Psen2 (presenilin 2) - Rat Genome Database

Name: Psen2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Psen2 (presenilin 2) Rattus norvegicus

Analyze

Symbol:

Psen2

Name:

presenilin 2

RGD ID:

621060

Description:

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Involved in response to hypoxia. Located in early endosome; synaptic membrane; and synaptic vesicle. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2); PARTICIPATES IN altered Notch signaling pathway involving the macromolecules modifying the main players; Alzheimer's disease pathway; Notch signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

presenilin-2; PS-2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PSEN2 (presenilin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):	Psen2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Psen2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PSEN2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PSEN2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Psen2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PSEN2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PSEN2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Psen2 (presenilin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PSEN2 (presenilin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Psen2 (presenilin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psen2 (presenilin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Psn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sel-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	psen2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	91,967,506 - 91,993,240 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,967,983 - 91,993,174 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,473,112 - 94,489,800 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,873,282 - 95,889,973 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	93,047,983 - 93,064,680 (-)	NCBI	Rnor_WKY
Rnor_6.0	13	98,513,600 - 98,539,347 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,513,570 - 98,530,724 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,934,674 - 95,951,836 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,123,177 - 96,145,989 (-)	NCBI
Celera	13	91,515,731 - 91,532,398 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Alzheimer's disease 4 (ISO)

asphyxia neonatorum (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

COVID-19 (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1V (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Huntington's Disease-Like Syndrome (ISO)

parathyroid carcinoma (ISO)

pulmonary fibrosis (ISO)

Pulmonary Hemorrhage (ISO)

thrombophilia due to thrombin defect (ISO)

vascular dementia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-naringenin (ISO)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

aldrin (ISO)

aminoguanidine (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

calcium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

cycloheximide (ISO)

D-glucose (ISO)

deguelin (ISO)

dibutyl phthalate (EXP)

diethyldithiocarbamic acid (ISO)

dioxygen (EXP)

doxorubicin (ISO)

enzalutamide (ISO)

epoxiconazole (ISO)

flutamide (EXP)

fucoxanthin (ISO)

genistein (EXP)

gentamycin (EXP)

glucose (ISO)

glyphosate (ISO)

lipopolysaccharide (ISO)

N-methyl-4-phenylpyridinium (ISO)

nimesulide (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

prostaglandin E2 (ISO)

quercetin (ISO)

resveratrol (ISO)

retinyl acetate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sarin (ISO)

scopolamine (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium azide (ISO)

staurosporine (ISO)

taurine (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid precursor protein catabolic process (IBA,ISO)

amyloid-beta formation (ISO)

amyloid-beta metabolic process (IBA,ISO)

apoptotic signaling pathway (ISO)

brain morphogenesis (ISO)

calcium ion transport (IBA,ISO)

cardiac muscle contraction (ISO)

cell fate specification (ISO)

dorsal/ventral neural tube patterning (ISO)

embryonic limb morphogenesis (ISO)

endoplasmic reticulum calcium ion homeostasis (ISO)

forebrain development (ISO)

hair follicle development (ISO)

hematopoietic progenitor cell differentiation (ISO)

intracellular signal transduction (IEA)

learning or memory (ISO)

locomotion (ISO)

lung alveolus development (ISO)

membrane protein ectodomain proteolysis (IBA,ISO)

memory (ISO)

mitochondrion-endoplasmic reticulum membrane tethering (ISO)

myeloid leukocyte differentiation (ISO)

negative regulation of apoptotic process (IBA)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of epidermal growth factor-activated receptor activity (ISO)

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO)

negative regulation of protein binding (ISO)

negative regulation of protein phosphorylation (ISO)

negative regulation of protein-containing complex assembly (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of ubiquitin-dependent protein catabolic process (ISO)

negative regulation of ubiquitin-protein transferase activity (ISO)

neuroinflammatory response (ISO)

neuron cellular homeostasis (ISO)

Notch receptor processing (IBA)

Notch signaling pathway (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of catalytic activity (ISO)

positive regulation of coagulation (ISO)

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of receptor recycling (ISO)

protein catabolic process at postsynapse (ISO)

protein maturation (ISO)

protein metabolic process (ISO)

protein processing (ISO)

protein transport (ISO)

regulation of calcium import into the mitochondrion (ISO)

regulation of epidermal growth factor-activated receptor activity (ISO)

regulation of postsynapse organization (ISO)

regulation of protein binding (ISO)

regulation of synaptic plasticity (ISO)

response to hypoxia (IEP)

skin morphogenesis (ISO)

somitogenesis (ISO)

T cell activation involved in immune response (ISO)

T cell receptor signaling pathway (ISO)

thymus development (ISO)

Cellular Component

apical plasma membrane (IBA)

cell cortex (IBA)

cell surface (IBA)

centrosome (ISO)

ciliary basal body (ISO)

ciliary rootlet (IBA)

cytosol (ISO)

dendritic shaft (IBA)

early endosome (IDA)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

gamma-secretase complex (ISO)

glutamatergic synapse (ISO)

Golgi apparatus (ISO)

Golgi membrane (IEA)

growth cone (IBA)

kinetochore (ISO)

lysosomal membrane (IBA)

membrane (ISO)

membrane raft (IBA)

mitochondrial inner membrane (IBA)

neuromuscular junction (IBA)

neuronal cell body (IBA,ISO)

nuclear inner membrane (ISO)

nucleus (IBA)

perinuclear region of cytoplasm (IBA)

plasma membrane (ISO)

postsynapse (IEA)

presynaptic membrane (IDA,IEP)

protein-containing complex (ISO)

synaptic membrane (IDA)

synaptic vesicle (IDA)

Z disc (IBA,ISO)

Molecular Function

aspartic endopeptidase activity, intramembrane cleaving (ISO)

endopeptidase activity (IBA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Notch signaling pathway involving the macromolecules modifying the main players (ISO)

Alzheimer's disease pathway (IEA,ISO)

neurotrophic factor signaling pathway (IEA)

Notch signaling pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The role of presenilin 1 in the genetics of Alzheimer's disease.	Clark RF, etal., Cold Spring Harb Symp Quant Biol 1996;61:551-8.
2.	Cell and molecular biology of Notch.	Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3.	Purification and characterization of the human gamma-secretase complex.	Fraering PC, etal., Biochemistry 2004 Aug 3;43(30):9774-89.
4.	Synaptic and endosomal localization of active gamma-secretase in rat brain.	Frykman S, etal., PLoS One. 2010 Jan 28;5(1):e8948. doi: 10.1371/journal.pone.0008948.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.	Herreman A, etal., Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11872-7.
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.	Lee SF, etal., J Biol Chem 2002 Nov 22;277(47):45013-9. Epub 2002 Sep 23.
9.	Familial Alzheimer's disease: site of mutation influences clinical phenotype.	Lippa CF, etal., Ann Neurol. 2000 Sep;48(3):376-9.
10.	Uncommon polymorphism in the presenilin genes in human familial Alzheimer's disease: not to be mistaken with a pathogenic mutation.	Lleo A, etal., Neurosci Lett 2002 Feb 1;318(3):166-8.
11.	Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.	Marambaud P, etal., Biochem Biophys Res Commun 1998 Nov 9;252(1):134-8.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Presenilins in the heart: presenilin-2 expression is increased by low glucose and by hypoxia in cardiac cells.	Mohuczy D, etal., Regul Pept 2002 Dec 31;110(1):1-7.
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22.	Cloning of cDNA and expression of the gene encoding rat presenilin-2.	Takahashi H, etal., Gene 1997 Sep 15;197(1-2):383-7.
23.	Cloning of the cDNA encoding rat presenilin-2.	Tanahashi H and Tabira T, Biochim Biophys Acta 1998 Mar 13;1396(3):259-62.
24.	Functional characterization of novel presenilin-2 variants identified in human breast cancers.	To MD, etal., Oncogene. 2006 Jun 15;25(25):3557-64. Epub 2006 Feb 13.
25.	Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.	Wolozin B, etal., Science 1996 Dec 6;274(5293):1710-3.

Additional References at PubMed

PMID:8940094	PMID:9203550	PMID:9298903	PMID:9353287	PMID:9535056	PMID:9632714	PMID:9950750	PMID:10557208	PMID:10846187	PMID:11943765	PMID:12460542	PMID:12646573
PMID:12684521	PMID:15066262	PMID:15122901	PMID:15148382	PMID:15280425	PMID:15489334	PMID:15525534	PMID:15886206	PMID:16169548	PMID:16204356	PMID:16257512	PMID:16603547
PMID:17097608	PMID:17418105	PMID:17556541	PMID:17614943	PMID:17626841	PMID:17698590	PMID:17920016	PMID:19376115	PMID:19779553	PMID:19946888	PMID:20208556	PMID:21285369
PMID:21703454	PMID:25429133	PMID:26721367	PMID:27804997

Genomics

Comparative Map Data

Psen2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	91,967,506 - 91,993,240 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	91,967,983 - 91,993,174 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,473,112 - 94,489,800 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	95,873,282 - 95,889,973 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	93,047,983 - 93,064,680 (-)	NCBI	Rnor_WKY
Rnor_6.0	13	98,513,600 - 98,539,347 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,513,570 - 98,530,724 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	95,934,674 - 95,951,836 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,123,177 - 96,145,989 (-)	NCBI
Celera	13	91,515,731 - 91,532,398 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

PSEN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	226,870,616 - 226,903,668 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	226,870,184 - 226,927,726 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	227,058,317 - 227,083,799 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	225,124,896 - 225,150,427 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	223,365,694 - 223,390,532	NCBI
Celera	1	200,249,068 - 200,274,610 (+)	NCBI		Celera
Cytogenetic Map	1	q42.13	NCBI
HuRef	1	197,575,178 - 197,600,711 (+)	NCBI		HuRef
CHM1_1	1	228,331,030 - 228,356,564 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	226,058,503 - 226,091,743 (+)	NCBI		T2T-CHM13v2.0

Psen2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,054,569 - 180,091,030 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,054,569 - 180,091,003 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	180,227,004 - 180,263,467 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,227,004 - 180,263,438 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,157,135 - 182,186,431 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,063,681 - 182,082,576 (-)	NCBI		MGSCv36	mm8
Celera	1	187,291,668 - 187,320,266 (-)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.19	NCBI

Psen2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	5,727,367 - 5,752,234 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	5,727,367 - 5,748,798 (+)	NCBI	ChiLan1.0	ChiLan1.0

PSEN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	22,592,732 - 22,618,185 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	202,328,987 - 202,354,440 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	207,320,937 - 207,346,295 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	207,320,937 - 207,346,295 (+)	Ensembl	panpan1.1		panPan2

PSEN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,147,157 - 38,163,023 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	38,147,173 - 38,166,722 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	37,629,753 - 37,654,335 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	37,981,322 - 38,006,377 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	37,980,700 - 38,006,369 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	37,820,678 - 37,845,261 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	37,827,826 - 37,852,402 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,098,241 - 38,122,853 (-)	NCBI		UU_Cfam_GSD_1.0

Psen2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	51,135,578 - 51,163,137 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	3,584,188 - 3,614,074 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936526	3,584,194 - 3,611,719 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSEN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,532,767 - 14,577,251 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,532,556 - 14,561,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,862,708 - 16,891,775 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	10	p16-p11	NCBI

PSEN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	2,862,354 - 2,888,735 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	2,862,251 - 2,877,386 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	2,849,316 - 2,875,698 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psen2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624771	17,183,447 - 17,224,188 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624771	17,183,538 - 17,205,460 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Psen2
73 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	40
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000040203
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Markers in Region

RH142771

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	91,986,573 - 91,986,728 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	98,532,666 - 98,532,820	NCBI	Rnor6.0
Rnor_5.0	13	103,540,526 - 103,540,680	UniSTS	Rnor5.0
RGSC_v3.4	13	95,953,778 - 95,953,932	UniSTS	RGSC3.4
Celera	13	91,534,340 - 91,534,494	UniSTS
RH 3.4 Map	13	617.2	UniSTS
Cytogenetic Map	13	q26	UniSTS

RH140726

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	91,967,785 - 91,967,913 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	98,513,880 - 98,514,007	NCBI	Rnor6.0
Rnor_5.0	13	103,521,740 - 103,521,867	UniSTS	Rnor5.0
RGSC_v3.4	13	95,934,520 - 95,934,647	UniSTS	RGSC3.4
Celera	13	91,515,577 - 91,515,704	UniSTS
RH 3.4 Map	13	630.9	UniSTS
Cytogenetic Map	13	q26	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	39	49	41	13	41			53	28	31	11
Low	1	4	8		6		8	11	21	7	10		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB004454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC139413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D83700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000040203 ⟹ ENSRNOP00000049605

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	91,967,983 - 91,993,174 (-)	Ensembl
Rnor_6.0 Ensembl	13	98,514,034 - 98,530,724 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091715 ⟹ ENSRNOP00000070964

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	98,513,570 - 98,529,040 (-)	Ensembl

RefSeq Acc Id:

NM_031087 ⟹ NP_112349

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,940 - 91,984,632 (-)	NCBI
Rnor_6.0	13	98,514,034 - 98,530,724 (-)	NCBI
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI
RGSC_v3.4	13	95,934,674 - 95,951,836 (-)	RGD
Celera	13	91,515,731 - 91,532,398 (-)	RGD

Sequence:

show sequence

GTGACTGACAGCTGCGTCAAGCTCCTCCCACCGTGAGGCGCCTGTCTGATGAGCTGAGAGCCAG
AATAAACTCTGGAACGGTGTTGTCGCTGAGACCATGCTCACATTCATGGCCTCTGATAGCGAGG
AAGAGGTGTGCGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCTACATCACGTTCCTGCCA
GGACAGCAGGCCAGGCCCAGAGGATGGAGAGAACACTGCCCAGTGGAGGAGCCAGGAGAACGAG
GACGACTGTGAGGAGGACCCGGACCACTATGCCTGCAGTGGGGTTCCTGGGCGACCATCGGGCC
TGGAGGAGGAGCTGACCCTCAAGTATGGGGCGAAGCACGTGATCATGCTGTTCGTGCCTGTCAC
GCTGTGCATGATTGTGGTGGTGGCCACCATCAAGTCCGTGCGTTTCTACACGGAGAAGAACGGG
CAGCTCATCTACACGCCCTTCACCGAGGACACACCCTCTGTGGGCCAGCGGCTCCTCAACTCCG
TGCTGAACACTCTGATCATGATCAGCGTCATTGTGGTCATGACTATCTTCCTAGTGGTACTCTA
CAAATATCGCTGTTACAAGTTCATCCATGGCTGGCTGATCATGTCCTCCCTGATGCTCCTCTTC
TTGTTCACCTACATCTACCTCGGGGAAGTGTTCAAGACCTACAATGTGGCCATGGACTACCCCA
CACTGTTCCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGGAAGGGTCC
CCTGGTGCTCCAGCAGGCTTACCTCATTGTGATCAGCGCACTCATGGCCCTGGTGTTCATCAAG
TACCTGCCGGAGTGGTCCGCTTGGGTCATCTTGGGCGCCATCTCTGTGTACGATCTCGTGGCTG
TGCTGTGCCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAAAGAAACGAGCCCAT
ATTTCCTGCCCTCATATACTCATCTGCCATGGTGTGGACGGTAGGCATGGCGAAGCTGGACCCC
TCCTCTCAGGGAGCACTGCAGCTCCCTTACGATCCAGAGATGGAAGAAGACTCCTATGACAGTT
TTGGGGAACCCTCATACCCTGAAGCCTTCGAAGCTCCCCAGCCTGGCTACCCAGGGGAAGAGCC
GGAGGAGGAGGAGGAAAGGGGTGTAAAGCTTGGTCTGGGAGACTTCATCTTCTACAGCGTTCTG
GTGGGCAAGGCAGCAGCCACAGGCAACGGAGACTGGAGCACGACGCTGGCCTGCTTTATCGCCA
TCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCTCGCCGTGTTCAAGAAGGCCCTGCCCGCCCT
CCCCATCTCCATCACCTTCGGGCTCATCTTTTACTTCTCCACAGACAACCTGGTGCGTCCTTTC
ATGGACACGTTGGCCTCCCACCAGCTCTACATCTGACAGAAGAGCTGCGGCTCTGAGAGCTGTA
GGACGCTTCGCCGAATGCAGGTGTATAGTTTTACACTCTAGTGCCATATATTTTTTTTTAAAAA
AACCTTTCTTTCCTTACAAAAGAAAAAAAAAGAATAAAAAAGTGTTGTGTTTACTTCGAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006250405 ⟹ XP_006250467

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,993,170 (-)	NCBI
Rnor_6.0	13	98,513,600 - 98,539,331 (-)	NCBI
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI

Sequence:

show sequence

GAACCGGGGCAGTGGGCGGGGCCGGCGCTAGCCTGGGAGAGGCGCTCCGTCCGCGGCGTAAACT
CTATCCCGCGCCGCGGCGGAGCAGTTGCTGTCTGACCAGGTCCTGTGTCCTGGAGTAAGGGCTG
CACGGTTTACACCTTCATCCCTACGGTCACAAGAGTGGGAGGCGCACTGGGTGAGATGTGACTG
ACAGCTGCGTCAAGCTCCTCCCACCGTGAGGCGCCTGTCTGATGAGCTGAGAGCCAGAATAAAC
TCTGGAACGGTGTTGTCGCTGAGACCATGCTCACATTCATGGCCTCTGATAGCGAGGAAGAGGT
GTGCGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCTACATCACGTTCCTGCCAGGACAGC
AGGCCAGGCCCAGAGGATGGAGAGAACACTGCCCAGTGGAGGAGCCAGGAGAACGAGGACGACT
GTGAGGAGGACCCGGACCACTATGCCTGCAGTGGGGTTCCTGGGCGACCATCGGGCCTGGAGGA
GGAGCTGACCCTCAAGTATGGGGCGAAGCACGTGATCATGCTGTTCGTGCCTGTCACGCTGTGC
ATGATTGTGGTGGTGGCCACCATCAAGTCCGTGCGTTTCTACACGGAGAAGAACGGGCAGCTCA
TCTACACGCCCTTCACCGAGGACACACCCTCTGTGGGCCAGCGGCTCCTCAACTCCGTGCTGAA
CACTCTGATCATGATCAGCGTCATTGTGGTCATGACTATCTTCCTAGTGGTACTCTACAAATAT
CGCTGTTACAAGTTCATCCATGGCTGGCTGATCATGTCCTCCCTGATGCTCCTCTTCTTGTTCA
CCTACATCTACCTCGGGGAAGTGTTCAAGACCTACAATGTGGCCATGGACTACCCCACACTGTT
CCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGGAAGGGTCCCCTGGTG
CTCCAGCAGGCTTACCTCATTGTGATCAGCGCACTCATGGCCCTGGTGTTCATCAAGTACCTGC
CGGAGTGGTCCGCTTGGGTCATCTTGGGCGCCATCTCTGTGTACGATCTCGTGGCTGTGCTGTG
CCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAAAGAAACGAGCCCATATTTCCT
GCCCTCATATACTCATCTGCCATGGTGTGGACGGTAGGCATGGCGAAGCTGGACCCCTCCTCTC
AGGGAGCACTGCAGCTCCCTTACGATCCAGAGATGGAAGAAGACTCCTATGACAGTTTTGGGGA
ACCCTCATACCCTGAAGCCTTCGAAGCTCCCCAGCCTGGCTACCCAGGGGAAGAGCCGGAGGAG
GAGGAGGAAAGGGGTGTAAAGCTTGGTCTGGGAGACTTCATCTTCTACAGCGTTCTGGTGGGCA
AGGCAGCAGCCACAGGCAACGGAGACTGGAGCACGACGCTGGCCTGCTTTATCGCCATCCTCAT
TGGCTTGTGTCTCACCCTCCTGCTGCTCGCCGTGTTCAAGAAGGCCCTGCCCGCCCTCCCCATC
TCCATCACCTTCGGGCTCATCTTTTACTTCTCCACAGACAACCTGGTGCGTCCTTTCATGGACA
CGTTGGCCTCCCACCAGCTCTACATCTGACAGAAGAGCTGCGGCTCTGAGAGCTGTAGGACGCT
TCGCCGAATGCAGGTGTATAGTTTTACACTCTAGTGCCATATATTTTTTTTTAAAAAAACCTTT
CTTTCCTTACAAAAGAAAAAAAAAGAATAAAAAAGTGTTGTGTTTACTTCGTGACGAGGAAGCA
GAAGCCGCCCTTCTGTGCTAGCTGTCTTGTCACCAGACTGAGGCTTGCCCGTCAGAGCATCTGT
GGCACCCGCAGGTGGGATGCTGGGCCAACAAGCCTATCTTCAGGGATGAGGTCACGTGTGTGGA
TCAGGTTGGAGAGGACGCAGGCCCCATCCAGGTCTGTAATCAATCCTTCAGGGCTGAGCAGGAG
GAACATGTGCGTCAGTGGGGACCAGGAGGCACGGTCAGGAAGGACGCTAAGCACCAACACCCTG
ACCAGAGGACAAAAGCCAGTTTGTCGTCATGAATGCCCCCAGTGCTTTGTTTGTGATGTCTGTT
ACCTTTAGTATCTTAGAAGCTGAGTCCTGTTCTTATTTCTGCAGTGGACTGCTGGGAAGTGGCT
TAATGACAATACCAATACATAGATGTCCCTGCTGGAA

hide sequence

RefSeq Acc Id:

XM_006250407 ⟹ XP_006250469

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,993,171 (-)	NCBI
Rnor_6.0	13	98,513,600 - 98,539,313 (-)	NCBI
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI

Sequence:

show sequence

GGGCCGGCGCTAGCCTGGGAGAGGCGCTCCGTCCGCGGCGTAAACTCTATCCCGCGCCGCGGCG
GAGCAGGTGAGATGTGACTGACAGCTGCGTCAAGCTCCTCCCACCGTGAGGCGCCTGTCTGATG
AGCTGAGAGCCAGAATAAACTCTGGAACGGTGTTGTCGCTGAGACCATGCTCACATTCATGGCC
TCTGATAGCGAGGAAGAGGTGTGCGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCTACAT
CACGTTCCTGCCAGGACAGCAGGCCAGGCCCAGAGGATGGAGAGAACACTGCCCAGTGGAGGAG
CCAGGAGAACGAGGACGACTGTGAGGAGGACCCGGACCACTATGCCTGCAGTGGGGTTCCTGGG
CGACCATCGGGCCTGGAGGAGGAGCTGACCCTCAAGTATGGGGCGAAGCACGTGATCATGCTGT
TCGTGCCTGTCACGCTGTGCATGATTGTGGTGGTGGCCACCATCAAGTCCGTGCGTTTCTACAC
GGAGAAGAACGGGCAGCTCATCTACACGCCCTTCACCGAGGACACACCCTCTGTGGGCCAGCGG
CTCCTCAACTCCGTGCTGAACACTCTGATCATGATCAGCGTCATTGTGGTCATGACTATCTTCC
TAGTGGTACTCTACAAATATCGCTGTTACAAGTTCATCCATGGCTGGCTGATCATGTCCTCCCT
GATGCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTGTTCAAGACCTACAATGTGGCC
ATGGACTACCCCACACTGTTCCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCC
ACTGGAAGGGTCCCCTGGTGCTCCAGCAGGCTTACCTCATTGTGATCAGCGCACTCATGGCCCT
GGTGTTCATCAAGTACCTGCCGGAGTGGTCCGCTTGGGTCATCTTGGGCGCCATCTCTGTGTAC
GATCTCGTGGCTGTGCTGTGCCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAAA
GAAACGAGCCCATATTTCCTGCCCTCATATACTCATCTGCCATGGTGTGGACGGTAGGCATGGC
GAAGCTGGACCCCTCCTCTCAGGGAGCACTGCAGCTCCCTTACGATCCAGAGATGGAAGAAGAC
TCCTATGACAGTTTTGGGGAACCCTCATACCCTGAAGCCTTCGAAGCTCCCCAGCCTGGCTACC
CAGGGGAAGAGCCGGAGGAGGAGGAGGAAAGGGGTGTAAAGCTTGGTCTGGGAGACTTCATCTT
CTACAGCGTTCTGGTGGGCAAGGCAGCAGCCACAGGCAACGGAGACTGGAGCACGACGCTGGCC
TGCTTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCTCGCCGTGTTCAAGAAGG
CCCTGCCCGCCCTCCCCATCTCCATCACCTTCGGGCTCATCTTTTACTTCTCCACAGACAACCT
GGTGCGTCCTTTCATGGACACGTTGGCCTCCCACCAGCTCTACATCTGACAGAAGAGCTGCGGC
TCTGAGAGCTGTAGGACGCTTCGCCGAATGCAGGTGTATAGTTTTACACTCTAGTGCCATATAT
TTTTTTTTAAAAAAACCTTTCTTTCCTTACAAAAGAAAAAAAAAGAATAAAAAAGTGTTGTGTT
TACTTCGTGACGAGGAAGCAGAAGCCGCCCTTCTGTGCTAGCTGTCTTGTCACCAGACTGAGGC
TTGCCCGTCAGAGCATCTGTGGCACCCGCAGGTGGGATGCTGGGCCAACAAGCCTATCTTCAGG
GATGAGGTCACGTGTGTGGATCAGGTTGGAGAGGACGCAGGCCCCATCCAGGTCTGTAATCAAT
CCTTCAGGGCTGAGCAGGAGGAACATGTGCGTCAGTGGGGACCAGGAGGCACGGTCAGGAAGGA
CGCTAAGCACCAACACCCTGACCAGAGGACAAAAGCCAGTTTGTCGTCATGAATGCCCCCAGTG
CTTTGTTTGTGATGTCTGTTACCTTTAGTATCTTAGAAGCTGAGTCCTGTTCTTATTTCTGCAG
TGGACTGCTGGGAAGTGGCTTAATGACAATACCAATACATAGATGTCCCTGCTGGAA

hide sequence

RefSeq Acc Id:

XM_006250408 ⟹ XP_006250470

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,993,240 (-)	NCBI
Rnor_6.0	13	98,513,600 - 98,539,347 (-)	NCBI
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI

Sequence:

show sequence

TGTCCGAGGCGCGGACGAACCGGGGCAGTGGGCGGGGCCGGCGCTAGCCTGGGAGAGGCGCTCC
GTCCGCGGCGTAAACTCTATCCCGCGCCGCGGCGGAGCAGACCATGCTCACATTCATGGCCTCT
GATAGCGAGGAAGAGGTGTGCGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCTACATCAC
GTTCCTGCCAGGACAGCAGGCCAGGCCCAGAGGATGGAGAGAACACTGCCCAGTGGAGGAGCCA
GGAGAACGAGGACGACTGTGAGGAGGACCCGGACCACTATGCCTGCAGTGGGGTTCCTGGGCGA
CCATCGGGCCTGGAGGAGGAGCTGACCCTCAAGTATGGGGCGAAGCACGTGATCATGCTGTTCG
TGCCTGTCACGCTGTGCATGATTGTGGTGGTGGCCACCATCAAGTCCGTGCGTTTCTACACGGA
GAAGAACGGGCAGCTCATCTACACGCCCTTCACCGAGGACACACCCTCTGTGGGCCAGCGGCTC
CTCAACTCCGTGCTGAACACTCTGATCATGATCAGCGTCATTGTGGTCATGACTATCTTCCTAG
TGGTACTCTACAAATATCGCTGTTACAAGTTCATCCATGGCTGGCTGATCATGTCCTCCCTGAT
GCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTGTTCAAGACCTACAATGTGGCCATG
GACTACCCCACACTGTTCCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACT
GGAAGGGTCCCCTGGTGCTCCAGCAGGCTTACCTCATTGTGATCAGCGCACTCATGGCCCTGGT
GTTCATCAAGTACCTGCCGGAGTGGTCCGCTTGGGTCATCTTGGGCGCCATCTCTGTGTACGAT
CTCGTGGCTGTGCTGTGCCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAAAGAA
ACGAGCCCATATTTCCTGCCCTCATATACTCATCTGCCATGGTGTGGACGGTAGGCATGGCGAA
GCTGGACCCCTCCTCTCAGGGAGCACTGCAGCTCCCTTACGATCCAGAGATGGAAGAAGACTCC
TATGACAGTTTTGGGGAACCCTCATACCCTGAAGCCTTCGAAGCTCCCCAGCCTGGCTACCCAG
GGGAAGAGCCGGAGGAGGAGGAGGAAAGGGGTGTAAAGCTTGGTCTGGGAGACTTCATCTTCTA
CAGCGTTCTGGTGGGCAAGGCAGCAGCCACAGGCAACGGAGACTGGAGCACGACGCTGGCCTGC
TTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCTCGCCGTGTTCAAGAAGGCCC
TGCCCGCCCTCCCCATCTCCATCACCTTCGGGCTCATCTTTTACTTCTCCACAGACAACCTGGT
GCGTCCTTTCATGGACACGTTGGCCTCCCACCAGCTCTACATCTGACAGAAGAGCTGCGGCTCT
GAGAGCTGTAGGACGCTTCGCCGAATGCAGGTGTATAGTTTTACACTCTAGTGCCATATATTTT
TTTTTAAAAAAACCTTTCTTTCCTTACAAAAGAAAAAAAAAGAATAAAAAAGTGTTGTGTTTAC
TTCGTGACGAGGAAGCAGAAGCCGCCCTTCTGTGCTAGCTGTCTTGTCACCAGACTGAGGCTTG
CCCGTCAGAGCATCTGTGGCACCCGCAGGTGGGATGCTGGGCCAACAAGCCTATCTTCAGGGAT
GAGGTCACGTGTGTGGATCAGGTTGGAGAGGACGCAGGCCCCATCCAGGTCTGTAATCAATCCT
TCAGGGCTGAGCAGGAGGAACATGTGCGTCAGTGGGGACCAGGAGGCACGGTCAGGAAGGACGC
TAAGCACCAACACCCTGACCAGAGGACAAAAGCCAGTTTGTCGTCATGAATGCCCCCAGTGCTT
TGTTTGTGATGTCTGTTACCTTTAGTATCTTAGAAGCTGAGTCCTGTTCTTATTTCTGCAGTGG
ACTGCTGGGAAGTGGCTTAATGACAATACCAATACATAGATGTCCCTGCTGGAA

