Tp53bp2 (tumor protein p53 binding protein, 2) - Rat Genome Database

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Gene: Tp53bp2 (tumor protein p53 binding protein, 2) Rattus norvegicus
Analyze
Symbol: Tp53bp2
Name: tumor protein p53 binding protein, 2
RGD ID: 1305461
Description: Predicted to enable NF-kappaB binding activity; identical protein binding activity; and p53 binding activity. Involved in positive regulation of neuron death. Located in nucleus. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptosis-stimulating of p53 protein 2; LOC305025; transformation related protein 53 binding protein 2; Trp53bp2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21394,088,769 - 94,145,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,088,709 - 94,145,432 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.013100,817,206 - 100,873,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,817,359 - 100,873,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,753,296 - 105,809,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,432,144 - 98,468,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,637,078 - 98,657,218 (+)NCBI
Celera1393,622,140 - 93,678,598 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo. Wilson AM, etal., J Neurosci. 2013 Jan 30;33(5):2205-16. doi: 10.1523/JNEUROSCI.2635-12.2013.
Additional References at PubMed
PMID:10498867   PMID:10646860   PMID:11684014   PMID:14985081   PMID:16702401   PMID:18448430   PMID:19377511  


Genomics

Comparative Map Data
Tp53bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21394,088,769 - 94,145,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,088,709 - 94,145,432 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.013100,817,206 - 100,873,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13100,817,359 - 100,873,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013105,753,296 - 105,809,937 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,432,144 - 98,468,555 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11398,637,078 - 98,657,218 (+)NCBI
Celera1393,622,140 - 93,678,598 (+)NCBICelera
Cytogenetic Map13q26NCBI
TP53BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,779,893 - 223,845,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1223,779,893 - 223,845,954 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,967,595 - 224,033,649 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361222,034,218 - 222,100,297 (-)NCBINCBI36Build 36hg18NCBI36
Build 341220,274,525 - 220,340,354NCBI
Celera1197,123,518 - 197,189,585 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1194,580,009 - 194,645,609 (-)NCBIHuRef
CHM1_11225,239,932 - 225,305,937 (-)NCBICHM1_1
T2T-CHM13v2.01222,969,626 - 223,035,675 (-)NCBIT2T-CHM13v2.0
Trp53bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,236,732 - 182,290,001 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,236,737 - 182,289,997 (+)EnsemblGRCm39 Ensembl
GRCm381182,409,167 - 182,462,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,409,172 - 182,462,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,339,298 - 184,392,567 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,265,679 - 184,299,107 (+)NCBIMGSCv36mm8
Celera1189,451,621 - 189,504,880 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.93NCBI
Tp53bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,257,216 - 1,285,322 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,254,853 - 1,285,118 (+)NCBIChiLan1.0ChiLan1.0
TP53BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11204,414,218 - 204,455,684 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1204,414,218 - 204,457,739 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01199,403,194 - 199,469,079 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TP53BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1740,296,278 - 40,329,818 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl740,252,697 - 40,329,828 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha739,756,134 - 39,812,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0740,106,096 - 40,162,517 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl740,106,090 - 40,162,517 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1739,948,627 - 40,004,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0739,956,926 - 40,012,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0740,225,931 - 40,281,873 (+)NCBIUU_Cfam_GSD_1.0
