Si (sucrase-isomaltase) - Rat Genome Database

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Gene: Si (sucrase-isomaltase) Rattus norvegicus
Analyze
Symbol: Si
Name: sucrase-isomaltase
RGD ID: 3675
Description: Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including response to fructose; response to insulin; and response to vitamin A. Located in brush border and membrane raft. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; glycogen storage disease type III pathway; glycogen storage disease type IV pathway; INTERACTS WITH (S)-naringenin; 17alpha-ethynylestradiol; acetylsalicylic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SUCIMAL; sucrase-isomaltase (alpha-glucosidase); sucrase-isomaltase, intestinal
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22157,505,893 - 157,586,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2164,628,371 - 164,709,000 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02162,678,862 - 162,759,493 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02157,311,634 - 157,392,265 (-)NCBIRnor_WKY
Rnor_6.02170,220,794 - 170,301,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2170,221,245 - 170,301,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02189,563,145 - 189,643,699 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42163,520,975 - 163,601,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12163,470,937 - 163,551,243 (-)NCBI
Celera2151,764,945 - 151,845,208 (-)NCBICelera
RH 3.4 Map21027.6RGD
Cytogenetic Map2q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. Adachi T, etal., Biochim Biophys Acta. 1999 Jan 4;1426(1):126-32.
2. Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats. Adachi T, etal., Endocr J. 2003 Jun;50(3):271-9.
3. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Amit-Romach E, etal., Int J Mol Med. 2006 Oct;18(4):721-7.
4. Premature stimulation of rat sucrase-isomaltase (SI) by exogenous insulin and the analog B-Asp10 is regulated by a receptor-mediated signal triggering SI gene transcription. Buts JP, etal., Pediatr Res. 1998 May;43(5):585-91.
5. Cloning and sequencing of a full-length rat sucrase-isomaltase-encoding cDNA. Chandrasena G, etal., Gene 1994 Dec 15;150(2):355-60.
6. Sucrase-isomaltase gene expression in suckling rat intestine: hormonal, dietary, and growth factor control. Emvo EN, etal., J Pediatr Gastroenterol Nutr. 1996 Oct;23(3):262-9.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants. Hauri HP, etal., J Biol Chem. 1982 Apr 25;257(8):4522-8.
10. Enhancement of brush border membrane peptidase activity in rat jejunum induced by starvation. Ihara T, etal., Pflugers Arch. 2000 May;440(1):75-83.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Enhancement of sucrase-isomaltase gene expression induced by luminally administered fructose in rat jejunum. Kishi K, etal., J Nutr Biochem. 1999 Jan;10(1):8-12.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Total intestinal lactase and sucrase activities are reduced in aged rats. Lee MF, etal., J Nutr. 1997 Jul;127(7):1382-7.
15. Sucrase-isomaltase ontogeny: synergism between glucocorticoids and thyroxine reflects increased mRNA and no change in cell migration. Leeper LL, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):765-70.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase. Spodsberg N, etal., J Biol Chem 2001 Dec 7;276(49):46597-604.
24. Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine. Traber PG Biochem Biophys Res Commun 1990 Dec 31;173(3):765-73.
25. A role for myosin-1A in the localization of a brush border disaccharidase. Tyska MJ and Mooseker MS, J Cell Biol. 2004 May 10;165(3):395-405.
26. Dietary regulation of sucrase-isomaltase gene expression in rat jejunum. Yasutake H, etal., Biochim Biophys Acta. 1995 Feb 23;1243(2):270-6.
27. Expression of intestinal brush-border membrane hydrolases and ferritin after segmental ischemia-reperfusion in rats. Yeh KY, etal., Am J Physiol. 1998 Sep;275(3 Pt 1):G572-83.
28. Vitamin A exerts its activity at the transcriptional level in the small intestine. Zaiger G, etal., Eur J Nutr. 2004 Oct;43(5):259-66. Epub 2004 Jan 28.
Additional References at PubMed
PMID:2400788   PMID:17272516   PMID:17673438   PMID:18313392   PMID:18617558   PMID:19352013   PMID:20356844   PMID:22896899   PMID:23533145  