hide sequence

RefSeq Acc Id:

XM_006250410 ⟹ XP_006250472

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,985,636 (-)	NCBI
Rnor_6.0	13	98,513,600 - 98,531,794 (-)	NCBI
Rnor_5.0	13	103,521,460 - 103,547,174 (-)	NCBI

Sequence:

show sequence

CTAAATCCCCAGCCCTACTAAGTATTCTTCCAAGTAAGACTTTGGTGCTCCTGCAGTAGTCCTC
ATCGGATAGTTGGATAGCCCGAAGTGGTGCTGAATACCAGATCCTGTGTGAACTGTGTTCTGTT
TTGGTTTAGTTCCTGAACATACATATTTATGATAGTTGAATTCATAAATTTGGCACAGCAAAAG
ATTAATAGCAACAACCCAGCAATAACAGCAGTACACTGTAGGGAAGCTATCTAAAACGTACGGA
TTGATTACTCTGGAATTTTCCACTTCACATTCTTGACCACTGATAACTATAACCACAGGAAGCA
GAATTGCAGATAAGCGGGGCGAGGGGGATTGAGTTCCTGTACTGGAGAAGAGAGGCAGAAATTT
CAGTCGTTTTTACTTTCTATGATAACAGATGACTACAGCACATATTTTTGTATGGATGTTTTTT
CTTAGATAAAATTCCTAGATGTAGCATTTCCGGATCTAAAAGGTCCAACTCTTTGCATAGCTTT
GGGGTTCTGTACAGACATTTTATCTCCATACACCCTTCCGTCCCCTGCATCATATGCCCAGTTC
TTCCAGCCCTCTTTCTCCATAGGCGACTTTGCTAGTCTGAGAAGCTCTCACCCCTCTCTTCCCA
GTTGCTGTCTGACCAGGTCCTGTGTCCTGGAGTAAGGGCTGCACGGTTTACACCTTCATCCCTA
CGGTCACAAGAGTGGGAGGCGCACTGGGTGAGATGTGACTGACAGCTGCGTCAAGCTCCTCCCA
CCGTGAGGCGCCTGTCTGATGAGCTGAGAGCCAGAATAAACTCTGGAACGGTGTTGTCGCTGAG
ACCATGCTCACATTCATGGCCTCTGATAGCGAGGAAGAGGTGTGCGATGAGCGGACGTCCTTGA
TGTCAGCCGAGAGCCCTACATCACGTTCCTGCCAGGACAGCAGGCCAGGCCCAGAGGATGGAGA
GAACACTGCCCAGTGGAGGAGCCAGGAGAACGAGGACGACTGTGAGGAGGACCCGGACCACTAT
GCCTGCAGTGGGGTTCCTGGGCGACCATCGGGCCTGGAGGAGGAGCTGACCCTCAAGTATGGGG
CGAAGCACGTGATCATGCTGTTCGTGCCTGTCACGCTGTGCATGATTGTGGTGGTGGCCACCAT
CAAGTCCGTGCGTTTCTACACGGAGAAGAACGGGCAGCTCATCTACACGCCCTTCACCGAGGAC
ACACCCTCTGTGGGCCAGCGGCTCCTCAACTCCGTGCTGAACACTCTGATCATGATCAGCGTCA
TTGTGGTCATGACTATCTTCCTAGTGGTACTCTACAAATATCGCTGTTACAAGTTCATCCATGG
CTGGCTGATCATGTCCTCCCTGATGCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTG
TTCAAGACCTACAATGTGGCCATGGACTACCCCACACTGTTCCTGGCTGTCTGGAACTTCGGGG
CAGTGGGCATGGTGTGCATCCACTGGAAGGGTCCCCTGGTGCTCCAGCAGGCTTACCTCATTGT
GATCAGCGCACTCATGGCCCTGGTGTTCATCAAGTACCTGCCGGAGTGGTCCGCTTGGGTCATC
TTGGGCGCCATCTCTGTGTACGATCTCGTGGCTGTGCTGTGCCCCAAAGGGCCACTGAGGATGC
TGGTGGAAACTGCCCAGGAAAGAAACGAGCCCATATTTCCTGCCCTCATATACTCATCTGCCAT
GGTGTGGACGGTAGGCATGGCGAAGCTGGACCCCTCCTCTCAGGGAGCACTGCAGCTCCCTTAC
GATCCAGAGATGGAAGACTCCTATGACAGTTTTGGGGAACCCTCATACCCTGAAGCCTTCGAAG
CTCCCCAGCCTGGCTACCCAGGGGAAGAGCCGGAGGAGGAGGAGGAAAGGGGTGTAAAGCTTGG
TCTGGGAGACTTCATCTTCTACAGCGTTCTGGTGGGCAAGGCAGCAGCCACAGGCAACGGAGAC
TGGAGCACGACGCTGGCCTGCTTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGC
TCGCCGTGTTCAAGAAGGCCCTGCCCGCCCTCCCCATCTCCATCACCTTCGGGCTCATCTTTTA
CTTCTCCACAGACAACCTGGTGCGTCCTTTCATGGACACGTTGGCCTCCCACCAGCTCTACATC
TGACAGAAGAGCTGCGGCTCTGAGAGCTGTAGGACGCTTCGCCGAATGCAGGTGTATAGTTTTA
CACTCTAGTGCCATATATTTTTTTTTAAAAAAACCTTTCTTTCCTTACAAAAGAAAAAAAAAGA
ATAAAAAAGTGTTGTGTTTACTTCGTGACGAGGAAGCAGAAGCCGCCCTTCTGTGCTAGCTGTC
TTGTCACCAGACTGAGGCTTGCCCGTCAGAGCATCTGTGGCACCCGCAGGTGGGATGCTGGGCC
AACAAGCCTATCTTCAGGGATGAGGTCACGTGTGTGGATCAGGTTGGAGAGGACGCAGGCCCCA
TCCAGGTCTGTAATCAATCCTTCAGGGCTGAGCAGGAGGAACATGTGCGTCAGTGGGGACCAGG
AGGCACGGTCAGGAAGGACGCTAAGCACCAACACCCTGACCAGAGGACAAAAGCCAGTTTGTCG
TCATGAATGCCCCCAGTGCTTTGTTTGTGATGTCTGTTACCTTTAGTATCTTAGAAGCTGAGTC
CTGTTCTTATTTCTGCAGTGGACTGCTGGGAAGTGGCTTAATGACAATACCAATACATAGATGT
CCCTGCTGGAA

