Gene: Xrcc4 (X-ray repair cross complementing 4) Rattus norvegicus
Analyze
Symbol:
Xrcc4
Name:
X-ray repair cross complementing 4
RGD ID:
1359573
Description:
Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in cellular response to lithium ion. Predicted to localize to cytosol; nucleus; and site of double-strand break. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; lithium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DNA repair protein XRCC4; MGC95022; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing protein 4
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
XRCC4 (X-ray repair cross complementing 4) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Xrcc4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
XRCC4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
XRCC4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Xrcc4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
XRCC4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
XRCC4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Xrcc4 (X-ray repair cross complementing 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
XRCC4 (X-ray repair cross complementing 4)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4)
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 18,674,496 - 18,927,463 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 18,677,220 - 18,927,365 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 18,550,304 - 18,803,313 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 19,904,490 - 20,158,358 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 19,824,860 - 20,078,727 (-) NCBI Celera 2 17,092,971 - 17,325,919 (-) NCBI Celera Cytogenetic Map 2 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
isolated growth hormone deficiency type IA ISO RGD:1353234 8554872 ClinVar Annotator: match by term: PITUITARY DWARFISM I ClinVar PMID:24389050 more ... Neurodevelopmental Disorders ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25728776 more ... SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:24033266 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25741868 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25728776 , PMID:25839420 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25839420 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:18695064 more ... SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25742519 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:26255102 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:25728776 SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 8554872 ClinVar Annotator: match by term: Short stature, microcephaly, and endocrine dysfunction ClinVar PMID:24389050 more ...
Imported Annotations - CTD
Chromosome Aberrations ISO RGD:1353234 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20726224 Imported Annotations - OMIM
SHORT STATURE, MICROCEPHALY, AND ENDOCRINE DYSFUNCTION ISO RGD:1353234 7240710 OMIM
(+)-taxifolin increases expression ISO RGD:1353234 6480464 taxifolin results in increased expression of XRCC4 mRNA CTD PMID:17541156 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1353234 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XRCC4 mRNA, epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of XRCC4 mRNA] CTD PMID:22079256 1,2-dimethylhydrazine multiple interactions ISO RGD:1550337 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of XRCC4 mRNA] CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1550337 6480464 1, 2-Dimethylhydrazine results in decreased expression of XRCC4 mRNA CTD PMID:22206623 1H-pyrazole increases expression ISO RGD:1550337 6480464 pyrazole results in increased expression of XRCC4 mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550337 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to XRCC4 promoter] CTD PMID:19654925 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of XRCC4 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1353234 6480464 Lactic Acid results in decreased expression of XRCC4 mRNA CTD PMID:30851411 3-chlorophenol increases expression ISO RGD:1353234 6480464 3-chlorophenol results in increased expression of XRCC4 mRNA CTD PMID:18486366 aflatoxin B1 affects expression ISO RGD:1353234 6480464 Aflatoxin B1 affects the expression of XRCC4 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1550337 6480464 Aflatoxin B1 results in decreased expression of XRCC4 mRNA CTD PMID:19770486 aflatoxin M1 decreases expression ISO RGD:1353234 6480464 Aflatoxin M1 results in decreased expression of XRCC4 mRNA CTD PMID:30928695 aphidicolin decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Aphidicolin CTD PMID:21785230 arsane decreases expression ISO RGD:1353234 6480464 Arsenic results in decreased expression of XRCC4 mRNA, Arsenic results in decreased expression of XRCC4 protein CTD PMID:21332098 arsane multiple interactions ISO RGD:1353234 6480464 Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA], Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein] CTD PMID:21332098 arsenic atom decreases expression ISO RGD:1353234 6480464 Arsenic results in decreased expression of XRCC4 mRNA, Arsenic results in decreased expression of XRCC4 protein CTD PMID:21332098 arsenic atom multiple interactions ISO RGD:1353234 6480464 Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA], Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein] CTD PMID:21332098 arsenous acid decreases expression ISO RGD:1353234 6480464 Arsenic Trioxide results in decreased expression of XRCC4 mRNA CTD PMID:17530438 benzo[a]pyrene decreases expression ISO RGD:1353234 6480464 Benzo(a)pyrene results in decreased expression of XRCC4 mRNA CTD PMID:20064835 more ... benzo[a]pyrene increases expression ISO RGD:1550337 6480464 Benzo(a)pyrene results in increased expression of XRCC4 mRNA CTD PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:1550337 6480464 Benzo(a)pyrene results in decreased expression of XRCC4 mRNA CTD PMID:19770486 , PMID:21715664 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1353234 6480464 7 more ... CTD PMID:19150397 more ... bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of XRCC4 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of XRCC4 mRNA CTD PMID:30816183 cadmium atom multiple interactions ISO RGD:1353234 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XRCC4 mRNA CTD PMID:31738976 cadmium dichloride multiple interactions ISO RGD:1353234 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XRCC4 mRNA CTD PMID:31738976 camptothecin decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Camptothecin CTD PMID:21785230 camptothecin increases methylation ISO RGD:1353234 6480464 Camptothecin results in increased methylation of XRCC4 gene CTD PMID:30720231 chlorpromazine decreases expression ISO RGD:1353234 6480464 Chlorpromazine results in decreased expression of XRCC4 mRNA CTD PMID:15924885 chromium(6+) decreases expression ISO RGD:1353234 6480464 chromium hexavalent ion results in decreased expression of XRCC4 mRNA CTD PMID:27793765 cisplatin decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Cisplatin CTD PMID:21785230 cisplatin decreases expression ISO RGD:1550337 6480464 Cisplatin results in decreased expression of XRCC4 mRNA CTD PMID:21151649 curcumin multiple interactions ISO RGD:1353234 6480464 Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA], Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein] CTD PMID:21332098 diarsenic trioxide decreases expression ISO RGD:1353234 6480464 Arsenic Trioxide results in decreased expression of XRCC4 mRNA CTD PMID:17530438 doxorubicin increases expression ISO RGD:1353234 6480464 Doxorubicin results in increased expression of XRCC4 mRNA CTD PMID:30031762 entinostat increases expression ISO RGD:1353234 6480464 entinostat results in increased expression of XRCC4 mRNA CTD PMID:27188386 etoposide multiple interactions ISO RGD:1353234 6480464 BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein] CTD PMID:16417649 etoposide decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Etoposide CTD PMID:21785230 etoposide increases expression ISO RGD:1353234 6480464 Etoposide results in increased expression of XRCC4 protein CTD PMID:16417649 floxuridine decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Floxuridine CTD PMID:21785230 folic acid decreases expression ISO RGD:1550337 6480464 Folic Acid results in decreased expression of XRCC4 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:1550337 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of XRCC4 mRNA] CTD PMID:22206623 formaldehyde decreases expression ISO RGD:1353234 6480464 Formaldehyde results in decreased expression of XRCC4 mRNA CTD PMID:23649840 hydroxyurea decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Hydroxyurea CTD PMID:21785230 irinotecan decreases expression ISO RGD:1353234 6480464 Irinotecan metabolite results in decreased expression of XRCC4 mRNA, Irinotecan results in decreased expression of XRCC4 mRNA CTD PMID:15956246 lead(0) affects expression ISO RGD:1353234 6480464 Lead affects the expression of XRCC4 mRNA CTD PMID:22313790 lead(0) affects response to substance ISO RGD:1353234 6480464 XRCC4 gene polymorphism affects the susceptibility to Lead CTD PMID:22466227 lead(2+) affects response to substance ISO RGD:1353234 6480464 XRCC4 gene polymorphism affects the susceptibility to Lead CTD PMID:22466227 lead(2+) affects expression ISO RGD:1353234 6480464 Lead affects the expression of XRCC4 mRNA CTD PMID:22313790 lithium chloride increases expression EXP 6480464 Lithium Chloride results in increased expression of XRCC4 mRNA