Predicted to enable several functions, including cysteine-type endopeptidase activator activity; identical protein binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; protein-containing complex assembly; and regulation of defense response. Predicted to act upstream of or within cellular response to xenobiotic stimulus and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrion. Predicted to be part of AIM2 inflammasome complex. Predicted to be active in cytosol; nucleoplasm; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2); PARTICIPATES IN interleukin-1 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein, [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AIM2 protein
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein, [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AIM2 protein
AIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein], AIM2 protein promotes the reaction [Melitten results in increased expression of IL1B protein]
AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP1 protein], AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein]
AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP1 protein], AIM2 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased secretion of IL1B protein]
[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein, [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of AIM2 protein