hide sequence

RefSeq Acc Id:

XM_008769877 ⟹ XP_008768099

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,989,929 (-)	NCBI
Rnor_6.0	13	98,513,600 - 98,536,024 (-)	NCBI

Sequence:

show sequence

GTGTGTAGTGTGTGTGGTGTGTACAGTGTGTGGTCTGTGTAGGTCACATGGATCTTTCTAACAA
AAACCTCTGGCTGTATTTTAGCTGTTTCTTTAAGGTTGAGCCTCTGATCAGCTGGGACCCAGCA
GAAGGCAAAGGTTTCTGTTGATGTCTTCTCACCTGCCCTGGGCTGTGACCGCCCGGGAGAGTTG
CTGTCTGACCAGGTCCTGTGTCCTGGAGTAAGGGCTGCACGGTTTACACCTTCATCCCTACGGT
CACAAGAGTGGGAGGCGCACTGGGTGAGATGTGACTGACAGCTGCGTCAAGCTCCTCCCACCGT
GAGGCGCCTGTCTGATGAGCTGAGAGCCAGAATAAACTCTGGAACGGTGTTGTCGCTGAGACCA
TGCTCACATTCATGGCCTCTGATAGCGAGGAAGAGGTGTGCGATGAGCGGACGTCCTTGATGTC
AGCCGAGAGCCCTACATCACGTTCCTGCCAGGACAGCAGGCCAGGCCCAGAGGATGGAGAGAAC
ACTGCCCAGTGGAGGAGCCAGGAGAACGAGGACGACTGTGAGGAGGACCCGGACCACTATGCCT
GCAGTGGGGTTCCTGGGCGACCATCGGGCCTGGAGGAGGAGCTGACCCTCAAGTATGGGGCGAA
GCACGTGATCATGCTGTTCGTGCCTGTCACGCTGTGCATGATTGTGGTGGTGGCCACCATCAAG
TCCGTGCGTTTCTACACGGAGAAGAACGGGCAGCTCATCTACACGCCCTTCACCGAGGACACAC
CCTCTGTGGGCCAGCGGCTCCTCAACTCCGTGCTGAACACTCTGATCATGATCAGCGTCATTGT
GGTCATGACTATCTTCCTAGTGGTACTCTACAAATATCGCTGTTACAAGTTCATCCATGGCTGG
CTGATCATGTCCTCCCTGATGCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTGTTCA
AGACCTACAATGTGGCCATGGACTACCCCACACTGTTCCTGGCTGTCTGGAACTTCGGGGCAGT
GGGCATGGTGTGCATCCACTGGAAGGGTCCCCTGGTGCTCCAGCAGGCTTACCTCATTGTGATC
AGCGCACTCATGGCCCTGGTGTTCATCAAGTACCTGCCGGAGTGGTCCGCTTGGGTCATCTTGG
GCGCCATCTCTGTGTACGATCTCGTGGCTGTGCTGTGCCCCAAAGGGCCACTGAGGATGCTGGT
GGAAACTGCCCAGGAAAGAAACGAGCCCATATTTCCTGCCCTCATATACTCATCTGCCATGGTG
TGGACGGTAGGCATGGCGAAGCTGGACCCCTCCTCTCAGGGAGCACTGCAGCTCCCTTACGATC
CAGAGATGGAAGAAGACTCCTATGACAGTTTTGGGGAACCCTCATACCCTGAAGCCTTCGAAGC
TCCCCAGCCTGGCTACCCAGGGGAAGAGCCGGAGGAGGAGGAGGAAAGGGGTGTAAAGCTTGGT
CTGGGAGACTTCATCTTCTACAGCGTTCTGGTGGGCAAGGCAGCAGCCACAGGCAACGGAGACT
GGAGCACGACGCTGGCCTGCTTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCT
CGCCGTGTTCAAGAAGGCCCTGCCCGCCCTCCCCATCTCCATCACCTTCGGGCTCATCTTTTAC
TTCTCCACAGACAACCTGGTGCGTCCTTTCATGGACACGTTGGCCTCCCACCAGCTCTACATCT
GACAGAAGAGCTGCGGCTCTGAGAGCTGTAGGACGCTTCGCCGAATGCAGGTGTATAGTTTTAC
ACTCTAGTGCCATATATTTTTTTTTAAAAAAACCTTTCTTTCCTTACAAAAGAAAAAAAAAGAA
TAAAAAAGTGTTGTGTTTACTTCGTGACGAGGAAGCAGAAGCCGCCCTTCTGTGCTAGCTGTCT
TGTCACCAGACTGAGGCTTGCCCGTCAGAGCATCTGTGGCACCCGCAGGTGGGATGCTGGGCCA
ACAAGCCTATCTTCAGGGATGAGGTCACGTGTGTGGATCAGGTTGGAGAGGACGCAGGCCCCAT
CCAGGTCTGTAATCAATCCTTCAGGGCTGAGCAGGAGGAACATGTGCGTCAGTGGGGACCAGGA
GGCACGGTCAGGAAGGACGCTAAGCACCAACACCCTGACCAGAGGACAAAAGCCAGTTTGTCGT
CATGAATGCCCCCAGTGCTTTGTTTGTGATGTCTGTTACCTTTAGTATCTTAGAAGCTGAGTCC
TGTTCTTATTTCTGCAGTGGACTGCTGGGAAGTGGCTTAATGACAATACCAATACATAGATGTC
CCTGCTGGAA