CTD PMID:19285016 methyl methanesulfonate decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Methyl Methanesulfonate CTD PMID:21785230 mitomycin C decreases response to substance ISO RGD:1353234 6480464 XRCC4 results in decreased susceptibility to Mitomycin CTD PMID:21785230 monocrotaline multiple interactions ISO RGD:1550337 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 N-Nitrosopyrrolidine decreases expression ISO RGD:1353234 6480464 N-Nitrosopyrrolidine results in decreased expression of XRCC4 mRNA CTD PMID:32234424 nickel atom increases expression ISO RGD:1353234 6480464 Nickel results in increased expression of XRCC4 mRNA CTD PMID:25583101 nickel dichloride increases expression ISO RGD:1353234 6480464 nickel chloride results in increased expression of XRCC4 protein CTD PMID:28472268 nickel dichloride affects expression ISO RGD:1353234 6480464 nickel chloride affects the expression of XRCC4 mRNA CTD PMID:28472268 O-methyleugenol decreases expression ISO RGD:1353234 6480464 methyleugenol results in decreased expression of XRCC4 mRNA CTD PMID:32234424 okadaic acid increases expression ISO RGD:1550337 6480464 Okadaic Acid results in increased expression of XRCC4 mRNA CTD PMID:25270620 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC4 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:1550337 6480464 Acetaminophen affects the expression of XRCC4 mRNA CTD PMID:29540258 paracetamol decreases expression ISO RGD:1353234 6480464 Acetaminophen results in decreased expression of XRCC4 mRNA CTD PMID:29067470 pentachlorophenol increases expression ISO RGD:1353234 6480464 Pentachlorophenol results in increased expression of XRCC4 mRNA CTD PMID:18486366 phenobarbital affects expression ISO RGD:1550337 6480464 Phenobarbital affects the expression of XRCC4 mRNA CTD PMID:19136022 phenytoin multiple interactions ISO RGD:1550337 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 pirinixic acid affects expression ISO RGD:1550337 6480464 pirinixic acid affects the expression of XRCC4 mRNA CTD PMID:19136022 pirinixic acid increases expression ISO RGD:1550337 6480464 pirinixic acid results in increased expression of XRCC4 mRNA CTD PMID:18301758 , PMID:23811191 potassium chromate decreases expression ISO RGD:1353234 6480464 potassium chromate(VI) results in decreased expression of XRCC4 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1353234 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XRCC4 mRNA, epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of XRCC4 mRNA] CTD PMID:22079256 progesterone increases expression ISO RGD:1353234 6480464 Progesterone results in increased expression of XRCC4 mRNA CTD PMID:18070364 rac-lactic acid decreases expression ISO RGD:1353234 6480464 Lactic Acid results in decreased expression of XRCC4 mRNA CTD PMID:30851411 rifampicin multiple interactions ISO RGD:1550337 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA CTD PMID:21224054 sodium arsenite decreases expression ISO RGD:1550337 6480464 sodium arsenite results in decreased expression of XRCC4 mRNA CTD PMID:25787150 taurine increases expression ISO RGD:1353234 6480464 Taurine results in increased expression of XRCC4 mRNA CTD PMID:16579726 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of XRCC4 mRNA CTD PMID:25729387 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of XRCC4 mRNA CTD PMID:30589522 valproic acid affects expression ISO RGD:1550337 6480464 Valproic Acid affects the expression of XRCC4 mRNA CTD PMID:17963808 valproic acid affects expression ISO RGD:1353234 6480464 Valproic Acid affects the expression of XRCC4 mRNA CTD PMID:25979313 vorinostat increases expression ISO RGD:1353234 6480464 vorinostat results in increased expression of XRCC4 mRNA CTD PMID:27188386 zinc atom decreases expression ISO RGD:1353234 6480464 Zinc deficiency results in decreased expression of XRCC4 mRNA CTD PMID:18356318 zinc(0) decreases expression ISO RGD:1353234 6480464 Zinc deficiency results in decreased expression of XRCC4 mRNA CTD PMID:18356318
Biological Process cellular response to lithium ion IEP 2317095 RGD central nervous system development ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 DNA ligation ISO RGD:1550337 1624291 (MGI:MGI:3052572, PMID:15194694) RGD MGI:MGI:3052572 , PMID:15194694 DNA ligation involved in DNA repair ISO RGD:1353234 1624291 (PMID:12517771) RGD PMID:12517771 DNA ligation involved in DNA repair IBA PANTHER:PTN002004633 , UniProtKB:Q13426 13792537 PMID:21873635 GO_Central double-strand break repair ISO RGD:1353234 1624291 (PMID:9242410) RGD PMID:9242410 double-strand break repair ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 more ... RGD MGI:MGI:1913213 more ... double-strand break repair via nonhomologous end joining ISO RGD:1550337 1624291 MGI:MGI:1926771 more ... RGD MGI:MGI:3758502 more ... double-strand break repair via nonhomologous end joining IBA MGI:MGI:1333799 more ... 