Acp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39922,038,023 - 22,047,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl922,038,023 - 22,047,007 (-)EnsemblGRCm39 Ensembl
GRCm38922,126,727 - 22,135,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl922,126,727 - 22,135,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,931,171 - 21,940,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,877,148 - 21,881,056 (-)NCBIMGSCv36mm8
Celera919,395,697 - 19,404,716 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.38NCBI
Acp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,939,984 - 28,946,639 (-)NCBIGRCr8
mRatBN7.2820,663,984 - 20,670,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,663,985 - 20,667,929 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,693,289 - 24,698,588 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,990,432 - 22,995,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,893,525 - 20,899,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,142,733 - 23,149,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0823,197,095 - 23,202,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera822,052,728 - 22,058,674 (-)NCBICelera
Cytogenetic Map8q13NCBI
Acp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,418,364 - 2,421,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,418,113 - 2,421,181 (+)NCBIChiLan1.0ChiLan1.0
ACP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,486,997 - 16,495,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,482,421 - 15,489,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01911,120,451 - 11,125,167 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,832,575 - 11,836,881 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,832,575 - 11,835,203 (-)Ensemblpanpan1.1panPan2
ACP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,812,444 - 49,816,262 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,814,032 - 49,816,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,684,989 - 49,687,385 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,330,836 - 50,334,545 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,332,449 - 50,334,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,542,471 - 49,544,878 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,968,636 - 49,971,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,211,593 - 50,213,981 (+)NCBIUU_Cfam_GSD_1.0
Acp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,712,098 - 208,756,454 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,598,177 - 1,600,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,598,252 - 1,642,615 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,206,162 - 70,208,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,206,159 - 70,209,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,615,520 - 70,616,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q21NCBI
ACP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,488,572 - 10,493,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,488,460 - 10,491,519 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,350,068 - 9,354,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,307,635 - 3,310,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,305,913 - 3,309,983 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in ACP5
297 total Variants

1 to 10 of 338 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_001611.5(ACP5):c.266C>T (p.Thr89Ile) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000022705] Chr19:11576839 [GRCh38]
Chr19:11687654 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_001611.5(ACP5):c.667C>T (p.Gln223Ter) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000022706] Chr19:11576311 [GRCh38]
Chr19:11687126 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_001611.5(ACP5):c.791T>A (p.Met264Lys) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000022707] Chr19:11575197 [GRCh38]
Chr19:11686012 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic|uncertain significance
NM_001611.5(ACP5):c.831_833del (p.Tyr278del) deletion Spondyloenchondrodysplasia with immune dysregulation [RCV000022710] Chr19:11575155..11575157 [GRCh38]
Chr19:11685970..11685972 [GRCh37]
Chr19:19p13.2		 pathogenic|uncertain significance
NM_001611.5(ACP5):c.602T>C (p.Leu201Pro) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000022711] Chr19:11576376 [GRCh38]
Chr19:11687191 [GRCh37]
Chr19:19p13.2		 pathogenic|uncertain significance
NM_001611.5(ACP5):c.643G>C (p.Gly215Arg) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000022708] Chr19:11576335 [GRCh38]
Chr19:11687150 [GRCh37]
Chr19:19p13.2		 pathogenic
NM_001611.5(ACP5):c.325G>A (p.Gly109Arg) single nucleotide variant ACP5-related disorder [RCV003421931]|Inborn genetic diseases [RCV000624296]|Spondyloenchondrodysplasia with immune dysregulation [RCV000022709] Chr19:11576780 [GRCh38]
Chr19:11687595 [GRCh37]
Chr19:19p13.2		 pathogenic|likely pathogenic
NM_001611.5(ACP5):c.245A>G (p.Asn82Ser) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000543872] Chr19:11577073 [GRCh38]
Chr19:11687888 [GRCh37]
Chr19:19p13.2		 uncertain significance
NM_001611.5(ACP5):c.276C>T (p.Asp92=) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000560827]|not provided [RCV004717654] Chr19:11576829 [GRCh38]
Chr19:11687644 [GRCh37]
Chr19:19p13.2		 benign
NM_001611.5(ACP5):c.855T>C (p.Thr285=) single nucleotide variant Spondyloenchondrodysplasia with immune dysregulation [RCV000548882]|not provided [RCV001653895] Chr19:11575133 [GRCh38]
Chr19:11685948 [GRCh37]
Chr19:19p13.2		 benign
1 to 10 of 338 rows

Predicted Target Of
Summary Value
Count of predictions:3350
Count of miRNA genes:907
Interacting mature miRNAs:1138
Transcripts:ENST00000218758, ENST00000412435, ENST00000433365, ENST00000588079, ENST00000588524, ENST00000588625, ENST00000589792, ENST00000590420, ENST00000590832, ENST00000591319, ENST00000592659, ENST00000592828
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298499UAE1_HUrinary albumin excretion QTL 1 (human)2.730.0009Urinary albumin excretionurine albumin:creatinine ratio (ACR)19116075902Human
1300034BP50_HBlood pressure QTL 50 (human)2.10.00094Blood pressuresystolic191108946337089463Human
1643451SLIPL6_HSerum lipid level QTL 6 (human)2.190.0008Lipid level19116075902Human
597284347GWAS1380421_Htartrate-resistant acid phosphatase type 5 measurement QTL GWAS1380421 (human)5e-08tartrate-resistant acid phosphatase type 5 measurement191157738511577386Human
1581534BP76_HBlood pressure QTL 76 (human)20.001Blood pressurepulse pressure19116075902Human
1581535BP65_HBlood pressure QTL 65 (human)3.10.001Blood pressurepulse pressure19116075902Human
597398316GWAS1494390_Htartrate-resistant acid phosphatase type 5 measurement QTL GWAS1494390 (human)2e-21tartrate-resistant acid phosphatase type 5 measurement191157638011576381Human
597322273GWAS1418347_Htartrate-resistant acid phosphatase type 5 measurement QTL GWAS1418347 (human)4e-19tartrate-resistant acid phosphatase type 5 measurement191157738511577386Human
2314591INSUL4_HInsulin level QTL 4 (human)3.80.000038Insulin levelfasting19116075902Human
1298476BP3_HBlood pressure QTL 3 (human)2.4Blood pressuresystolic19116075902Human

1 to 10 of 10 rows
RH93921  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371911,685,780 - 11,685,958UniSTSGRCh37
Build 361911,546,780 - 11,546,958RGDNCBI36
Celera1911,580,518 - 11,580,696RGD
Cytogenetic Map19p13.2UniSTS
HuRef1911,260,145 - 11,260,323UniSTS
GeneMap99-GB4 RH Map1973.59UniSTS
G06617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371911,685,482 - 11,685,820UniSTSGRCh37
Build 361911,546,482 - 11,546,820RGDNCBI36
Celera1911,580,220 - 11,580,558RGD
Cytogenetic Map19p13.2UniSTS
HuRef1911,259,847 - 11,260,185UniSTS
G10515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371911,685,521 - 11,685,704UniSTSGRCh37
Build 361911,546,521 - 11,546,704RGDNCBI36
Celera1911,580,259 - 11,580,442RGD
Cytogenetic Map19p13.2UniSTS
HuRef1911,259,886 - 11,260,069UniSTS
ACP5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371911,687,076 - 11,687,401UniSTSGRCh37
Build 361911,548,076 - 11,548,401RGDNCBI36
Celera1911,581,814 - 11,582,139RGD
HuRef1911,261,346 - 11,261,671UniSTS
ACP5__4244  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371911,685,440 - 11,686,069UniSTSGRCh37