hide sequence

RefSeq Acc Id:

XM_039091112 ⟹ XP_038947040

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,985,630 (-)	NCBI

RefSeq Acc Id:

XM_039091113 ⟹ XP_038947041

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	91,967,506 - 91,989,931 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_112349	(Get FASTA)	NCBI Sequence Viewer
	XP_006250467	(Get FASTA)	NCBI Sequence Viewer
	XP_006250469	(Get FASTA)	NCBI Sequence Viewer
	XP_006250470	(Get FASTA)	NCBI Sequence Viewer
	XP_006250472	(Get FASTA)	NCBI Sequence Viewer
	XP_008768099	(Get FASTA)	NCBI Sequence Viewer
	XP_038947040	(Get FASTA)	NCBI Sequence Viewer
	XP_038947041	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78805	(Get FASTA)	NCBI Sequence Viewer
	BAA20406	(Get FASTA)	NCBI Sequence Viewer
	BAA22832	(Get FASTA)	NCBI Sequence Viewer
	CAA67663	(Get FASTA)	NCBI Sequence Viewer
	EDL94820	(Get FASTA)	NCBI Sequence Viewer
	EDL94821	(Get FASTA)	NCBI Sequence Viewer
	EDL94822	(Get FASTA)	NCBI Sequence Viewer
	EDL94823	(Get FASTA)	NCBI Sequence Viewer
	O88777	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_112349 ⟸ NM_031087

- UniProtKB:

O35546 (UniProtKB/Swiss-Prot), O88777 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA
CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT
PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF
KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL
GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD
PEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGD
WSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

hide sequence

RefSeq Acc Id:	XP_006250470 ⟸ XM_006250408
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot), O88777 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD PEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGD WSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI hide sequence

RefSeq Acc Id:	XP_006250467 ⟸ XM_006250405
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot), O88777 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD PEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGD WSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI hide sequence

RefSeq Acc Id:	XP_006250469 ⟸ XM_006250407
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot), O88777 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD PEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGD WSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI hide sequence

RefSeq Acc Id:

XP_006250472 ⟸ XM_006250410

- Peptide Label:

isoform X2

- Sequence:

show sequence

MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA
CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT
PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF
KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL
GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD
PEMEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDW
STTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI

hide sequence

RefSeq Acc Id:	XP_008768099 ⟸ XM_008769877
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot), O88777 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYA CSGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDT PSVGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVF KTYNVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVIL GAISVYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYD PEMEEDSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGD WSTTLACFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI hide sequence

RefSeq Acc Id:

ENSRNOP00000049605 ⟸ ENSRNOT00000040203

RefSeq Acc Id:

ENSRNOP00000070964 ⟸ ENSRNOT00000091715

RefSeq Acc Id:	XP_038947041 ⟸ XM_039091113
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038947040 ⟸ XM_039091112
- Peptide Label:	isoform X1
- UniProtKB:	O35546 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88777-F1-model_v2	AlphaFold	O88777	1-448	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621060	AgrOrtholog
BioCyc Gene	G2FUF-17132	BioCyc
Ensembl Genes	ENSRNOG00000002879	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000049605	ENTREZGENE
	ENSRNOP00000049605.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000040203	ENTREZGENE
	ENSRNOT00000040203.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.472.100	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7109917	IMAGE-MGC_LOAD
InterPro	Pept_A22A_PS2	UniProtKB/Swiss-Prot
	Peptidase_A22A	UniProtKB/Swiss-Prot
	Preselin/SPP	UniProtKB/Swiss-Prot
	Presenilin_C	UniProtKB/Swiss-Prot
KEGG Report	rno:81751	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93382	IMAGE-MGC_LOAD
NCBI Gene	81751	ENTREZGENE
PANTHER	PRESENILIN-2	UniProtKB/Swiss-Prot
	PTHR10202	UniProtKB/Swiss-Prot
Pfam	Presenilin	UniProtKB/Swiss-Prot
PhenoGen	Psen2	PhenoGen
PRINTS	PRESENILIN	UniProtKB/Swiss-Prot
	PRESENILIN2	UniProtKB/Swiss-Prot
SMART	PSN	UniProtKB/Swiss-Prot
UniProt	O35546	ENTREZGENE
	O88777	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	O08947	UniProtKB/Swiss-Prot
	O35546	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Psen2	presenilin 2		presenilin-2	Name updated	1299863	APPROVED
2002-08-07	Psen2	presenilin-2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_homology	95% amino acid identity to human homolog	729647
gene_protein	448 amino acids	729647

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)