13792537 PMID:21873635 GO_Central double-strand break repair via nonhomologous end joining ISO RGD:1353234 1624291 UniProtKB:P49917 (PMID:12517771), (PMID:9809069) RGD PMID:12517771 , PMID:9809069 immunoglobulin V(D)J recombination ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 immunoglobulin V(D)J recombination IBA MGI:MGI:1333799 , PANTHER:PTN002822613 13792537 PMID:21873635 GO_Central in utero embryonic development ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 isotype switching ISO RGD:1550337 1624291 MGI:MGI:1926771 more ... RGD MGI:MGI:3761960 , PMID:17713479 negative regulation of neuron apoptotic process ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 negative regulation of protection from non-homologous end joining at telomere ISO RGD:1550337 1624291 (MGI:MGI:3758502, PMID:14690602) RGD MGI:MGI:3758502 , PMID:14690602 positive regulation of fibroblast proliferation ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 positive regulation of ligase activity ISO RGD:1353234 1624291 (PMID:9242410) RGD PMID:9242410 positive regulation of ligase activity IBA PANTHER:PTN002004633 , UniProtKB:Q13426 13792537 PMID:21873635 GO_Central positive regulation of neurogenesis ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 pro-B cell differentiation ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 protein localization to nuclear envelope ISO RGD:12427565 1624291 (PMID:27644316) RGD PMID:27644316 response to gamma radiation ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 response to ionizing radiation ISO RGD:1550337 1624291 MGI:MGI:1926771 more ... RGD MGI:MGI:3761960 , PMID:17713479 response to X-ray ISO RGD:1353234 1624291 (PMID:9242410) RGD PMID:9242410 response to X-ray IBA MGI:MGI:1333799 more ... 13792537 PMID:21873635 GO_Central response to X-ray ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 T cell differentiation in thymus ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:1913213 , PMID:9875844) RGD MGI:MGI:1913213 , PMID:9875844 telomeric DNA-containing double minutes formation ISO RGD:1550337 1624291 (MGI:MGI:3758502, PMID:14690602) RGD MGI:MGI:3758502 , PMID:14690602 V(D)J recombination ISO RGD:1550337 1624291 MGI:MGI:1926771 (MGI:MGI:3641390 , PMID:10716994) RGD MGI:MGI:3641390 , PMID:10716994 Cellular Component cellular_component ND 1598407 03/2010: no relevant rat data RGD condensed chromosome NOT ISO RGD:1353234 1624291 (PMID:12589063) RGD PMID:12589063 cytosol ISO RGD:1353234 1624291 (PMID:9259561) RGD PMID:9259561 DNA ligase IV complex ISO RGD:1353234 1624291 (PMID:9242410) RGD PMID:9242410 DNA ligase IV complex IBA PANTHER:PTN002004633 , UniProtKB:Q13426 13792537 PMID:21873635 GO_Central DNA-dependent protein kinase-DNA ligase 4 complex ISO RGD:1353234 1624291 (PMID:15194694) RGD PMID:15194694 DNA-dependent protein kinase-DNA ligase 4 complex IBA MGI:MGI:1333799 more ... 13792537 PMID:21873635 GO_Central DNA-dependent protein kinase-DNA ligase 4 complex ISO RGD:1550337 1624291 (MGI:MGI:3052572, PMID:15194694) RGD MGI:MGI:3052572 , PMID:15194694 ERCC4-ERCC1 complex ISO RGD:1550337 1624291 (MGI:MGI:3758502, PMID:14690602) RGD MGI:MGI:3758502 , PMID:14690602 nonhomologous end joining complex ISO RGD:1353234 1624291 (PMID:20383123), (PMID:25941166) RGD PMID:20383123 , PMID:25941166 nuclear chromosome, telomeric region ISO RGD:1550337 1624291 (MGI:MGI:3758502, PMID:14690602) RGD MGI:MGI:3758502 , PMID:14690602 nucleoplasm ISO RGD:1353234 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q13426 , ensembl:ENSP000004214911600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024RAQ8 , ensembl:ENSP000004214911600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1353234 1624291 (PMID:12589063), (PMID:9259561) RGD PMID:12589063 , PMID:9259561 site of double-strand break ISO RGD:12427565 1624291 (PMID:27644316) RGD PMID:27644316 Molecular Function 3' overhang single-stranded DNA endodeoxyribonuclease activity contributes_to ISO RGD:1550337 1624291 (MGI:MGI:3758502, PMID:14690602) RGD MGI:MGI:3758502 , PMID:14690602 DNA binding NOT ISO RGD:1353234 1624291 (PMID:9259561) RGD PMID:9259561 identical protein binding ISO RGD:1353234 1624291 UniProtKB:Q13426 , UniProtKB:Q13426-2 (PMID:16169070), (PMID:21070942), (PMID:21768349), (PMID:25416956), (PMID:31515488), (PMID:32296183) RGD PMID:16169070 more ... ligase activity NOT ISO RGD:1353234 1624291 (PMID:9242410) RGD PMID:9242410 molecular_function ND 1598407 03/2010: no relevant rat data RGD protein binding ISO RGD:1353234 1624291 UniProtKB:O00499 more ... RGD PMID:11702069 more ... protein C-terminus binding ISO RGD:1353234 1624291 UniProtKB:P49917 (PMID:9259561) RGD PMID:9259561
Gene-Chemical Interaction Annotations