Build 361911,546,440 - 11,547,069RGDNCBI36
Celera1911,580,178 - 11,580,807RGD
HuRef1911,259,805 - 11,260,434UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2417 2787 2243 4941 1721 2324 5 621 1922 462 2266 7242 6433 47 3706 1 844 1719 1593 173 1


1 to 30 of 38 rows
RefSeq Transcripts NG_028127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005259938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011528069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC020947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI755033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM708166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP334409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP367008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX365007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB775570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 38 rows

Ensembl Acc Id: ENST00000218758   ⟹   ENSP00000218758
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,579,107 (-)Ensembl
Ensembl Acc Id: ENST00000412435   ⟹   ENSP00000392374
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,579,030 (-)Ensembl
Ensembl Acc Id: ENST00000588079
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,576,840 - 11,577,700 (-)Ensembl
Ensembl Acc Id: ENST00000588524
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,976 (-)Ensembl
Ensembl Acc Id: ENST00000588625
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,576,379 - 11,577,317 (-)Ensembl
Ensembl Acc Id: ENST00000589792   ⟹   ENSP00000468685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,963 (-)Ensembl
Ensembl Acc Id: ENST00000590420   ⟹   ENSP00000468509
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,575,000 - 11,577,632 (-)Ensembl
Ensembl Acc Id: ENST00000590832   ⟹   ENSP00000465127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,577,527 (-)Ensembl
Ensembl Acc Id: ENST00000591319   ⟹   ENSP00000464831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,579,008 (-)Ensembl
Ensembl Acc Id: ENST00000592659   ⟹   ENSP00000465498
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,954 (-)Ensembl
Ensembl Acc Id: ENST00000592828   ⟹   ENSP00000468767
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,653 - 11,578,987 (-)Ensembl
Ensembl Acc Id: ENST00000648477   ⟹   ENSP00000496973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,577,645 (-)Ensembl
Ensembl Acc Id: ENST00000649386   ⟹   ENSP00000497140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,988 (-)Ensembl
Ensembl Acc Id: ENST00000695791   ⟹   ENSP00000512173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,786 (-)Ensembl
Ensembl Acc Id: ENST00000695809   ⟹   ENSP00000512189
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,961 (-)Ensembl
Ensembl Acc Id: ENST00000695810   ⟹   ENSP00000512190
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,961 (-)Ensembl
Ensembl Acc Id: ENST00000695811   ⟹   ENSP00000512191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,981 (-)Ensembl
Ensembl Acc Id: ENST00000695812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,981 (-)Ensembl
Ensembl Acc Id: ENST00000695813   ⟹   ENSP00000512192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,982 (-)Ensembl
Ensembl Acc Id: ENST00000695814   ⟹   ENSP00000512193
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,982 (-)Ensembl
Ensembl Acc Id: ENST00000695815   ⟹   ENSP00000512194
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,990 (-)Ensembl
Ensembl Acc Id: ENST00000695816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,672 - 11,578,971 (-)Ensembl
Ensembl Acc Id: ENST00000695817   ⟹   ENSP00000512195
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,742 - 11,578,970 (-)Ensembl
Ensembl Acc Id: ENST00000695818   ⟹   ENSP00000512196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,767 - 11,579,993 (-)Ensembl
Ensembl Acc Id: ENST00000695819
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,820 - 11,578,975 (-)Ensembl
Ensembl Acc Id: ENST00000695820   ⟹   ENSP00000512198
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,963 (-)Ensembl