Tp53bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934453,747,260 - 53,810,316 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526936,359 - 1,000,076 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936526936,981 - 1,000,070 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,823,936 - 19,889,869 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,823,932 - 19,889,883 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21024,461,166 - 24,527,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TP53BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,774,037 - 5,841,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl255,774,063 - 5,841,709 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660555,987,406 - 6,055,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,744,543 - 5,790,603 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,744,973 - 5,790,840 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tp53bp2
272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000004330
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
BF390313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,142,295 - 94,142,466 (+)MAPPERmRatBN7.2
Rnor_6.013100,870,702 - 100,870,872NCBIRnor6.0
Rnor_5.013105,806,802 - 105,806,972UniSTSRnor5.0
RGSC_v3.41398,465,420 - 98,465,590UniSTSRGSC3.4
Celera1393,675,518 - 93,675,688UniSTS
RH 3.4 Map13654.8UniSTS
Cytogenetic Map13q26UniSTS
BE102377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,145,214 - 94,145,389 (+)MAPPERmRatBN7.2
Rnor_6.013100,873,620 - 100,873,794NCBIRnor6.0
Rnor_5.013105,809,720 - 105,809,894UniSTSRnor5.0
RGSC_v3.41398,468,338 - 98,468,512UniSTSRGSC3.4
Celera1393,678,381 - 93,678,555UniSTS
RH 3.4 Map13639.5UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 18 11 7 11 2 73 31 33 11
Low 1 17 39 30 12 30 8 9 1 4 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004330   ⟹   ENSRNOP00000004330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,088,709 - 94,145,432 (+)Ensembl
Rnor_6.0 Ensembl13100,817,359 - 100,873,890 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105977   ⟹   ENSRNOP00000095274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,109,244 - 94,139,460 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106232   ⟹   ENSRNOP00000086362
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,115,136 - 94,145,432 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112631   ⟹   ENSRNOP00000094906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,109,177 - 94,145,432 (+)Ensembl
RefSeq Acc Id: XM_039091490   ⟹   XP_038947418
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21394,088,769 - 94,145,432 (+)NCBI
RefSeq Acc Id: XM_223012   ⟹   XP_223012
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21394,088,769 - 94,145,436 (+)NCBI
Rnor_6.013100,817,206 - 100,873,837 (+)NCBI
Rnor_5.013105,753,296 - 105,809,937 (+)NCBI
RGSC_v3.41398,432,144 - 98,468,555 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_038947418 (Get FASTA)   NCBI Sequence Viewer  
  XP_223012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94874 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_223012   ⟸   XM_223012
- Peptide Label: isoform X1
- UniProtKB: F1M5H6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004330   ⟸   ENSRNOT00000004330
RefSeq Acc Id: XP_038947418   ⟸   XM_039091490
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086362   ⟸   ENSRNOT00000106232
RefSeq Acc Id: ENSRNOP00000095274   ⟸   ENSRNOT00000105977
RefSeq Acc Id: ENSRNOP00000094906   ⟸   ENSRNOT00000112631
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5H6-F1-model_v2 AlphaFold F1M5H6 1-1128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305461 AgrOrtholog
BioCyc Gene G2FUF-17075 BioCyc
Ensembl Genes ENSRNOG00000003237 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004330 ENTREZGENE
  ENSRNOP00000004330.6 UniProtKB/TrEMBL
  ENSRNOP00000086362.1 UniProtKB/TrEMBL
  ENSRNOP00000094906.1 UniProtKB/TrEMBL
  ENSRNOP00000095274.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004330 ENTREZGENE
  ENSRNOT00000004330.8 UniProtKB/TrEMBL
  ENSRNOT00000105977.1 UniProtKB/TrEMBL
  ENSRNOT00000106232.1 UniProtKB/TrEMBL
  ENSRNOT00000112631.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:305025 UniProtKB/TrEMBL
NCBI Gene 305025 ENTREZGENE
PANTHER APOPTOSIS-STIMULATING OF P53 PROTEIN UniProtKB/TrEMBL
  APOPTOSIS-STIMULATING OF P53 PROTEIN 2 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Tp53bp2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6A5P5_RAT UniProtKB/TrEMBL
  A0A8I6AMB5_RAT UniProtKB/TrEMBL
  A0A8I6ANU5_RAT UniProtKB/TrEMBL
  F1M5H6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tp53bp2  tumor protein p53 binding protein, 2  Trp53bp2  transformation related protein 53 binding protein 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Trp53bp2  transformation related protein 53 binding protein 2   Trp53bp2_predicted  transformation related protein 53 binding protein 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Trp53bp2_predicted  transformation related protein 53 binding protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED