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Gene: Bmp3 (bone morphogenetic protein 3) Rattus norvegicus

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Symbol:

Bmp3

Name:

bone morphogenetic protein 3

RGD ID:

2212

Description:

Enables growth factor activity. Predicted to be involved in negative regulation of ossification. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Orthologous to human BMP3 (bone morphogenetic protein 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BMP-3; PBMP3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BMP3 (bone morphogenetic protein 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Bmp3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bmp3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BMP3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BMP3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bmp3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BMP3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BMP3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bmp3 (bone morphogenetic protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Bmp3 (bone morphogenetic protein 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BMP3 (bone morphogenetic protein 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bmp3 (bone morphogenetic protein 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-129	Alliance	DIOPT (Hieranoid\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	bmp3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	11,012,564 - 11,041,282 (-)	NCBI		GRCr8
mRatBN7.2	14	10,712,489 - 10,737,153 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	10,712,489 - 10,737,153 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	10,681,236 - 10,705,924 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	11,981,060 - 12,005,746 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	10,676,050 - 10,700,766 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	12,362,912 - 12,387,572 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,359,363 - 12,387,102 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,306,370 - 12,331,030 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	12,065,635 - 12,090,295 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	12,065,634 - 12,090,295 (-)	NCBI
Celera	14	10,801,184 - 10,825,826 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Tibial Fractures (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

dibutyl phthalate (EXP)

endosulfan (EXP)

ethanol (ISO)

ethylparaben (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

glycerol 2-phosphate (EXP)

glyphosate (EXP)

L-ascorbic acid (EXP)

lead diacetate (EXP)

lead(0) (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodimethylamine (EXP)

naringin (ISO)

nitrofen (EXP)

ozone (ISO)

paraquat (EXP)

pentane-2,3-dione (EXP)

quercetin (EXP)

rotenone (ISO)

Senkirkine (EXP)

sodium arsenite (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage development (IEA)

cell differentiation (IEA)

negative regulation of ossification (IEA,ISO)

ossification (IEA)

osteoblast differentiation (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IDA,IEA)

vesicle (IDA)

Molecular Function

BMP receptor binding (IEA,ISO)

cytokine activity (IBA,IEA)

growth factor activity (IDA,IEA,TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins.	Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats.	Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Transcripts for two members of the transforming growth factor-beta superfamily BMP-3 and BMP-7 are expressed in developing rat embryos.	Takahashi H and Ikeda T, Dev Dyn 1996 Dec;207(4):439-49.
10.	Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3.	Takao M, etal., Biochem Biophys Res Commun 1996 Feb 15;219(2):656-62.
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:1468569	PMID:7811286	PMID:7880444	PMID:12689682	PMID:16048524	PMID:16217479	PMID:19199708	PMID:21415150	PMID:27130896	PMID:32568738

Genomics

Comparative Map Data

Bmp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	11,012,564 - 11,041,282 (-)	NCBI		GRCr8
mRatBN7.2	14	10,712,489 - 10,737,153 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	10,712,489 - 10,737,153 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	10,681,236 - 10,705,924 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	11,981,060 - 12,005,746 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	10,676,050 - 10,700,766 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	12,362,912 - 12,387,572 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	12,359,363 - 12,387,102 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	12,306,370 - 12,331,030 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	12,065,635 - 12,090,295 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	12,065,634 - 12,090,295 (-)	NCBI
Celera	14	10,801,184 - 10,825,826 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

BMP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	81,030,708 - 81,057,627 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	81,030,708 - 81,057,627 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	81,951,862 - 81,978,781 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	82,171,143 - 82,197,709 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	82,309,297 - 82,331,904	NCBI
Celera	4	79,245,158 - 79,271,726 (+)	NCBI		Celera
Cytogenetic Map	4	q21.21	NCBI
HuRef	4	77,696,010 - 77,722,586 (+)	NCBI		HuRef
CHM1_1	4	81,928,619 - 81,955,186 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	84,360,741 - 84,387,664 (+)	NCBI		T2T-CHM13v2.0

Bmp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	99,002,274 - 99,031,912 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	99,002,274 - 99,032,255 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	98,854,415 - 98,884,053 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	98,854,415 - 98,884,396 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	99,283,458 - 99,309,979 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	99,094,741 - 99,120,430 (+)	NCBI		MGSCv36	mm8
Celera	5	96,176,773 - 96,203,304 (+)	NCBI		Celera
Cytogenetic Map	5	E3	NCBI
cM Map	5	48.24	NCBI

Bmp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	5,211,592 - 5,246,194 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	5,194,312 - 5,246,125 (+)	NCBI	ChiLan1.0	ChiLan1.0

BMP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	49,012,023 - 49,039,117 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	49,200,736 - 49,227,920 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	43,143,784 - 43,170,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	48,992,172 - 49,018,780 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	48,992,266 - 49,019,205 (-)	Ensembl	panpan1.1		panPan2

BMP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	5,206,040 - 5,233,848 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	5,207,833 - 5,231,966 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	36,645,845 - 36,674,004 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	5,238,247 - 5,266,418 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	5,237,314 - 5,263,865 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	5,267,894 - 5,294,547 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	5,175,043 - 5,202,995 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	34,764,153 - 34,792,337 (-)	NCBI		UU_Cfam_GSD_1.0

Bmp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	7,106,302 - 7,130,557 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936749	1,025,546 - 1,053,902 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936749	1,025,867 - 1,053,578 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BMP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	136,880,456 - 136,904,739 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	136,880,456 - 136,904,739 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	146,174,734 - 146,199,020 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BMP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	29,454,394 - 29,482,560 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	29,455,761 - 29,482,896 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	7,954,672 - 7,982,356 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bmp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	9,956,293 - 9,980,234 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624757	9,952,847 - 9,980,259 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bmp3
273 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	88
Interacting mature miRNAs:	92
Transcripts:	ENSRNOT00000038872
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat

Markers in Region

D14Wox27

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,736,928 - 10,737,099 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,387,348 - 12,387,518	NCBI	Rnor6.0
Rnor_5.0	14	12,330,806 - 12,330,976	UniSTS	Rnor5.0
RGSC_v3.4	14	12,090,071 - 12,090,241	UniSTS	RGSC3.4
Celera	14	10,825,602 - 10,825,772	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH94474

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,712,529 - 10,712,629 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,362,953 - 12,363,052	NCBI	Rnor6.0
Rnor_5.0	14	12,306,411 - 12,306,510	UniSTS	Rnor5.0
RGSC_v3.4	14	12,065,676 - 12,065,775	UniSTS	RGSC3.4
Celera	14	10,801,225 - 10,801,324	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH138863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	10,712,044 - 10,712,177 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	12,362,468 - 12,362,600	NCBI	Rnor6.0
Rnor_5.0	14	12,305,926 - 12,306,058	UniSTS	Rnor5.0
RGSC_v3.4	14	12,065,191 - 12,065,323	UniSTS	RGSC3.4
Celera	14	10,800,740 - 10,800,872	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	84	83	52	25	52	6	211	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D29768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D63860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038872 ⟹ ENSRNOP00000032031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	10,719,670 - 10,737,153 (-)	Ensembl
Rnor_6.0 Ensembl	14	12,359,363 - 12,387,102 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104172 ⟹ ENSRNOP00000084580

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	10,712,489 - 10,737,153 (-)	Ensembl

RefSeq Acc Id:

NM_017105 ⟹ NP_058801

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	11,016,620 - 11,041,282 (-)	NCBI
mRatBN7.2	14	10,712,489 - 10,737,153 (-)	NCBI
Rnor_6.0	14	12,362,912 - 12,387,572 (-)	NCBI
Rnor_5.0	14	12,306,370 - 12,331,030 (-)	NCBI
RGSC_v3.4	14	12,065,635 - 12,090,295 (-)	RGD
Celera	14	10,801,184 - 10,825,826 (-)	RGD