Ensembl Acc Id: ENST00000695821   ⟹   ENSP00000512199
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,753 - 11,578,954 (-)Ensembl
Ensembl Acc Id: ENST00000695838
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1911,574,660 - 11,578,953 (-)Ensembl
RefSeq Acc Id: NM_001111034   ⟹   NP_001104504
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,740 (-)NCBI
GRCh371911,685,475 - 11,689,801 (-)ENTREZGENE
HuRef1911,259,840 - 11,264,071 (-)ENTREZGENE
CHM1_11911,685,335 - 11,689,458 (-)NCBI
T2T-CHM13v2.01911,702,190 - 11,706,270 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001111035   ⟹   NP_001104505
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
GRCh371911,685,475 - 11,689,801 (-)ENTREZGENE
HuRef1911,259,840 - 11,264,071 (-)ENTREZGENE
CHM1_11911,685,335 - 11,689,686 (-)NCBI
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001111036   ⟹   NP_001104506
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
GRCh371911,685,475 - 11,689,801 (-)ENTREZGENE
HuRef1911,259,840 - 11,264,071 (-)ENTREZGENE
CHM1_11911,685,335 - 11,689,686 (-)NCBI
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322023   ⟹   NP_001308952
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,257 (-)NCBI
CHM1_11911,685,335 - 11,688,872 (-)NCBI
T2T-CHM13v2.01911,702,190 - 11,705,787 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001611   ⟹   NP_001602
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,577,645 (-)NCBI
GRCh371911,685,475 - 11,689,801 (-)ENTREZGENE
Build 361911,546,477 - 11,549,496 (-)NCBI Archive
HuRef1911,259,840 - 11,264,071 (-)ENTREZGENE
CHM1_11911,685,335 - 11,688,419 (-)NCBI
T2T-CHM13v2.01911,702,190 - 11,705,175 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005259938   ⟹   XP_005259995
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
GRCh371911,685,475 - 11,689,801 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011528069   ⟹   XP_011526371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047438944   ⟹   XP_047294900
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
RefSeq Acc Id: XM_047438945   ⟹   XP_047294901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,574,660 - 11,578,975 (-)NCBI
RefSeq Acc Id: XM_054321228   ⟹   XP_054177203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
RefSeq Acc Id: XM_054321229   ⟹   XP_054177204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
RefSeq Acc Id: XM_054321230   ⟹   XP_054177205
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
RefSeq Acc Id: XM_054321231   ⟹   XP_054177206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBI
1 to 30 of 48 rows
Protein RefSeqs NP_001104504 (Get FASTA)   NCBI Sequence Viewer  
  NP_001104505 (Get FASTA)   NCBI Sequence Viewer  
  NP_001104506 (Get FASTA)   NCBI Sequence Viewer  
  NP_001308952 (Get FASTA)   NCBI Sequence Viewer  
  NP_001602 (Get FASTA)   NCBI Sequence Viewer  
  XP_005259995 (Get FASTA)   NCBI Sequence Viewer  
  XP_011526371 (Get FASTA)   NCBI Sequence Viewer  
  XP_047294900 (Get FASTA)   NCBI Sequence Viewer  
  XP_047294901 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177203 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177204 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177205 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA76849 (Get FASTA)   NCBI Sequence Viewer  
  AAH25414 (Get FASTA)   NCBI Sequence Viewer  
  AAI11015 (Get FASTA)   NCBI Sequence Viewer  
  BAF83406 (Get FASTA)   NCBI Sequence Viewer  
  CAA32771 (Get FASTA)   NCBI Sequence Viewer  
  CAG33359 (Get FASTA)   NCBI Sequence Viewer  
  CAV30742 (Get FASTA)   NCBI Sequence Viewer  
  EAW84232 (Get FASTA)   NCBI Sequence Viewer  
  EAW84233 (Get FASTA)   NCBI Sequence Viewer  
  EAW84234 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000218758
  ENSP00000218758.4
  ENSP00000392374
  ENSP00000392374.1
  ENSP00000464831.2
  ENSP00000465127.2
  ENSP00000465498.2
1 to 30 of 48 rows
1 to 5 of 34 rows
1 to 5 of 34 rows
RefSeq Acc Id: NP_001104506   ⟸   NM_001111036
- Peptide Label: precursor