Genomics

Comparative Map Data
Si
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22157,505,893 - 157,586,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2164,628,371 - 164,709,000 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02162,678,862 - 162,759,493 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02157,311,634 - 157,392,265 (-)NCBIRnor_WKY
Rnor_6.02170,220,794 - 170,301,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2170,221,245 - 170,301,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02189,563,145 - 189,643,699 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42163,520,975 - 163,601,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12163,470,937 - 163,551,243 (-)NCBI
Celera2151,764,945 - 151,845,208 (-)NCBICelera
RH 3.4 Map21027.6RGD
Cytogenetic Map2q32NCBI
SI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383164,978,898 - 165,157,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3164,978,898 - 165,078,496 (-)EnsemblGRCh38hg38GRCh38
GRCh373164,696,686 - 164,796,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,179,380 - 166,278,976 (-)NCBINCBI36Build 36hg18NCBI36
Build 343166,179,388 - 166,278,984NCBI
Celera3163,095,850 - 163,195,264 (-)NCBICelera
Cytogenetic Map3q26.1NCBI
HuRef3162,066,552 - 162,166,109 (-)NCBIHuRef
CHM1_13164,659,546 - 164,759,127 (-)NCBICHM1_1
T2T-CHM13v2.03167,761,814 - 167,861,399 (-)NCBIT2T-CHM13v2.0
Sis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39372,795,890 - 72,875,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl372,795,890 - 72,875,196 (-)EnsemblGRCm39 Ensembl
GRCm38372,888,557 - 72,967,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl372,888,557 - 72,967,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv37372,692,482 - 72,770,788 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36372,976,489 - 73,055,789 (-)NCBIMGSCv36mm8
Celera373,012,488 - 73,086,863 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map332.59NCBI
Si
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544814,685,963 - 14,777,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544814,686,315 - 14,777,298 (-)NCBIChiLan1.0ChiLan1.0
SI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13170,057,282 - 170,156,983 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,057,750 - 170,154,502 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03161,961,038 - 162,104,054 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,284,869 - 30,373,749 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,284,858 - 30,373,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3439,346,430 - 39,434,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03430,347,263 - 30,435,400 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13430,290,443 - 30,378,872 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03430,241,911 - 30,330,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03430,511,922 - 30,599,883 (-)NCBIUU_Cfam_GSD_1.0
Si
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560296,367,610 - 96,445,267 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367071,153,538 - 1,228,220 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367071,153,538 - 1,228,220 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13104,296,283 - 104,379,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113104,296,281 - 104,379,558 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213112,716,702 - 112,812,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11524,480,060 - 24,582,468 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1524,482,865 - 24,582,394 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606333,458,175 - 33,557,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Si
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473042,984,431 - 43,112,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473042,984,277 - 43,112,819 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Si
881 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000046681
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat

Markers in Region
RH94508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22157,506,068 - 157,506,194 (+)MAPPERmRatBN7.2
Rnor_6.02170,220,969 - 170,221,094NCBIRnor6.0
Rnor_5.02189,563,320 - 189,563,445UniSTSRnor5.0
RGSC_v3.42163,521,150 - 163,521,275UniSTSRGSC3.4
Celera2151,765,120 - 151,765,245UniSTS
RH 3.4 Map21027.6UniSTS
Cytogenetic Map2q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium 2
Low 8
Below cutoff 1 18 3 1 2 1 32 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046681   ⟹   ENSRNOP00000045106
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)Ensembl
Rnor_6.0 Ensembl2170,221,245 - 170,300,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088131   ⟹   ENSRNOP00000072960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)Ensembl
Rnor_6.0 Ensembl2170,240,644 - 170,301,348 (-)Ensembl
RefSeq Acc Id: NM_001389226   ⟹   NP_001376155
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22157,505,893 - 157,586,228 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376155 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42144 (Get FASTA)   NCBI Sequence Viewer  
  AAA65097 (Get FASTA)   NCBI Sequence Viewer  
  CAA33552 (Get FASTA)   NCBI Sequence Viewer  
  P23739 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000045106   ⟸   ENSRNOT00000046681
RefSeq Acc Id: ENSRNOP00000072960   ⟸   ENSRNOT00000088131
RefSeq Acc Id: NP_001376155   ⟸   NM_001389226
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23739-F1-model_v2 AlphaFold P23739 1-1841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691378
Promoter ID:EPDNEW_R1901
Type:multiple initiation site
Name:Si_1
Description:sucrase-isomaltase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02170,301,376 - 170,301,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3675 AgrOrtholog
BioCyc Gene G2FUF-52801 BioCyc
Ensembl Genes ENSRNOG00000031067 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045106 ENTREZGENE
  ENSRNOP00000045106.5 UniProtKB/TrEMBL
  ENSRNOP00000072960.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046681 ENTREZGENE
  ENSRNOT00000046681.5 UniProtKB/TrEMBL
  ENSRNOT00000088131.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gal_mutarotase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gal_mutarotase_sf_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_31_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_31_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro_31_N_dom UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 497756 ENTREZGENE
Pfam Gal_mutarotas_2 UniProtKB/TrEMBL
  Glyco_hydro_31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NtCtMGAM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trefoil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Si PhenoGen
PROSITE GLYCOSYL_HYDROL_F31_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYCOSYL_HYDROL_F31_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_TREFOIL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_TREFOIL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74650 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K499_RAT UniProtKB/TrEMBL
  F1M792_RAT UniProtKB/TrEMBL
  P23739 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Si  sucrase-isomaltase  Si  sucrase-isomaltase (alpha-glucosidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Si  sucrase-isomaltase (alpha-glucosidase)  Si  Sucrase-isomaltase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Si  Sucrase-isomaltase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization sorted to apical pole of cell 70229
gene_expression expressed in intestine 70229