Sequence:

show sequence

GTCGAGCTAGAGGCTAGAGGGAGAACTTGGCCACAGGCGGACCAGACAGATCAGATCAGGGCAA
GAAGGAACAGAACCAGTCTGTCTCTCTGTCTCTGTCTCTCTGTCTCTGTGTGTGTGTGTGTCTC
TCTCTGTCTCTCTGTGTCTCTACACACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACCACGTCCTCTGAGAACTCAGCTGGCTGCGACCGCGCACACCCCGCCC
GGGCGCGCGTCCCAGGCTGGTGGAGCGCAGATCCAGATCCCCATAGCGGCCGGGTGTTCCCGAG
TCTCAGGTGGCGCGGAAGGGAGAACCCGCGCTTGACAACTCGTCTGCGCTCGCCCAGACCTTCC
GCCCTCGGACCGGCCGGTGAGCGGAGCTGAGCGGGTGCGGCTGCCACCCAGAGCCCACCTGCCG
ACCCTCGCGTCGCGGCCCCGCGCCAGCTGTGCCGGGCTCCCGGCGCCCGCTCCGCAGCTGGAGC
GCCACCCCGGCTCTACTACAGTCCCTTCCGTCTCCAGAGTGTCCCGGACGACGGCGACCCGAAG
TAGCGCGGCACGACAGCGGGACTTGACTATGGCTGGGGCTCGCGGGCTGCTGTGTCTGTGGCTA
GGTTGTTTCTGCCTGAACCTGGCACAGGGACAGAGACCAAATTTGCACCTCCCGGGACTCCGCG
GGACTGAGTCAAGCGACCGCATGACAGGTGGTGGCCCGAGCCCGGACCTGAGGCCTCACGACAA
GGTGTCAGAGCATATGCTGTGGCTCTATGACAGGTACAGCGGCAGCAACAGAGCCCAGGCTACC
CGGACACCGGGCTCGCAGCTCCCGGGTCCCCAACCCCTGCGTGGCGGTAACACGGTTCGTAGCT
TCAGAGCCGCAGCCGCAGGAACTCTTCAAAGAAAGGGCTTGCACACTTTTAATCTGACTTCTCT
AACCAAGTCTGAGAACATTTTGTCAGCCACACTGTATTTCTACATTGGAGAATTGGTGAACACC
AGTGTGAACTGTCCAGAATCCCAAGGTTGTTCCCATGACAGCCAGAGACAACACATCCAGATAG
ACCTCTCTGCATGGACCCTCCAATCCAACCAAAGCCAGCTCTTGGGTCATCTGTCAGTAGATAC
GGCCAAACCTTATAGAGACAGCATGTCTTGGCTGTCAAAAGACATCACTCAGCTCTTACGGAAG
GCCAAGCAAGACGAGGAGTTTCTCATAGGATTTAACATTACCTCCAGAGCACACGAGCTTCCCA
AGAGGATGCTGCTTTTCCCGGAACCTTATATCTTGGTGTATGCCAACGATGCCGCCATTTGTGA
GCCTGAAAGCGTGGTATCTAGCCTACAGAGACACCGCGATTTCACAGCAGGAACTGTGCCCAGA
CTGGATAGCCACGTCAGAGAAGCCCTCTCTGTTGAGAGGAGGAAGAAGCGCTCTACTGGGATCT
TGTTGCCATTGCAGAACAACGAGCTCCCTGGGGCCGAGTATCAGTACAAGGAGGCTGGAGTGTG
GGAGGAGAGAAAGCCTTACAAGAGCCTTCAGACTCAGCCTCCTGAAAAGAGCCGGAGCAAAAAG
AAACAGAGGAAAGGGCCTCATCAAAAGGGACAGACACTGCAGTTTGATGAGCAGACACTGAAGA
AGGCGAGGCGAAAGCAGTGGATCGAGCCTCGGAACTGTGCCCGCAGGTACCTTAAAGTGGACTT
TGCCGATATTGGCTGGAGCGAATGGATTATCTCCCCCAAGTCATTTGATGCCTACTATTGCTCC
GGAGCCTGCCAGTTCCCCATGCCAAAGTCTTTGAAGCCATCAAATCACGCCACCATCCAGAGCA
TAGTGAGAGCCGTGGGGGTCGTCTCTGGGATTCCTGAGCCCTGCTGTGTTCCGGAGAAGATGTC
CTCGCTCAGCATCTTGTTCTTTGACGAGAACAAGAATGTGGTCCTCAAAGTCTATCCTAACATG
ACAGTAGACTCTTGTGCTTGTAGATAACCTAGCAGAGAACACACTCAAACGCTCCATTCAATCA
TTAATTGGGTTTTATGGACTTTTATTTTTGTCTTTTGCACTGCCAATGCATTTTGTCCCAAAAG
ATGTTTTATAGCAGAAAGAAAATGAACAAAGAGATCGAAGATTTCC

hide sequence

RefSeq Acc Id:

XM_063272879 ⟹ XP_063128949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	11,012,564 - 11,038,264 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_058801	(Get FASTA)	NCBI Sequence Viewer
	XP_063128949	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA09922	(Get FASTA)	NCBI Sequence Viewer
	BAA31852	(Get FASTA)	NCBI Sequence Viewer
	EDL99613	(Get FASTA)	NCBI Sequence Viewer
	EDL99614	(Get FASTA)	NCBI Sequence Viewer
	EDL99615	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000084580
GenBank Protein	P49002	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058801 ⟸ NM_017105
- Peptide Label:	precursor
- UniProtKB:	P49002 (UniProtKB/Swiss-Prot), A0A8I6A2A8 (UniProtKB/TrEMBL), A6K643 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGARGLLCLWLGCFCLNLAQGQRPNLHLPGLRGTESSDRMTGGGPSPDLRPHDKVSEHMLWLY DRYSGSNRAQATRTPGSQLPGPQPLRGGNTVRSFRAAAAGTLQRKGLHTFNLTSLTKSENILSA TLYFYIGELVNTSVNCPESQGCSHDSQRQHIQIDLSAWTLQSNQSQLLGHLSVDTAKPYRDSMS WLSKDITQLLRKAKQDEEFLIGFNITSRAHELPKRMLLFPEPYILVYANDAAICEPESVVSSLQ RHRDFTAGTVPRLDSHVREALSVERRKKRSTGILLPLQNNELPGAEYQYKEAGVWEERKPYKSL QTQPPEKSRSKKKQRKGPHQKGQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWI ISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVSGIPEPCCVPEKMSSLSILFFDE NKNVVLKVYPNMTVDSCACR hide sequence

Ensembl Acc Id:

ENSRNOP00000032031 ⟸ ENSRNOT00000038872

Ensembl Acc Id:

ENSRNOP00000084580 ⟸ ENSRNOT00000104172

RefSeq Acc Id:	XP_063128949 ⟸ XM_063272879
- Peptide Label:	isoform X1

Protein Domains

TGF-beta family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P49002-F1-model_v2	AlphaFold	P49002	1-468	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2212	AgrOrtholog
BioCyc Gene	G2FUF-16366	BioCyc
Ensembl Genes	ENSRNOG00000002381	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000104172	ENTREZGENE
Gene3D-CATH	2.10.90.10	UniProtKB/Swiss-Prot
	2.60.120.970	UniProtKB/Swiss-Prot
InterPro	BMP3/BMP3B	UniProtKB/Swiss-Prot
	Cystine-knot_cytokine	UniProtKB/Swiss-Prot
	TGF-b_C	UniProtKB/Swiss-Prot
	TGF-beta-rel	UniProtKB/Swiss-Prot
	TGFb_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:25667	UniProtKB/Swiss-Prot
NCBI Gene	25667	ENTREZGENE
PANTHER	BONE MORPHOGENETIC PROTEIN 3	UniProtKB/Swiss-Prot
	PTHR11848	UniProtKB/Swiss-Prot
Pfam	TGF_beta	UniProtKB/Swiss-Prot
PhenoGen	Bmp3	PhenoGen
PIRSF	BMP3/GDF10	UniProtKB/Swiss-Prot
PROSITE	TGF_BETA_1	UniProtKB/Swiss-Prot
	TGF_BETA_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002381	RatGTEx
SMART	TGFB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57501	UniProtKB/Swiss-Prot
TIGR	TC210053
UniProt	A0A8I6A2A8	ENTREZGENE, UniProtKB/TrEMBL
	A6K643	ENTREZGENE, UniProtKB/TrEMBL
	A6K645_RAT	UniProtKB/TrEMBL
	BMP3_RAT	UniProtKB/Swiss-Prot
	G3V903_RAT	UniProtKB/TrEMBL
	P49002	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Bmp3	Bone morphogenetic protein 3			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in developing hair follicle, tooth, kidney, and lung tissues	631741
gene_expression	expressed in femur, calvaria, trachea, lung and ovary	631791
gene_function	growth factor molecule	631741
gene_homology	has 98% identity to human protein	631791
gene_process	may play important role in organogenesis	631741
gene_product	member of the transforming growth factor beta superfamily	631741

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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