- UniProtKB: Q9UCJ6 (UniProtKB/Swiss-Prot),   Q9UCJ5 (UniProtKB/Swiss-Prot),   Q6IAS6 (UniProtKB/Swiss-Prot),   Q2TAB1 (UniProtKB/Swiss-Prot),   A8K3V2 (UniProtKB/Swiss-Prot),   Q9UCJ7 (UniProtKB/Swiss-Prot),   P13686 (UniProtKB/Swiss-Prot),   A0A8Q3SI79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104505   ⟸   NM_001111035
- Peptide Label: precursor
- UniProtKB: Q9UCJ6 (UniProtKB/Swiss-Prot),   Q9UCJ5 (UniProtKB/Swiss-Prot),   Q6IAS6 (UniProtKB/Swiss-Prot),   Q2TAB1 (UniProtKB/Swiss-Prot),   A8K3V2 (UniProtKB/Swiss-Prot),   Q9UCJ7 (UniProtKB/Swiss-Prot),   P13686 (UniProtKB/Swiss-Prot),   A0A8Q3SI79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104504   ⟸   NM_001111034
- Peptide Label: precursor
- UniProtKB: Q9UCJ6 (UniProtKB/Swiss-Prot),   Q9UCJ5 (UniProtKB/Swiss-Prot),   Q6IAS6 (UniProtKB/Swiss-Prot),   Q2TAB1 (UniProtKB/Swiss-Prot),   A8K3V2 (UniProtKB/Swiss-Prot),   Q9UCJ7 (UniProtKB/Swiss-Prot),   P13686 (UniProtKB/Swiss-Prot),   A0A8Q3SI79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001602   ⟸   NM_001611
- Peptide Label: precursor
- UniProtKB: Q9UCJ6 (UniProtKB/Swiss-Prot),   Q9UCJ5 (UniProtKB/Swiss-Prot),   Q6IAS6 (UniProtKB/Swiss-Prot),   Q2TAB1 (UniProtKB/Swiss-Prot),   A8K3V2 (UniProtKB/Swiss-Prot),   Q9UCJ7 (UniProtKB/Swiss-Prot),   P13686 (UniProtKB/Swiss-Prot),   A0A8Q3SI79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005259995   ⟸   XM_005259938
- Peptide Label: isoform X1
- UniProtKB: Q9UCJ6 (UniProtKB/Swiss-Prot),   Q9UCJ5 (UniProtKB/Swiss-Prot),   Q6IAS6 (UniProtKB/Swiss-Prot),   Q2TAB1 (UniProtKB/Swiss-Prot),   A8K3V2 (UniProtKB/Swiss-Prot),   Q9UCJ7 (UniProtKB/Swiss-Prot),   P13686 (UniProtKB/Swiss-Prot),   A0A8Q3SI79 (UniProtKB/TrEMBL)
- Sequence:
Calcineurin-like phosphoesterase

Name Modeler Protein Id AA Range Protein Structure
AF-P13686-F1-model_v2 AlphaFold P13686 1-325 view protein structure

RGD ID:6795100
Promoter ID:HG_KWN:28934
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   K562,   Lymphoblastoid
Transcripts:NM_001111034,   NM_001111035,   NM_001111036,   UC010DYE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361911,550,399 - 11,550,899 (-)MPROMDB
RGD ID:7238623
Promoter ID:EPDNEW_H25058
Type:initiation region
Name:ACP5_1
Description:acid phosphatase 5, tartrate resistant
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25059  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,577,645 - 11,577,705EPDNEW
RGD ID:7238625
Promoter ID:EPDNEW_H25059
Type:initiation region
Name:ACP5_2
Description:acid phosphatase 5, tartrate resistant
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25058  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381911,578,974 - 11,579,034EPDNEW


1 to 40 of 59 rows
Database
Acc Id
Source(s)
COSMIC ACP5 COSMIC
Ensembl Genes ENSG00000102575 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000218758 ENTREZGENE
  ENST00000218758.10 UniProtKB/Swiss-Prot
  ENST00000412435 ENTREZGENE
  ENST00000412435.7 UniProtKB/Swiss-Prot
  ENST00000589792.6 UniProtKB/Swiss-Prot
  ENST00000590832.2 UniProtKB/Swiss-Prot
  ENST00000591319.2 UniProtKB/Swiss-Prot
  ENST00000592659.2 UniProtKB/Swiss-Prot
  ENST00000592828 ENTREZGENE
  ENST00000592828.7 UniProtKB/Swiss-Prot
  ENST00000648477 ENTREZGENE
  ENST00000648477.1 UniProtKB/Swiss-Prot
  ENST00000649386 ENTREZGENE
  ENST00000649386.2 UniProtKB/Swiss-Prot
  ENST00000695791 ENTREZGENE
  ENST00000695791.1 UniProtKB/Swiss-Prot
  ENST00000695811 ENTREZGENE
  ENST00000695811.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
GTEx ENSG00000102575 GTEx
HGNC ID HGNC:124 ENTREZGENE
Human Proteome Map ACP5 Human Proteome Map
InterPro Acid_PPase UniProtKB/Swiss-Prot
  Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  Metallophosphoesterase_PAP UniProtKB/Swiss-Prot
KEGG Report hsa:54 UniProtKB/Swiss-Prot
NCBI Gene 54 ENTREZGENE
OMIM 171640 OMIM
PANTHER TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/Swiss-Prot
  TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
PharmGKB PA24448 PharmGKB
PIRSF Acid_Ptase_5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A3B3IS75_HUMAN UniProtKB/TrEMBL
  A0A8Q3SI79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8Q3WKS0_HUMAN UniProtKB/TrEMBL
1 to 40 of 59 rows