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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2022
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acp5
Name: acid phosphatase 5, tartrate resistant
Acc ID: CHEBI:31859
Term: modafinil
Definition: A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
Chemical ID: MESH:C048833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acp5increases expressionEXP 6480464CTDmodafinil results in increased expression of ACP5 mRNA; modafinil results in increased expression of ACP5 proteinPMID:29649498
Acp5multiple interactionsEXP 6480464CTDAlendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]PMID:29649498
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